D. Steadman

发表

Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function.

Jing Ma, Meir J Stampfer, K. Brown, 2002, Cancer research.

Medicinal chemistry and drug discovery in an opening era

C. Southan, G. Wynne, D. Sattelle, 2020 .

Simultaneous optimization of donor and acceptor substrate specificity for transketolase by a small but smart library

P. Dalby, Haoran Yu, D. Steadman, 2019, bioRxiv.

Second generation engineering of transketolase for polar aromatic aldehyde substrates.

P. Dalby, D. Steadman, H. Hailes, 2015, Enzyme and microbial technology.

α,α'-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes.

Mark E. B. Smith, P. Dalby, D. Steadman, 2010, Chemical communications.

Investigating the reaction mechanism and organocatalytic synthesis of α,α'-dihydroxy ketones.

D. Steadman, H. Hailes, J. Galman, 2012, Organic & biomolecular chemistry.

DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1.

E. Gelmann, D. Steadman, D. Giuffrida, 2000, Nucleic acids research.

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

G. Waksman, P. Gane, A. Lo, 2013, The Journal of antimicrobial chemotherapy.

Structural Analysis and Development of Notum Fragment Screening Hits

P. Fish, E. Jones, K. Harlos, 2022, ACS chemical neuroscience.

New approaches for the treatment of Alzheimer's disease.

P. Fish, P. Whiting, D. Steadman, 2019, Bioorganic & medicinal chemistry letters.

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

F. Svensson, P. Fish, E. Jones, 2021, Journal of medicinal chemistry.

Virulence‐targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

G. Waksman, D. Steadman, H. Remaut, 2015, Chemical biology & drug design.

Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α‐hydroxyketones

P. Dalby, Haoran Yu, D. Steadman, 2020, The FEBS journal.

Rational substrate and enzyme engineering of transketolase for aromatics.

Paul A Dalby, P. Dalby, D. Steadman, 2012, Organic & biomolecular chemistry.

Genetic complementation and resistance to 5-fluoro-2'-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase.

D. Steadman, J. Zapf, S. Berger, 1999, Biochemical pharmacology.

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

P. Fish, E. Jones, D. Steadman, 2019 .

Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors*

L. Lebioda, W. Minor, D. Steadman, 2001, The Journal of Biological Chemistry.

Structural Insights into Notum Covalent Inhibition

F. Svensson, P. Fish, Weixian Lu, 2021, Journal of medicinal chemistry.

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

C. Milagre, S. Tsirka, P. Frankel, 2018, Journal of medicinal chemistry.

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling

F. Svensson, P. Fish, P. Whiting, 2021, Journal of medicinal chemistry.

Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity.

F. Svensson, P. Fish, E. Jones, 2020, Journal of medicinal chemistry.

An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

P. Fish, D. Steadman, G. Papageorgiou, 2019, Beilstein journal of organic chemistry.

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

F. Svensson, P. Fish, E. Jones, 2019, Bioorganic & medicinal chemistry letters.

Bacterial surface appendages as targets for novel antibacterial therapeutics.

G. Waksman, A. Lo, D. Steadman, 2014, Future microbiology.

Medicinal chemistry and drug discovery in an opening era

P. Fish, D. Steadman, G. Papageorgiou, 2023 .

Medicinal chemistry and drug discovery in an opening era

P. Fish, D. Steadman, G. Papageorgiou, 2022 .

An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

P. Fish, D. Steadman, G. Papageorgiou, 2019, Beilstein Journal of Organic Chemistry.

Directed evolution to re-adapt a co-evolved network within an enzyme

Helen C. Hailes, Edward G. Hibbert, Paul A. Dalby, 2012, Journal of biotechnology.

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT

P. Fish, D. Steadman, M. Bictash, 2019 .

Bacterial surface appendages as targets for novel antibacterial therapeutics.

G. Waksman, A. Lo, D. Steadman, 2014, Future microbiology.

Directed evolution to re-adapt a co-evolved network within an enzyme

P. Dalby, D. Steadman, H. Hailes, 2012, Journal of biotechnology.