H. Steinmetz

发表

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

J. Ross, W. Koch, K. Chien, 1996, The Journal of clinical investigation.

Spirangien A and B, Highly Cytotoxic and Antifungal Spiroketals from the Myxobacterium Sorangium cellulosum: Isolation, Structure Elucidation and Chemical Modifications

H. Reichenbach, H. Steinmetz, U. Flörke, 2005 .

Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition/macrolactonization.

A. Kirschning, R. Müller, H. Steinmetz, 2011, Angewandte Chemie.

Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species.

H. Reichenbach, R. Müller, H. Steinmetz, 2016, Organic letters.

Revealing the macromolecular targets of complex natural products.

Petra Schneider, Gisbert Schneider, Daniel Reker, 2014, Nature chemistry.

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution†

H. Reichenbach, D. Schomburg, H. Steinmetz, 1996 .

Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology

J. Díez, A. Meyerhans, R. Frank, 2013, RNA biology.

Spiroketal polyketide formation in Sorangium: identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes.

H. Blöcker, M. Scharfe, R. Müller, 2007, Chemistry & biology.

Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part I): Structural revision and stereochemical assignment of gephyronic acid.

S. Laschat, H. Steinmetz, F. Sasse, 2011, Angewandte Chemie.

Synthesis and Biological Characterization of Argyrin F

R. Frank, H. Steinmetz, T. Carlomagno, 2010, ChemMedChem.

Carolacton – A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated Bacterium Streptococcus mutans†

A. Kirschning, R. Müller, H. Steinmetz, 2010 .

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

K. Sleegers, C. van Broeckhoven, M. Cruts, 2011, The Journal of Neuroscience.

Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties.

H. Reichenbach, H. Steinmetz, F. Sasse, 2003, The Journal of antibiotics.

Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin.

L. Rangell, F.J. Sauvage, F. D. de Sauvage, 1997, Blood.

Archazolid and apicularen: Novel specific V-ATPase inhibitors

H. Steinmetz, H. Wieczorek, B. Kunze, 2005, BMC Biochemistry.

The Mechanism of Action of Lysobactin.

R. Müller, Wonsik Lee, S. Walker, 2016, Journal of the American Chemical Society.

Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part II): Total synthesis of gephyronic acid.

S. Laschat, H. Steinmetz, F. Sasse, 2011, Angewandte Chemie.

Thuggacins, macrolide antibiotics active against Mycobacterium tuberculosis: isolation from myxobacteria, structure elucidation, conformation analysis and biosynthesis.

H. Reichenbach, H. Steinmetz, B. Kunze, 2007, Chemistry.

Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.

H. Reichenbach, H. Steinmetz, K. Gerth, 2001, The Journal of antibiotics.

Sulfangolids, macrolide sulfate esters from Sorangium cellulosum.

R. Müller, H. Steinmetz, W. Kessler, 2012, Chemistry.

Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.

H. Reichenbach, H. Steinmetz, R. Jansen, 2007, Journal of natural products.

A Unique Mechanism for Methyl Ester Formation via an Amide Intermediate Found in Myxobacteria

H. Steinmetz, T. Mahmud, Sheeba Veluthoor, 2006, Chembiochem : a European journal of chemical biology.

Isolation and Structure Elucidation of Cruentarens A and B — Novel Members of the Benzolactone Class of ATPase Inhibitors from the Myxobacterium Byssovorax cruenta

H. Reichenbach, H. Steinmetz, B. Kunze, 2006 .

Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton.

H. Reichenbach, H. Steinmetz, K. Gerth, 2000, The Journal of antibiotics.

Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties.

H. Reichenbach, C. Heusser, H. Steinmetz, 2002, The Journal of antibiotics.

Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity.

R. Müller, H. Steinmetz, M. Stadler, 2014, Angewandte Chemie.

Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.

H. Reichenbach, H. Steinmetz, F. Sasse, 2004, Angewandte Chemie.

Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin

H. Steinmetz, F. Sasse, G. Höfle, 2003 .

Biosynthesis of Myxothiazol Z, the Ester-analog of Myxothiazol A in Myxococcus fulvus

H. Reichenbach, H. Steinmetz, G. Höfle, 2000 .

Antibiotics from gliding bacteria. XLIV, Ambruticins VS : new members of the antifungal ambruticin family from Sorangium cellulosum

H. Reichenbach, H. Steinmetz, K. Gerth, 1991 .

Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin.

H. Reichenbach, R. Müller, H. Steinmetz, 2016, Angewandte Chemie.

Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties.

H. Reichenbach, H. Steinmetz, F. Sasse, 2000, The Journal of antibiotics.

Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria)

R. Müller, H. Steinmetz, W. Schubert, 2008 .

Biosynthesis and Heterologous Production of Argyrins.

H. Steinmetz, S. Wenzel, Domen Pogorevc, 2019, ACS synthetic biology.

Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry.

H. Steinmetz, L. Oberer, G. Rihs, 2002, The Journal of antibiotics.

New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.

H. Reichenbach, H. Steinmetz, F. Sasse, 2001, Journal of natural products.

Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum

A. Lemme, H. Steinmetz, Andreas Dötsch, 2010, BMC Microbiology.

Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae

R. Daniel, R. Müller, H. Steinmetz, 2014, Chembiochem : a European journal of chemical biology.

Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.

M. Manns, R. Geffers, S. Kubicka, 2008, Cancer cell.

Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.

H. Reichenbach, H. Steinmetz, F. Sasse, 1993, The Journal of antibiotics.

Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay

J. Díez, A. Meyerhans, R. Frank, 2013, Microbial Cell Factories.

Characterization of Antimycins – Producing Streptomycete Strain VY46 Isolated from Slovak Soil

H. Steinmetz, J. Wink, Ivana Charousová, 2016 .

Resistance mechanisms of cancer cells to the novel vacuolar H+-ATPase inhibitor archazolid B

T. Efferth, Y. Sugimoto, H. Steinmetz, 2014, Investigational New Drugs.

Cruentaren, a New Antifungal Salicylate-Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity

H. Reichenbach, H. Steinmetz, H. Wieczorek, 2006, The Journal of Antibiotics.

Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticus.

R. Müller, H. Steinmetz, K. Gerth, 2012, Journal of natural products.

Cruentaren, a New Antifungal Salicylate‐Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity. Fermentation and Biological Properties. Part 104. Antibiotics from Gliding Bacteria.

H. Reichenbach, H. Steinmetz, H. Wieczorek, 2007 .

Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa

R. Hartmann, R. Müller, H. Steinmetz, 2012, Chembiochem : a European journal of chemical biology.

Association and the Adh locus with a lethal factor (l(2) Stm) in Drosophila melanogaster

H. Steinmetz, F. Leibenguth, 1976, Biochemical Genetics.

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

O. Werz, R. Müller, H. Steinmetz, 2014, Biochemical pharmacology.

Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F.

H. Reichenbach, H. Steinmetz, K. Gerth, 2002, Journal of antibiotics (Tokyo. 1968).

Biosynthesis of Epothilones: Hydroxylation of Epo A and B to Epothilones E and F.

H. Reichenbach, H. Steinmetz, K. Gerth, 2002 .

The First Hydroxylated Archazolid from the Myxobacterium Cystobacter violaceus: Isolation, Structural Elucidation and V-ATPase Inhibition

H. Steinmetz, H. Wieczorek, F. Sasse, 2007, The Journal of Antibiotics.

Stereochemical determination of Archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the Myxobacterium Archangium gephyra.

C. Farés, H. Steinmetz, T. Carlomagno, 2006, Organic letters.

The First Hydroxylated Archazolid from the Myxobacterium Cystobacter violaceus: Isolation, Structural Elucidation and V‐ATPase Inhibition.

H. Steinmetz, H. Wieczorek, F. Sasse, 2007 .

Archazolid‐7‐O‐β‐D‐glucopyranoside — Isolation, Structural Elucidation and Solution Conformation of a Novel V‐ATPase Inhibitor from the Myxobacterium Cystobacter violaceus.

H. Steinmetz, H. Wieczorek, F. Sasse, 2007 .

Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525.

H. Steinmetz, K. Gerth, R. Jansen, 2008, Angewandte Chemie.

Archazolid‐7‐O‐β‐D‐glucopyranoside – Isolation, Structural Elucidation and Solution Conformation of a Novel V‐ATPase Inhibitor from the Myxobacterium Cystobacter violaceus

H. Steinmetz, H. Wieczorek, F. Sasse, 2007 .

Chlorotonil A, a Macrolide with a Unique gem‐Dichloro‐1,3‐dione Functionality from Sorangium cellulosum, So ce1525.

H. Steinmetz, K. Gerth, R. Jansen, 2008 .

Precursor‐Directed Syntheses and Biological Evaluation of New Elansolid Derivatives

A. Kirschning, R. Müller, H. Steinmetz, 2012, Chembiochem : a European journal of chemical biology.

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria

H. Schwalbe, K. Büssow, C. Richter, 2018, PloS one.

The myxovalargins, new peptide antibiotics from Myxococcus fulvus (Myxobacterales). I. Cultivation, isolation, and some chemical and biological properties.

H. Reichenbach, H. Steinmetz, K. Gerth, 1983, The Journal of antibiotics.

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

R. Müller, H. Steinmetz, Srikanth Duddela, 2018, Nature Communications.

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

Rolf Müller, Rolf Jansen, Thomas Hoffmann, 2018, Nature Communications.

Soil myxobacteria as a potential source of polyketide-peptide substances

H. Steinmetz, J. Wink, Ivana Charousová, 2017, Folia Microbiologica.

Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti.

A. Kirschning, R. Müller, H. Steinmetz, 2011, Chemistry.

Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties.

H. Reichenbach, H. Steinmetz, B. Kunze, 1999, The Journal of antibiotics.

Antibiotics from Gliding Bacteria. Part 84. Melithiazols, New β‐Methoxyacrylate Inhibitors of the Respiratory Chain Isolated from Myxobacteria. Production, Isolation, Physico‐chemical, and Biological Properties.

H. Reichenbach, H. Steinmetz, B. Kunze, 2000 .

Gephyronic acid, a novel inhibitor of eukaryotic protein synthesis from Archangium gephyra (myxobacteria). Production, isolation, physico-chemical and biological properties, and mechanism of action.

H. Reichenbach, H. Steinmetz, F. Sasse, 1995, The Journal of antibiotics.

Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.

R. Müller, H. Steinmetz, K. Gerth, 2012, Journal of natural products.

Tubulysins , NewCytostatic Peptides from Myxobacteria Acting on Microtubuli Production , Isolation , Physico-chemical and Biological Properties '

H. Reichenbach, H. Steinmetz, F. Sasse, 2006 .

The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization.

Gregor Hagelueken, Rolf Jansen, Wolf-Dieter Schubert, 2009, Angewandte Chemie.

Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physicochemical and Biological Properties.

H. Reichenbach, H. Steinmetz, F. Sasse, 2001 .

Antibiotics from Gliding Bacteria. Part 77. Epothilone A and B - Novel 16-Membered Macrolides with Cytotoxic Activity. Isolation, Crystal Structure, and Conformation in Solution.

H. Reichenbach, D. Schomburg, H. Steinmetz, 1996 .

Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers.

A. Kirschning, R. Müller, H. Steinmetz, 2011, Angewandte Chemie.

Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers.

A. Kirschning, H. Steinmetz, K. Gerth, 2011 .

The Mechanism of Action of Lysobactin.

R. Müller, Wonsik Lee, S. Walker, 2016, Journal of the American Chemical Society.

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

O. Werz, R. Müller, H. Steinmetz, 2014, Biochemical pharmacology.