D. Motto

发表

Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex (*)

A. Saltiel, G. Koretzky, J. Pessin, 1996, The Journal of Biological Chemistry.

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

G. Koretzky, S. Ross, J. Wu, 1996, The Journal of experimental medicine.

Endothelial cells and thrombotic microangiopathy.

D. Motto, 2012, Seminars in nephrology.

Review in translational hematology ADAMTS 13 turns 3

D. Motto, D. Ginsburg, G. Levy, 2005 .

Cloning, expression and functional characterization of the full‐length murine ADAMTS13

D. Motto, F. Dorner, F. Scheiflinger, 2005, Journal of thrombosis and haemostasis : JTH.

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.

J. Wu, A. Weiss, G. Koretzky, 1996, Immunity.

Diagnostic approach to von Willebrand disease.

D. Motto, J. Di Paola, C. Ng, 2015, Blood.

INHERITED BLEEDING DISORDERS Diagnostic approach to von Willebrand disease

D. Motto, C. Ng, J. Paola, 2015 .

Systemic antithrombotic effects of ADAMTS13

A. Chauhan, D. Wagner, D. Motto, 2006, The Journal of experimental medicine.

Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.

P. Zoltick, D. Motto, A. Flake, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Red blood cells mediate the onset of thrombosis in the ferric chloride murine model.

A. Chauhan, D. Motto, J. K. Hansen, 2013, Blood.

The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.

J. Fish, C. Matouk, P. Marsden, 2012, The Journal of clinical investigation.

Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis

A. Chauhan, D. Motto, S. Lentz, 2013, Circulation.

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

G. Koretzky, S. Ross, D. Motto, 1996, Journal of immunology.

Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

D. Meyerholz, F. Domann, D. Motto, 2013, Free radical biology & medicine.

ADAMTS13 reduces VWF‐mediated acute inflammation following focal cerebral ischemia in mice

D. Motto, M. Khan, S. Lentz, 2012, Journal of thrombosis and haemostasis : JTH.

von Willebrand factor is a major determinant of ADAMTS‐13 decrease during mouse sepsis induced by cecum ligation and puncture

D. Baruch, C. Denis, D. Motto, 2009, Journal of thrombosis and haemostasis : JTH.

ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.

A. Chauhan, D. Motto, S. Lentz, 2012, Blood.

Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.

A. Chauhan, D. Wagner, D. Motto, 2005, The Journal of clinical investigation.

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein

D. Wechsler, D. Motto, D. Roulston, 2003, Genes, chromosomes & cancer.

ADAMTS 13 deficiency exacerbates VWF-dependent acute myocardial ischemia / reperfusion injury in mice

A. Chauhan, D. Motto, S. Lentz, 2012 .

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells (*)

C. Turck, G. Peltz, G. Koretzky, 1995, The Journal of Biological Chemistry.

Alternatively-Spliced Extra Domain A of Fibronectin Promotes Acute Inflammation and Brain Injury After Cerebral Ischemia in Mice

A. Chauhan, D. Motto, M. Khan, 2012, Stroke.

Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura

P. Mulder, V. Richard, C. Denis, 2016, Journal of thrombosis and haemostasis : JTH.

Complement Activation Associated with ADAMTS13 Deficiency in Human and Murine Thrombotic Microangiopathy

D. Motto, C. Licht, D. Karpman, 2013, The Journal of Immunology.

Coagulation and metastasis – an unexpected role for von Willebrand factor

D. Motto, J. Shavit, D. G. MOTTO, 2006, Journal of thrombosis and haemostasis : JTH.

Rituximab for refractory childhood autoimmune hemolytic anemia.

D. Motto, L. Boxer, James A. Williams, 2002, The Israel Medical Association journal : IMAJ.

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice.

D. Motto, D. Bundle, Jing Huang, 2010, Blood.

The CXCR 4 / CXCR 7 / SDF-1 pathway contributes to the pathogenesis of Shiga toxin – associated hemolytic uremic syndrome in humans and mice

J. Fish, C. Matouk, P. Marsden, 2011 .

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases*

C. Turck, G. Koretzky, D. Motto, 1997, The Journal of Biological Chemistry.

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase*

G. Koretzky, D. Motto, D. Rothstein, 1996, The Journal of Biological Chemistry.

SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells*

Juan Zhang, G. Koretzky, D. Motto, 1997, The Journal of Biological Chemistry.

Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells

G. Koretzky, S. Ross, D. Motto, 1996, Molecular and cellular biology.

Tyrosine Phosphorylation of Grb2-Associated Proteins Correlates with Phospholipase C (cid:103) 1 Activation in T Cells

G. Koretzky, D. Motto, S. Ross, 1996 .

Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone

G. Koretzky, D. Motto, M. A. Musci, 1994, The Journal of experimental medicine.

Modulation of von Willebrand Factor by ADAMTS13

D. Motto, Jennifer Y Barr, 2011 .

Three domains of SLP-76 are required for its optimal function in a T cell line.

G. Koretzky, S. Ross, D. Motto, 1997, Journal of immunology.

Thrombotic thrombocytopenic purpura in humans and mice.

D. Motto, K. Desch, 2007, Arteriosclerosis, thrombosis, and vascular biology.

ATVB In Focus Regulation of Hemostasis and Thrombosis: Insights from Murine Models

D. Motto, K. Desch, 2007 .

Systemic antithrombotic eff ects of ADAMTS13

D. Wagner, D. Motto, W. Bergmeier, 2006 .

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model

E. Ostertag, M. Poncz, K. Bdeir, 2016, Transfusion.

Is there a shared pathophysiology for thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome?

D. Motto, K. Desch, 2007, Journal of the American Society of Nephrology : JASN.

Blood group O and black race are independent risk factors for thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency

S. Vesely, J. George, B. Lämmle, 2011, Transfusion.

Murine Thrombotic Microangiopathy ADAMTS13 Deficiency in Human and Complement Activation Associated with

D. Motto, C. Licht, D. Karpman, 2013 .

Hemoglobin versus ADAMTS13

D. Motto, 2005 .

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

G. Remuzzi, A. Benigni, D. Motto, 2009, Gene Therapy.

Recombinant ADAMTS13 Processing by FXIa Is Distinct from Thrombin.

D. Motto, E. Guinto, R. Greenfield, 2006 .

Phenotypic Expression of ADAMTS13 in Glomerular Endothelial Cells

S. Satchell, P. Mathieson, D. Motto, 2011, PloS one.

Phenotypic Expression of ADAMTS 13 in Glomerular Endothelial Cells

Simon, P. Mathieson, D. Motto, 2011 .

Title Phenotypic expression of ADAMTS 13 in glomerular endothelialcells

Simon, P. Mathieson, D. Motto, 2011 .

SH3 Domain-mediated Interaction of Dystroglycan and Grb2(*)

K. Campbell, G. Koretzky, D. Motto, 1995, The Journal of Biological Chemistry.

Contribution of Drosophila DEG/ENaC Genes to Salt Taste

W. A. Johnson, M. Welsh, D. Motto, 2003, Neuron.

Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons

W. A. Johnson, C. M. Adams, M. Welsh, 1998, The Journal of cell biology.

ADAMTS13 turns 3.

D. Motto, D. Ginsburg, G. Levy, 2005, Blood.

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

Q. Sun, G. Koretzky, S. Ross, 1994, The Journal of biological chemistry.

Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.

G. Koretzky, S. Ross, D. Motto, 1993, Science.

The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.

A. Chauhan, D. Wagner, D. Motto, 2008, Blood.

Clues to DVT pathogenesis.

D. Motto, 2011, Blood.

Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter.

G. Koretzky, D. Motto, S. Sunden, 1996, Genomics.

Endothelial Injury and Thrombus Formation In the Ferric Chloride Murine Model of Hemostasis

A. Chauhan, D. Motto, J. Barr, 2010 .

ADAMTS13 Binds VWF Via its C-Terminal CUB2 Domain.

D. Motto, D. Ginsburg, Weirui Zhang, 2004 .

The Metalloprotease ADAMTS13 Is a Natural Anti-Thrombotic.

A. Chauhan, D. Wagner, D. Motto, 2005 .

Additional Environmental and/or Genetic Factors Are Required to Trigger TTP in ADAMTS13-Deficient Mice.

D. Motto, D. Ginsburg, J. Homeister, 2004 .

ADAMTS-13, VWF, inflammation, and thrombosis

D. Motto, 2004 .