R. Gum

发表

Regulation of urokinase‐type plasminogen activator expression by an ERK1‐dependent signaling pathway in a squamous cell carcinoma cell line

E. Lengyel, D. Boyd, J. Juarez, 1996, Journal of cellular biochemistry.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Hua Tang, Bo Liu, Gang Liu, 2011, ACS chemical biology.

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Michael F. Jarvis, R. Gum, M. Jarvis, 2011, Purinergic Signalling.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Chaohong Sun, E. Olejniczak, Eric F. Johnson, 2006, Journal of medicinal chemistry.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

Eric F. Johnson, C. Abad-Zapatero, H. Sham, 2006, Journal of Medicinal Chemistry.

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras(*)

E. Lengyel, D. Boyd, R. Gum, 1995, The Journal of Biological Chemistry.

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

C. Abad-Zapatero, R. Gum, C. Hutchins, 2006, Bioorganic & medicinal chemistry letters.

Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes.

R. Mayer, P. Young, L. Marshall, 1998, Journal of immunology.

Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation.

P. Young, R. Gum, Peter Young, 1999, Biochemical and biophysical research communications.

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

H. Sham, R. Gum, D. Haasch, 2006, Bioorganic & medicinal chemistry letters.

Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade

E. Lengyel, Y. Wang, D. Boyd, 1997, Oncogene.

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

J. Waring, R. Ulrich, B. Monia, 2002, Diabetes.

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in

J. Waring, R. Ulrich, B. Monia, 2002 .

Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules

H. Allgayer, A. Mazar, Y. Wang, 1998, Oncogene.

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

E. Lengyel, D. Boyd, J. Juarez, 1997, Oncogene.

in Human Kinase Modulate IL-4 Induction of Low Inhibitors of the p38 Mitogen-Activated

R. Mayer, P. Young, L. Marshall, 1998 .

Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.

E. Lengyel, G. Clayman, H. Sato, 1995, Cancer research.

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences (*)

E. Lengyel, H. Sato, D. Boyd, 1996, The Journal of Biological Chemistry.

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.

C. Abad-Zapatero, H. Sham, R. Gum, 2006, Bioorganic & medicinal chemistry letters.

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

C. Abad-Zapatero, R. Gum, C. Hutchins, 2006, Bioorganic & medicinal chemistry letters.

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

J. Waring, R. Ulrich, S. Crosby, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor.

J. Waring, R. Ulrich, R. Gum, 2002, Toxicology.

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).

R G Ulrich, R. Ulrich, S. Davidsen, 2001, Biochemical pharmacology.

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket*

Elizabeth J. Goldsmith, Jerry L. Adams, E. Goldsmith, 1998, The Journal of Biological Chemistry.

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.

J C Lee, John C. Lee, P. Young, 1997, Biochemical and biophysical research communications.

Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.

Xudong Dai, Yudong D. He, Guy Cavet, 2007, Genomics.

Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.

J. Waring, R. Ulrich, C. Rondinone, 2003, Molecular endocrinology.

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

J. Waring, R. Ulrich, C. Rondinone, 2003, Molecular and Cellular Endocrinology.

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

R. Gum, M. Jarvis, Brian D Wakefield, 2012, Purinergic Signalling.

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

C. Abad-Zapatero, H. Sham, C. Rondinone, 2007, Bioorganic & medicinal chemistry letters.

Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.

E. Lengyel, M. Hung, D. Yu, 1995, Anticancer research.

Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

R. Ulrich, C. Rondinone, R. Gum, 2003, Diabetes.

Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.

A. Sabichi, M. Birrer, D. Boyd, 1995, Oncogene.

Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms

C. Rondinone, R. Gum, J. Trevillyan, 2004 .

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.

Celerino Abad-Zapatero, Chaohong Sun, C. Abad-Zapatero, 2006, Bioorganic & medicinal chemistry letters.

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.

G. Gintant, R. Gum, T. Neelands, 2022, Bioorganic & medicinal chemistry.

Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.

R. Gum, T. Neelands, M. Kort, 2016, Journal of medicinal chemistry.