B. Titz

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Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

M. Peitsch, A. Sewer, J. Hoeng, 2020, Computational and structural biotechnology journal.

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis

M. Peitsch, R. Laaksonen, J. Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.

Ashraf Elamin, Julia Hoeng, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

Manuel C. Peitsch, Kim Ekroos, Julia Hoeng, 2016, International journal of molecular sciences.

Proteomics for systems toxicology

Manuel C. Peitsch, Ashraf Elamin, Sophie Dijon, 2014, Computational and structural biotechnology journal.

Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer

Evan O. Paull, Joshua M. Stuart, Tanya Stoyanova, 2016, Cell.

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

M. Peitsch, J. Hoeng, B. Titz, 2018, International journal of molecular sciences.

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects.

M. Peitsch, A. Sewer, K. Luettich, 2015, Journal of proteomics.

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx

M C Peitsch, N V Ivanov, M. Peitsch, 2017, Toxicology research.

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Tom Misteli, Mark C. Kelley, Neal Rosen, 2011, Nature.

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

M. Peitsch, J. Hoeng, S. Boué, 2020, Toxicology reports.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

T. Graeber, A. Ribas, Hubing Shi, 2016, Cell Discovery.

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Quantitative proteomics analysis using 2 D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modi fi ed risk tobacco product on the lung proteome in C 57 BL / 6 mice

M. Peitsch, J. Hoeng, Marcel Geertz, 2016 .

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.

M. Peitsch, J. Hoeng, Marcel Geertz, 2016, Journal of proteomics.

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Chemico-biological interactions.

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis

Rémi H. J. Dulize, M. Peitsch, V. Belcastro, 2016, Inhalation toxicology.

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.

M. Peitsch, Ashutosh Kumar, A. Sewer, 2020, American journal of physiology. Heart and circulatory physiology.

Phosphoproteomic Analysis of Platelets Activated by Pro-Thrombotic Oxidized Phospholipids and Thrombin

T. Graeber, E. Podrez, S. Biswas, 2014, PloS one.

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

M. Peitsch, F. Springer, P. Augat, 2020, Archives of Toxicology.

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

John H. Miller, Rémi H. J. Dulize, M. Peitsch, 2021, Archives of Toxicology.

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

M. Peitsch, J. Hoeng, Sam Ansari, 2018, Inhalation toxicology.

Systems biology reveals anatabine to be an NRF2 activator

Dimitris E. Messinis, Rémi H. J. Dulize, M. Peitsch, 2022, Frontiers in Pharmacology.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model

M. Peitsch, J. Hoeng, B. Titz, 2021, Journal of applied toxicology : JAT.

A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

M. Peitsch, Ashutosh Kumar, J. Hoeng, 2021, Toxicology Research and Application.

Lipid-based biomarkers for CVD, COPD, and aging - A translational perspective.

J. Hoeng, B. Titz, O. Lavrynenko, 2020, Progress in lipid research.

CRAF R391W is a melanoma driver oncogene

T. Graeber, A. Ribas, B. Titz, 2016, Scientific Reports.

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Systems Biology: Methods and Applications

M. Peitsch, A. Sewer, J. Hoeng, 2017 .

Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma

Antoni Ribas, Lidia Robert, Bjoern Titz, 2014, Clinical Cancer Research.

Analysis of Proteomic Data for Toxicological Applications

Manuel C. Peitsch, Bjoern Titz, Thomas Schneider, 2015 .

Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis

J. Hoeng, B. Titz, T. Schneider, 2021, Toxicology Research and Application.

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

M. Peitsch, A. Sewer, K. Luettich, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

A Systems-Based Approach to Toxicity Testing

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2021 .

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

T. Graeber, A. Ribas, Helena Escuin-Ordinas, 2015, Molecular Cancer.

Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids

J. Hoeng, B. Titz, Catherine Nury, 2022, Toxicology mechanisms and methods.

Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis.

T. Graeber, J. Berliner, Sharon Chen, 2010, Journal of proteome research.

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Manuel C. Peitsch, Ashraf Elamin, Julia Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Translational Models for ENDP Assessment

M. Peitsch, J. Hoeng, B. Titz, 2021 .

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.

Julia Hoeng, Manuel C Peitsch, Jenny Ho, 2016, Regulatory toxicology and pharmacology : RTP.

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies.

M. Peitsch, J. Hoeng, B. Titz, 2020, Life sciences.

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Manuel C. Peitsch, Kim Ekroos, Ashraf Elamin, 2016, Scientific Data.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine.

J. Hoeng, B. Titz, S. Lebrun, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System

J. Hoeng, B. Titz, K. Renggli, 2022, Bioengineering.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.