W. Schlage

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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis

M. Peitsch, R. Laaksonen, J. Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.

Ashraf Elamin, Julia Hoeng, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Enhancement of COPD biological networks using a web-based collaboration interface

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015, F1000Research.

Case study: the role of mechanistic network models in systems toxicology.

Julia Hoeng, Marja Talikka, Manuel C Peitsch, 2014, Drug discovery today.

Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology

David A. Drubin, M. Peitsch, A. Sewer, 2014 .

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Manuel C. Peitsch, Marcel Geertz, Julia Hoeng, 2014, Toxicology mechanisms and methods.

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx

M C Peitsch, N V Ivanov, M. Peitsch, 2017, Toxicology research.

Construction of a Computable Network Model of Tissue Repair and Angiogenesis in the Lung

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013 .

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia

M. Peitsch, J. Hoeng, W. Schlage, 2021, Biochemistry and Biophysics Reports.

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Animal Models for Three Major Cigarette-Smoke-Induced Diseases

H. Haussmann, W. Schlage, J. Borzelleca, 2005 .

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

M. Peitsch, J. Hoeng, S. Boué, 2020, Toxicology reports.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Atherosclerosis.

Aerosol Dosimetry and Human-Relevant Exposure

J. Hoeng, P. Vanscheeuwijck, W. Schlage, 2021 .

A microscope perfusion respirometer for continuous respiration measurement of cultured cells during microscopic observation.

J. Bereiter-Hahn, W. Schlage, 1983, Microscopica acta.

Structure of the Basement Membrane Protein Laminin: Variations on a Theme

K. Beck, M. Chiquet, W. Schlage, 1989 .

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Use of the HET-CAM Test for the Determination of the Irritant Potential of Cigarette Sidestream Smoke.

W. Schlage, B. Kurkowsky, H. Bülles, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Quantitative proteomics analysis using 2 D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modi fi ed risk tobacco product on the lung proteome in C 57 BL / 6 mice

M. Peitsch, J. Hoeng, Marcel Geertz, 2016 .

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.

M. Peitsch, J. Hoeng, Marcel Geertz, 2016, Journal of proteomics.

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

M. Peitsch, J. Hoeng, S. Boué, 2019, Regulatory toxicology and pharmacology : RTP.

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Chemico-biological interactions.

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.

M. Peitsch, Ashutosh Kumar, A. Sewer, 2020, American journal of physiology. Heart and circulatory physiology.

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC-MS deconvolution procedures.

M. Peitsch, J. Hoeng, N. Ivanov, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cigarette-Smoke- and Age-Dependent Oxidative Stress Effects in Rats

A. Humeny, W. Schlage, M. Kasper, 2014 .

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

John H. Miller, Rémi H. J. Dulize, M. Peitsch, 2021, Archives of Toxicology.

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

M. Peitsch, J. Hoeng, S. Boué, 2015, Inhalation toxicology.

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice.

M. Peitsch, R. Laaksonen, J. Hoeng, 2012, Atherosclerosis.

Construction of a computable cell proliferation network focused on non-diseased lung cells

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2011, BMC Systems Biology.

28-day rat inhalation study: how systems toxicology complements OECD inhalation studies

M. Peitsch, J. Hoeng, Sam Ansari, 2015 .

A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Cytokeratin Expression Patterns in the Rat Respiratory Tract as Markers of Epithelial Differentiation in Inhalation Toxicology. II. Changes in Cytokeratin Expression Patterns Following 8-Day Exposure to Room-Aged Cigarette Sidestream Smoke

W. Schlage, D. Friedrichs, P. Terpstra, 1998, Toxicologic pathology.

Tobacco smoke-induced alterations of cytokeratin expression in the rat nasal activity cavity following chronic inhalation of room-aged sidestream smoke.

W. Schlage, D. Friedrichs, P. Terpstra, 1998, Toxicology letters.

Cytokeratin Expression Patterns in the Rat Respiratory Tract as Markers of Epithelial Differentiation in Inhalation Toxicology. I. Determination of Normal Cytokeratin Expression Patterns in Nose, Larynx, Trachea, and Lung

W. Schlage, D. Friedrichs, A. Teredesai, 1998, Toxicologic pathology.

Determination of human factor VIII (AHG-associated protein)-antigen in endothelial cells from Xenopus laevis (XTH cells)

W. Schlage, 1986, Cell and Tissue Research.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

Hepatocholangiocellular carcinoma in a rat--case report.

W. Schlage, T. Wöhrmann, A. Teredesai, 2002, Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.

A rapid and sensitive microassay for bacterial collagenase and other proteolytic activities on collagenous substrates.

W. Schlage, 1988, Biological chemistry Hoppe-Seyler.

Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

W. Schlage, A. Kuczaj, T. Sosnowski, 2018, Inhalation toxicology.

Melanogenesis in genetically determined pigment cell tumors of platyfish and platyfish-swordtail hybrids: correlation between tyrosinase activity and degree of malignancy

W. Schlage, F. Anders, Dr. Ursula Vielkind, 1977, Zeitschrift für Krebsforschung und Klinische Onkologie.

Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species

J. Hoeng, Csaba Laszlo, N. Ivanov, 2022, Molecules.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model

M. Peitsch, J. Hoeng, B. Titz, 2021, Journal of applied toxicology : JAT.

Assessment of ENDPs in Animal Models of Disease

M. Peitsch, K. Luettich, J. Hoeng, 2021 .

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

M. Peitsch, J. Hoeng, K. Koshibu, 2019, Toxicology reports.

Experimental Models of Environmental Tobacco Smoke Exposure: Structural and Functional Changes in Epithelial Cells of the Respiratory Tract

W. Schlage, A. Teredesai, 2000 .

Cytokeratin patterns of epithelial cells of the rat nasal cavity in vivo and in vitro.

W. Schlage, D. Friedrichs, A. Teredesai, 1996, Toxicology letters.

Chapter 10 Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2017 .

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Manuel C. Peitsch, Ashraf Elamin, Julia Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Jennifer Park, Manuel C. Peitsch, Carine Poussin, 2011, BMC Systems Biology.

Quantifying the Biological Impact of Active Substances Using Causal Network Models

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015 .

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

M. Peitsch, S. Gebel, J. Hoeng, 2014, Journal of Translational Medicine.

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Toxicology.

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

Jennifer Park, Manuel C. Peitsch, William Hayes, 2015, Database J. Biol. Databases Curation.

Toxicological Assessment In Vitro

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2021 .

Translational Models for ENDP Assessment

M. Peitsch, J. Hoeng, B. Titz, 2021 .

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, BioMed research international.

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Manuel C. Peitsch, Kim Ekroos, Ashraf Elamin, 2016, Scientific Data.

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

M. Peitsch, B. Titz, A. Sewer, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00152e

Julia Hoeng, Carole Mathis, Manuel C Peitsch, 2017, Toxicology research.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Carine Poussin, Julia Hoeng, Stephan Gebel, 2014, Journal of Translational Medicine.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Julia Hoeng, Stephan Gebel, Marja Talikka, 2013, Toxicology and applied pharmacology.

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Julia Hoeng, Stephan Gebel, Manuel C Peitsch, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2016, Chemical research in toxicology.

Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2021, Archives of Toxicology.

Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine.

J. Hoeng, B. Titz, S. Lebrun, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Enhancement of COPD biological networks using a web-based collaboration interface.

Jennifer Park, Julia Hoeng, Marja Talikka, 2015, F1000Research.

On Crowd-verification of Biological Networks

Raquel Norel, Kahn Rhrissorrakrai, Manuel C. Peitsch, 2013, Bioinformatics and biology insights.

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

M. Peitsch, A. Sewer, K. Luettich, 2014, Interdisciplinary toxicology.

Cigarette Smoke-induced Morphological Transformation of Bhas 42 Cells In Vitro

W. Schlage, A. Poth, E. Roemer, 2013, Alternatives to laboratory animals : ATLA.

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis.

J. Hoeng, S. Lebrun, W. Schlage, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2013, Bioinformatics and biology insights.

Two-Stage Transformation Assay for Cigarette Smoke Condensates using Murine c3h-10t1/2 Fibroblasts.

W. Schlage, D. Friedrichs, B. Kurkowsky, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

The extracellular matrix (mesoglea) of hydrozoan jellyfish and its ability to support cell adhesion and spreading

K. Beck, W. Schlage, V. Schmid, 1991, Hydrobiologia.

Isolation and characterization of a fibronectin from marine coelenterates

W. Schlage, 1988 .

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

M. Peitsch, V. Belcastro, A. Sewer, 2013, Toxicology and applied pharmacology.