J. Roth

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A Synthetic Peptide Derived from a COOH-terminal Domain of the Insulin Receptor Specifically Enhances Insulin Receptor Signaling*

M. Bernier, C. Montrose‐Rafizadeh, H. Kole, 1996, The Journal of Biological Chemistry.

Identification of insulin in rat brain.

M. Brownstein, D. Schmechel, J. Roth, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents.

M. Brownstein, J. Roth, J. Havránková, 1979, The Journal of clinical investigation.

Relationship between impact strength and spherulite growth in linear polyethylene

R. Raff, J. Roth, S. Ohlberg, 1959 .

Insulin and insulin receptors in rodent brain.

M. Brownstein, J. Roth, J. Havránková, 1981, Diabetologia.

Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus.

P. Savage, P. Bennett, J. Roth, 1979, The Journal of clinical endocrinology and metabolism.

Diabetes insipidus: celebrating a century of vasopressin therapy.

D. Bichet, J. Roth, S. Qureshi, 2014, Endocrinology.

Characteristics of the human lymphocyte insulin receptor.

J. Roth, P. Gorden, J. Gavin, 1973, The Journal of biological chemistry.

Effects of chronic glucocorticoid excess in man on insulin binding to circulating cells: differences between endogenous and exogenous hypercorticism.

M. Muggeo, J. Roth, A. Saviolakis, 1983, The Journal of clinical endocrinology and metabolism.

Beneficial effect of the insulin sensitizer (HSP inducer) BGP-15 on olanzapine-induced metabolic disorders

K. Tory, Zsuzsanna Literáti-Nagy, L. Korányi, 2010, Brain Research Bulletin.

Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells.

J. Egan, Yihong Wang, C. Montrose‐Rafizadeh, 1995, Endocrinology.

Cooperativity in ligand binding: a new graphic analysis.

J. Roth, P. De Meyts, P. Meyts, 1975, Biochemical and biophysical research communications.

Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.

J. Roth, M. Lesniak, 1976, The Journal of biological chemistry.

The insulin resistance of acromegaly: evidence for two alterations in the insulin receptor on circulating monocytes.

C. Kahn, M. Muggeo, J. Roth, 1979, The Journal of clinical endocrinology and metabolism.

Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction.

J. Roth, P. Gorden, J. A. Archer, 1975, The Journal of clinical investigation.

Insulin receptor deficiency in genetic and acquired obesity.

C. Kahn, D. Neville, J. Roth, 1975, The Journal of clinical investigation.

Insulin receptor status in disease states of man.

J. Roth, R. S. Bar, 1977, Archives of internal medicine.

Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat.

C. Kahn, I. Goldfine, J. Roth, 1974, The Journal of biological chemistry.

BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION

I. Pastan, J. Roth, V. Macchia, 1966, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic Modeling of Insulin Binding to Receptors and Degradation In Vivo in the Rabbit

A. Zeleznik, J. Roth, M. Berman, 1980, Diabetes.

Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity

J. Roth, S. L. Marbán, 1996 .

Insulin reverses the growth retardation effect of phorbol ester in chicken embryos during organogenesis.

J. Roth, L. Bassas, F. de Pablo, 1989, Life sciences.

Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors.

M. Rechler, L. Harrison, M. Muggeo, 1978, The New England journal of medicine.

The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian.

S. Lillioja, T. Kadowaki, S. Taylor, 1990, The Journal of clinical endocrinology and metabolism.

TRP64ARG β3-adrenergic receptor and obesity in Mexican Americans

A. Shuldiner, K. Silver, J. Sorkin, 1997, Human Genetics.

Hormonal regulation of human growth.

M. Rechler, S. Nissley, J. Roth, 1987, The New England journal of medicine.

Control of blood glucose and diabetic vascular disease.

J. Roth, D. W. Foster, L. Madison, 1977, The New England journal of medicine.

Inhibition of Cyclic 3′,5′-AMP Phosphodiesterase in Islet Cells and Other Tissues by Tolbutamide

I. Goldfine, J. Roth, R. Perlman, 1971, Nature.

Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma

I. Pastan, R. Lefkowitz, J. Roth, 1970, Science.

The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate

C. Kahn, E. Van Obberghen, S. Emdin, 1979, Diabetes.

Identification and high yield purification of insulin-like growth factors (nonsuppressible insulin-like activities and somatomedins) from human plasma by use of endogenous binding proteins.

C. Kahn, J. Roth, B. Ginsberg, 1979, The Journal of clinical endocrinology and metabolism.

Insulin and non-suppressible insulin-like activity (NSILA-s): evidence for separate plasma membrane receptor sites.

C. Kahn, D. Neville, J. Roth, 1974, Biochemical and biophysical research communications.

Peptide hormone binding to receptors: a review of direct studies in vitro.

J. Roth, 1973, Metabolism: clinical and experimental.

Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes.

D. Neville, J. Roth, P. Freychet, 1971, Biochemical and biophysical research communications.

Circulating insulin: the proinsulin-like properties of “big” insulin in patients without islet cell tumors

J. Roth, P. Gorden, B. Sherman, 1971 .

Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance

C. Kahn, J. Roth, J. Flier, 1975, Science.

The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia.

C. Kahn, J. Flier, M. Muggeo, 1978, The Journal of clinical endocrinology and metabolism.

Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance.

C. Kahn, D. Neville, I. Goldfine, 1973, Biochemical and biophysical research communications.

Receptors, antireceptor antibodies and mechanisms of insulin resistance.

C. Kahn, H. L. Bleich, J. Flier, 1979, The New England journal of medicine.

Novel signal transduction and peptide specificity of glucagon‐like peptide receptor in 3T3‐L1 adipocytes

Yihong Wang, L. Adams, C. Montrose‐Rafizadeh, 1997, Journal of cellular physiology.

Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone

J. Roth, S. Berson, R. Yalow, 1963, Science.

Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity.

C. Kahn, J. Roth, P. De Meyts, 1976, The Journal of biological chemistry.

PLASMA INSULIN AND GROWTH HORMONE LEVELS IN OBESITY AND DIABETES

J. Roth, S. Berson, R. Yalow, 1965, Annals of the New York Academy of Sciences.

Insulin Receptors in Disorders of Glucose Tolerance and Insulin Sensitivity

E. Obberghen, J. Roth, F. Pablo, 1981 .

Insulin receptors in human circulating cells and fibroblasts.

J. Roth, J. Gavin, P. Freychet, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man.

J. Roth, P. Gorden, J. Gavin, 1973, The Journal of clinical endocrinology and metabolism.

Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse

C. Kahn, J. Roth, P. Gorden, 1972, FEBS letters.

Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect.

C. Kahn, J. Imperato-McGinley, M. Muggeo, 1978, The Journal of clinical endocrinology and metabolism.

Glucose intolerance in cystic fibrosis.

J. Roth, P. Gorden, G. Peter, 1969, The New England journal of medicine.

Change in affinity of insulin receptors following oral glucose in normal adults.

M. Muggeo, J. Roth, R. S. Bar, 1977, The Journal of clinical endocrinology and metabolism.

Effect of altered nutritional states on insulin receptors.

D. Leroith, M. Adamo, J. Simon, 1988, Annual review of nutrition.

Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans

C. Kahn, M. Muggeo, J. Roth, 1980, Diabetologia.

Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration.

J. Roth, P. Gorden, C. Siebert, 1977, The Journal of clinical endocrinology and metabolism.

EFFECTS OF STARVATION, REFEEDING, AND DIETING

C. Kahn, J. Roth, P. Gorden, 1976 .

Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli.

J. Roth, P. Gorden, 1969, The Journal of clinical investigation.

Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.

J. Roth, P. Gorden, B. Sherman, 1971, The Journal of clinical investigation.

Radioreceptor assay of insulin: Comparison of plasma and pancreatic insulins and proinsulins.

C. Kahn, D. Neville, J. Roth, 1975, The Journal of clinical endocrinology and metabolism.

Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man.

C. Kahn, D. Neville, I. Goldfine, 1975, Recent progress in hormone research.

Insulin and insulin receptors in early chick embryo development

J. Roth, F. Pablo, L. Bassas, 1986 .

Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance.

S. Taylor, J. Roth, P. Gorden, 1984, The Journal of clinical investigation.

Preparation of solubilized insulin receptors from human lymphocytes.

J. Roth, J. Gavin, D. Buell, 1972, Biochemical and biophysical research communications.

Water-Soluble Insulin Receptors from Human Lymphocytes

J. Roth, J. Gavin, D. Buell, 1972, Science.

Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay.

J. Roth, P. Gorden, J. Gavin, 1974, The Journal of biological chemistry.

Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay.

C. Kahn, J. Roth, P. Gorden, 1974, The Journal of clinical endocrinology and metabolism.

"Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay

J. Roth, P. Gorden, M. Lesniak, 1973, Science.

ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase.

I. Pastan, R. Lefkowitz, J. Roth, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation

I. Pastan, R. Lefkowitz, J. Roth, 1970, Nature.

Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse.

C. Kahn, D. Neville, J. Roth, 1972, Biochemical and biophysical research communications.

Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts.

C. Kahn, C. Grunfeld, J. Roth, 1979, Endocrinology.

The Insulin Receptor and its Function

E. Obberghen, J. Roth, 1981 .

Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance.

M. Kasuga, S. Taylor, J. Roth, 1982, The Journal of clinical endocrinology and metabolism.

Hormone resistance and hormone sensitivity.

C. Kahn, D. Neville, J. Roth, 1977, The New England journal of medicine.

Hormonal regulation of the affinity and concentration of hormone receptors in target cells.

C. Kahn, J. Roth, R. S. Bar, 1976, Metabolism: clinical and experimental.

Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells.

G. Striker, J. Roth, L. Striker, 1988, Endocrinology.

Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor.

S. Taylor, J. Roth, P. Gorden, 1982, Annals of internal medicine.

Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.

A. Shuldiner, J. Roth, F. Pablo, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.

J. Egan, Yihong Wang, M. Bernier, 1994, Endocrinology.

Tumor Hypoglycemia Linked to IGF-II

K. Rother, J. Roth, C. A. Koch, 1999 .

The influence of plasma insulin concentrations on tissue insulin levels in rodents: a study of the diabetic Chinese hamster and the ob/ob mouse.

C. Agardh, J. Roth, G. Gerritsen, 1986, Metabolism: clinical and experimental.

Insulin Binding to Its Receptor: Is the Receptor More Important Than the Hormone?

J. Roth, 1981, Diabetes Care.

Increased 125I-Insulin Receptor Binding to Erythrocytes of Hypoglycemic Infants and Children

G. Chrousos, A. Adams, J. Roth, 1981, Pediatric Research.

Insulin in Insects and Annelids

D. Leroith, J. Roth, M. Lesniak, 1981, Diabetes.

Protein kinase activity of the insulin receptor in human circulating and cultured mononuclear cells.

G. Grunberger, Y. Zick, J. Roth, 1983, Biochemical and biophysical research communications.

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

C. Kahn, M. Kasuga, Y. Zick, 1983, The Journal of biological chemistry.

Insulin stimulates phosphorylation of serine residues in soluble insulin receptors.

G. Grunberger, S. Taylor, Y. Zick, 1983, Biochemical and biophysical research communications.

The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor.

C. Kahn, D. Neville, S. Nissley, 1975, The Journal of biological chemistry.

Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor.

Y. Zick, J. Roth, J. Whittaker, 1983, Journal of Biological Chemistry.

Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity.

C. Kahn, E. Van Obberghen, M. Kasuga, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Insulin-stimulated phosphorylation of the insulin receptor precursor.

Y. Zick, J. Roth, J. A. Hedo, 1983, Biochemical and biophysical research communications.

The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor.

S. Taylor, Y. Zick, J. Roth, 1984, The Journal of biological chemistry.

Insulin and insulin receptors in rodent brain

M. Brownstein, J. Roth, J. Havránková, 1981, Diabetologia.

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes

C. Kahn, J. Larner, J. Lawrence, 1978, Molecular and Cellular Biochemistry.

Insulin receptors in brain.

M. Brownstein, J. Roth, J. Havránková, 1983, Advances in metabolic disorders.

Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution.

C. Kahn, J. Roth, R. Cohen, 1978, Biochimica et biophysica acta.

Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.

C. Kahn, J. Roth, D. Jarrett, 1977, The Journal of clinical investigation.

Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation

I. Pastan, P. Thomopoulos, J. Roth, 1976, Cell.

ACTH‐RECEPTOR INTERACTION IN THE ADRENAL: A MODEL FOR THE INITIAL STEP IN THE ACTION OF HORMONES THAT STIMULATE ADENYL CYCLASE

I. Pastan, R. Lefkowitz, J. Roth, 1971, Annals of the New York Academy of Sciences.

GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.

J. Egan, Yihong Wang, C. Montrose‐Rafizadeh, 1998, American journal of physiology. Cell physiology.

Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states

J. Roth, P. Gorden, C. Hendricks, 1974, Diabetologia.

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

D. Neville, J. Roth, P. De Meyts, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Downregulation Occurs Normally in Cultured Epstein-Barr Virus-transformed Lymphocytes from Patients with Extreme Insulin Resistance: Discrepancy Between Downregulation In Vivo and In Vitro

S. Taylor, J. Roth, P. Gorden, 1984, Diabetes.

Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function.

C. Kahn, L. Harrison, J. Roth, 1979, Science.

Dynamic regulation of intact and C-terminal truncated insulin receptor phosphorylation in permeabilized cells.

D. D. Shock, M. Bernier, H. Kole, 1994, Biochemistry.

Post-translational modifications of the insulin receptor.

J. Roth, M. Lesniak, C. Hart, 1988, Advances in experimental medicine and biology.

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

M. Brownstein, J. Roth, J. Rosenzweig, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The insulin receptor of rat brain is coupled to tyrosine kinase activity.

Robert, J. Roth, S. Hendricks, 1984, The Journal of biological chemistry.

Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor.

M. Kasuga, S. Taylor, J. Roth, 1982, The Journal of clinical endocrinology and metabolism.

Receptors for peptide hormones: alterations in diseases of humans.

S. Taylor, J. Roth, 1982, Annual review of physiology.

Circulating NSILA-s in man: Preliminary studies of stimuli in vivo and of binding to plasma components.

C. Kahn, J. Roth, P. Gorden, 1975, The Journal of clinical endocrinology and metabolism.

The insulin receptors of chick embryo show tissue-specific structural differences which parallel those of the insulin-like growth factor I receptors.

J. Roth, L. Bassas, F. de Pablo, 1987, Endocrinology.

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.

C. Kahn, J. Roth, D. Jarrett, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man.

C. Kahn, J. Roth, D. Jarrett, 1976, The Journal of clinical investigation.

The immunology of the insulin receptor.

C. Kahn, J. Roth, D. Jarrett, 1976, Immunological communications.

Specificity spillover at the hormone receptor--exploring its role in human disease.

J. Roth, R. Eastman, M. Lesniak, 1989, The New England journal of medicine.

Methods for assessing immunologic and biologic properties of iodinated peptide hormones.

J. Roth, 1975, Methods in enzymology.

Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts.

S. Taylor, J. Roth, M. S. Ríos, 1983, The Journal of clinical endocrinology and metabolism.

Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH.

S. Taylor, J. Roth, R. Blizzard, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors.

C. Kahn, J. Roth, P. Gorden, 1981, The New England journal of medicine.

GLP-1 action in L 6 myotubes is via a receptor different from the pancreatic GLP-1 receptor

C. Montrose‐Rafizadeh, J. Roth, M. Montrose, 1998 .

Genes for the insulin receptor and the insulin-like growth factor I receptor are expressed in the chicken embryo blastoderm and throughout organogenesis.

J. Roth, F. de Pablo, L. Scavo, 1991, Biochemical and biophysical research communications.

Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.

C. Montrose‐Rafizadeh, J. Roth, J. Egan, 1994, Endocrinology.

In Vivo Imaging of Insulin Receptors in Monkeys Using 18F-Labeled Insulin and Positron Emission Tomography

K. Jacobson, R. Carson, J. Roth, 1992, Diabetes.

Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.

J. Busby‐Whitehead, J. Tobin, M. Blackman, 1997, Metabolism: clinical and experimental.

β3-adrenoceptor gene variant in obesity and insulin resistance

K. Silver, A. Shuldiner, J. Roth, 1996, The Lancet.

Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin.

C. Pert, J. Roth, W. Kiess, 1988, Endocrinology.

Unique Features of the Insulin Receptor in Rat Brain

C. Agardh, Simeon I. Taylor, S. Taylor, 1984, Journal of neurochemistry.

Developmental Regulation of Insulin and Type I Insulin-Like Growth Factor Receptors and Absence of Type II Receptors in Chicken Embryo Tissues

J. Roth, L. Bassas, F. de Pablo, 1988, Diabetes.

18F-labeled insulin: a prosthetic group methodology for incorporation of a positron emitter into peptides and proteins.

K. Jacobson, Y. Shai, J. Roth, 1989, Biochemistry.

Early development and tissue-specific patterns of insulin binding in chick embryo.

J. Roth, F. Pablo, F. de Pablo, 1984, Endocrinology.

The underlying insulin receptor in patients with antireceptor autoantibodies: demonstration of normal binding and immunological properties.

C. Kahn, M. Rechler, M. Muggeo, 1979, The Journal of clinical endocrinology and metabolism.

Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.

C. Kahn, D. Neville, J. Roth, 1974, The Journal of biological chemistry.

[4] Assay of peptide hormones using cell receptors: Application to insulin and to human growth hormone

J. Roth, 1975 .

Studies of plasma insulin in myotonic dystrophy.

W. Engel, R. Griggs, S. Nissley, 1969, The Journal of clinical endocrinology and metabolism.

Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos.

A. Shuldiner, J. Roth, F. de Pablo, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

C. Kahn, J. Roth, P. Gorden, 1976, The New England journal of medicine.

ANTIBODIES TO INSULIN RECEPTORS: PROBES OF RECEPTOR STRUCTURE AND FUNCTION

C. Kahn, J. Roth, P. Gorden, 1978 .

Glucagon receptors in -cells. Binding of 125 I-glucagon and activation of adenylate cyclase.

L. Birnbaumer, I. Goldfine, J. Roth, 1972, The Journal of biological chemistry.

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.

Simeon I. Taylor, S. Taylor, E. Wertheimer, 1994, The Journal of biological chemistry.

A synthetic tris-sulfotyrosyl dodecapeptide analogue of the insulin receptor 1146-kinase domain inhibits tyrosine dephosphorylation of the insulin receptor in situ.

M. Bernier, H. Kole, A. Liotta, 1994, The Journal of biological chemistry.

Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.

I. Pastan, N. Richert, S. Taylor, 1985, Science.

Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain.

D. Leroith, J. Roth, J. Shemer, 1987, The Journal of biological chemistry.

Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors.

D. Leroith, J. Mcmurtry, M. Adamo, 1986, The Journal of biological chemistry.

Insulin-stimulated receptor phosphorylation appears normal in cultured Epstein-Barr virus-transformed lymphocyte cell lines derived from patients with extreme insulin resistance.

S. Taylor, Y. Zick, J. Roth, 1985, The Journal of clinical endocrinology and metabolism.

Inappropriate vasopressin secretion and carcinoma of the pancreas.

J. Roth, D. Nabseth, B. Berde, 1968, The American journal of medicine.

Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification.

C. Kahn, L. Harrison, J. Roth, 1979, The Journal of clinical endocrinology and metabolism.

An Introduction to Receptors and Receptor Disorders

J. Flier, L. Harrison, M. Muggeo, 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.

J. Roth, F. C. Kosmakos, 1980, The Journal of biological chemistry.

Ontogeny of receptors for insulin-like peptides in chick embryo tissues: early dominance of insulin-like growth factor over insulin receptors in brain.

J. Roth, F. Pablo, L. Bassas, 1985, Endocrinology.

The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors.

C. Kahn, J. Roth, B. Ginsberg, 1977, Endocrinology.

Insulin and insulin-like growth factor I in early development: peptides, receptors and biological events.

L. A. Scott, J. Roth, F. de Pablo, 1990, Endocrine reviews.

Insulin Antibodies Retard and Insulin Accelerates Growth and Differentiation in Early Embryos

J. Roth, F. Pablo, E. Hernández, 1985, Diabetes.

Syndromes associated with inappropriate hormone synthesis by tumors: an evolutionary interpretation.

D. Leroith, J. Roth, 1985, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Assay of peptide hormones using cell receptors: application to insulin and to human growth hormone.

J. Roth, 1975, Methods in enzymology.

Prolactin stimulation by thyrotropin-releasing hormone in a patient with isolated thyrotropin deficiency.

A. Frantz, P. Cuatrecasas, J. Roth, 1972, The New England journal of medicine.

Insulin receptors in brain and other tissues: similarities and differences

J. Roth, M. Rojeski, Derek Lerorrtt, 1988, Neurochemistry International.

Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.

I. Pastan, J. Roth, O. D. Taunton, 1969, The Journal of biological chemistry.

Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.

J Roth, D. Neville, J. Roth, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Treatment with Growth Hormone: Focus on Specificity with a View to the Future

J. Roth, 1995 .

Effect of propranolol and phentolamine on canine and bovine responses to TSH.

I. Pastan, J. Roth, G. Levey, 1969, Endocrinology.

Transport to cell surface of intestinal sucrase-isomaltase is blocked in the Golgi apparatus in a patient with congenital sucrase-isomaltase deficiency.

H. Hauri, J. Roth, M. Lentze, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Evolutionary origins of neuropeptides, hormones, and receptors: possible applications to immunology.

D. Leroith, J. Roth, S. Glick, 1985, Journal of immunology.

Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

J. Shiloach, D. Le Roith, J. Roth, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Insulin receptors are widely distributed in the central nervous system of the rat

M. Brownstein, J. Roth, J. Havránková, 1978, Nature.

Inhibition of insulin receptor binding by dimethyl sulfoxide.

E. Van Obberghen, J. Roth, P. De Meyts, 1979, Biochimica et biophysica acta.

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

D. Neville, J. Roth, P. De Meyts, 1973, Biochemical and biophysical research communications.

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

J. Roth, P. Demeyts, A. R. Bainco, 1976, The Journal of biological chemistry.

The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology.

J. Shiloach, H. L. Bleich, D. Leroith, 1982, The New England journal of medicine.

Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins?

D. Leroith, J. Roth, L. Bassas, 1986, Progress in brain research.

Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance.

J Roth, C. Kahn, D. Neville, 1973, The Journal of biological chemistry.

Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man

C. Roberts, D. Leroith, J. Roth, 1986, Experientia.

Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man.

C. Roberts, D. Leroith, J. Roth, 1986, Experientia.

Hormones and other Messenger Molecules: An Approach to Unity

J. Shiloach, D. Leroith, J. Roth, 1984 .

Insulin in brain and other extrapancreatic tissues of vertebrates and nonvertebrates.

M. Brownstein, D. Le Roith, J. Roth, 1983, Advances in metabolic disorders.

Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity.

C. Kahn, J. Roth, B. Ginsberg, 1976, Biochemical and biophysical research communications.

Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation.

D. Neville, J. Roth, P. Freychet, 1972, The Journal of biological chemistry.

Monoiodo-oxytocin: Demonstration of Its Biological Activity and Specific Binding to Isolated Fat Cells

J. Roth, P. Freychet, E. Thompson, 1972 .

Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes.

L. A. Scott, A. Shuldiner, J. Roth, 1990, Biochemical and biophysical research communications.

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations.

C. Yen, A. Shuldiner, R. Andersen, 1998, Diabetes.

Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense Mutation

K. Silver, C. Yen, D. Yarnall, 1997 .

Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.

K. Silver, A. Shuldiner, R. Andersen, 2000, The Journal of clinical endocrinology and metabolism.

Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.

A. Shuldiner, C. Roberts, D. Leroith, 1989, The Journal of biological chemistry.

Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive.

D. Leroith, K. Rother, R. Vigneri, 2013, Endocrine reviews.

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

C. Pert, J. Roth, M. Lesniak, 1986, Neuroscience.

Endocrinization of the early embryo: an emerging role for hormones and hormone-like factors.

J. Roth, F. de Pablo, 1990, Trends in biochemical sciences.

Insulin-like growth factor I activity is stored in the yolk of the avian egg.

J. Roth, F. de Pablo, L. Scavo, 1989, Biochemical and biophysical research communications.

Insulin is present in chicken eggs and early chick embryos.

J. Roth, F. de Pablo, R. Pruss, 1982, Endocrinology.

The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself.

C. Kahn, D. Neville, M. Muggeo, 1979, Endocrinology.

Isolation and characterization of two different insulins from an amphibian, Xenopus laevis.

A. Shuldiner, J. Roth, E. Robinson, 1989, Endocrinology.

Development of receptors for insulin and insulin-like growth factor-I in head and brain of chick embryos: autoradiographic localization.

J. Roth, L. Bassas, F. de Pablo, 1989, Endocrinology.

Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers.

E. Van Obberghen, J. Roth, P. De Meyts, 1976, The Journal of biological chemistry.

Immunoassay of plasma vasopressin in man.

J. Roth, P. Gorden, G. Robertson, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Corticotropin and β-endorphin-like materials are native to unicellular organisms

C. Pert, J. Shiloach, D. Leroith, 1982 .

J. Grizard, J. Roth, M. Lesniak, 1990, Neurochemistry International.

Are messenger molecules in microbes the ancestors of the vertebrate hormones and tissue factors?

J. Shiloach, D. Krieger, D. Le Roith, 1983, Federation proceedings.

Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation.

C. Kahn, J. Roth, K. Megyesi, 1976, The Journal of clinical investigation.

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

E. Obberghen, J. Roth, A. Wollmer, 1978, Nature.

Increased insulin binding to erythrocytes in anorexia nervosa: restoration to normal with refeeding.

D Rodbard, J Roth, D. Rodbard, 1979, The New England journal of medicine.

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

C. Kahn, J. Roth, P. Gorden, 1976, The Journal of clinical investigation.

Cell membrane receptors for polypeptide hormones. Application to the study of disease states in mice, and men.

C. Kahn, J. Roth, 1975, American journal of clinical pathology.

INSULIN IN THE BRAIN AND OTHER EXTRAPANCREATIC TISSUES

M. Brownstein, J. Roth, J. Havránková, 1981 .

Radiohistochemical localization of insulin receptors in the adult and developing rat brain

M. Brownstein, M. Kuhar, J. Roth, 1980, Neuropeptides.

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.

R. Carson, D. Orloff, C. Roberts, 1992, The Journal of clinical investigation.

Brain glucose metabolism in noninsulin-dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic glucose clamp.

R E Carson, S M Larson, J Roth, 1990, The Journal of clinical endocrinology and metabolism.

Growth Hormone Releasing Hormone (GHRH) Effects in Healthy Aging Men

P. L. Smith, J. Busby‐Whitehead, J. Tobin, 1996 .

Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.

Simeon I. Taylor, T. Kadowaki, S. Taylor, 1990, The Journal of clinical investigation.

The insulin-stimulated receptor kinase is a tyrosine-specific casein kinase.

G. Grunberger, S. Taylor, Y. Zick, 1983, European journal of biochemistry.

A novel chicken homeobox-containing gene expressed in neurulating embryos.

E. J. de la Rosa, J. Roth, F. de Pablo, 1993, Biochemical and biophysical research communications.

Evolutionary origins of vertebrate hormones: material very similar to adrenocorticotropic hormone, beta-endorphin, and dynorphin in protozoa.

C. Pert, J. Shiloach, D. Krieger, 1981, Transactions of the Association of American Physicians.

The insulin receptor of the turkey erythrocyte. Characterization of the membrane-bound receptor.

C. Kahn, J. Roth, B. Ginsberg, 1976, Biochimica et biophysica acta.

Corticotropin and beta-endorphin-like materials are native to unicellular organisms.

C. Pert, J. Shiloach, D. Krieger, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Ontogeny, circadian rhythm pattern, and hormonal modulation of 5 alpha-dihydrotestosterone receptors in the rat pineal.

C. Haldar, J. Roth, D. Gupta, 1993, Neuroendocrinology.

Two distinct insulins in the guinea pig: the broad relevance of these findings to evolution of peptide hormones.

D. Le Roith, J. Roth, J. Rosenzweig, 1983, Federation proceedings.

Receptors: Birth, Eclipse, and Rediscovery

J. Roth, 1988 .

Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients

C. Kahn, L. Harrison, J. Roth, 1982, Diabetologia.

Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone.

A. Zeleznik, J. Roth, 1978, The Journal of clinical investigation.

TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans.

A. Shuldiner, K. Silver, J. Sorkin, 1997, Human genetics.

Insulin-induced receptor loss in the cultured human lymphocyte: quantitative morphological perturbations in the cell and plasma membrane.

L. Orci, E. Van Obberghen, E. Obberghen, 1979, Journal of cell science.

Two distinct insulin-related molecules in the guinea pig: immunological and biochemical characterization of insulin-like immunoactivity from extrapancreatic tissues of the guinea pig

D. Krieger, D. Leroith, L. Frohman, 1985, Diabetologia.

Insulin immunoreactive sites demonstrated in the Golgi apparatus of pancreatic B cells.

L. Orci, J. Roth, A. Perrelet, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Rapid effects of insulin on cyclic GMP location in an intact protozoan

L. Kőhidai, J. Roth, S. Marx, 1992, Experientia.

Water-soluble specific growth hormone binding sites from cultured human lymphocytes: preparation and partial characterization.

J. Roth, P. Gorden, J. Gavin, 1976, Endocrinology.

Circulating insulin: th proinsulin-like properties of "big" insulin in patients withou islet cell tumors.

J. Roth, P. Gorden, B. Sherman, 1971, Journal of Clinical Investigation.

Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain

C. Pert, J. Roth, Joannam . Hill, 1987 .

Insulin and Insulin Receptors in the Nervous System of Mammals

M. Brownstein, W. Young, J. Roth, 1981 .

Regulation of insulin receptors in normal and abnormal physiology in humans.

C. Kahn, L. Harrison, M. Muggeo, 1979, Advances in internal medicine.

Receptors for Insulin and Insulin-Like Growth Factors I and II in PCD Mice and Diabetic Rats are Unaltered: An Autoradiographic Study

J. Roth, M. Rojeski, 1989 .

Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive.

D. Leroith, K. Rother, R. Vigneri, 2013, Endocrine reviews.