Y. Shechter

Y. Mardor, D. Last, D. Guez, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Hydroxyphenyl acetate derivatives inhibit protein tyrosine kinase activity and proliferation in Nb2 rat lymphoma cells and insulin-induced lipogenesis in rat adipocytes

Y. Shechter, A. Gertler, E. Sakal, 1991, Molecular and Cellular Endocrinology.

Purification and properties of insulin receptors from rat liver membranes.

P. Cuatrecasas, Y. Shechter, S. Jacobs, 1977, Biochemical and Biophysical Research Communications - BBRC.

mechanism to enhance glucose metabolism Vanadate restores glucose 6-phosphate in diabetic rats: a

Y. Shechter, I. Goldwaser, M. Fridkin, 2016 .

Engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

Y. Shechter, M. Fridkin, M. Fridkin, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Insulin-like effects of tungstate and molybdate: mediation through insulin receptor independent pathways

J. Libman, A. Shanzer, G. Elberg, 1995, Endocrine.

Albumin-insulin conjugate releasing insulin slowly under physiological conditions: a new concept for long-acting insulin.

Y. Shechter, M. Fridkin, S. Rubinraut, 2005, Bioconjugate chemistry.

Phenylarsine oxide and vanadate: apparent paradox of inhibition of protein phosphotyrosine phosphatases in rat adipocytes.

G. Elberg, J. Li, Y. Shechter, 1996, Biochimica et biophysica acta.

A dynamic system for suppression and re-expression of insulin and pervanadate bioresponses in rat adipocytes. Treatment with okadaic acid and staurosporine.

A. Shisheva, Y. Shechter, 1994, Biochemical pharmacology.

Mechanism of pervanadate stimulation and potentiation of insulin-activated glucose transport in rat adipocytes: dissociation from vanadate effect.

A. Shisheva, Y. Shechter, 1993, Endocrinology.

A cytosolic protein tyrosine kinase in rat adipocytes

A. Shisheva, Y. Shechter, 1992, FEBS letters.

Preparation and application of radioiodinated sulfhydryl reagents for the covalent labeling of SH-proteins present in minute quantities.

A. Shisheva, Y. Shechter, E. Hazum, 1992, Journal of biochemical and biophysical methods.

Hydrophobic carriers of vanadyl ions augment the insulinomimetic actions of vanadyl ions in rat adipocytes.

J. Libman, A. Shanzer, A. Shisheva, 1992, Biochemistry.

Differential effects of two phosphodiesterase inhibitors on fat cell metabolism.

Y. Shechter, Yoram Shechter, 1984, Endocrinology.

Mice immunized to insulin develop antibody to the insulin receptor

I. Cohen, Y. Shechter, D. Elias, 1983, Journal of cellular biochemistry.

Bound lectins that mimic insulin produce persistent insulin-like activities.

Y. Shechter, 1983, Endocrinology.

Evaluation of adenosine or related nucleosides as physiological regulators of lipolysis in adipose tissue.

Y. Shechter, Yoram Shechter, 1982, Endocrinology.

Evaluation of factors responsible for the inability of insulin to antagonize lipolysis due to high concentrations of catecholamines.

A. Hizi, Y. Shechter, P. Reitman, 1982, Biochemical and biophysical research communications.

Insulin-like effects of wax bean agglutinin in rat adipocytes.

Y. Shechter, B. Sela, 1981, Biochemical and biophysical research communications.

Vanadyl ions stimulate K+ uptake into isolated perfused rat liver via the Na+/K+-pump by a tyrosine kinase-dependent mechanism

Z. Halpern, Y. Shechter, H. Aeed, 1998, Pflügers Archiv.

Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes.

A. Shisheva, Y. Shechter, 1992, Biochemistry.

Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Y. Shechter, M. Schnaider-Beeri, M. Fridkin, 2021, Pharmaceutics.

Trifluoperazine inhibits insulin action on glucose metabolism in fat cells without affecting inhibition of lipolysis.

Y. Shechter, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Reversible PEGylation of peptide YY3‐36 prolongs its inhibition of food intake in mice

Y. Shechter, M. Fridkin, M. Rubinstein, 2005, FEBS letters.

Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli.

A. Hershko, Y. Shechter, D. Rafaeli-Eshkol, 1973, Biochemical and biophysical research communications.

Oral absorption of biologically active insulin in common carp (Cyprinus carpio L.).

Z. Madar, Y. Shechter, A. Gertler, 1992, Comparative biochemistry and physiology. A, Comparative physiology.

Multiple sites of vanadate and peroxovanadate action in Xenopus oocytes

Y. Shechter, D. Miller, D. Barnes, 1995, Journal of cellular physiology.

VII. Insulin Mimetic Effects of Vanadium

H. Degani, J. Sack, J. Meyerovitch, 1990 .

Insulin Mimetic Effects of Vanadium

S. Amir, H. Degani, J. Sack, 1990 .

Prolonging the Action of Protein and Peptide Drugs by a Novel Approach of Reversible Polyethylene Glycol Modification*

Y. Shechter, M. Fridkin, M. Mironchik, 2004, Journal of Biological Chemistry.

Vanadate elevates lipogenicity of starved rat adipose tissue: mechanism of action.

Y. Shechter, S. Qian, N. Sekar, 1998, Endocrinology.

Vanadate stimulates in vivo glucose uptake in brain and arrests food intake and body weight gain in rats

S. Amir, J. Meyerovitch, Y. Shechter, 1989, Physiology & Behavior.

Fluorescent and photo-affinity enkephalin derivatives: preparation and interaction with opiate receptors.

P. Cuatrecasas, Y. Shechter, S. Wilkinson, 1979, Biochemical and biophysical research communications.

Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists.

I. Cohen, M. Rapoport, Y. Shechter, 1988, The Journal of clinical investigation.

Studies on Insulin Receptors: Implications for Insulin Action

Y. Shechter, 1985 .

Chapter 20 – Immunization to Insulin Generates Antiidiotypes That Behave as Antibodies to the Insulin Hormone Receptor and Cause Diabetes Mellitus

I. Cohen, Y. Shechter, D. Elias, 1984 .

Non-receptor cytosolic protein tyrosine kinases from various rat tissues.

G. Elberg, J. Li, Y. Shechter, 1995, Biochimica et biophysica acta.

Vanadate ions: central nervous system action on glucoregulation

S. Amir, J. Meyerovitch, Y. Shechter, 1987, Brain Research.

Centrally mediated hypoglycemic effect of insulin: apparent involvement of specific insulin receptors

S. Amir, Y. Shechter, 1987, Brain Research.

Insulin receptor: covalent labeling and identification of subunits.

P. Cuatrecasas, Y. Shechter, E. Hazum, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

I. Pastan, M. Willingham, P. Cuatrecasas, 1978, Proceedings of the National Academy of Sciences of the United States of America.

New Technologies to Prolong Life-time of Peptide and Protein Drugs In vivo

B. Mester, Y. Shechter, M. Fridkin, 2007, International Journal of Peptide Research and Therapeutics.

Effect of depletion of bicarbonate or phosphate ions on insulin action in rat adipocytes. Further characterization of the receptor-effector system.

Y. Shechter, A. Ron, 1986, The Journal of biological chemistry.

Effect of oxidation of methionine residues in chicken ovoinhibitor on its inhibitory activities against trypsin, chymotrypsin, and elastase.

Y. Shechter, A. Gertler, Y. Burnstein, 1977, Biochemistry.

Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Characterization of the antibodies.

I. Cohen, Y. Shechter, D. Elias, 1984, The Journal of biological chemistry.

The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats.

A. Shisheva, Y. Shechter, O. Ikonomov, 1994, Endocrinology.

A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine.

A. Shisheva, Y. Shechter, O. Leitner, 1991, Journal of biochemical and biophysical methods.

Production and properties of anti-idiotypic antibodies that recognize insulin receptor.

I. Cohen, M. Rapoport, Y. Shechter, 1989, Methods in enzymology.

Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins*

Y. Shechter, M. Schnaider-Beeri, M. Fridkin, 2012, The Journal of Biological Chemistry.

Intramolecular azo-bridge as a cystine disulfide bond surrogate: Somatostatin-14 and brain natriuretic peptide (BNP) analogs.

Y. Levy, Y. Shechter, Y. Vachutinsky, 2011, Bioorganic & medicinal chemistry.

Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2.

G. Schreiber, Y. Shechter, M. Fridkin, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Insulin-like Effects of Vanadium: Mechanisms of Action, Clinical and Basic Implications

Y. Shechter, 1998, Letters in Peptide Science.

Biological activity of a fluorescein human growth hormone derivative prepared by specific covalent labeling of lysine-70.

Y. Shechter, A. Gertler, E. Sakal, 1991, Biochemistry.

Selective oxidation and reduction of methionine residues in peptides and proteins by oxygen exchange between sulfoxide and sulfide.

Y. Shechter, Yoram ShechterS, 1986, The Journal of biological chemistry.

Enhancement of α-chymotrypsin-catalyzed hydrolysis of specific p-nitroanilide substrates by 4-phenylbutylamine derivative of hen egg-white lysozyme☆

Y. Shechter, A. Gertler, 1978 .

Selective covalent binding of methionyl-containing peptides and proteins to water insoluble polymeric reagent and their regeneration.

Y. Shechter, M. Rubinstein, A. Patchornik, 1977, Biochemistry.

Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

D. Gefel, Y. Shechter, I. Goldwaser, 2003 .

Electron paramagnetic resonance studies and insulin-like effects of vanadium in rat adipocytes.

H. Degani, M. Gochin, Y. Shechter, 1981, Biochemistry.

Insulinlike Effects of Zinc Ion in Vitro and in Vivo: Preferential Effects on Desensitized Adipocytes and Induction of Normoglycemia in Streptozocin-Induced Rats

A. Shisheva, D. Gefel, Y. Shechter, 1992, Diabetes.

Insulin-like effects of vanadium: basic and clinical implications.

D. Gefel, Y. Shechter, I. Goldwaser, 2000, Journal of inorganic biochemistry.

Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action.

J. Meyerovitch, Y. Shechter, Z. Farfel, 1987, The Journal of biological chemistry.

Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.

A. Shisheva, Y. Shechter, 1993, The Journal of biological chemistry.

Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

Y. Shechter, S. Karlish, 1980, Nature.

Modulation of the enzymic activity of chicken pepsin by the covalent modification of its single -- SH group.

Y. Shechter, M. Rubinstein, Z. Bohak, 1975, European journal of biochemistry.

Organic vanadium chelators potentiate vanadium-evoked glucose metabolism in vitro and in vivo: establishing criteria for optimal chelators.

Y. Shechter, I. Goldwaser, M. Fridkin, 2000, Molecular pharmacology.

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.

I. Pastan, M. Willingham, J. Schlessinger, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Newly designed modifier prolongs the action of short-lived peptides and proteins by allowing their binding to serum albumin.

Y. Shechter, M. Fridkin, K. Sasson, 2012, Bioconjugate chemistry.

Insulin-Mimetic Effects of Vanadate: Possible Implications for Future Treatment of Diabetes

Y. Shechter, 1990, Diabetes.

Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

I. Pastan, M. Willingham, J. Schlessinger, 1978, Cell.

Antilipolytic Actions of Vanadate and Insulin in Rat Adipocytes Mediated by Distinctly Different Mechanisms.

G. Elberg, Y. Shechter, Zhibin He, 1997, Endocrinology.

Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.

C. Kahn, S. Bonner-Weir, J. Meyerovitch, 1991, The Journal of clinical investigation.

Suppression of lymphocyte reactivity in vitro by a soluble factor secreted by explants of human decidua

Y. Shechter, V. Zakuth, Z. Spirer, 1981, European journal of immunology.

Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin.

P. Cuatrecasas, J. Schlessinger, Y. Shechter, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Apparent involvement of protein kinase C in the central glucoregulatory action of insulin

S. Amir, Y. Shechter, 1988, Brain Research.

Polymyxin B is a potent inhibitor of insulin hypoglycemia in mice.

S. Amir, Y. Shechter, 1985, European journal of pharmacology.

Glucose transport

S. Amir, Y. Shechter, 1988, Nature.

Sulfenylation of tryptophan-62 in hen egg-white lysozyme.

Y. Burstein, Y. Shechter, A. Patchornik, 1972, Biochemistry.

Epidermal growth factor: biological activity requires persistent occupation of high-affinity cell surface receptors.

P. Cuatrecasas, Y. Shechter, L. Hernaez, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Selective chemical cleavage of tryptophanyl peptide bonds by oxidative chlorination with N-chlorosuccinimide.

Y. Burstein, Y. Shechter, A. Patchornik, 1976, Biochemistry.

Lactogenic hormones rapidly activate p21ras/mitogen-activated protein kinase in Nb2-11C rat lymphoma cells

G. Elberg, Y. Shechter, A. Gertler, 1996, Endocrine.

Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases

G. Elberg, A. Shisheva, J. Meyerovitch, 1995, Molecular and Cellular Biochemistry.

Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity.

G. Elberg, J. Li, Y. Shechter, 1994, The Journal of biological chemistry.

Reversible pegylation of insulin facilitates its prolonged action in vivo.

Y. Shechter, M. Fridkin, Y. Marcus, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line.

E. Neufeld, J. Schlessinger, Y. Shechter, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action.

P. Cuatrecasas, Y. Shechter, S. Jacobs, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Quantitation of methionyl peptides in nanomole quantities by a fluorometric method.

Y. Shechter, I. Parikh, W. L. Anderson, 1978, Analytical biochemistry.

A family of polypeptide substrates and inhibitors of insulin receptor kinase.

C. Kahn, J. Meyerovitch, Y. Shechter, 1990, Biochemistry.

Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

Y. Shechter, M. Fridkin, I. Cooper, 2016, PloS one.

Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

M. Sharon, Y. Shechter, Gili Ben-Nissan, 2021, Pharmaceutics.

Establishing the principle of reversibility in peptide/protein and small-molecule therapy.

Y. Shechter, M. Fridkin, Y. Marcus, 2012, Therapeutic delivery.

Prolonging the half-life of human interferon-α2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-α2

Gideon Schreiber, G. Schreiber, Y. Shechter, 2001 .

A novel approach for a water-soluble long-acting insulin prodrug: design, preparation, and analysis of [(2-sulfo)-9-fluorenylmethoxycarbonyl](3)-insulin.

Y. Shechter, I. Goldwaser, M. Fridkin, 2000, Journal of medicinal chemistry.

New concept for long-acting insulin: spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-fluorenylmethoxycarbonyl derivative of insulin.

Y. Shechter, M. Fridkin, E. Gershonov, 1999, Diabetes.

Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research.

J. Li, Y. Shechter, N. Sekar, 1996, Critical reviews in biochemistry and molecular biology.

Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats.

Y. Shechter, M. Fridkin, H. Tsubery, 2003, Biochemical and biophysical research communications.

Delivery of neuropeptides from the periphery to the brain: studies with enkephalin.

Y. Shechter, E. Heldman, M. Fridkin, 2010, ACS chemical neuroscience.

[2-Sulfo-9-fluorenylmethoxycarbonyl]3-exendin-4-a long-acting glucose-lowering prodrug.

Y. Shechter, M. Fridkin, H. Tsubery, 2003, Biochemical and biophysical research communications.

A new approach for prolonging the half-life of peptides, proteins and low-molecular-weight drugs in vivo

B. Mester, Y. Shechter, I. Goldwaser, 2001 .

Inhibition of insulin‐dependent lipogenesis and anti‐lipolysis by protein tyrosine kinase inhibitors.

A. Levitzki, Y. Shechter, C. Gilon, 1989, The EMBO journal.

Evidence for the distinct vanadyl(+4)-dependent activating system for manifesting insulin-like effects.

G. Elberg, J. Li, Y. Shechter, 1996, Biochemistry.

Reversible PEGylation: a novel technology to release native interferon alpha2 over a prolonged time period.

Gideon Schreiber, G. Schreiber, Y. Shechter, 2004, Journal of medicinal chemistry.

Mice Immunized to Insulin Develop Anti-idiotypic Antibody to the Insulin Receptor

I. Cohen, Y. Shechter, D. Elias, 1988 .

Antibodies to Insulin Receptor Followed by Anti-Idiotype: Antibodies to Insulin in Child With Hypoglycemia

I. Cohen, Y. Shechter, D. Elias, 1987, Diabetes.

Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes

B. M. Jongh, I. Cohen, Y. Shechter, 1983, Nature.

N-[(2-Sulfo)-9-fluorenylmethoxycarbonyl](3)-gentamicin C(1) is a long-acting prodrug derivative.

Y. Shechter, M. Fridkin, H. Tsubery, 2002, Journal of medicinal chemistry.

Covalent chromatography - the isolation of tryptophanyl containing peptides by novel polymeric reagents.

Y. Shechter, M. Rubinstein, A. Patchornik, 1976, Biochemical and biophysical research communications.

Converting bleomycin into a prodrug that undergoes spontaneous reactivation under physiological conditions.

A. Horovitz, Y. Shechter, M. Walker, 2019, Toxicology and applied pharmacology.

Vanadium in Biological Systems

H. Degani, H. Sakurai, J. Meyerovitch, 1990, Springer Netherlands.

Effect of okadaic acid in rat adipocytes: differential stimulation of glucose and lipid metabolism and induction of refractoriness to insulin and vanadate.

A. Shisheva, Y. Shechter, 1991, Endocrinology.

Vanadate restores glucose 6-phosphate in diabetic rats: a mechanism to enhance glucose metabolism.

Y. Shechter, I. Goldwaser, M. Fridkin, 2000, American journal of physiology. Endocrinology and metabolism.

Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide.

Y. Schwarz, Y. Shechter, Y. Vachutinsky, 2008, Bioconjugate chemistry.

Delivery of neuropeptides from the periphery to the brain: studies with enkephalin.

Y. Shechter, E. Heldman, M. Fridkin, 2010, ACS chemical neuroscience.

The use of post-binding agents in studying insulin action and its relation to experimental diabetes.

S. Amir, Y. Shechter, Joseph Meyerovetch, 1988, Biochemical pharmacology.

Vanadate inhibits glucose output from isolated perfused rat liver

Y. Shechter, R. Bruck, Y. Shechter, 1991, Hepatology.

Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins*

Y. Shechter, M. Schnaider-Beeri, M. Fridkin, 2012, Journal of Biological Chemistry.