C. Moxham

发表

5 G Proteins Regulating Insulin Action and Obesity Analysis by Conditional Targeted Expression of Antisense RNA in vivo

C. Malbon, P. Galvin, C. Moxham, 1998 .

G Proteins Regulating Insulin Action and Obesity

P. Galvin-Parton, Hsien-yu Wang, C. Malbon, 1998 .

Conditional, tissue-specific expression of Q205L Gαi2 in vivo mimics insulin action

Hsien-yu Wang, C. Malbon, J. Guo, 1997, Journal of Molecular Medicine.

Insulin action impaired by deficiency of the G-protein subunit Giα2

C. Malbon, C. Moxham, 1996, Nature.

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

D. Sall, Jonathan A. Lee, C. Moxham, 2012, Journal of medicinal chemistry.

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.

M. Malamas, C. Moxham, J. Sredy, 2000, Journal of medicinal chemistry.

Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity

J. Haidar, M. Kalos, S. Eastman, 2020, Cancer Immunology Research.

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys.

C. Kenific, C. Moxham, B. Pan, 2015, Bioorganic & medicinal chemistry letters.

Giα2 mediates the inhibitory regulation of adenylylcyclase in vivo: Analysis in transgenic mice with Giα2 suppressed by inducible antisense RNA

Y. Hod, C. Malbon, C. Moxham, 1993 .

Induction of Gαq-specific Antisense RNA in Vivo Causes Increased Body Mass and Hyperadiposity*

P. Galvin-Parton, C. Malbon, C. Moxham, 1997, The Journal of Biological Chemistry.

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.

M. Malamas, C. Moxham, J. Sredy, 2000, Journal of medicinal chemistry.

Potent benzoazepinone γ-secretase modulators with improved bioavailability.

C. Kenific, A. Szewczak, C. Moxham, 2015, Bioorganic & medicinal chemistry letters.

Suppression of Gi alpha 2 enhances phospholipase C signalling.

C. Malbon, C. Moxham, A. Morris, 1994, The Biochemical journal.

Induction of G alpha i2-specific antisense RNA in vivo inhibits neonatal growth.

Y. Hod, C. Malbon, C. Moxham, 1993, Science.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

A. Szewczak, C. Moxham, Hua Zhou, 2012, Bioorganic & medicinal chemistry letters.

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.

I. Kariv, C. Moxham, Thomas A. Miller, 2012, Bioorganic & medicinal chemistry letters.

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

[20]In vivo analysis of signaling elements via targeted, inducible antisense RNA

P. Galvin-Parton, Hsien-yu Wang, C. Malbon, 1996 .

[23] Antisense DNA/RNA-based strategies to analysis of signal transduction via G proteins

C. Malbon, C. Moxham, M. Shih, 1995 .

[1] G proteins controlling differentiation, growth, and development: Analysis by antisense RNA/DNA technology

Hsien-yu Wang, C. Malbon, C. Moxham, 1996 .

jun N-terminal Kinase Mediates Activation of Skeletal Muscle Glycogen Synthase by Insulin in Vivo*

C. Malbon, C. Moxham, R. Davis, 1996, The Journal of Biological Chemistry.

Development of a Cell-Based Assay for Measurement of c-Met Phosphorylation Using AlphaScreenTM Technology and High-Content Imaging Analysis

I. Kariv, C. Moxham, Anjili Mathur, 2009, Journal of biomolecular screening.

Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.

C. Malbon, H. Wang, C. Moxham, 1997, Journal of molecular medicine.

Insulin action impaired by deficiency of the G-protein subunit G ialpha2.

C. Malbon, C. Moxham, 1996, Nature.

Ftx-6058 Induces Fetal Hemoglobin Production and Ameliorates Disease Pathology in Sickle Cell Mice

S. Silver, C. Moxham, I. Efremov, 2021, Blood.

Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel

Shaoyou Chu, Saba Husain, Jonathan A. Lee, 2011, Journal of biomolecular screening.

Suramin interacts with RANK and inhibits RANKL-induced osteoclast differentiation.

C. Moxham, Rachelle J Sells Galvin, A. Regmi, 2005, Bone.

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.

C. Moxham, Z. Zhang, J. Sredy, 1999, Journal of medicinal chemistry.

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

Jonathan A. Lee, C. Moxham, M. Uhlik, 2012, Journal of medicinal chemistry.