M. Kobayashi

发表

Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.

H. Ishihara, T. Sasaoka, H. Hori, 1999, Biochemical and biophysical research communications.

Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.

H. Ishihara, T. Sasaoka, T. Wada, 1999, Endocrinology.

Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.

T. Imamura, T. Sasaoka, T. Haruta, 1997, Biochemical and biophysical research communications.

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Diabetes.

Impaired Autophosphorylation of Insulin Receptors From Abdominal Skeletal Muscles in Nonobese Subjects With NIDDM

H. Maegawa, K. Egawa, M. Kobayashi, 1991, Diabetes.

Insulin binding to differentiating muscle cell line L6.

M. Kobayashi, Y. Takata, O. Ishibashi, 1986, Diabetes research and clinical practice.

SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes

H. Ishihara, T. Sasaoka, H. Hori, 2001, Diabetologia.

Insulin-like growth factor I receptors on erythrocytes in NIDDM.

T. Haruta, M. Kobayashi, Y. Takata, 1989, Diabetes research and clinical practice.

Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

T. Imamura, H. Ishihara, T. Sasaoka, 1997, Diabetologia.

Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion.

A. Kashiwagi, M. Kobayashi, H. Yasuda, 1981, The Journal of clinical endocrinology and metabolism.

Erythrocyte insulin receptors in patients with chronic liver diseases.

M. Kobayashi, Y. Shigeta, T. Takimoto, 1982, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

J. Olefsky, M. Kobayashi, 1979, Diabetes.

[A case of familial insulin resistance due to type A insulin receptor disorder].

K. Egawa, T. Haruta, M. Kobayashi, 1993, Nihon Naibunpi Gakkai zasshi.

Effect of diet change on insulin action: difference between muscles and adipocytes.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, The American journal of physiology.

In vivo and in vitro effect of p-chlorophenoxyisobutyrate on insulin binding and glucose transport in isolated rat adipocytes.

H. Maegawa, M. Kobayashi, Y. Takata, 1985, Endocrinologia japonica.

Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats.

M. Kobayashi, M. Iwanishi, 1993, Metabolism: clinical and experimental.

Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase

K. Egawa, M. Kobayashi, Y. Shigeta, 1992, Diabetes.

Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes.

J. Olefsky, M. Kobayashi, 1978, The American journal of physiology.

Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity.

H. Maegawa, K. Inouye, M. Kobayashi, 1982, The Biochemical journal.

Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats.

J. Olefsky, M. Kobayashi, 1978, The Journal of clinical investigation.

Low Frequency of the Large Insertion in the Human Insulin Gene in Japanese

H. Maegawa, M. Haneda, M. Kobayashi, 1986, Diabetes.

Effect of glimepiride (HOE 490) on insulin receptors of skeletal muscles from genetically diabetic KK-Ay mouse.

T. Imamura, H. Ishihara, M. Kobayashi, 1996, European journal of pharmacology.

Improvement of Glucose Tolerance in NIDDM by Clofibrate Randomized Double-Blind Study

M. Kobayashi, Y. Omori, Y. Shigeta, 1988, Diabetes Care.

Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes

J. Olefsky, M. Kobayashi, 1979, Diabetologia.

W-7 specifically inhibits insulin-induced increase in glucose transport.

T. Sasaoka, M. Kobayashi, O. Ishibashi, 1989, Diabetes research and clinical practice.

Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Long-term in vitro effects of insulin on insulin binding and glucose transport.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Diabetes research and clinical practice.

Ability of circulating insulin to chronically regulate the cellular glucose transport system.

J. Olefsky, M. Kobayashi, 1978, Metabolism: clinical and experimental.

Mechanisms of fasting-induced increase in insulin binding to rat adipocytes.

J. Olefsky, M. Kobayashi, 1978, The Journal of clinical investigation.

Insulin, S-sulphonate A and S-sulphonate B-chain receptor binding to human cultured lymphocytes

M. Kobayashi, J. Meek, 1977, Diabetologia.

Effect of acute exercise on insulin binding to erythrocytes in type II diabetes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1982, Endocrinologia japonica.

Clarification of Signaling Pathways Mediated by Insulin and Insulin-Like Growth Factor I Receptors in Fibroblasts From Patients With Specific Defect in Insulin Receptor

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Effect of duration of diabetic state on insulin action in isolated rat soleus muscles.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

A new potentiator of insulin action

H. Maegawa, M. Kobayashi, Y. Shigeta, 1983, FEBS letters.

Insulin binding and glucose uptake of adipocytes in rats adapted to hypergravitational force.

M. Kobayashi, C. Mondon, J. Oyama, 1980, The American journal of physiology.

Effect of age and sex on insulin binding to human erythrocytes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1981, Endocrinologia japonica.

Unprocessed insulin proreceptor in cultured fibroblasts from a patient with extreme insulin resistance.

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Metabolism: clinical and experimental.

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

J. Olefsky, T. Imamura, H. Ishihara, 1996, Endocrinology.

Fluctuation of insulin resistance in a leprechaun with a primary defect in insulin binding.

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, The Journal of clinical endocrinology and metabolism.

A primary defect in insulin receptor in a young male patient with insulin resistance.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis.

H. Ishihara, T. Sasaoka, H. Hori, 1999, Endocrinology.

Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Diabetologia.

The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Metabolism: clinical and experimental.

Diabetes due to secretion of an abnormal insulin.

J. Olefsky, M. Kobayashi, O. Kolterman, 1980, The New England journal of medicine.

Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine]- and [B24-leucine, B25-leucine]-analogues of human insulin

K. Inouye, M. Kobayashi, Y. Shigeta, 2005, Experientia.

Semisynthesis and properties of some insulin analogs

K. Inouye, M. Kobayashi, Y. Shigeta, 1981, Biopolymers.

Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism.

J. Olefsky, M. Kobayashi, R. Hintz, 1978, Proceedings of the National Academy of Sciences of the United States of America.

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

J. Olefsky, Prem M. Sharma, K. Egawa, 2000, Molecular endocrinology.

Inhibition of down regulation by chloroquine in cultured lymphocytes (RPMI-1788 line).

H. Maegawa, M. Kobayashi, Y. Takata, 1985, Diabetes research and clinical practice.

The insulin receptor in myotonic dystrophy.

M. Kobayashi, J. Meek, E. Streib, 1977, The Journal of clinical endocrinology and metabolism.

Immunoreactivity and Biologic Activity of Semisynthetic [LeuB30]-Insulin: Potential Value in the Treatment of Insulin Antibody-Mediated Insulin Resistance

M. Kobayashi, K. Morihara, Y. Shigeta, 1981, Diabetes.

Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.

H. Ishihara, T. Sasaoka, H. Hori, 2001, Endocrinology.

Intracellular signalling pathways of okadaic acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors: okadaic acid regulates Shc phosphorylation by mechanisms independent of insulin.

H. Ishihara, T. Sasaoka, T. Wada, 1999, Cellular signalling.

Functional Importance of Amino-terminal Domain of Shc for Interaction with Insulin and Epidermal Growth Factor Receptors in Phosphorylation-independent Manner*

T. Imamura, H. Ishihara, T. Sasaoka, 1996, The Journal of Biological Chemistry.

Receptor binding and negative cooperativity of a mutant insulin, [LeuA3]-insulin.

K. Inouye, T. Sasaoka, M. Kobayashi, 1986, Biochemical and biophysical research communications.

[A case of leprechaunism with extreme insulin resistance due to a primary defect in insulin receptors].

M. Kobayashi, Y. Takata, K. Goji, 1985, Nihon Naibunpi Gakkai zasshi.

Characterization of unprocessed insulin proreceptors in COS 7 cells transfected with cDNA with Arg735----Ser735 point mutation at the cleavage site.

M. Kobayashi, H. Teraoka, Y. Shigeta, 1992, Metabolism: clinical and experimental.

Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors.

H. Maegawa, K. Inouye, M. Kobayashi, 1982, Biochemical and biophysical research communications.

Surgical and chemical approaches to regulate hyperinsulinemia after pancreas transplantation in rats.

M. Kobayashi, Y. Takata, T. Oka, 1998, Transplantation Proceedings.

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts.

J. Olefsky, H. Maegawa, D. McClain, 1990, Biochimica et biophysica acta.

Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.

T. Sasaoka, T. Haruta, M. Kobayashi, 2000, Biochemical and biophysical research communications.

Receptor-mediated degradation by rat adipocytes: comparison of A-14 with A-19 125I-labelled insulin.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1984, Endocrinologia japonica.

Evaluation of the method of insulin binding studies in human erythrocytes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1980, Endocrinologia japonica.

Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.

H. Ishihara, T. Sasaoka, T. Wada, 1998, Biochemical and biophysical research communications.

[A case of Cushing syndrome caused by ACTH producing atypical lung carcinoid tumor].

H. Maegawa, M. Kobayashi, H. Masuzaki, 1992, Nihon Naibunpi Gakkai zasshi.

Receptor binding and biological activity of [SerB24]-insulin, an abnormal mutant insulin.

H. Maegawa, M. Haneda, K. Inouye, 1984, Biochemical and biophysical research communications.

Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors.

T. Imamura, H. Ishihara, T. Sasaoka, 1997, Endocrinology.

Co-expression of mutant and normal human insulin receptors in COS 7 cells.

H. Maegawa, A. Kashiwagi, K. Egawa, 1993, Biochimica et biophysica acta.

Bellidifolin stimulates glucose uptake in rat 1 fibroblasts and ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats.

M. Kobayashi, Y. Takata, S. Kadota, 1995, Planta medica.

Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Diabetes.

A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

T. Imamura, K. Egawa, T. Sasaoka, 1993, Diabetologia.

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

J. Olefsky, M. Kobayashi, Helen Chang, 1979, Diabetes.

The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.

T. Sasaoka, M. Kobayashi, 2000, Endocrine journal.

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site.

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Biochemical and biophysical research communications.

Insulin Resistance by Uncleaved Insulin Proreceptor: Emergence of Binding Site by Trypsin

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Biochemical and biophysical research communications.

Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes

T. Asano, M. Funaki, H. Ishihara, 2005, Diabetologia.

A structurally abnormal insulin causing human diabetes

J. Olefsky, M. Kobayashi, O. Kolterman, 1979, Nature.

Transfection of cDNA with G----T point mutation at the cleavage site of insulin receptors to COS 7 cells.

K. Egawa, T. Sasaoka, M. Kobayashi, 1990, Biochemical and Biophysical Research Communications - BBRC.

Amplification and analysis of promoter region of insulin receptor gene in a patient with leprechaunism associated with severe insulin resistance.

T. Imamura, K. Egawa, T. Haruta, 1995, Metabolism: clinical and experimental.

Receptor-binding kinetics of A-14 and A-19 125I-labelled insulin.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1984, Biochimica et biophysica acta.

Receptor mediated insulin degradation decreased by chloroquine in isolated rat adipocytes.

M. Kobayashi, Y. Shigeta, M. Iwasaki, 1980, Journal of biochemistry.

Receptor binding and biologic activity of biosynthetic human insulin and mini-proinsulin produced by recombinant gene technology.

T. Sasaoka, M. Kobayashi, Y. Shigeta, 1989, Diabetes research and clinical practice.

In vitro effects of glucocorticoid on glucose transport in rat adipocytes: evidence of a post-receptor coupling defect in insulin action.

H. Maegawa, M. Kobayashi, Y. Takata, 1984, Journal of biochemistry.

Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus.

M. Kobayashi, Y. Shigeta, K. Murakami, 1984, British journal of clinical pharmacology.

Differential Effects of Palmitate on Glucose Uptake in Rat-1 Fibroblasts and 3T3-L1 Adipocytes

H. Ishihara, T. Sasaoka, T. Wada, 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Potential Role of Gab1 and Phospholipase C-γ in Osmotic Shock-Induced Glucose Uptake in 3T3-L1 Adipocytes

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Unprocessed insulin proreceptors due to point mutation at the cleavage site.

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Diabetes research and clinical practice.

Decreased Biologic Activity and Degradation of Human [SerB24]-Insulin, a Second Mutant Insulin

H. Maegawa, M. Haneda, K. Inouye, 1985, Diabetes.

Evidence of the lack of receptor-mediated insulin degradation in human cultured lymphocytes (RPMI-1788 line).

H. Maegawa, M. Kobayashi, H. Yasuda, 1983, Endocrinologia japonica.

Effect of L-Dopa Administration on Insulin Binding: Possible Role of Growth Hormone in Regulation of Insulin Receptor Affinity

H. Maegawa, M. Kobayashi, Y. Shigeta, 1982, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

The Effect of High-Glucose Condition on Insulin Binding to IM-9 Lymphocytes

M. Kobayashi, Y. Takata, O. Ishibashi, 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Prolonged disappearance rate of a structurally abnormal mutant insulin from the circulation in humans.

H. Maegawa, M. Haneda, M. Kobayashi, 1985, The Journal of clinical endocrinology and metabolism.