I. Bebu

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Combining Epidemiologic and Biostatistical Tools to Enhance Variable Selection in HIV Cohort Analyses

Ionut Bebu, Brian K. Agan, Vincent Marconi, 2014, PloS one.

DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

Angelo J. Canty, J. Keith Jones, A. Paterson, 2020, Clinical Epigenetics.

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

B. Zinman, R. Bergenstal, D. Nathan, 2017, Diabetes Care.

Confidence intervals for limited moments and truncated moments in normal and lognormal models

Thomas Mathew, Ionut Bebu, T. Mathew, 2009 .

Confidence intervals for confirmatory adaptive two‐stage designs with treatment selection

I. Bebu, V. Dragalin, G. Luta, 2013, Biometrical journal. Biometrische Zeitschrift.

Likelihood inference for a two‐stage design with treatment selection

Vladimir Dragalin, Ionut Bebu, George Luta, 2010, Biometrical journal. Biometrische Zeitschrift.

Environmental data analysis based on the gamma distribution: compliance assessment using tolerance limits and exceedance fractions

T. Mathew, I. Bebu, 2016 .

Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.

W. Herman, R. Bergenstal, D. Nathan, 2019, Diabetes technology & therapeutics.

The minimum intensity of a mixed exposure that increases the risk of an outcome

J. Lachin, I. Bebu, B. Braffett, 2020, Statistics in medicine.

Urinary estrogen metabolites and prostate cancer risk: A pilot study

T. Veenstra, J. Lynch, O. Kosti, 2011, The Prostate.

Analysis of Microarray Titration Experiments

Hongfang Liu, Françoise Seillier-Moiseiwitsch, Ionut Bebu, 2008, BIOCOMP.

D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events

B. Agan, A. Ganesan, A. Justice, 2016, PloS one.

Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study.

I. D. de Boer, A. Schwartz, M. Rubin, 2022, The lancet. Diabetes & endocrinology.

Characterizing the Association Between Alcohol and HIV Virologic Failure in a Military Cohort on Antiretroviral Therapy.

B. Agan, A. Ganesan, I. Bebu, 2016, Alcoholism, clinical and experimental research.

Large sample inference for a win ratio analysis of a composite outcome based on prioritized components.

J. Lachin, I. Bebu, 2016, Biostatistics.

Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: the DCCT/EDIC Study.

L. Aiello, W. Tamborlane, J. Lachin, 2020, Ophthalmology.

Moderation of the Effect of Glycemia on the Risk of Cardiovascular Disease in Type 1 Diabetes: the DCCT/EDIC Study.

W. Herman, D. Nathan, J. Lachin, 2020, Diabetes research and clinical practice.

Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

M. Budoff, J. Lachin, P. Cleary, 2016, PloS one.

Response to Comment on Braffett et al. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2019;42:657–664

J. Lachin, I. Bebu, W. Sivitz, 2019, Diabetes Care.

Longitudinal Plasma Kallikrein Levels and Their Association With the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC

K. Hunt, J. Lachin, T. Lyons, 2020, Diabetes.

Cardiometabolic Risk Factors and Incident Cardiovascular Disease Events in Women vs Men With Type 1 Diabetes

C. Cowie, D. Nathan, J. Lachin, 2022, JAMA network open.

The Association of Coronary Artery Calcification (CAC) With Subsequent Incidence of Cardiovascular Disease (CVD) in DCCT/EDIC

M. Budoff, D. Bluemke, S. Strowig, 2019 .

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

B. Zinman, R. Bergenstal, D. Nathan, 2017, Diabetes Care.

Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.

Andrea L. Cherrington, S. Fortmann, D. Nathan, 2022, The New England journal of medicine.

Application of the Wei–Lachin multivariate one-directional test to multiple event-time outcomes

J. Lachin, I. Bebu, 2015, Clinical trials.

Practice of Epidemiology Models to Assess the Association of a Semiquantitative Exposure With Outcomes

J. Lachin, I. Bebu, B. Braffett, 2020 .

Refining Measurement of Hemoglobin A1c.

J. Lachin, D. Sacks, I. Bebu, 2017, Clinical chemistry.

Reﬁning Measurement of Hemoglobin A 1c

J. Lachin, I. Bebu, D. Sacks, 2017 .

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

J. Lachin, P. Cleary, I. Bebu, 2016, Diabetes Care.

Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes

L. Aiello, I. D. de Boer, W. Tamborlane, 2021, Diabetes Care.

Biomarkers of tubulointerstitial damage and function in type 1 diabetes

A. Paterson, B. Zinman, I. D. de Boer, 2017, BMJ Open Diabetes Research & Care.

Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study

J. Lachin, I. Bebu, W. Sivitz, 2019, Diabetes Care.

Randomized, Double-Blind, Placebo-Controlled Study on Decolonization Procedures for Methicillin-Resistant Staphylococcus aureus (MRSA) among HIV-Infected Adults

B. Agan, A. Weintrob, N. Crum‐Cianflone, 2015, PloS one.

Early Glomerular Hyperfiltration and Long-Term Kidney Outcomes in Type 1 Diabetes: The DCCT/EDIC Experience.

A. Paterson, B. Zinman, I. D. de Boer, 2019, Clinical journal of the American Society of Nephrology : CJASN.

The Beneficial Effects of Earlier Versus Later Implementation of Intensive Therapy in Type 1 Diabetes

D. Nathan, J. Lachin, I. Bebu, 2021, Diabetes Care.

Emotional Distress, Self-Management, and Glycemic Control among Participants enrolled in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study.

A. Naik, E. Walker, D. Ehrmann, 2022, Diabetes research and clinical practice.

A simple framework to identify optimal cost‐effective risk thresholds for a single screen: Comparison to Decision Curve Analysis

I. Bebu, Hormuzd A. Katki, 2021, Journal of the Royal Statistical Society. Series A,.

Microarray probes and probe sets.

Hongfang Liu, Xin Li, Ionut Bebu, 2010, Frontiers in bioscience.

HIV Outcomes in Hepatitis B Virus Coinfected Individuals on HAART

C. Thio, B. Agan, W. Bradley, 2014, Journal of acquired immune deficiency syndromes.

Frequency of Evidence‐Based Screening for Retinopathy in Type 1 Diabetes

R. Klein, W. Tamborlane, D. Nathan, 2017, The New England journal of medicine.

Anesthetic outcomes in pediatric patients with COVID‐19: A matched cohort study

E. Heitmiller, I. Bebu, B. Braffett, 2021, Paediatric anaesthesia.

Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes

B. Stranger, A. Skol, A. Swaroop, 2020, eLife.

Risk Factors for Kidney Disease in Type 1 Diabetes

A. Paterson, I. D. de Boer, W. Tamborlane, 2019, Diabetes Care.

The VACS Index Predicts Mortality in a Young, Healthy HIV Population Starting Highly Active Antiretroviral Therapy

B. Agan, A. Weintrob, A. Ganesan, 2014, Journal of acquired immune deficiency syndromes.

Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation

R Clarke, E. Petricoin, R. Clarke, 2016, Oncogene.

Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study.

J. Luchsinger, J. Lachin, C. Ryan, 2021, The lancet. Diabetes & endocrinology.

Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study.

E. Soliman, W. Tamborlane, R. Bergenstal, 2022, Diabetes care.

Mediation analysis of gestational age, congenital heart defects, and infant birth-weight

C. Loffredo, I. Bebu, G. Luta, 2014, BMC Research Notes.

Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC

S. Genuth, V. Monnier, J. Lachin, 2022, BMJ Open Diabetes Research & Care.

Electrocardiographic Abnormalities and Cardiovascular Disease Risk in Type 1 Diabetes: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study.

B. Zinman, E. Soliman, J. Lachin, 2017, Diabetes care.

Tolerance limits and tolerance intervals for ratios of normal random variables using a bootstrap calibration

T. Mathew, I. Bebu, Shuyan Zhai, 2017, Biometrical journal. Biometrische Zeitschrift.

Testosterone and cardiac mass and function in men with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

P. Cleary, M. Steffes, T. Orchard, 2016, Clinical endocrinology.

Utility of using electrocardiogram measures of heart rate variability as a measure of cardiovascular autonomic neuropathy in type 1 diabetes patients

E. Soliman, N. White, J. Lachin, 2021, Journal of diabetes investigation.

Prevalence of Microvascular and Macrovascular Disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study Cohort.

E. Soliman, E. Seaquist, D. Wexler, 2020, Diabetes research and clinical practice.

Study of emotional distress in a comparative effectiveness trial of diabetes treatments: Rationale and design.

Andrea L. Cherrington, A. Naik, E. Walker, 2021, Contemporary clinical trials.

Mediation of the Effect of Glycemia on the Risk of CVD Outcomes in Type 1 Diabetes: The DCCT/EDIC Study

J. Lachin, T. Orchard, I. Bebu, 2019, Diabetes Care.

Mendelian randomization identifies folliculin expression as a mediator of diabetic retinopathy

B. Stranger, A. Skol, A. Swaroop, 2020, bioRxiv.

Serum urate and cardiovascular events in the DCCT/EDIC study

B. Zinman, A. Jenkins, D. Nathan, 2021, Scientific Reports.

Coprogression of Cardiovascular Risk Factors in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study

S. Genuth, J. Lachin, I. Bebu, 2016, Diabetes Care.

Progression of Electrocardiographic Abnormalities in Type 1 Diabetes During 16 Years of Follow‐up: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study

E. Soliman, J. Lachin, P. Cleary, 2016, Journal of the American Heart Association.

Risk Factors for Cardiovascular Disease in Type 1 Diabetes

C. Cowie, D. Nathan, J. Lachin, 2016, Diabetes.

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

P. Cleary, T. Orchard, I. Bebu, 2015, The journal of sexual medicine.

Albuminuria Changes and Cardiovascular and Renal Outcomes in Type 1 Diabetes: The DCCT/EDIC Study.

A. Paterson, B. Zinman, I. D. de Boer, 2016, Clinical journal of the American Society of Nephrology : CJASN.

The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC study

D. Nathan, J. Lachin, T. Orchard, 2017, Diabetologia.

Frequency of Evidence-Based Screening for Diabetic Retinopathy.

D. Nathan, J. Lachin, I. Bebu, 2017, The New England journal of medicine.

Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study

Shriji N. Patel, L. Aiello, N. White, 2019, Diabetes Care.

Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus

A. Rademaker, R. Nelson, D. Batlle, 2019, Physiological reports.

Optimal Frequency of Urinary Albumin Screening in Type 1 Diabetes.

B. Zinman, I. D. de Boer, D. Nathan, 2022, Diabetes care.

Closed testing using surrogate hypotheses with restricted alternatives

J. Lachin, I. Bebu, N. Younes, 2019, PloS one.

Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D

M. Budoff, A. Jenkins, J. Stoner, 2019, Journal of Lipid Research.

The Association of Coronary Artery Calcification With Subsequent Incidence of Cardiovascular Disease in Type 1 Diabetes: The DCCT/EDIC Trials.

M. Budoff, P. Raskin, D. Bluemke, 2019, JACC. Cardiovascular imaging.

Optimal screening schedules for disease progression with application to diabetic retinopathy.

J. Lachin, I. Bebu, 2018, Biostatistics.

An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study

W. Herman, J. Lachin, I. Bebu, 2020, Diabetes Care.

Comparing the means and variances of a bivariate log‐normal distribution

Thomas Mathew, Ionut Bebu, T. Mathew, 2008, Statistics in medicine.

Cost‐efficient clinical studies with continuous time survival outcomes

J. Lachin, I. Bebu, Grecio J Sandoval, 2021, Statistics in medicine.

Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study.

R. Bryan, J. Luchsinger, M. Habes, 2022, Diabetes care.

Models to Assess the Association of a Semi-Quantitative Exposure With Outcomes.

J. Lachin, I. Bebu, B. Braffett, 2020, American journal of epidemiology.

Retinopathy During the First 5 Years of Type 1 Diabetes and Subsequent Risk of Advanced Retinopathy.

L. Aiello, P. Raskin, W. Tamborlane, 2022, Diabetes Care.

Screening eye exams in youth with type 1 diabetes under 18 years of age: Once may be enough?

W. Tamborlane, N. White, J. Lachin, 2019, Pediatric diabetes.

Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes

C. Davatzikos, R. Bryan, J. Luchsinger, 2023, JAMA network open.

DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

Angelo J. Canty, J. Keith Jones, A. Paterson, 2020, Clinical Epigenetics.

Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study

D. Bluemke, E. Soliman, W. Herman, 2020, Diabetes Care.

Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.

S. Mudaliar, J. McGill, I. D. de Boer, 2023, JAMA internal medicine.

Generalized fiducial inference for the restricted mean survival time

I. Bebu, G. Diao, T. Hamasaki, 2023, Statistical methods in medical research.

Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study

J. Keith Jones, A. Paterson, S. Mudaliar, 2018, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease.

Generalized Confidence Intervals and Fiducial Intervals for Some Epidemiological Measures

T. Mathew, B. Agan, I. Bebu, 2016, International journal of environmental research and public health.

Immune Complexes and the Risk of CVD in Type 1 Diabetes

K. Hunt, J. Lachin, I. Bebu, 2019, Diabetes.

Immune Complexes and the Risk of CVD in Type 1 Diabetes Writing Group:

K. Hunt, I. Bebu, M. Lopes-Virella, 2019 .

Inference for Surrogate Endpoint Validation in the Binary Case

T. Mathew, B. Agan, I. Bebu, 2015, Journal of biopharmaceutical statistics.

Accurate confidence intervals for inter-laboratory calibration and common mean estimation

Jian Zhao, Thomas Mathew, Ionut Bebu, 2021 .

Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study

Angelo J. Canty, A. Paterson, W. Herman, 2021, Diabetes Care.

Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes.

B. Zinman, I. D. de Boer, I. Hirsch, 2022, Diabetes Care.

Emotional Distress and Cardiovascular Disease Risk among Participants enrolled in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study.

A. Naik, E. Walker, D. Ehrmann, 2023, Diabetes Research and Clinical Practice.

Physical Function in Middle-aged and Older Adults With Type 1 Diabetes: Long-term Follow-up of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.

W. Herman, J. Lachin, I. Bebu, 2022, Diabetes care.

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

J. Lachin, P. Cleary, I. Bebu, 2016, Diabetes Care.

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

P. Cleary, T. Orchard, I. Bebu, 2015, The journal of sexual medicine.

Electrocardiographic Abnormalities and Cardiovascular Disease Risk in Type 1 Diabetes: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study

B. Zinman, E. Soliman, J. Lachin, 2017, Diabetes Care.

Probabilistic measures of cost‐effectiveness

T. Mathew, J. Lachin, I. Bebu, 2016, Statistics in medicine.

Parametric cost-effectiveness inference with skewed data

Thomas Mathew, George Luta, Paul A. Kennedy, 2016, Comput. Stat. Data Anal..

Combining Multivariate Bioassays: Accurate Inference Using Small Sample Asymptotics

T. Mathew, I. Bebu, Gaurav Sharma, 2014 .

Characterizing the Association Between Alcohol and HIV Virologic Failure in a Military Cohort on Antiretroviral Therapy.

B. Agan, A. Ganesan, I. Bebu, 2016, Alcoholism, clinical and experimental research.

Coronary Artery Disease Events and Carotid Intima‐Media Thickness in Type 1 Diabetes in the DCCT/EDIC Cohort

P. Raskin, J. Polak, J. Lachin, 2021, Journal of the American Heart Association.