S. Pellegrini

发表

A protein tyrosine kinase in the interferon α β signaling pathway

M. Fellous, L. Velazquez, G. Stark, 1992, Cell.

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

Joseph K. Pickrell, K. Kidd, J. Kidd, 2009, PLoS genetics.

COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death.

A. Neri, S. Pellegrini, G. Tedeschi, 2020, Cancer letters.

Rat fibroblasts expressing high levels of human c‐myc transcripts are anchorage‐independent and tumorigenic

S. Pellegrini, C. Basilico, 1986, Journal of cellular physiology.

USP 18 establishes the transcriptional and antiproliferative interferon α / β differential

M. Livingstone, S. Pellegrini, Véronique François-Newton, 2012 .

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential.

M. Livingstone, S. Pellegrini, Véronique François-Newton, 2012, The Biochemical journal.

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

Philippe A. Robert, M. Livingstone, O. Larsson, 2015, PloS one.

An Old Cytokine Against a New Virus?

S. Pellegrini, G. Uzé, 2020, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

NF‐κB is required for STAT‐4 expression during dendritic cell maturation

E. Coccia, M. Severa, E. Giacomini, 2007 .

IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

Y. Richard, S. Pellegrini, P. Galanaud, 1996, FEBS letters.

The Stat3-activating Tyk2 V678F Mutant Does Not Up-regulate Signaling through the Type I Interferon Receptor but Confers Ligand Hypersensitivity to a Homodimeric Receptor*

S. Constantinescu, S. Pellegrini, J. Ragimbeau, 2008, Journal of Biological Chemistry.

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation

B. Schwikowski, S. Shorte, F. Rieux-Laucat, 2022, Cell Reports.

Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent

L. Rönnblom, S. Pellegrini, J. Ragimbeau, 2013, The Journal of Immunology.

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

Consuelo D. Quinto-Cortés, D. Weeks, E. Hagelberg, 2022, The Journal of experimental medicine.

Post‐translational up‐regulation of the cell surface‐associated α component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon

G. Rainaldi, S. Pellegrini, F. Belardelli, 1997, European journal of immunology.

T Cell Receptor Signal Initiation Induced by Low-Grade Stimulation Requires the Cooperation of LAT in Human T Cells

S. Pellegrini, K. Nika, F. Michel, 2010, PloS one.

IFNA2: The prototypic human alpha interferon.

S. Pellegrini, F. Paul, G. Uzé, 2015, Gene.

β by Transforming Growth Factor- Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells

G. Trinchieri, Xiaojing Ma, S. Chouaib, 2013 .

Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling.

G. Trinchieri, Xiaojing Ma, S. Chouaib, 1999, Blood.

Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.

M. Fellous, G. Barbieri, L. Velazquez, 1994, European journal of biochemistry.

Function in Cytotoxic T Lymphocytes Differentiation and Has an Inhibitory Jakmip1 Is Expressed upon T Cell

Dörte Schulte, L. Rogge, S. Pellegrini, 2013 .

Jakmip1 Is Expressed upon T Cell Differentiation and Has an Inhibitory Function in Cytotoxic T Lymphocytes1

Dörte Schulte, L. Rogge, S. Pellegrini, 2008, The Journal of Immunology.

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.

E. Coccia, M. Severa, E. Giacomini, 2007, Journal of leukocyte biology.

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN- (cid:1) / (cid:2) on antigen cross-presentation

R. Darnell, C. Rice, M. Albert, 2007 .

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

S. Pellegrini, F. Vuillier, Melania Cruciani, 2022, Frontiers in Immunology.

Comparable potency of IFNalpha 2 and IFNbeta on immediate JAK / STAT activation but differential down-regulation of IFNAR 2

S. Pellegrini, J. V. D. Heyden, J. Ragimbeau, 2019 .

Ligand-independent pathway that controls stability of interferon alpha receptor.

D. Baker, S. Fuchs, S. Pellegrini, 2008, Biochemical and biophysical research communications.

Comparable potency of IFNα2 and IFNβ on immediate JAK/STAT activation but differential down-regulation of IFNAR2

S. Pellegrini, J. V. D. Heyden, J. Ragimbeau, 2007 .

Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.

S. Pellegrini, J. Ragimbeau, Z. Marijanovic, 2007, The Biochemical journal.

TYK2 activity promotes ligand-induced IFNAR1 proteolysis.

S. Fuchs, K. G. S. Kumar, S. Pellegrini, 2006, The Biochemical journal.

Dear Granger: I appreciate the opportunity to submit a revised manuscript to Cell Metabolism entitled: “Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity”. We have modified the manuscript to include most of the experiments the reviewers suggested. Below

K. Rajewsky, P. Seale, T. Harris, 2022 .

Selective Expression of Type I IFN Genes in Human Dendritic Cells Infected with Mycobacterium tuberculosis1

E. Coccia, G. Lutfalla, E. Giacomini, 2002, The Journal of Immunology.

Selective Expression of Type I IFN Genes in Human Dendritic Cells Infected with Mycobacterium tuberculosis1

E. Coccia, G. Lutfalla, E. Giacomini, 2002, The Journal of Immunology.

Useofa Selectable MarkerRegulated byAlphaInterferon To Obtain Mutations intheSignaling Pathwayt

S. Pellegrini, 1989 .

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

W. V. van IJcken, Y. Crow, T. Goldmann, 2016, The Journal of experimental medicine.

Constitutive production of alpha and beta interferons in mutant human cell lines

G. Stark, I. Kerr, S. Pellegrini, 1994, Journal of virology.

Regulation of polyomavirus late promoter activity by viral early proteins

F. Kern, S. Pellegrini, A. Cowie, 1986, Journal of virology.

Regulation ofPolyomavirus LatePromoter Activity by Viral EarlyProteins

S. Pellegrini, A. Cowie, Claudio Basilicoi, 1986 .

Production of IL‐4 and leukemia inhibitory factor by T cells of the cumulus oophorus: a favorable microenvironment for pre‐implantation embryo development

I. Natali, S. Pellegrini, P. Romagnani, 2001, European journal of immunology.

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

G. Schreiber, S. Pellegrini, I. Moraga, 2009, Molecular and Cellular Biology.

Type I interferon potentiates T‐cell receptor mediated induction of IL‐10‐producing CD4+ T cells

S. Pellegrini, F. Michel, S. Cerboni, 2013, European journal of immunology.

Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication

S. Pellegrini, C. Basilico, L. Dailey, 1984, Cell.

Deletion of the origin of replication impairs the ability of polyomavirus DNA to transform cells and to form tandem insertions

S. Pellegrini, C. Basilico, L. Dailey, 1984, Journal of virology.

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

A. Cumano, B. Rocha, S. Pellegrini, 2016, Biology Direct.

Negative regulation of type I interferon signaling: facts and mechanisms.

S. Pellegrini, G. Uzé, E. Coccia, 2006, Cellular and molecular biology.

The amino-terminal region of Tyk2 sustains the level of interferon a receptor 1, a component of the interferon ayb receptor

M. Fellous, G. Barbieri, S. Pellegrini, 1997 .

Familial Study of Paracentric Inversion in Chromosome 3p

S. Pellegrini, M. Ribeiro, M. Ribeiro, 2016 .

Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif*

S. Constantinescu, D. Baker, S. Fuchs, 2008, Journal of Biological Chemistry.

Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection

B. Schwikowski, S. Shorte, J. Fellay, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

N. Tchitchek, S. Pellegrini, A. Rolland, 2021, Frontiers in Genetics.

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

J. Casanova, H. Ochs, S. Tangye, 2018, Science Immunology.

Diploid/triploid mosaicism: further delineation of the phenotype.

S. Pellegrini, M. Ribeiro, E. Teich, 1994, American journal of medical genetics.

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.

J. Casanova, Shen-Ying Zhang, B. Boisson, 2020, The Journal of clinical investigation.

Down-Modulation of Responses to Type I IFN Upon T Cell Activation1

G. Lutfalla, L. Rogge, S. Pellegrini, 2003, The Journal of Immunology.

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

J. Casanova, L. Notarangelo, Y. Crow, 2014, Nature.

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways.

Stephen T Warren, Christa L Martin, S. Spence, 2007, Human molecular genetics.

Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons*

I. Kerr, M. White, S. Pons, 1997, The Journal of Biological Chemistry.

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

F. Rieux-Laucat, C. Picard, S. Hanein, 2018, PloS one.

Functional characterization of naturally occurring genetic variants in the human TLR1‐2‐6 gene family

L. Quintana-Murci, S. Pellegrini, L. Barreiro, 2011, Human mutation.

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

M. Rotival, E. Patin, S. Pellegrini, 2019, bioRxiv.

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation

R. Darnell, C. Rice, M. Albert, 2007 .

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

G. Yancopoulos, O. Silvennoinen, J. Ihle, 1994, Science.

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway

G. Stark, I. Kerr, J. John, 1989, Molecular and cellular biology.

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

S. S. Koh, S. Fuchs, R. Srisuttee, 2012, International journal of molecular medicine.

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

D. Duffy, S. Pellegrini, V. Bondet, 2021, Frontiers in Immunology.

Jamip1 (Marlin-1) Defines a Family of Proteins Interacting with Janus Kinases and Microtubules*

C. Steindler, A. Alcover, S. Pellegrini, 2004, Journal of Biological Chemistry.

Early events in signalling by interferons.

C. Schindler, S. Pellegrini, C. Schindler, 1993, Trends in biochemical sciences.

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Ming Yan, F. Colland, J. Heinisch, 2017, Nature Structural &Molecular Biology.

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

G. Stark, C. Schindler, O. Silvennoinen, 1993, Nature.

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-/ and for Signal Transduction *

L. Velazquez, S. Pellegrini, G. Uzé, 1995, The Journal of Biological Chemistry.

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.

S. Pellegrini, E. Dondi, G. Uzé, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The Janus kinase family of protein tyrosine kinases and their role in signaling

S. Pellegrini, T. Yeh, 1999, Cellular and Molecular Life Sciences CMLS.

The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).

I. Dusanter-Fourt, S. Pellegrini, S Pellegrini, 1997, European journal of biochemistry.

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

W. Dietrich, S. Pellegrini, Michael H. Shaw, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase*

M. Fellous, L. Velazquez, S. Pellegrini, 1996, The Journal of Biological Chemistry.

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

A. Alcover, S. Pellegrini, P. Eid, 2003, The EMBO journal.

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.

M. Fellous, G. Barbieri, S. Pellegrini, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.

G. Stark, P. Heinrich, J. Briscoe, 1995, The EMBO journal.

Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons

G. Stark, I. Kerr, J. John, 1991, Molecular and cellular biology.

Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Y. Crow, Salima El-Chehadeh, J. Marsh, 2023, Journal of Clinical Immunology.

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

S. Pellegrini, J. Piehler, L. Pichard-Garcia, 2011, PloS one.

A partial form of inherited human USP18 deficiency underlies infection and inflammation

J. Casanova, A. Sher, A. Bousfiha, 2022, The Journal of experimental medicine.

A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

G. Stark, M. Fellous, L. Velazquez, 1992, Cell.

The receptor of the type I interferon family.

G. Schreiber, S. Pellegrini, J. Piehler, 2007, Current topics in microbiology and immunology.

The Receptor Interaction Region of Tyk2 Contains a Motif Required for Its Nuclear Localization*

Pilar Romero, S. Pellegrini, J. Ragimbeau, 2001, The Journal of Biological Chemistry.

Identification of signalling components in tyrosine kinase cascades using phosphopeptide affinity chromatography.

M. Rubini, M. Fellous, R. Baserga, 1997, Biochemical and biophysical research communications.

A morphological study of the expression of the small G protein RhoA in resting and activated MDCK cells

S. Pellegrini, F. Bianchi, L. Mattii, 2000, Cellular and Molecular Life Sciences CMLS.

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

A. Cumano, B. Rocha, S. Pellegrini, 2016, Biology Direct.

ISG15 deficiency and increased viral resistance in humans but not mice

O. Sanal, I. Tezcan, A. García-Sastre, 2016, Nature Communications.

Human USP18 is regulated by miRNAs via the 3’UTR, a sequence duplicated in lincRNA genes residing in chr22q11.21

N. Tchitchek, S. Pellegrini, A. Rolland, 2020, bioRxiv.

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

S. Pellegrini, J. Piehler, C. You, 2015, The Journal of cell biology.

Differential responsiveness to IFN‐α and IFN‐β of human mature DC through modulation of IFNAR expression

E. Coccia, M. Severa, E. Giacomini, 2006 .

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression.

E. Coccia, M. Severa, E. Giacomini, 2006, Journal of leukocyte biology.

Regulation of Gene Expression from the Polyoma Late Promoter

F. Kern, S. Pellegrini, C. Basilico, 1987 .

Type I interferon‐enhanced IL‐10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

S. Pellegrini, F. Michel, U. Govender, 2017, Journal of leukocyte biology.

The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α

A. Cuddihy, S. Labrecque, G. Matlashewski, 1999, Oncogene.

The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.

A. Cuddihy, S. Labrecque, G. Matlashewski, 1999, Oncogene.

A Dual Role of IFN-α in the Balance between Proliferation and Death of Human CD4+ T Lymphocytes during Primary Response1

G. Roué, S. Pellegrini, V. Yuste, 2004, The Journal of Immunology.

Lymphocytes during Primary Response T + Proliferation and Death of Human CD 4 in the Balance between α A Dual Role of IFN-Susin and

G. Roué, S. Pellegrini, V. Yuste, 2004 .

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.

R. Darnell, C. Rice, M. Albert, 2007, Blood.

Specific Contribution of Tyk2 JH Regions to the Binding and the Expression of the Interferon α/β Receptor Component IFNAR1*

M. Fellous, S. Pellegrini, G. Duménil, 1998, The Journal of Biological Chemistry.

Interferon α Inhibits a Src-mediated Pathway Necessary for Shigella-induced Cytoskeletal Rearrangements in Epithelial Cells

J. Olivo, P. Sansonetti, M. Fellous, 1998, The Journal of cell biology.

IFN Upon T Cell Activation Down-Modulation of Responses to Type I

G. Lutfalla, L. Rogge, S. Pellegrini, 2002 .

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes.

R. Chiarle, S. Pellegrini, M. Capello, 2010, Immunology letters.

Induction of β-R1/I-TAC by Interferon-β Requires Catalytically Active TYK2*

R. Ransohoff, E. Fish, S. Pellegrini, 1999, The Journal of Biological Chemistry.

Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis*

L. Pfeffer, S. Goelz, S. Pellegrini, 1998, The Journal of Biological Chemistry.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

A. Russell, K. Rajewsky, P. Seale, 2012, Cell metabolism.

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor.

S. Pellegrini, B. Payelle‐Brogard, 2010, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

S. Pellegrini, F. Vuillier, P. Commere, 2019, Scientific Reports.

Erratum: Human intracellular ISG15 prevents interferon-α±/β 2 over-amplification and auto-inflammation (Nature 517 (2015) (89-93) 10.1038/nature13801))

J. Casanova, L. Notarangelo, Y. Crow, 2015 .

Down-modulation of Type 1 Interferon Responses by Receptor Cross-competition for a Shared Jak Kinase*

J. Tavernier, G. Lutfalla, X. Van Ostade, 2001, The Journal of Biological Chemistry.

P111 USP18 establishes the transcriptional and anti-proliferative interferon alpha/beta differential

M. Livingstone, S. Pellegrini, Véronique François-Newton, 2012 .

Isolation andCharacterization ofaNew MutantHumanCellLine Unresponsive toAlphaandBetaInterferons

S. Pellegrini, D. Flavell, 1991 .

Chairman’s Overview on Integration and Expression of the Polyoma Virus Oncogenes In Transformed Cells

R. Fenton, S. Pellegrini, C. Basilico, 1983 .