C. Davio

发表

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia

S. Copsel, A. Bruzzone, M. May, 2014, Oncotarget.

Coumarins: old compounds with novel promising therapeutic perspectives.

C. Shayo, C. Davio, N. de Kimpe, 2010, Current medicinal chemistry.

Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells.

E. Rozengurt, C. Davio, O. Rey, 2019, The international journal of biochemistry & cell biology.

Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness

M. May, C. Shayo, C. Davio, 2020, Scientific Reports.

Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells.

C. Shayo, C. Davio, M. Riveiro, 2008, Biochemical pharmacology.

Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum.

C. Shayo, C. Davio, N. de Kimpe, 2004, Cancer letters.

An experimental model of diabetes and cancer in rats.

C. Davio, G. Martín, C. Cocca, 1998, European journal of cancer.

Effect of tamoxifen on intraperitoneal N-nitroso-N-methylurea induced tumors.

C. Davio, N. Andrade, G. Martín, 1996, Cancer letters.

Biased agonism at histamine H1 receptor: desensitization, internalization and MAPK activation triggered by antihistamines.

C. Shayo, C. Davio, C. Zappia, 2021, European journal of pharmacology.

Apotransferrin induces cAMP/CREB pathway and cell cycle exit in immature oligodendroglial cells

P. Paez, C. Davio, J. Pasquini, 2004, Journal of neuroscience research.

Expression of a G Protein-coupled Receptor (GPCR) Leads to Attenuation of Signaling by Other GPCRs

S. Copsel, C. Shayo, C. Davio, 2010, The Journal of Biological Chemistry.

Agonist Effects of Propranolol on Non-Tumor Human Breast Cells

A. Bruzzone, C. Davio, M. Buffone, 2020, Cells.

Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model.

C. Shayo, C. Davio, M. Riveiro, 2003, Molecular pharmacology.

F127 poloxamer effect on cytotoxicity induction of tumour cell cultures treated with doxorubicin

C. Davio, N. Gómez, J. Oubiña, 2019, The Journal of pharmacy and pharmacology.

G‐protein‐coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß‐d‐glucuronide‐induced cholestasis

M. Larocca, C. Davio, A. Zucchetti, 2014, Hepatology.

Semen Promotes the Differentiation of Tolerogenic Dendritic Cells

C. Davio, M. Ostrowski, C. Rodríguez Rodrígues, 2012, The Journal of Immunology.

Induction of mammary tumors in rat by intraperitoneal injection of NMU: histopathology and estral cycle influence.

C. Davio, N. Andrade, G. Martín, 1994, Cancer letters.

Extracellular cAMP activates molecular signalling pathways associated with sperm capacitation in bovines

C. Osycka-Salut, L. Castellano, C. A. Alonso, 2017, Molecular human reproduction.

Fibronectin induces capacitation-associated events through the endocannabinoid system in bull sperm.

C. Osycka-Salut, L. Castellano, A. Franchi, 2020, Theriogenology.

Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines

C. Osycka-Salut, C. A. Alonso, C. Davio, 2020, Scientific Reports.

On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells.

C. Davio, J. Incicco, P. Schwarzbaum, 2013, American journal of physiology. Cell physiology.

Roles of Phosphorylation-dependent and -independent Mechanisms in the Regulation of Histamine H2 Receptor by G Protein-coupled Receptor Kinase 2*

C. Shayo, C. Davio, F. Monczor, 2011, The Journal of Biological Chemistry.

Histamine regulates the expression of histidine decarboxylase in N-nitroso-N-methylurea (NMU)-induced mammary tumors in rats

C. Davio, G. Martín, G. Cricco, 1996, Inflammation Research.

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

C. Shayo, C. Davio, F. Monczor, 2020, Frontiers in Pharmacology.

The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation.

C. Shayo, C. Davio, M. Riveiro, 2004, Biochemical and biophysical research communications.

Physiological implications of biased signaling at histamine H2 receptors

C. Shayo, C. Davio, C. Zappia, 2015, Front. Pharmacol..

Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats

C. Davio, N. Di Siervi, M. Razori, 2019, Archives of Toxicology.

Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells.

C. Shayo, C. Davio, M. Riveiro, 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation

C. Shayo, C. Davio, C. Zappia, 2019, European journal of pharmacology.

Tolerogenic Dendritic Cells Semen Promotes the Differentiation Of

C. Davio, M. Cabrini, C. Jancic, 2022 .

Endogenous lysophosphatidic acid participates in vascularisation and decidualisation at the maternal-fetal interface in the rat.

J. Beltrame, A. Franchi, C. Davio, 2017, Reproduction, fertility, and development.

Heparin exerts anti-apoptotic effects on uterine explants by targeting the endocannabinoid system

A. Franchi, C. Davio, F. Correa, 2016, Apoptosis.

Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways

F. Dominici, C. Davio, M. Muñoz, 2019, Front. Pharmacol..

Evidence for CB2 receptor involvement in LPS-induced reduction of cAMP intracellular levels in uterine explants from pregnant mice: pathophysiological implications

A. Franchi, C. Davio, F. Correa, 2017, Molecular human reproduction.

Differential β2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

S. Copsel, A. Bruzzone, C. Davio, 2014, Oncotarget.

Inhibition of Endothelin system during the postnatal nephrogenic period in the rat. Its relationship with hypertension and renal disease in adulthood

C. Davio, N. Di Siervi, M. F. Albertoni Borghese, 2020, PloS one.

Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors.

C. Davio, M. Sabbatini, M. Vatta, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPRC receptors

C. Davio, M. Vatta, B. Fernández, 2003 .

Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H(2) receptors in the U937 cell line.

C. Shayo, C. Davio, F. Monczor, 2000, Biochemical pharmacology.

Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor.

C. Shayo, C. Davio, M. Riveiro, 2013, Biochemical pharmacology.

Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.

C. Shayo, C. Davio, A. Baldi, 1997, Molecular pharmacology.

Apotransferrin promotes the differentiation of two oligodendroglial cell lines

Corina I. García, P. Paez, A. Campagnoni, 2004, Glia.

Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration

J. Gutkind, C. Notcovich, C. Shayo, 2013, Molecular Pharmacology.

Antihistaminergics and inverse agonism: potential therapeutic applications.

C. Shayo, C. Davio, F. Monczor, 2013, European journal of pharmacology.

Histamine H2 Receptor Trafficking: Role of Arrestin, Dynamin, and Clathrin in Histamine H2 Receptor Internalization

C. Shayo, C. Davio, F. Monczor, 2008, Molecular Pharmacology.

Histamine H 2 Receptor Trafficking : Role of Arrestin , Dynamin , and Clathrin in Histamine H 2 Receptor Internalization

C. Shayo, C. Davio, F. Monczor, 2008 .

Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation.

C. Notcovich, C. Shayo, C. Davio, 2002, Molecular pharmacology.

Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases.

C. Shayo, C. Davio, F. Monczor, 2001, Molecular pharmacology.

Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis

B. Molinari, C. Davio, M. Palmieri, 1997, Inflammation Research.

Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways.

M. Kazanietz, C. Notcovich, C. Shayo, 2010, Experimental cell research.

Forskolin induces U937 cell line differentiation as a result of a sustained cAMP elevation.

C. Shayo, C. Davio, A. Morelli, 1998, European journal of pharmacology.

C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas.

C. Davio, M. Sabbatini, M. Vatta, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Synthesis, Structural Characterization, and Pro‐apoptotic Activity of 1‐Indanone Thiosemicarbazone Platinum(II) and Palladium(II) Complexes: Potential as Antileukemic Agents

C. Shayo, C. Davio, Á. Mombrú, 2011, ChemMedChem.

Atrial natriuretic factor intracellular signaling in the rat submandibular gland

C. Davio, M. Vatta, L. Bianciotti, 2008, Regulatory Peptides.

H1 and H2 histamine receptors in histiocytic lymphoma cell line U-937

C. Shayo, C. Davio, A. Baldi, 1995, Inflammation Research.

Expression of histamine receptors in different cell lines derived from mammary gland and human breast carcinomas

C. Davio, A. Baldi, G. Cricco, 1995, Inflammation Research.

Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas.

C. Davio, M. Sabbatini, M. Vatta, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes

John D. Chan, C. Davio, A. M. Celentano, 2018, PLoS neglected tropical diseases.

Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.

C. Shayo, C. Davio, L. Piehl, 2008, Bioorganic & medicinal chemistry.

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

C. Shayo, C. Davio, L. Piehl, 2012, Bioorganic & medicinal chemistry.

Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.

C. Shayo, C. Davio, Sven Mangelinckx, 2009, Bioorganic & medicinal chemistry.

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

C. Shayo, C. Davio, F. Remes Lenicov, 2015, PloS one.

Total synthesis of naturally occurring 5,6,7- and 5,7,8-trioxygenated coumarins

C. Shayo, C. Davio, M. Riveiro, 2008 .

Histamine H 2 Receptor Biased Signaling Methods

C. Shayo, C. Davio, F. Monczor, 2017 .

Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation*

Corina I. García, S. Copsel, C. Shayo, 2011, The Journal of Biological Chemistry.

Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling.

C. Shayo, C. Davio, F. Monczor, 2006, Biochemical pharmacology.

Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein*

C. Shayo, C. Davio, F. Monczor, 2004, Journal of Biological Chemistry.

Melanocortin 4 receptor constitutive activity inhibits L-type voltage-gated calcium channels in neurons

C. Davio, M. Perelló, J. Raingo, 2017, Neuroscience.

Identification of inhibitors of the RGS homology domain of GRK2 by docking-based virtual screening.

Ezequiel I. Juritz, C. Davio, P. L. Menna, 2019, Life sciences.

Hormone dependence of mammary tumors induced in rats by intraperitoneal NMU injection.

C. Davio, N. Andrade, G. Martín, 1997, Cancer investigation.

Histamine H2 Receptor in Blood Cells: A Suitable Target for the Treatment of Acute Myeloid Leukemia.

S. Copsel, C. Shayo, C. Davio, 2016, Handbook of experimental pharmacology.

Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

C. Davio, M. Vatta, L. Bianciotti, 2015, Molecular medicine.

Atrial natriuretic factor stimulates efflux of cAMP in rat exocrine pancreas via multidrug resistance-associated proteins.

S. Copsel, C. Davio, M. Vatta, 2011, Gastroenterology.

Natriuretic peptides and their receptors

C. Davio, M. Vatta, L. Bianciotti, 2011 .

Regulatory mechanisms underlying GKR2 levels in U937 cells: evidence for GRK3 involvement.

C. Shayo, C. Davio, F. Monczor, 2007, Biochemical pharmacology.

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

C. Davio, G. Cardama, N. González, 2017, Oncotarget.

Role of 3′-5′-cyclic adenosine monophosphate on the epidermal growth factor dependent survival in mammary epithelial cells

Diego M. Presman, C. Davio, O. Coso, 2016, Molecular and Cellular Endocrinology.

Epidermal growth factor in NMU-induced mammary tumors in rats

C. Davio, G. Martín, C. Cocca, 1998, Breast Cancer Research and Treatment.

MRP4/ABCC4 As a New Therapeutic Target: Meta-Analysis to Determine cAMP Binding Sites as a Tool for Drug Design.

C. Shayo, C. Davio, A. Sahores, 2019, Current medicinal chemistry.

Altered expression of Aquaporin‐2 in one‐kidney, one‐clip hypertension

C. Davio, M. Vatta, M. Barchuk, 2018, Life sciences.

H1 and H2 histamine receptors in N-nitroso-N-methylurea (NMU)-induced carcinomas with atypical coupling to signal transducers.

C. Davio, G. Cricco, E. Rivera, 1995, Biochemical pharmacology.

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux

C. Shayo, C. Davio, M. Abba, 2019, Molecular Pharmacology.

Histamine Improves Antigen Uptake and Cross-Presentation by Dendritic Cells1

C. Davio, A. Ceballos, J. Geffner, 2007, The Journal of Immunology.

Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways

C. Shayo, C. Davio, C. Zappia, 2015, Scientific Reports.

A Novel Effect of β-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer

S. Copsel, A. Bruzzone, M. May, 2017, Journal of Mammary Gland Biology and Neoplasia.

Synthesis and degradation of cAMP in Giardia lamblia: possible role and characterization of a nucleotidyl cyclase with a single cyclase homology domain.

C. Davio, A. Zurita, N. Di Siervi, 2017, The Biochemical journal.

Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine.

M. May, C. Shayo, C. Davio, 2023, Biochimica et biophysica acta. General subjects.

MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux

C. Shayo, C. Davio, F. Monczor, 2020, The FEBS journal.

Multidrug resistance protein 4 (MRP4/ABCC4) is overexpressed in clear cell renal cell carcinoma (ccRCC) and is essential to regulate cell proliferation.

M. May, C. Davio, Carlos Guijas, 2020, International journal of biological macromolecules.

Dual Role of cAMP in the Transcriptional Regulation of Multidrug Resistance-Associated Protein 4 (MRP4) in Pancreatic Adenocarcinoma Cell Lines

C. Shayo, C. Davio, A. Carozzo, 2015, PloS one.

Synthesis and structural revision of naturally occurring ayapin derivatives

C. Davio, Sven Mangelinckx, S. Debenedetti, 2005 .

Discovery of a New Potent N-(piperidin-4-yl)-1H-pyrrole-2-carboxamide Inhibitor of Adenylyl Cyclase of G. lamblia. Biological Evaluation and Molecular Modeling Studies.

R. Enriz, C. Davio, M. Anderluh, 2021, ChemMedChem.

Signal transduction mechanism of biased ligands at histamine H2 receptors.

C. Shayo, C. Davio, F. Monczor, 2014, The Biochemical journal.

Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons

Cambria Chou-Freed, C. Davio, J. Raingo, 2020, The Journal of general physiology.

Molecular mechanisms involved in the actions of apotransferrin upon the central nervous system: Role of the cytoskeleton and of second messengers

C. Davio, L. Pasquini, J. Pasquini, 2002, Journal of neuroscience research.

Histamine receptors in an experimental mammary carcinoma.

C. Davio, R. Caro, A. Venturino, 1994, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Histamine as an autocrine growth factor in experimental mammary carcinomas

C. Davio, G. Martín, G. Cricco, 1994, Agents and Actions.

Effect of histamine on growth and differentiation of the rat mammary gland

C. Davio, G. Martín, G. Cricco, 1994, Agents and Actions.

Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats

C. Davio, N. Di Siervi, M. Razori, 2019, Archives of Toxicology.

Iron and holotransferrin induce cAMP-dependent differentiation of Schwann cells

C. Davio, J. Pasquini, N. Urtasun, 2012, Neurochemistry International.

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

J. Gutkind, C. Shayo, C. Davio, 2016, Biochimica et biophysica acta.

Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation.

C. Osycka-Salut, A. Franchi, C. Davio, 2014, Molecular human reproduction.

H1 and H2 histamine receptors in human mammary carcinomas

C. Davio, N. Andrade, G. Cricco, 1993, Agents and Actions.

Histamine receptors in neoplastic transformation: Studies in human cell lines

C. Shayo, C. Davio, A. Baldi, 1996, Inflammation Research.

Endothelins participate in the central and peripheral regulation of submandibular gland secretion in the rat.

C. Davio, M. Vatta, L. Bianciotti, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Histamine receptors in human mammary gland, different benign lesions and mammary carcinomas

C. Davio, G. Martín, G. Cricco, 1995, Inflammation Research.

MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation

C. Davio, M. Buffone, N. Di Siervi, 2019, Journal of Cell Science.

Involvement of cAMP efflux, through MRP4 transporter, in the acquisition of fertilization ability of mouse spermatozoa.

S. Perez Martinez, C. Davio, M. Buffone, 2019, Journal of cell science.

ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.

C. Davio, A. Batlle, L. Oliveri, 2012, The Biochemical journal.

H1 and H2 histamine receptors mediate the production of inositol phosphates but not cAMP in human breast epithelial cells

C. Shayo, C. Davio, F. Monczor, 2002, Inflammation Research.

Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model

C. Shayo, C. Davio, C. Zappia, 2019, Pharmacology research & perspectives.

Inhibition of tumor growth induced by histamine: In vivo and in vitro studies

C. Davio, G. Cricco, E. Rivera, 1993, Agents and Actions.

Total and Extracellular Vesicle cAMP Contents in Urine Are Associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD) Progression

C. Davio, P. Azurmendi, N. Goette, 2023, Life.