M. K. Pflum

发表

K‐BILDS: A Kinase Substrate Discovery Tool

D. M. Embogama, M. K. Pflum, 2017, Chembiochem : a European journal of chemical biology.

The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.

M. K. Pflum, S. Choi, 2012, Bioorganic & medicinal chemistry letters.

Mutagenesis Studies of the 14 Å Internal Cavity of Histone Deacetylase 1: Insights toward the Acetate-Escape Hypothesis and Selective Inhibitor Design

M. K. Pflum, M. Wambua, Dhanusha A. Nalawansha, 2014, Journal of medicinal chemistry.

Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.

G. Estiu, O. Wiest, M. K. Pflum, 2008, Journal of medicinal chemistry.

Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

M. K. Pflum, Sujith V. W. Weerasinghe, Anton V. Bieliauskas, 2007, Bioorganic & medicinal chemistry letters.

LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.

M. K. Pflum, Dhanusha A. Nalawansha, 2017, ACS chemical biology.

A histone deacetylase-dependent screen in yeast.

M. K. Pflum, Sujith V. W. Weerasinghe, M. Wambua, 2010, Bioorganic & medicinal chemistry.

ATP Analogs in Protein Kinase Research

D. M. Embogama, M. K. Pflum, A. Fouda, 2015 .

l‐Lactate Dehydrogenase Identified as a Protein Tyrosine Phosphatase 1B Substrate by Using K‐BIPS

M. K. Pflum, Nuwan P N Acharige, 2020 .

Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid

M. K. Pflum, Sujith V. W. Weerasinghe, Ahmed T Negmeldin, 2016, Archiv der Pharmazie.

Kinase-Catalyzed Biotinylation.

M. K. Pflum, Keith D. Green, C. Senevirathne, 2012, Current protocols in chemical biology.

The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.

M. K. Pflum, Ahmed T Negmeldin, Joseph R Knoff, 2018, European journal of medicinal chemistry.

Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.

M. K. Pflum, Ahmed T Negmeldin, Anton V. Bieliauskas, 2017, ACS medicinal chemistry letters.

Limited proteolysis of human histone deacetylase 1

M. K. Pflum, Nayana Kamath, Paulina Karwowska-Desaulniers, 2006, BMC Biochemistry.

Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation.

M. K. Pflum, Yuchen Zhang, Rafael Andrade, 2022, Cell chemical biology.

Identification of PP1-Gadd34 substrates involved in the unfolded protein response using K-BIPS, a method for phosphatase substrate identification.

M. K. Pflum, Nuwan P N Acharige, Pavithra Dedigama-Arachchige, 2018, Molecular omics.

HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation.

M. K. Pflum, M. Wambua, Dhanusha A. Nalawansha, 2017, Cell chemical biology.

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.

M. K. Pflum, Sujith V. W. Weerasinghe, Po-Shen Pan, 2008, Bioorganic & medicinal chemistry letters.

Optimal Substrate‐Trapping Mutants to Discover Substrates of HDAC1

M. K. Pflum, Inosha D Gomes, 2019, Chembiochem : a European journal of chemical biology.

Identification of kinases and interactors of p53 using kinase-catalyzed crosslinking and immunoprecipitation (K-CLIP)

M. K. Pflum, Todd R. Faner, Pavithra Dedigama-Arachchige, 2019 .

K-CLASP: A Tool to Identify Phosphosite Specific Kinases and Interacting Proteins.

M. K. Pflum, Pavithra Dedigama-Arachchige, 2016, ACS chemical biology.

Structural analysis of ATP analogues compatible with kinase-catalyzed labeling.

M. K. Pflum, Sujit Suwal, C. Senevirathne, 2012, Bioconjugate chemistry.

Kinase‐Catalyzed Crosslinking and Immunoprecipitation (K‐CLIP) to Explore Kinase‐Substrate Pairs

Rachel J. Beltman, M. K. Pflum, 2022, Current protocols.

Histone Deacetylase 1 Phosphorylation Promotes Enzymatic Activity and Complex Formation*

S. Schreiber, William Arbuthnot Sir Lane, M. K. Pflum, 2001, The Journal of Biological Chemistry.

First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids.

M. K. Pflum, Z. Shah, L. Tillekeratne, 2022, Journal of medicinal chemistry.

New Ionization Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art

Scott M. Grayson, V. Shulaev, T. Sanderson, 2020 .

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.

L. Perera, Christin L. Hanigan, M. K. Pflum, 2016, Journal of medicinal chemistry.

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.

M. K. Pflum, Sujith V. W. Weerasinghe, S. Choi, 2011, Bioorganic & medicinal chemistry letters.

Phosphorylation-dependent kinase-substrate cross-linking.

M. K. Pflum, Sujit Suwal, 2010, Angewandte Chemie.

Development of an ELISA-Based HDAC Activity Assay for Characterization of Isoform-Selective Inhibitors

M. K. Pflum, Geetha Padige, Ahmed T. Negmeldin, 2015, Journal of biomolecular screening.

Identification of Kinases and Interactors of p53 Using Kinase-Catalyzed Cross-Linking and Immunoprecipitation.

M. K. Pflum, Todd R. Faner, Pavithra Dedigama-Arachchige, 2018, Journal of the American Chemical Society.

Stereochemistry of 1,2-elimination reactions at the E2-E1cB interface--tert-butyl 3-tosyloxybutanoate and its thioester.

M. K. Pflum, A. Snover, Shelby R. Anderson, 2008, Organic & biomolecular chemistry.

Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling.

D. M. Embogama, M. K. Pflum, Vindya Ramanayake-Mudiyanselage, 2021, Journal of proteome research.

The generality of kinase-catalyzed biotinylation.

D. M. Embogama, M. K. Pflum, A. Fouda, 2016, Bioorganic & medicinal chemistry.

A comparative study of ATP analogs for phosphorylation-dependent kinase-substrate crosslinking.

M. K. Pflum, C. Senevirathne, Satish Garre, 2014, Bioorganic & medicinal chemistry.

A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation.

M. K. Pflum, A. Fouda, 2015, Angewandte Chemie.

Biotinylated Phosphoproteins from Kinase‐Catalyzed Biotinylation are Stable to Phosphatases: Implications for Phosphoproteomics

M. K. Pflum, C. Senevirathne, 2013, Chembiochem : a European journal of chemical biology.

Kinase‐Catalyzed Biotinylation of Peptides, Proteins, and Lysates

M. K. Pflum, Keith D. Green, C. Senevirathne, 2012 .

Isoform-selective histone deacetylase inhibitors.

M. K. Pflum, Anton V. Bieliauskas, Anton V. Bieliauskas, 2008, Chemical Society reviews.

Histone deacetylase 1 phosphorylation at S421 and S423 is constitutive in vivo, but dispensable in vitro.

M. K. Pflum, Nayana Kamath, Paulina Karwowska-Desaulniers, 2007, Biochemical and biophysical research communications.

EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function

E. Seto, M. K. Pflum, Sonali Bahl, 2021, Cell Death & Disease.

HDAC1 Substrate Profiling Using Proteomics-Based Substrate Trapping.

M. K. Pflum, Dhanusha A. Nalawansha, Yuchen Zhang, 2018, ACS chemical biology.

The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity.

M. K. Pflum, Ahmed T. Negmeldin, 2017, Bioorganic & medicinal chemistry letters.

H-NS gives invading DNA the silent treatment

M. K. Pflum, 2006, Nature chemical biology.

Exploring Kinase Cosubstrate Promiscuity: Monitoring Kinase Activity through Dansylation

M. K. Pflum, Keith D. Green, Mary Kay H. Pflum, 2009, Chembiochem : a European journal of chemical biology.

Kinase-catalyzed biotinylation of DNA.

M. K. Pflum, Thilani M. Anthony, 2018, Bioorganic & medicinal chemistry.

Differential profiles of HDAC1 substrates and associated proteins in breast cancer cells revealed by trapping.

M. K. Pflum, Dhanusha A. Nalawansha, Yuchen Zhang, 2021, Molecular omics.

Identification of L-lactate Dehydrogenase as a Protein Tyrosine Phosphatase 1B substrate using K-BIPS.

M. K. Pflum, Nuwan P N Acharige, 2020, Chembiochem : a European journal of chemical biology.

Protein kinase A is a functional component of focal adhesions

Rachel J. Beltman, M. K. Pflum, A. Howe, 2023, bioRxiv.

Affinity-Based Kinase-Catalyzed Crosslinking to Study Kinase-Substrate Pairs.

Rachel J. Beltman, M. K. Pflum, A. Herppich, 2023, Bioconjugate chemistry.

Kinase-catalyzed biotinylation for phosphoprotein detection.

M. K. Pflum, Keith D. Green, Keith D Green, 2007, Journal of the American Chemical Society.

Phosphopeptide modification and enrichment by oxidation-reduction condensation.

M. K. Pflum, Mangalika Warthaka, Paulina Karwowska-Desaulniers, 2006, ACS chemical biology.

Identification of PP1-Gadd34 substrates involved in the unfolded protein response using K-BIPS, a method for phosphatase substrate identification.

M. K. Pflum, Pavithra Dedigama-Arachchige, Nuwan P. N. Acharige, 2018, Molecular omics.