M. Toda

发表

Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.

E. Corey, J. Drazen, K. Austen, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana.

M. Toda, Y. Fukuyama, T. Hasegawa, 1992, Chemical & pharmaceutical bulletin.

Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin.

Y. Takei, M. Toda, E. Gabazza, 2017, The American journal of pathology.

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

M. Toda, S. Sakaguchi, M. Toda, 1995, Journal of immunology.

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach.

H. Ohno, M. Toda, Shingo Yamamoto, 2005, Bioorganic & medicinal chemistry.

Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis

Y. Takei, M. Toda, E. Gabazza, 2017, Gene Therapy.

Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.

H. Mitsuya, K. Maeda, M. Toda, 2006, Journal of medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.

H. Mitsuya, K. Maeda, M. Toda, 2007, Bioorganic & medicinal chemistry letters.

Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis

M. Toda, E. Gabazza, Kentaro Fujiwara, 2019, International journal of molecular sciences.

Protein S Exacerbates Chronic Liver Injury and Fibrosis.

Y. Takei, M. Toda, E. Gabazza, 2018, The American journal of pathology.

Efficacy of osimertinib in a patient with non-small cell lung cancer harboring epithelial growth factor receptor exon 19 deletion/T790M mutation, with poor performance status

M. Toda, E. Gabazza, N. Yamamoto, 2017, Molecular and clinical oncology.

High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double‐deficient mice

K. Shiraki, Y. Takei, M. Toda, 2010, Journal of thrombosis and haemostasis : JTH.

Coagulation markers as predictors for clinical events in COPD

P. Bakke, M. Toda, E. Gabazza, 2020, Respirology.

Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis.

S. Rennard, Y. Takei, P. Wagner, 2012, American journal of respiratory cell and molecular biology.

Subcritical Water Extracts from Agaricus blazei Murrill’s Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor

M. Toda, E. Gabazza, C. D'Alessandro-Gabazza, 2021, Journal of fungi.

Direct effects of protein S in ameliorating acute lung injury

Y. Takei, M. Toda, E. Gabazza, 2009, Journal of thrombosis and haemostasis : JTH.

Presence of Thrombin‐Activatable Fibrinolysis Inhibitor in Helicobacter pylori‐Associated Gastroduodenal Disease

Y. Takei, M. Toda, E. Gabazza, 2009, Helicobacter.

Differential role of regulatory T cells in early and late stages of pulmonary fibrosis.

Takahiro Matsumoto, M. Toda, E. Gabazza, 2013, Immunobiology.

Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism.

Hiroshi Yamamoto, Yasuhiko Yamamoto, M. Toda, 2014, Allergology international : official journal of the Japanese Society of Allergology.

Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma

Y. Takei, M. Toda, E. Gabazza, 2019, Front. Immunol..

Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

M. Toda, E. Gabazza, M. Nagao, 2018, Front. Immunol..

Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV.

M. Toda, T. Kondo, H. Nakai, 2007, Bioorganic & medicinal chemistry.

autoimmune diseases self-tolerance causes various Breakdown of a single mechanism of receptor alpha-chains (CD25). by activated T cells expressing IL-2 Immunologic self-tolerance maintained

M. Toda, S. Sakaguchi, N. Sakaguchi, 2010 .

T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases.

S. Morse, M. Toda, S. Sakaguchi, 1996, Journal of autoimmunity.

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

P. A. Peterson, M. Davis, M. Toda, 1994, Journal of immunology.

Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.

Y. Takei, Hiroshi Yamamoto, Yasuhiko Yamamoto, 2011, American journal of respiratory and critical care medicine.

Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration.

M. Toda, T. Kondo, H. Nakai, 2007, Bioorganic & medicinal chemistry.

Differential Gene Expression in Thrombomodulin (TM; CD141)+ and TM− Dendritic Cell Subsets

H. Salamon, M. Toda, E. Gabazza, 2013, PloS one.

ONO-LB-457: a novel and orally active leukotriene B4 receptor antagonist.

M. Toda, A. Kawasaki, N. Matsunaga, 1991, Advances in prostaglandin, thromboxane, and leukotriene research.

Structure-activity study of L-amino acid-based N-type calcium channel blockers.

H. Takimizu, M. Toda, H. Kohno, 2003, Bioorganic & medicinal chemistry.

L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models.

H. Takimizu, M. Toda, H. Kohno, 2002, Bioorganic & medicinal chemistry letters.

Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.

H. Takimizu, M. Toda, H. Kohno, 2002, Bioorganic & medicinal chemistry letters.

Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.

H. Takimizu, M. Toda, H. Kohno, 2001, Bioorganic & medicinal chemistry letters.

Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.

M. Toda, T. Kondo, H. Nakai, 2008, Bioorganic & medicinal chemistry.

Contractile activities of structural analogs of leukotrienes C and D: role of the polar substituents.

E. Corey, J. Drazen, K. Austen, 1981, Proceedings of the National Academy of Sciences of the United States of America.

ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions.

M. Toda, K. Kishikawa, T. Miyamoto, 1992, Prostaglandins.

Disease as a Consequence o f Deve lopmenta l Abnormal

M. Toda, S. Sakaguchi, N. Sakaguchi, 2003 .

UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10.

M. Toda, Kanako Saito, H. Shiku, 2010, Immunobiology.

UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses

K. Matsushima, M. Toda, M. Kurachi, 2011, International journal of cancer.

Post-immune UV irradiation induces Tr1-like regulatory T cells that suppress humoral immune responses.

T. Horii, M. Toda, Kanako Saito, 2008, International immunology.

Pulmonary hypertension is ameliorated in mice deficient in thrombin‐activatable fibrinolysis inhibitor

Y. Takei, M. Toda, E. Gabazza, 2010, Journal of thrombosis and haemostasis : JTH.

ONO-5046, a novel inhibitor of human neutrophil elastase.

M. Suzuki, M. Toda, M. Sugitani, 1991, Biochemical and biophysical research communications.

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.

S. Kusuda, K. Hirai, M. Toda, 2002, Bioorganic & medicinal chemistry letters.

Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance

Y. Takei, M. Toda, E. Gabazza, 2020, Allergy.

Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells

Y. Takei, M. Toda, E. Gabazza, 2015, Journal of thrombosis and haemostasis : JTH.

Efficacy of a Novel Class of RNA Interference Therapeutic Agents

Hiroshi I. Suzuki, T. Ochiya, Takahiro Matsumoto, 2012, PloS one.

Eosinophils Promote Epithelial to Mesenchymal Transition of Bronchial Epithelial Cells

Takahiro Matsumoto, M. Toda, E. Gabazza, 2013, PloS one.

Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis

Y. Takei, M. Toda, E. Gabazza, 2020, Frontiers in Pharmacology.

Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway.

Y. Takei, A. Mizoguchi, M. Toda, 2020, Kidney international.

Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.

M. Toda, Y. Nakayama, H. Nakai, 2002, Bioorganic & medicinal chemistry letters.

Role of Thrombin-Activatable Fibrinolysis Inhibitor in Allergic Bronchial Asthma

Y. Takei, M. Toda, E. Gabazza, 2012, Lung.

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry letters.

Effective anti-tumor adoptive immunotherapy: utilization of exogenous IL-2-independent cytotoxic T lymphocyte clones.

M. Toda, Takuma Kato, K. Kuribayashi, 2002, International immunology.

Thrombomodulin inhibits the activation of eosinophils and mast cells.

M. Toda, E. Gabazza, Tetsu Kobayashi, 2015, Cellular immunology.

Dose‐dependent differential effects of thrombin in allergic bronchial asthma

M. Toda, E. Gabazza, Tetsu Kobayashi, 2013, Journal of thrombosis and haemostasis : JTH.

Plant growth regulators and Axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus

M. Toda, E. Gabazza, Hirofumi Hirai, 2020, Bioscience, biotechnology, and biochemistry.

Role of the coagulation system in allergic inflammation in the upper airways.

Y. Takei, M. Toda, Tatsuya Hayashi, 2008, Clinical immunology.

Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils.

M. Toda, E. Gabazza, M. Nagao, 2014, Biochemical and biophysical research communications.

Design and synthesis of a highly selective EP2-receptor agonist.

M. Toda, S. Ohuchida, T. Maruyama, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists.

M. Toda, T. Maruyama, T. Maruyama, 2012, Bioorganic & medicinal chemistry.

Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.

M. Toda, T. Maruyama, T. Maruyama, 2012, Bioorganic & medicinal chemistry.

Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.

M. Toda, A. Konaka, T. Maruyama, 2012, Bioorganic & medicinal chemistry letters.

Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists.

M. Toda, T. Matsui, Shingo Yamamoto, 2006, Bioorganic & medicinal chemistry.

Fulminant liver failure triggered by therapeutic antibody treatment in a mouse model.

M. Toda, K. Kakimi, Y. Matsuda, 2006, International journal of oncology.

Discovery of new orally active phosphodiesterase (PDE4) inhibitors.

M. Toda, H. Nakai, K. Kusumi, 2004, Chemical & pharmaceutical bulletin.

New orally active PDE4 inhibitors with therapeutic potential.

M. Toda, H. Nakai, K. Kusumi, 2004, Bioorganic & medicinal chemistry letters.

Orally active PDE4 inhibitor with therapeutic potential.

M. Toda, H. Nakai, A. Ishida, 2004, European journal of medicinal chemistry.

Highly potent PDE4 inhibitors with therapeutic potential.

M. Toda, H. Kohno, H. Nakai, 2004, Bioorganic & medicinal chemistry.

Orally active PDE4 inhibitors with therapeutic potential.

M. Toda, H. Nakai, A. Ishida, 2004, Bioorganic & medicinal chemistry letters.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships.

M. Toda, H. Nakai, N. Katsube, 1988, Journal of medicinal chemistry.

Design and synthesis of new prostaglandin D₂ receptor antagonists.

M. Toda, H. Nakai, M. Iwahashi, 2011, Bioorganic & medicinal chemistry.

Discovery of selective indole-based prostaglandin D₂ receptor antagonist.

M. Toda, H. Nakai, M. Iwahashi, 2011, Bioorganic & medicinal chemistry.

Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead.

M. Toda, H. Nakai, M. Iwahashi, 2005, European journal of medicinal chemistry.

Discovery of new chemical leads for prostaglandin D2 receptor antagonists.

M. Toda, H. Nakai, M. Iwahashi, 2004, Bioorganic & medicinal chemistry letters.

New antagonists of leukotrienes: ONO-RS-411 and ONO-RS-347.

M. Toda, H. Nakai, N. Katsube, 1985, Advances in prostaglandin, thromboxane, and leukotriene research.

ONO-1078: an antagonist of leukotrienes.

M. Toda, T. Okegawa, A. Kawasaki, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives.

M. Toda, S. Ohuchida, T. Maruyama, 2002, Bioorganic & medicinal chemistry.

Interleukin‐33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells

H. Ishinaga, M. Toda, E. Gabazza, 2017, Cytokine.

A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues

I. Cann, M. Sugimoto, M. Toda, 2021, Cells.

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.

S. Kusuda, K. Hirai, M. Toda, 2003, Bioorganic & medicinal chemistry.

Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin.

Y. Takei, M. Toda, E. Gabazza, 2017, Atherosclerosis.

Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity.

M. Toda, T. Shiraishi, S. Ohuchida, 2001, Bioorganic & medicinal chemistry.

Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.

Takahiro Matsumoto, Y. Takei, M. Toda, 2013, American journal of respiratory cell and molecular biology.

Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis

H. Kawachi, K. Yan, K. Tryggvason, 2021, Scientific Reports.

Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein?

M. Toda, E. Gabazza, J. Akada, 2022, Gut Pathogens.

Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions

M. Toda, E. Gabazza, Tetsu Kobayashi, 2022, International journal of molecular sciences.

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.

M. Toda, H. Nakai, T. Nagase, 2004, Bioorganic & medicinal chemistry.

Modified Clemmensen Reductions of Keto Groups to Methylene Groups

M. Toda, Y. Hirata, S. Yamamura, 1972 .

6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.

M. Toda, T. Matsui, T. Kondo, 2011, Bioorganic & medicinal chemistry.

Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF₁) receptor antagonists.

M. Toda, H. Nakai, Naoya Matsumura, 2011, Bioorganic & medicinal chemistry.

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

L. W. Spruce, M. Toda, H. Nakai, 2001, Journal of medicinal chemistry.

Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

L. W. Spruce, M. Toda, H. Nakai, 2000, Journal of medicinal chemistry.

Total synthesis of (±)aplysin and (±)debromoaplysin

M. Toda, D. Uemura, Kiyoyuki Yamada, 1969 .

Further optimization of sulfonamide analogs as EP1 receptor antagonists: synthesis and evaluation of bioisosteres for the carboxylic acid group.

M. Toda, T. Matsui, S. Ohuchida, 2006, Bioorganic & medicinal chemistry.

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Identification of 2-azabicyclo[4.1.0]heptan-3-imines.

S. Kusuda, K. Hirai, M. Toda, 2003, Bioorganic & medicinal chemistry.

Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability.

S. Kusuda, K. Hirai, M. Toda, 2003, European journal of medicinal chemistry.

Design and synthesis of a selective EP4-Receptor agonist. Part 1: discovery of 3,7-DithiaPGE1 derivatives and identification of Their ω chains

M. Toda, T. Shiraishi, S. Ohuchida, 2002 .

Highly potent inhibitors of TNF-alpha production. Part I: discovery of new chemical leads and their structure-activity relationships.

H. Ohno, M. Toda, T. Matsui, 2002, Bioorganic & medicinal chemistry.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.

M. Toda, H. Nakai, Y. Tobe, 2010, Bioorganic & medicinal chemistry.

The structure of daphniphyllidine

M. Toda, H. Niwa, Y. Hirata, 1973 .

Highly potent inhibitors of TNF-alpha production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer.

H. Ohno, M. Toda, T. Matsui, 2002, Bioorganic & medicinal chemistry.

Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping

R. Mackie, I. Cann, M. Toda, 2018, Front. Microbiol..

Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-alpha production.

H. Ohno, M. Toda, T. Matsui, 2003, Bioorganic & medicinal chemistry.

Highly Potent Inhibitors of TNF-α Production. Part 1: Discovery of Chemical Leads

H. Ohno, M. Toda, T. Matsui, 2002 .

Highly potent inhibitors of TNF-α production. Part 2: Identification of drug candidates

H. Ohno, M. Toda, T. Matsui, 2002 .

Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens

M. Toda, E. Gabazza, Hirofumi Hirai, 2020, The Journal of Antibiotics.

Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.

M. Toda, H. Nakai, K. Yoshikawa, 2010, Bioorganic & medicinal chemistry letters.

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Sayuri Yamazaki, Masaaki Toda, Shimon Sakaguchi, 2001, Immunological reviews.

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

M. Toda, J. Shimizu, S. Sakaguchi, 1998, International immunology.

Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscina

M. Toda, E. Gabazza, Hirofumi Hirai, 2022, Molecules.

Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.

M. Toda, Y. Konishi, Y. Konishi, 1983, Journal of medicinal chemistry.

The structure of prostaglandin B1 dimer

T. Iwashita, M. Toda, N. Hamanaka, 1982 .

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma

M. Toda, E. Gabazza, H. Kawagishi, 2022, Cells.

Pyrido[2,3-d]pyrimidine Derivatives: Synthesis via the Intermolecular Aza-Wittig Reaction/Heterocyclization and the Crystal Structure

S. Eguchi, M. Toda, A. Kakehi,, 1998 .

Design and synthesis of new orally active inhibitors of human neutrophil elastase.

M. Toda, H. Nakai, H. Imawaka, 2001, Bioorganic & medicinal chemistry.

The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.

M. Toda, H. Nakai, Y. Katsuya, 2001, Bioorganic & medicinal chemistry.

Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer.

M. Toda, E. Gabazza, C. D'Alessandro-Gabazza, 2015, Journal of medicinal food.

Oral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice

M. Toda, E. Gabazza, C. D'Alessandro-Gabazza, 2021, Journal of inflammation research.

The Medicinal Mushroom, Grifola gargal, Ameliorates Allergic Bronchial Asthma.

M. Toda, E. Gabazza, H. Kawagishi, 2017, Journal of medicinal food.

Frequency of clonally expanded T cells evaluated by PCR from a single cell.

M. Toda, K. Nishioka, T. Matsui, 1999, Journal of immunological methods.

Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus.

Y. Takei, I. Cann, M. Toda, 2018, Metabolism: clinical and experimental.

Survival-promoting activity of IL-7 on IL-2-dependent cytotoxic T lymphocyte clones: resultant induction of G1 arrest.

T. Yoshida, M. Toda, K. Kuribayashi, 2000, Journal of immunological methods.

The synthesis of (±)-aplysin and (±)-debromoaplysin

M. Toda, Kiyoyuki Yamada, Y. Hirata, 1968 .

Renal Injury during Long-Term Crizotinib Therapy

M. Toda, E. Gabazza, Tetsu Kobayashi, 2018, International journal of molecular sciences.

De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma

Y. Takei, M. Toda, E. Gabazza, 2020, Cancers.

Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.

Masaaki Toda, Shimon Sakaguchi, Masanao Asano, 2011, Journal of immunology.

Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary ﬁ brosis

Alessandro, R. Ono, Y. Kondoh, 2022 .

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis

R. Ono, A. Tsirigos, Y. Kondoh, 2021, Nature Microbiology.

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

Y. Kondoh, R. Mackie, I. Cann, 2020, Nature Communications.

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

Y. Kondoh, R. Mackie, I. Cann, 2020, Nature Communications.

Atherosclerosis amelioration by moderate alcohol consumption is associated with increased circulating levels of stromal cell-derived factor-1.

Y. Takei, M. Toda, E. Gabazza, 2011, Circulation journal : official journal of the Japanese Circulation Society.

Protein S is protective in pulmonary fibrosis

Y. Takei, M. Toda, E. Gabazza, 2016, Journal of thrombosis and haemostasis : JTH.

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

M. Toda, T. Shiraishi, S. Ohuchida, 2002, Bioorganic & medicinal chemistry.

Discovery of new chemical leads for selective EP1 receptor antagonists.

M. Toda, S. Ohuchida, T. Maruyama, 2006, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors.

M. Toda, H. Nakai, K. Kusumi, 2004, Bioorganic & medicinal chemistry.

Highly potent PDE4 inhibitors with therapeutic potential.

M. Toda, H. Kohno, H. Nakai, 2004, Bioorganic & medicinal chemistry letters.

The structure of yuzurine

M. Toda, K. Sasaki, Y. Hirata, 1974 .

The alkaloids from the fruits of the plant Daphniphyllaceae

M. Toda, H. Niwa, Y. Hirata, 1974 .

Biosynthesis of daphniphyllum alkaloids

M. Toda, H. Niwa, S. Okuda, 1973 .

Daphnilactone-B, a major alkaloid, from the fruits of daphniphyllaceae☆

M. Toda, H. Niwa, Y. Hirata, 1972 .

Daphniphyllum alkaloids—II: Secodaphniphylline and methyl homosecodaphniphyllate

M. Toda, Y. Hirata, S. Yamamura, 1972 .

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus

M. Toda, E. Gabazza, Tetsu Kobayashi, 2021, Cells.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.

M. Toda, H. Nakai, K. Yoshikawa, 2010, Bioorganic & medicinal chemistry.

Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract.

Y. Takei, M. Toda, E. Gabazza, 2018, Biochemical and biophysical research communications.

Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

Makoto Nakamura, M. Sugimoto, M. Toda, 2021, Scientific Reports.

Activated protein C modulates the proinflammatory activity of dendritic cells

Takahiro Matsumoto, M. Toda, E. Gabazza, 2015, Journal of asthma and allergy.

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression

M. Toda, E. Gabazza, Tetsu Kobayashi, 2023, International journal of molecular sciences.

Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury

M. Toda, E. Gabazza, Tetsu Kobayashi, 2023, The American Journal of Pathology.

Modified Clemmensen Reduction: Cholestane

M. Toda, Y. Hirata, S. Yamamura, 2003 .

Degradation Products of Complex Arabinoxylans by Bacteroides intestinalis Enhance the Host Immune Response

R. Mackie, I. Cann, M. Toda, 2021, Microorganisms.

β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells

M. Toda, E. Gabazza, M. Nagao, 2017, Respiratory Research.

Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites

Y. Takikawa, M. Toda, E. Gabazza, 2023, Antibiotics.

Exogenous activated protein C inhibits the progression of diabetic nephropathy

Y. Takei, M. Toda, E. Gabazza, 2012, Journal of thrombosis and haemostasis : JTH.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

M. Toda, H. Nakai, K. Yoshikawa, 2010, Bioorganic & medicinal chemistry.

Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.

M. Toda, H. Nakai, T. Nagase, 2009, Bioorganic & medicinal chemistry.

Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group.

M. Toda, T. Kondo, H. Nakai, 2008, Bioorganic & medicinal chemistry.

Potent orally active inhibitors of angiotensin-converting enzyme (ACE).

M. Toda, T. Okegawa, A. Kawasaki, 1981, Chemical & pharmaceutical bulletin.

Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists.

M. Toda, T. Maruyama, T. Maruyama, 2011, Chemical & pharmaceutical bulletin.

Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-alpha production.

H. Ohno, M. Toda, T. Matsui, 2002, Bioorganic & medicinal chemistry.

Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.

M. Toda, T. Maruyama, T. Maruyama, 2012, Bioorganic & medicinal chemistry.

Discovery of an 8-aza-5-thiaProstaglandin E1 analog as a highly selective EP4 receptor agonist.

M. Toda, T. Maruyama, T. Maruyama, 2011, Chemical & pharmaceutical bulletin.

The Daphniphyllum Alkaloids with A New Nitrogen Heterocyclic Skeleton

M. Toda, Y. Hirata, S. Yamamura, 1977 .

A Zwitterionic Alkaloid from Daphniphyllum Teijsmanni Zollinger

M. Toda, Y. Hirata, S. Yamamura, 1976 .

CHEMICAL STUDIES ON NITROGEN HETEROCYCLIC SKELETON OF THE DAPHNIPHYLLUM ALKALOIDS

M. Toda, H. Niwa, Y. Hirata, 1974 .

Isolation and the structure of methyl homodaphniphyllate, a plausible intermediate between daphniphylline and yuzurimine

M. Toda, Y. Hirata, S. Yamamura, 1969 .

Formation of methyl homodaphniphyllate, a plausible intermediate between daphniphylline and yuzurimine, and isolation of two new alkaloids

M. Toda, Y. Hirata, S. Yamamura, 1969 .

Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist.

M. Toda, T. Shiraishi, Y. Shinagawa, 2002, Bioorganic & medicinal chemistry.

Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.

M. Toda, T. Shiraishi, Y. Shinagawa, 2001, Bioorganic & medicinal chemistry letters.

Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces

M. Toda, E. Gabazza, C. D'Alessandro-Gabazza, 2023, Mycobiology.

Intravenous Delivery of miR-21 Inhibitor in Mice With Head and Neck Squamous Cell Carcinoma

H. Ishinaga, M. Toda, E. Gabazza, 2023, AntiCancer Research.

Discovery of new orally active prostaglandin D2 receptor antagonists.

M. Toda, H. Nakai, M. Iwahashi, 2011, Bioorganic & medicinal chemistry.

Coagulation markers in COPD

P. Bakke, M. Toda, E. Gabazza, 2018, Epidemiology.

Amelioration of Diabetes by Protein S

Y. Takei, I. Cann, M. Toda, 2016, Diabetes.

Design and synthesis of an orally active matrix metalloproteinase inhibitor.

H. Ohno, M. Toda, Shingo Yamamoto, 2006, Bioorganic & medicinal chemistry.

Differential Gene Expression in Thrombomodulin (TM; CD141)+ and TM− Dendritic Cell Subsets

H. Salamon, M. Toda, E. Gabazza, 2013, PloS one.

UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses

K. Matsushima, M. Toda, M. Kurachi, 2011, International journal of cancer.

Discovery of orally active prostaglandin D2 receptor antagonists.

M. Toda, H. Nakai, T. Nagase, 2004, Bioorganic & medicinal chemistry letters.

Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.

M. Toda, T. Matsui, Shingo Yamamoto, 2006, Bioorganic & medicinal chemistry.

Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.

M. Toda, A. Konaka, T. Maruyama, 2012, Bioorganic & medicinal chemistry letters.