K. Derkach

发表

On the tyrosine kinase mechanism of the novel effect of insulin and insulinlike growth factor I. Stimulation of the adenylyl cyclase system in muscle tissues.

M. Pertseva, S. Plesneva, L. Kuznetsova, 1996, Biochemical pharmacology.

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

A. Shpakov, K. Derkach, L. Berstein, 2015, International journal of endocrinology.

Regulation by cyclic adenosine monophosphate of functional activity of the adenylyl cyclase system in the infusorian Dileptus anser

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2010, Journal of Evolutionary Biochemistry and Physiology.

Functional characteristics of calcium-sensitive adenylyl cyclase of the infusorian Tetrahymena pyriformis

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2010, Cell and Tissue Biology.

Effects of three types of bariatric interventions on myocardial infarct size and vascular function in rats with type 2 diabetes mellitus.

A. Shpakov, K. Derkach, Y. Toropova, 2021, Life sciences.

The Effect of Different Types of Bariatric Surgery on Metabolic and Hormonal Parameters in Rats with a Decompensated Form of Type II Diabetes Mellitus

A. Shpakov, K. Derkach, L. Litvinova, 2019, Advances in Gerontology.

Effects of Intranasally Administered Insulin and Gangliosides on Metabolic Parameters and Activity of the Hepatic Insulin System in Rats with Type 2 Diabetes Mellitus

A. Shpakov, K. Derkach, I. O. Zakharova, 2022, Journal of Evolutionary Biochemistry and Physiology.

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

A. Shpakov, K. Derkach, I. O. Zakharova, 2021, International journal of molecular sciences.

The Influence of Intranasally Administered Insulin and C-peptide on AMP-Activated Protein Kinase Activity, Mitochondrial Dynamics and Apoptosis Markers in the Hypothalamus of Rats with Streptozotocin-Induced Diabetes

A. Shpakov, K. Derkach, I. Zorina, 2020, Journal of Evolutionary Biochemistry and Physiology.

The effect of metformin treatment on the basal and gonadotropin‐stimulated steroidogenesis in male rats with type 2 diabetes mellitus

A. Shpakov, K. Derkach, I. Zorina, 2020, Andrologia.

The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents

A. Shpakov, K. Derkach, A. Mikhrina, 2018, Neurochemical Research.

The influence of prolonged streptozotocin diabetes on the thyroid gland function in rats

A. Shpakov, K. Derkach, I. V. Moyseyuk, 2013, Doklady Biochemistry and Biophysics.

Androgen Deficiency in Male Rats with Prolonged Neonatal Streptozotocin Diabetes

A. Shpakov, K. Derkach, O. Chistyakova, 2013, Bulletin of Experimental Biology and Medicine.

The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus

A. Shpakov, K. Derkach, 2013, Journal of signal transduction.

Decrease in the Basal and Luteinizing Hormone Receptor Agonist–Stimulated Testosterone Production in Aging Male Rats

A. Shpakov, K. Derkach, D. Dar'in, 2019, Advances in Gerontology.

Glucose and Cyclic Adenosine Monophosphate Stimulate Activities of Adenylate Cyclase and Guanylate Cyclase of Tetrahymena Pyriformis Infusoria

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2012, Bulletin of Experimental Biology and Medicine.

Prospects of intranasal insulin for correction of cognitive impairments, in particular those associated with diabetes mellitus.

A. Shpakov, K. Derkach, E. Surkova, 2019, Problemy endokrinologii.

The effect of 2-month bromocriptine treatment on the activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes

A. Shpakov, K. Derkach, I. V. Moiseyuk, 2015, Cell and Tissue Biology.

Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia–reperfusion injury in non-obese non-diabetic rats

A. Shpakov, K. Derkach, E. Shlyakhto, 2021, Scientific Reports.

Molecular mechanisms of action of natural amino acids and serotonin on infusorian adenylyl cyclase and guanylyl cyclase

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2012, Cell and Tissue Biology.

Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa

A. Shpakov, K. Derkach, 2014, Journal of Evolutionary Biochemistry and Physiology.

Restoration of β-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats

A. Shpakov, K. Derkach, M. Galagudza, 2020, Bulletin of Experimental Biology and Medicine.

Antibodies to extracellular regions of G protein-coupled receptors and receptor tyrosine kinases as one of the causes of autoimmune diseases

A. Shpakov, K. Derkach, O. Zharova, 2017, Journal of Evolutionary Biochemistry and Physiology.

The Role of Apelin in the Functioning of the Reproductive System

A. Shpakov, K. Derkach, 2019, Acta Biomedica Scientifica (East Siberian Biomedical Journal).

Effect of long-term L-thyroxine treatment on the activity of NO-synthases in tissues of rats with obesity induced by high-fat diet

L. Kuznetsova, A. Shpakov, K. Derkach, 2015, Journal of Evolutionary Biochemistry and Physiology.

Regulatory calcium effect on adenylyl cyclase functional activity in the infusorian Dileptis anser

M. Pertseva, S. Plesneva, L. Kuznetsova, 2007, Journal of Evolutionary Biochemistry and Physiology.

[Perspectives of application of intranasally administered insulin for correction of metabolic and hormonal disorders in diabetes mellitus and metabolic syndrome].

A. Shpakov, K. Derkach, E. Surkova, 2019, Problemy endokrinologii.

The Effect of Diet-Induced and Melanocortin Obesity on Expression of Tryptophan Hydroxylase 2 in the Dorsal Raphe Nucleus and Ventral Tegmental Area in Mice

A. Shpakov, K. Derkach, I. Romanova, 2019, Journal of Evolutionary Biochemistry and Physiology.

Changes in Hormone Sensitivity of the Adenylate Cyclase Signaling System in the Testicular Tissue of Rats with Neonatal Streptozotocin-Induced Diabetes

A. Shpakov, K. Derkach, V. Bondareva, 2009, Bulletin of Experimental Biology and Medicine.

Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet

A. Shpakov, K. Derkach, N. Verlov, 2017, Advances in Gerontology.

Changes in Nociceptive Thresholds and Adenylyl Cyclase System Activity in Skeletal Muscles in Rats with Acute and Mild Type 1 Diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2017, Neuroscience and Behavioral Physiology.

Metabolic parameters and functional state of hypothalamic signaling systems in AY/a mice with genetic predisposition to obesity and the effect of metformin

A. Shpakov, K. Derkach, I. Zorina, 2017, Doklady Biochemistry and Biophysics.

Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome

A. Shpakov, K. Derkach, A. Kulikova, 2017, Bulletin of experimental biology and medicine.

Androgen Deficiency in Male Rats with Prolonged Neonatal Streptozotocin Diabetes

A. Shpakov, K. Derkach, O. Chistyakova, 2013, Bulletin of Experimental Biology and Medicine.

The Effect of Intranasal Administration of Proinsulin C-peptide and Its C-terminal Fragment on Metabolic Parameters in Rats with Streptozotocin Diabetes

A. Shpakov, K. Derkach, V. Bondareva, 2018, Journal of Evolutionary Biochemistry and Physiology.

Molecular Mechanisms of the Effects of Metformin on the Functional Activity of Brain Neurons

A. Shpakov, K. Derkach, 2018, Neuroscience and Behavioral Physiology.

New achievements in development and application of GPCR-peptides

A. Shpakov, K. Derkach, 2015, Journal of Evolutionary Biochemistry and Physiology.

Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin

O. V. Chistyakova, A. Shpakov, K. Derkach, 2013 .

Hormonal Signaling Systems of the Brain in Diabetes Mellitus

O. V. Chistyakova, A. Shpakov, K. Derkach, 2011 .

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats

A. Shpakov, K. Derkach, D. Dar'in, 2020, International journal of molecular sciences.

Specificity of heterotrimeric G protein regulation by human chorionic gonadotropin and low-molecular agonist of luteinizing hormone receptor

A. Shpakov, K. Derkach, A. Bakhtyukov, 2017, Cell and Tissue Biology.

The Low-Molecular-Weight Ligands of the Gonadotropin Receptors as the New Generation of the Regulators of the Reproductive Functions and Steroidogenesis

A. Shpakov, K. Derkach, D. Dar'in, 2019, Innovations In Assisted Reproduction Technology.

Intratesticular, intraperitoneal, and oral administration of thienopyrimidine derivatives increases the testosterone level in male rats

A. Shpakov, K. Derkach, D. Dar'in, 2014, Doklady Biological Sciences.

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

A. Shpakov, K. Derkach, A. Bakhtyukov, 2018 .

Peptide 612–627 of thyrotropin receptor and its modified analogs as regulators of adenylyl cyclase in rat thyroid gland

A. Shpakov, K. Derkach, I. Tarasenko, 2014, Cell and Tissue Biology.

Peptides Derived from the Third Cytoplasmic Loop of the Serotonin Subtype 1B Receptor Selectively Inhibit Transmission of Serotoninergic Signals via Their Homologous Receptors

O. V. Chistyakova, A. Shpakov, K. Derkach, 2012, Neuroscience and Behavioral Physiology.

Functional state of adenylyl cyclase signaling system in rat testis and ovary under conditions of fasting

O. V. Chistyakova, A. Shpakov, K. Derkach, 2011, Journal of Evolutionary Biochemistry and Physiology.

Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa

A. Shpakov, K. Derkach, 2014, Journal of Evolutionary Biochemistry and Physiology.

The Melanocortin Signal System of the Hypothalamus and Its Functional State in Type 2 Diabetes Mellitus and Metabolic Syndrome

A. Shpakov, K. Derkach, 2017, Neuroscience and Behavioral Physiology.

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

A. Shpakov, K. Derkach, I. Zorina, 2023, International journal of molecular sciences.

Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases

A. Shpakov, K. Derkach, L. Berstein, 2015, Future science OA.

Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones

A. Shpakov, K. Derkach, I. Balova, 2023, International journal of molecular sciences.

Effect of Different Luteinizing Hormone Receptor Agonists on Ovarian Steroidogenesis in Mature Female Rats

A. Shpakov, K. Derkach, A. Bakhtyukov, 2023, Journal of Evolutionary Biochemistry and Physiology.

[Characterization and biological activity of new 4-oxo-1,4-dihydrocinnoline-based inhibitors of the tyrosine phosphatase PTP1B and TCPTP].

A. Shpakov, K. Derkach, A. Bakhtyukov, 2022, Biomeditsinskaia khimiia.

The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect

A. Shpakov, K. Derkach, I. Zorina, 2019, PloS one.

A change of hormonal regulation of adenylyl cyclase in epididymal adipose tissue of rats with experimental models of diabetes mellitus

O. V. Chistyakova, A. Shpakov, K. Derkach, 2014, Journal of Evolutionary Biochemistry and Physiology.

The New Pharmacological Approaches for the Regulation of Functional Activity of G Protein-Coupled Receptors

A. Shpakov, K. Derkach, 2018 .

Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2011, Central European Journal of Biology.

Comparative study of functional activity of the D2-dopaminergic system in the hypothalamus of rats with different models of diabetes mellitus

A. Shpakov, K. Derkach, I. Sukhov, 2016, Journal of Evolutionary Biochemistry and Physiology.

Effect of long-term L-thyroxine treatment on the activity of NO-synthases in tissues of rats with obesity induced by high-fat diet

L. Kuznetsova, A. Shpakov, K. Derkach, 2015, Journal of Evolutionary Biochemistry and Physiology.

Peptidergic signaling brain systems in diabetes mellitus

A. Shpakov, K. Derkach, 2013, Cell and Tissue Biology.

Effect of intranasal insulin and serotonin on functional activity of the adenylyl cyclase system in myocardium, ovary, and uterus of rats with prolonged neonatal model of diabetes mellitus

O. V. Chistyakova, A. Shpakov, K. Derkach, 2013, Journal of Evolutionary Biochemistry and Physiology.

Hormonal Sensitivity of Adenylyl Cyclase in the Myocardium, Brain and Testes of 18-month -old Non -Diabetic and Diabetic Rats

O. V. Chistyakova, A. Shpakov, K. Derkach, 2013 .

The Brain Adenylyl Cyclase Signaling System and Cognitive Functions in Rats with Neonatal Diabetes under the Influence of Intranasal Serotonin

O. V. Chistyakova, A. Shpakov, K. Derkach, 2012 .

Metabolic Syndrome

O. V. Chistyakova, A. Shpakov, K. Derkach, 2012 .

Activity of receptor guanylyl cyclases in rats with neonatal streptozotocin diabetes and effect of intranasal administration of insulin and serotonin

O. V. Chistyakova, A. Shpakov, K. Derkach, 2011, Cell and Tissue Biology.

Peptidergic signaling brain systems in diabetes mellitus

A. Shpakov, K. Derkach, 2013, Cell and Tissue Biology.

Effect of intranasal insulin and serotonin on functional activity of the adenylyl cyclase system in myocardium, ovary, and uterus of rats with prolonged neonatal model of diabetes mellitus

O. V. Chistyakova, A. Shpakov, K. Derkach, 2013, Journal of Evolutionary Biochemistry and Physiology.

[The brain peptidergic signaling systems in diabetes mellitus].

A. Shpakov, K. Derkach, 2012, Tsitologiia.

[A decrease of sensitivity of adenylyl cyclase and heterotrimeric G-proteins to chorionic gonadotropin and peptide hormones action in the tissues of reproductive system of the rats in the condition of experimental type 2 diabetes].

A. Shpakov, K. Derkach, V. Bondareva, 2010, Biomeditsinskaia khimiia.

Differential Stimulation of Testicular Steroidogenesis by Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor

A. Shpakov, K. Derkach, D. Dar'in, 2020, Journal of Evolutionary Biochemistry and Physiology.

Changes in the hormonal status of cardiovascular and the thyroid systems in rats with 18-month type 2 diabetes mellitus

A. Shpakov, K. Derkach, P. A. Ignatieva, 2016, Advances in Gerontology.

Regulation of the Melanocortin-Sensitive Adenylate Cyclase System by N-Acylated Peptide 71-82 of Type 4 Melanocortin Receptor

A. Shpakov, K. Derkach, E. Shpakova, 2015, Bulletin of Experimental Biology and Medicine.

Relationship between the changes in peripheral thresholds of nociception and activity of the adenylyl cyclase system in the skeletal muscles of rats with streptozotocin-induced diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2014, Doklady Biological Sciences.

Regulatory Effects of Intranasal C-peptide and Insulin on Thyroid and Androgenic Status of Male Rats with Moderate Type 1 Diabetes Mellitus

A. Shpakov, K. Derkach, V. Bondareva, 2019, Journal of Evolutionary Biochemistry and Physiology.

Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome

A. Shpakov, K. Derkach, A. Kulikova, 2017, Bulletin of Experimental Biology and Medicine.

Functional state of hypothalamic signaling systems in rats with type 2 diabetes mellitus treated with intranasal insulin

O. V. Chistyakova, A. Shpakov, K. Derkach, 2016, Journal of Evolutionary Biochemistry and Physiology.

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

A. Shpakov, K. Derkach, L. Berstein, 2015, Hormone and Metabolic Research.

Effect of High-Dose Metformin on the Metabolic Parameters and Functional State of the Liver of Agouti Mice with Melanocortin Obesity

A. Shpakov, K. Derkach, I. Zorina, 2020, Advances in Gerontology.

Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice

A. Shpakov, K. Derkach, G. Gurusubramanian, 2020, Molecular reproduction and development.

Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus

A. Shpakov, K. Derkach, A. Bakhtyukov, 2022, Bulletin of Experimental Biology and Medicine.

The stimulating effect of thienopyrimidines structurally similar to Org 43553 on adenylate cyclase activity in the testes and on testosterone production in male rats

A. Shpakov, K. Derkach, A. S. Legkodukh, 2017, Cell and Tissue Biology.

In vitro and in vivo studies of functional activity of new low molecular weight agonists of the luteinizing hormone receptor

A. Shpakov, K. Derkach, A. Bakhtyukov, 2016, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

The thyroid status of rats immunized with peptides derived from the extracellular regions of the types 3 and 4 melanocortin receptors and the 1B-subtype 5-hydroxytryptamine receptor

A. Shpakov, K. Derkach, I. V. Moiseyuk, 2015, Journal of Evolutionary Biochemistry and Physiology.

Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries

A. Shpakov, K. Derkach, D. Dar'in, 2014, Cell and Tissue Biology.

Receptor and tissue specificity of the effects of peptides corresponding to intracellular regions of the serpentine type receptors

A. Shpakov, K. Derkach, I. Tarasenko, 2012, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

The effect of four-week levothyroxine treatment on hormonal regulation of adenylyl cyclase in the brain and peripheral tissues of obese rats

O. V. Chistyakova, L. Kuznetsova, A. Shpakov, 2015, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

Effects of Intranasally Administered Insulin and Gangliosides on Hypothalamic Signaling and Expression of Hepatic Gluconeogenesis Genes in Rats with Type 2 Diabetes Mellitus

A. Shpakov, K. Derkach, L. Bayunova, 2022, Journal of Evolutionary Biochemistry and Physiology.

The Restorative Effect of Combined Insulin and C-Peptide Intranasal Administration on Hormonal Status and Hypothalamic Signaling in the Male Rat Model of Severe Short-Term Streptozotocin-Induced Diabetes

A. Shpakov, K. Derkach, I. Zorina, 2022, Journal of Evolutionary Biochemistry and Physiology.

Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus

A. Shpakov, K. Derkach, I. Zorina, 2020, Bulletin of Experimental Biology and Medicine.

Intranasal Administration of Proinsulin C-Peptide Enhances the Stimulating Effect of Insulin on Insulin System Activity in the Hypothalamus of Diabetic Rats

A. Shpakov, K. Derkach, D. Buzanakov, 2019, Bulletin of Experimental Biology and Medicine.

Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus

A. Shpakov, K. Derkach, I. Zorina, 2020, Bulletin of experimental biology and medicine.

Insulin and Leptin Levels in Blood and Brain Structures of Rats with Diet-Induced Obesity and the Effect of Various Drugs on Them

A. Shpakov, K. Derkach, V. Bondareva, 2022, Journal of Evolutionary Biochemistry and Physiology.

4-oxo-1,4-dihydrocinnoline Derivative with Phosphatase 1B Inhibitor Activity Enhances Leptin Signal Transduction in Hypothalamic Neurons

A. Shpakov, K. Derkach, L. Bayunova, 2018, Journal of Evolutionary Biochemistry and Physiology.

The Effect of Metformin Therapy on Luteinizing Hormone Receptor Agonist-Mediated Stimulation of Testosterone Production and Spermatogenesis in Diabetic Rats

A. Shpakov, K. Derkach, A. Bakhtyukov, 2021, Journal of Evolutionary Biochemistry and Physiology.

Functional Interaction between the Dopamine and Melanocortin Systems of the Brain

A. Shpakov, K. Derkach, I. V. Romanova, 2016, Neuroscience and Behavioral Physiology.

Alterations in adenylyl cyclase sensitivity to hormones in the brain, myocardium, and testes of rats immunized with BSA-conjugated peptide 269–280 of type 3 melanocortin receptor

A. Shpakov, K. Derkach, V. Bondareva, 2015, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

The functional activity of the adenylate cyclase system in the brains of rats with metabolic syndrome induced by immunization with peptide 11–25 of the type 4 melanocortin receptor

A. Shpakov, K. Derkach, O. Zharova, 2015, Neurochemical Journal.

The influence of prolonged streptozotocin diabetes on the thyroid gland function in rats

A. Shpakov, K. Derkach, I. V. Moyseyuk, 2013, Doklady Biochemistry and Biophysics.

Antibodies to extracellular regions of G protein-coupled receptors and receptor tyrosine kinases as one of the causes of autoimmune diseases

A. Shpakov, K. Derkach, O. Zharova, 2017, Journal of Evolutionary Biochemistry and Physiology.

Functional activity of thyroid gland in male rats with acute and mild streptozotocin diabetes

A. Shpakov, K. Derkach, I. V. Moiseyuk, 2014, Journal of Evolutionary Biochemistry and Physiology.

Functional Interaction between the Dopamine and Melanocortin Systems of the Brain

A. Shpakov, K. Derkach, I. Romanova, 2016, Neuroscience and Behavioral Physiology.

Thienopyrimidine Derivatives Specifically Activate Testicular Steroidogenesis but Do Not Affect Thyroid Functions

A. Shpakov, K. Derkach, D. Dar'in, 2019, Journal of Evolutionary Biochemistry and Physiology.

Conservation of Steroidogenic Effect of the Low-Molecular-Weight Agonist of Luteinizing Hormone Receptor in the Course of Its Long-Term Administration to Male Rats

A. Shpakov, K. Derkach, D. Dar'in, 2019, Doklady Biochemistry and Biophysics.

Effect of Low-Molecular-Weight Allosteric Agonists of the Luteinizing Hormone Receptor on Its Expression and Distribution in Rat Testes

A. Shpakov, K. Derkach, T. Sokolova, 2021, Journal of Evolutionary Biochemistry and Physiology.

Low-Molecular-Weight Ligands of Luteinizing Hormone Receptor with the Activity of Antagonists

A. Shpakov, K. Derkach, D. Dar'in, 2020, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology.

Specificity of heterotrimeric G protein regulation by human chorionic gonadotropin and low-molecular agonist of luteinizing hormone receptor

A. Shpakov, K. Derkach, D. Dar'in, 2017, Cell and Tissue Biology.

In vitro and in vivo studies of functional activity of new low molecular weight agonists of the luteinizing hormone receptor

A. Shpakov, K. Derkach, D. Dar'in, 2016, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

The stimulating effect of thienopyrimidines structurally similar to Org 43553 on adenylate cyclase activity in the testes and on testosterone production in male rats

A. Shpakov, K. Derkach, D. Dar'in, 2017, Cell and Tissue Biology.

Intranasal and Intramuscular Administration of Lysine-Palmitoylated Peptide 612–627 of Thyroid-Stimulating Hormone Receptor Increases the Level of Thyroid Hormones in Rats

A. Shpakov, K. Derkach, A. Titov, 2015, International Journal of Peptide Research and Therapeutics.

Intratesticular, intraperitoneal, and oral administration of thienopyrimidine derivatives increases the testosterone level in male rats

A. Shpakov, K. Derkach, D. Dar'in, 2014, Doklady Biological Sciences.

The stimulating influence of thienopyrimidine compounds on the adenylyl cyclase signaling systems in the rat testes

A. Shpakov, K. Derkach, D. Dar'in, 2014, Doklady Biochemistry and Biophysics.

The Peptides Mimicking the Third Intracellular Loop of 5-Hydroxytryptamine Receptors of the Types 1B and 6 Selectively Activate G Proteins and Receptor-Specifically Inhibit Serotonin Signaling via the Adenylyl Cyclase System

A. Shpakov, K. Derkach, I. Tarasenko, 2010, International Journal of Peptide Research and Therapeutics.

The effect of long-term diabetes mellitus induced by treatment with streptozotocin in 6-week-old rats on functional activity of the adenylyl cyclase system

O. V. Chistyakova, A. Shpakov, K. Derkach, 2014, Cell and Tissue Biology.

Expression and localization of apelin and its receptor in the testes of diabetic mice and its possible role in steroidogenesis.

A. Shpakov, K. Derkach, G. Gurusubramanian, 2021, Cytokine.

A Low Molecular Weight Agonist of the Luteinizing Hormone Receptor Stimulates Adenylyl Cyclase in the Testicular Membranes and Steroidogenesis in the Testes of Rats with Type 1 Diabetes

A. Shpakov, K. Derkach, D. Dar'in, 2019, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology.

The Effect of Intranasal Administration of Proinsulin C-peptide and Its C-terminal Fragment on Metabolic Parameters in Rats with Streptozotocin Diabetes

A. Shpakov, K. Derkach, V. Bondareva, 2018, Journal of Evolutionary Biochemistry and Physiology.

The effect of 2-month bromocriptine treatment on the activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes

A. Shpakov, K. Derkach, I. V. Moiseyuk, 2015, Cell and Tissue Biology.

[The role of sulfhydryl groups in functioning of components of adenylate cyclase signal system in smooth muscles of the mollusk Anodonta cygnea (effect of N-ethylmaleimide and p-chloromercuribenzoic acid)].

A. Shpakov, K. Derkach, 1999, Tsitologiya.

Peptides Derived from the Third Cytoplasmic Loop of the Serotonin Subtype 1B Receptor Selectively Inhibit Transmission of Serotoninergic Signals via Their Homologous Receptors

A. Shpakov, K. Derkach, I. Tarasenko, 2012, Neuroscience and Behavioral Physiology.

New Thieno-[2,3-d]pyrimidine-Based Functional Antagonist for the Receptor of Thyroid Stimulating Hormone

A. Shpakov, K. Derkach, A. Bakhtyukov, 2020, Doklady Biochemistry and Biophysics.

Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity

A. Shpakov, K. Derkach, A. Bakhtyukov, 2022, Doklady Biochemistry and Biophysics.

The Study of Biological Activity of a New Thieno[2,3-D]-Pyrimidine-Based Neutral Antagonist of Thyrotropin Receptor

A. Shpakov, K. Derkach, V. Sorokoumov, 2022, Bulletin of Experimental Biology and Medicine.

Biological activity in vitro and in vivo of peptides corresponding to the third intracellular loop of thyrotropin receptor

O. V. Chistyakova, A. Shpakov, K. Derkach, 2012, Doklady Biochemistry and Biophysics.

Effect of Peptides Corresponding to Extracellular Domains of Serotonin 1B/1D Receptors and Melanocortin 3 and 4 Receptors on Hormonal Regulation of Adenylate Cyclase in Rat Brain

A. Shpakov, K. Derkach, E. Shpakova, 2014, Bulletin of Experimental Biology and Medicine.

Coadministration of Intranasally Delivered Insulin and Proinsulin C-Peptide to Rats with Types 1 and 2 Diabetes Mellitus Restores Their Metabolic Parameters

A. Shpakov, K. Derkach, V. Bondareva, 2018, Advances in Gerontology.

C-Peptide and Insulin during Combined Intranasal Administration Improve the Metabolic Parameters and Activity of the Adenylate Cyclase System in the Hypothalamus, Myocardium, and Epididymal Fat of Rats with Type 2 Diabetes

A. Shpakov, K. Derkach, V. Bondareva, 2019, Cell and Tissue Biology.

The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin

L. Kuznetsova, A. Shpakov, K. Derkach, 2016, Doklady Biochemistry and Biophysics.

Erratum: “Functional state of hypothalamic signaling systems in rats with type 2 diabetes mellitus treated with intranasal insulin”

O. V. Chistyakova, A. Shpakov, K. Derkach, 2016, Journal of Evolutionary Biochemistry and Physiology.

Proinsulin C-peptide and its C-terminal fragments stimulate Gi/o-proteins but do not influence adenylyl cyclase activity

A. Shpakov, K. Derkach, I. Tarasenko, 2015, Journal of Evolutionary Biochemistry and Physiology.

Molecular mechanisms of action of natural amino acids and serotonin on infusorian adenylyl cyclase and guanylyl cyclase

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2012, Cell and Tissue Biology.

Alterations in adenylyl cyclase sensitivity to hormones in the brain, myocardium, and testes of rats immunized with BSA-conjugated peptide 269–280 of type 3 melanocortin receptor

A. Shpakov, K. Derkach, V. Bondareva, 2015, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats

A. Shpakov, K. Derkach, E. Kaznacheyeva, 2023, International journal of molecular sciences.

Inhibition of functional activity of the adenylyl cyclase signaling system of the ciliate Dileptus anser by colchicine and vinblastine

L. Kuznetsova, A. Shpakov, K. Derkach, 2010, Cell and Tissue Biology.

Adenylyl cyclase stimulation by cyclic adenosine monophosphate in the infusorian Dileptus anser cell culture

A. Shpakov, K. Derkach, Z. I. Uspenskaya, 2009, Doklady Biochemistry and Biophysics.

Regulation of the Adenylyl Cyclase System of the Infusorian Tetrahymena pyriformis by Hormonal and Non-Hormonal Agents and Its Dependence on the Basal Activity Level of Adenylyl Cyclase

M. Pertseva, S. Plesneva, L. Kuznetsova, 2003, Journal of Evolutionary Biochemistry and Physiology.

Regulation of the Activity of Adenylate Cyclase and Protein Kinase A of the Infusorians Dileptus anserand Tetrahymena pyriformis by Biogenic Amines and Peptide Hormones

M. Pertseva, S. Plesneva, L. Kuznetsova, 2004, Doklady Biochemistry and Biophysics.

Changes in Nociceptive Thresholds and Adenylyl Cyclase System Activity in Skeletal Muscles in Rats with Acute and Mild Type 1 Diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2017, Neuroscience and Behavioral Physiology.

[Molecular mechanisms of regulatory action of adrenergic receptor agonists on functional activity of adenylyl cyclase signaling system of the ciliates Dileptus anser and Tetrahymena pyriformis].

M. Pertseva, S. Plesneva, L. Kuznetsova, 2004, Tsitologiia.

[The functional role of membrane-bound adenylyl cyclases and the receptors and G-proteins coupled with them in regulation of spermatozoa fertility].

A. Shpakov, K. Derkach, 2014, Zhurnal evoliutsionnoi biokhimii i fiziologii.

The effect of prolonged intranasal administration of serotonin on the activity of hypothalamic signaling systems in male rats with neonatal diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2016, Cell and Tissue Biology.

A Comparative Study of the Steroidogenic Effect of 5-Amino-N-tert-butyl-2-(methylthio)-4-(3-(nicotinamido)phenyl)thieno[2,3-d]-pyrimidine-6-carboxamide and Chorionic Gonadotropin with Different Methods of Administration to Male Rats

A. Shpakov, K. Derkach, V. Sorokoumov, 2022, Journal of Evolutionary Biochemistry and Physiology.

The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents

A. Shpakov, K. Derkach, A. Mikhrina, 2018, Neurochemical Research.

Relationship between the changes in peripheral thresholds of nociception and activity of the adenylyl cyclase system in the skeletal muscles of rats with streptozotocin-induced diabetes

O. V. Chistyakova, A. Shpakov, K. Derkach, 2014, Doklady Biological Sciences.

Efficacy of Various Metformin Doses for the Restoration of Metabolic Indices and Hormonal Status in Early Weaned Male Rats

A. Shpakov, K. Derkach, V. Bondareva, 2022, Journal of Evolutionary Biochemistry and Physiology.

Efficacy of Various Metformin Doses for the Restoration of Metabolic Indices and Hormonal Status in Early Weaned Male Rats

A. Shpakov, K. Derkach, V. Bondareva, 2022, Journal of Evolutionary Biochemistry and Physiology.

The effect of prolonged metformin treatment on the activity of the adenylyl cyclase system and NO-synthase in the brain and myocardium of obese rats

L. Kuznetsova, A. Shpakov, K. Derkach, 2015, Cell and Tissue Biology.

Functional activity of adenylyl and guanylyl cyclases in human spermatozoa with different motility

A. Shpakov, K. Derkach, A. Gryaznov, 2013, Cell and Tissue Biology.

Regulatory properties of adenylyl and guanylyl cyclase in human spermatozoa

A. Shpakov, K. Derkach, A. Gryaznov, 2013, Journal of Evolutionary Biochemistry and Physiology.

Comparative and Ontogenic Biochemistry Functional State of Hypothalamic Signaling Systems in Rats with Type 2 Diabetes Mellitus Treated with Intranasal Insulin

A. Shpakov, K. Derkach, V. Bondareva, 2022 .

Prospects of intranasal insulin for correction of cognitive impairments, in particular those associated with diabetes mellitus.

A. Shpakov, K. Derkach, E. Surkova, 2019, Problemy endokrinologii.

Effects of biogenic amines and glucagon on the adenylate cyclase system in molluscan, holothurian and ascidian muscle membranes

M. Pertseva, L. Kuznetsova, K. Derkach, 1995 .

Efficacy of Metformin Course Application Combined with Intranasal Insulin in Treating Rats with Cafeteria Diet-Induced Obesity

A. Shpakov, K. Derkach, I. Zorina, 2024, Journal of Evolutionary Biochemistry and Physiology.

The relationship between micelle formation and biological activity of peptide 562–572 of luteinizing hormone receptor modified with decanoyl radicals

A. Shpakov, K. Derkach, T. Tennikova, 2017, Cell and Tissue Biology.

Restoration of hypothalamic signaling systems as a cause of improved metabolic parameters in rats with neonatal diabetes model during treatment with bromocriptine mesylate

A. Shpakov, K. Derkach, I. Sukhov, 2017, Cell and Tissue Biology.

Comparative study of functional activity of the D2-dopaminergic system in the hypothalamus of rats with different models of diabetes mellitus

A. Shpakov, K. Derkach, I. Sukhov, 2016, Journal of Evolutionary Biochemistry and Physiology.

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

A. Shpakov, K. Derkach, L. Berstein, 2015, Hormone and Metabolic Research.

The functional activity of adenylyl cyclase signaling system in the brain, myocardium, and testes of rats with 8- and 18-month neonatal diabetes

A. Shpakov, K. Derkach, O. Chistyakova, 2013, Doklady Biochemistry and Biophysics.

Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes

A. Shpakov, K. Derkach, V. Bondareva, 2012, Doklady Biochemistry and Biophysics.

The influence of bromocryptine treatment on activity of the adenylyl cyclase system in the brain of rats with type 2 diabetes mellitus induced by high-fat diet

A. Shpakov, K. Derkach, V. Bondareva, 2014, Doklady Biochemistry and Biophysics.

Development of Approaches to Reducing the Effective Gonadotropin Dose in Treating Androgen Insufficiency in Male Rats with Type 1 Diabetes Mellitus

A. Shpakov, K. Derkach, A. Bakhtyukov, 2022, Journal of Evolutionary Biochemistry and Physiology.

Biological activity of lipophilic derivatives of peptide 562–572 of rat luteinizing hormone receptor

A. Shpakov, K. Derkach, E. Shpakova, 2013, Doklady Biochemistry and Biophysics.

Effect of Metformin on Metabolic Parameters and Hypothalamic Signaling Systems in Rats with Obesity Induced by a High-Carbohydrate and High-Fat Diet

A. Shpakov, K. Derkach, V. Bondareva, 2018, Advances in Gerontology.

Regulation of Adenylyl Cyclase Signaling System in Cell Cultures of Infusoria Dileptus anser and Tetrahymena pyriformis by Peptides of Insulin Superfamily

M. Pertseva, S. Plesneva, L. Kuznetsova, 2004, Journal of Evolutionary Biochemistry and Physiology.

The New Pharmacological Approaches for the Regulation of Functional Activity of G Protein-Coupled Receptors

A. Shpakov, K. Derkach, 2018 .

COMPARATIVE AND ONTOGENIC BIOCHEMISTRY 4-oxo-1 , 4-dihydrocinnoline Derivative with Phosphatase 1 B Inhibitor Activity Enhances Leptin Signal Transduction in Hypothalamic Neurons

A. Shpakov, K. Derkach, V. Sorokoumov, 2018 .

Effectiveness of Course Use of Metformin and its Combination with Intranasal Insulin for Treatment of Rats with “Cafeteria Diet”-Induced Obesity

A. Shpakov, K. Derkach, I. Zorina, 2024, Rossijskij fiziologičeskij žurnal im. I.M. Sečenova.

[Influence of intranasally administered insulin on metabolic and hormonal parameters in adult male rats, impaired due to three-day fasting in the early postnatal period].

A. Shpakov, K. Derkach, V. Bondareva, 2022, Biomeditsinskaia khimiia.

EFFECTIVENESS OF THE COMBINATION OF METFORMIN AND INTRANASAL INSULIN FOR THE CORRECTION OF METABOLIC AND HORMONAL DISTURBANCES IN ADULT MALE RATS WITH METABOLIC SYNDROME INDUCED BY IMPAIRED BREASTFEEDING

A. Shpakov, K. Derkach, N. E. Basova, 2024, Reviews on Clinical Pharmacology and Drug Therapy.