Y. Takata

发表

Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.

H. Ishihara, T. Sasaoka, T. Wada, 1999, Endocrinology.

Functional Importance of Shc Tyrosine 317 on Insulin Signaling in Rat1 Fibroblasts Expressing Insulin Receptors*

T. Imamura, H. Ishihara, T. Sasaoka, 1997, The Journal of Biological Chemistry.

Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.

T. Imamura, T. Sasaoka, T. Haruta, 1997, Biochemical and biophysical research communications.

Insulin binding to differentiating muscle cell line L6.

M. Kobayashi, Y. Takata, O. Ishibashi, 1986, Diabetes research and clinical practice.

Insulin-like growth factor I receptors on erythrocytes in NIDDM.

T. Haruta, M. Kobayashi, Y. Takata, 1989, Diabetes research and clinical practice.

Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

T. Imamura, H. Ishihara, T. Sasaoka, 1997, Diabetologia.

Effect of diet change on insulin action: difference between muscles and adipocytes.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, The American journal of physiology.

In vivo and in vitro effect of p-chlorophenoxyisobutyrate on insulin binding and glucose transport in isolated rat adipocytes.

H. Maegawa, M. Kobayashi, Y. Takata, 1985, Endocrinologia japonica.

Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome*

T. Imamura, H. Ishihara, T. Sasaoka, 1998, The Journal of Biological Chemistry.

Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.

Jerrold, J. Olefsky, J. Kusari, 1991, The Journal of biological chemistry.

Effect of glimepiride (HOE 490) on insulin receptors of skeletal muscles from genetically diabetic KK-Ay mouse.

T. Imamura, H. Ishihara, M. Kobayashi, 1996, European journal of pharmacology.

Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Long-term in vitro effects of insulin on insulin binding and glucose transport.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Diabetes research and clinical practice.

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

J. Olefsky, C. Yip, D. Reichart, 1995, Endocrinology.

The insulin receptor C-terminus is involved in regulation of the receptor kinase activity.

E. Van Obberghen, J. Olefsky, N. Webster, 1993, Biochemistry.

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.

J. Olefsky, N. Webster, Y. Takata, 1991, The Journal of biological chemistry.

Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase.

J. Olefsky, A. Saltiel, M. Ohmichi, 1994, The Journal of biological chemistry.

Clarification of Signaling Pathways Mediated by Insulin and Insulin-Like Growth Factor I Receptors in Fibroblasts From Patients With Specific Defect in Insulin Receptor

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Effect of duration of diabetic state on insulin action in isolated rat soleus muscles.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

Unprocessed insulin proreceptor in cultured fibroblasts from a patient with extreme insulin resistance.

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Metabolism: clinical and experimental.

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

J. Olefsky, T. Imamura, H. Ishihara, 1996, Endocrinology.

Fluctuation of insulin resistance in a leprechaun with a primary defect in insulin binding.

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, The Journal of clinical endocrinology and metabolism.

A primary defect in insulin receptor in a young male patient with insulin resistance.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Diabetologia.

The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Metabolism: clinical and experimental.

Inhibition of down regulation by chloroquine in cultured lymphocytes (RPMI-1788 line).

H. Maegawa, M. Kobayashi, Y. Takata, 1985, Diabetes research and clinical practice.

Functional Importance of Amino-terminal Domain of Shc for Interaction with Insulin and Epidermal Growth Factor Receptors in Phosphorylation-independent Manner*

T. Imamura, H. Ishihara, T. Sasaoka, 1996, The Journal of Biological Chemistry.

Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

J. Olefsky, N. Webster, Y. Takata, 1992, The Journal of biological chemistry.

Receptor binding and negative cooperativity of a mutant insulin, [LeuA3]-insulin.

K. Inouye, T. Sasaoka, M. Kobayashi, 1986, Biochemical and biophysical research communications.

[A case of leprechaunism with extreme insulin resistance due to a primary defect in insulin receptors].

M. Kobayashi, Y. Takata, K. Goji, 1985, Nihon Naibunpi Gakkai zasshi.

A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation.

J. Olefsky, T. Sasaoka, J. Kusari, 1993, Endocrinology.

Surgical and chemical approaches to regulate hyperinsulinemia after pancreas transplantation in rats.

M. Kobayashi, Y. Takata, T. Oka, 1998, Transplantation Proceedings.

Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors.

T. Imamura, H. Ishihara, T. Sasaoka, 1997, Endocrinology.

Bellidifolin Stimulates Glucose Uptake in Rat 1 Fibroblasts and Ameliorates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Rats

M. Kobayashi, Y. Takata, S. Kadota, 1995, Planta medica.

Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

T. Sasaoka, T. Haruta, Y. Takata, 2001 .

Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Diabetes.

Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.

J. Olefsky, C. Anderson, T. Sasaoka, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Ala1048→Asp Mutation in the Kinase Domain of Insulin Receptor Causes Defective Kinase Activity and Insulin Resistance

T. Imamura, H. Maegawa, K. Egawa, 1993, Diabetes.

A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

T. Imamura, K. Egawa, T. Sasaoka, 1993, Diabetologia.

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site.

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Biochemical and biophysical research communications.

Insulin Resistance by Uncleaved Insulin Proreceptor: Emergence of Binding Site by Trypsin

T. Sasaoka, M. Kobayashi, Y. Takata, 1988, Diabetes.

Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Biochemical and biophysical research communications.

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

J. Olefsky, Y. Takata, B. Draznin, 1993, The Journal of biological chemistry.

In vitro effects of glucocorticoid on glucose transport in rat adipocytes: evidence of a post-receptor coupling defect in insulin action.

H. Maegawa, M. Kobayashi, Y. Takata, 1984, Journal of biochemistry.

Differential Effects of Palmitate on Glucose Uptake in Rat-1 Fibroblasts and 3T3-L1 Adipocytes

H. Ishihara, T. Sasaoka, T. Wada, 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.

T. Imamura, T. Sasaoka, T. Haruta, 1994, The Journal of biological chemistry.

Unprocessed insulin proreceptors due to point mutation at the cleavage site.

T. Sasaoka, M. Kobayashi, Y. Takata, 1989, Diabetes research and clinical practice.

Decreased Biologic Activity and Degradation of Human [SerB24]-Insulin, a Second Mutant Insulin

H. Maegawa, M. Haneda, K. Inouye, 1985, Diabetes.

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.

J. Olefsky, Y. Takata, Nicholas J. G. Webster, 1991, The Journal of biological chemistry.

The Effect of High-Glucose Condition on Insulin Binding to IM-9 Lymphocytes

M. Kobayashi, Y. Takata, O. Ishibashi, 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Prolonged disappearance rate of a structurally abnormal mutant insulin from the circulation in humans.

H. Maegawa, M. Haneda, M. Kobayashi, 1985, The Journal of clinical endocrinology and metabolism.