J. Capdevila

发表

Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.

D. Zeldin, B. Hammock, J. Kobayashi, 1993, The Journal of biological chemistry.

Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.

D. Zeldin, B. Hammock, J. Falck, 1995, Archives of biochemistry and biophysics.

Peroxisomal Proliferator-activated Receptor-α-dependent Inhibition of Endothelial Cell Proliferation and Tumorigenesis*

A. Pozzi, J. Falck, J. Capdevila, 2007, Journal of Biological Chemistry.

The Anti-tumorigenic Properties of Peroxisomal Proliferator-activated Receptor α Are Arachidonic Acid Epoxygenase-mediated*

R. Caprioli, A. Pozzi, J. Capdevila, 2010, The Journal of Biological Chemistry.

Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites.

K. Proctor, J. Falck, J. Capdevila, 1988, Circulation.

The CYP P450 arachidonate monooxygenases: enzymatic relays for the control of kidney function and blood pressure.

V. Holla, J. Capdevila, K. Nakagawa, 2003, Advances in experimental medicine and biology.

Androgens augment proximal tubule transport.

Jian-Kang Chen, Jianchun Chen, R. Harris, 2004, American journal of physiology. Renal physiology.

Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension

M. Waterman, L. Cupples, C. O’Donnell, 2005, Circulation.

Characterization of 5,6- and 8,9-Epoxyeicosatrienoic Acids (5,6- and 8,9-EET) as Potent in Vivo Angiogenic Lipids*

A. Pozzi, J. Falck, J. Capdevila, 2005, Journal of Biological Chemistry.

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

M. Waterman, V. Holla, M. Magnuson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mitogenic Activity and Signaling Mechanism of 2-(14,15- Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite

Jian-Kang Chen, Jianchun Chen, R. Harris, 2007, Molecular and Cellular Biology.

Tumor and Stem Cell Biology PPAR a ActivationCanHelpPrevent andTreatNon – SmallCell Lung Cancer

Xiwu Chen, A. Pozzi, J. Falck, 2014 .

PPARα activation can help prevent and treat non-small cell lung cancer.

Xiwu Chen, A. Pozzi, J. Falck, 2014, Cancer research.

Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension.

M. Waterman, J. Capdevila, M. Schwartzman, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.

J. Falck, N. Abraham, J. Capdevila, 2018, American journal of physiology. Regulatory, integrative and comparative physiology.

The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt*

J. Falck, Wen‐Hui Wang, R. Harris, 2013, The Journal of Biological Chemistry.

ReviewArticle PPARα Ligands as Antitumorigenic and Antiangiogenic Agents

A. Pozzi, J. Capdevila, 2008 .

Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains.

J. Capdevila, C. Helvig, 2000, Biochemistry.

Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.

J. Falck, J. Capdevila, J. H. Moltz, 1983, Biochemical and biophysical research communications.

Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs).

R. Estabrook, R. Murphy, J. Falck, 1985, Archives of biochemistry and biophysics.

Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.

R. Estabrook, J. Falck, J. Capdevila, 1985, Archives of biochemistry and biophysics.

Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid.

C. Thompson, H. Strobel, J. Capdevila, 2000, The Journal of pharmacology and experimental therapeutics.

Recombinant Cytochrome P 450 2 D 18 Metabolism of Dopamine and Arachidonic Acid 1

C. Thompson, H. Strobel, J. Capdevila, 2000 .

Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration.

S. Orrenius, J. Capdevila, B. Jernström, 1975, Cancer research.

Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites.

J. Falck, J. Capdevila, G. Snyder, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.

J. Falck, J. Capdevila, S. Wei, 1992, Biochemical and biophysical research communications.

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450.

J. Falck, J. Capdevila, S. Manna, 1986, Biochemical and biophysical research communications.

Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.

J. Falck, J. Capdevila, L. Cowart, 2001, Archives of biochemistry and biophysics.

Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells.

J. Falck, K. Malik, J. Capdevila, 2005, Life sciences.

5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells.

J. Falck, J. Capdevila, G. Snyder, 1986, Biochemical and biophysical research communications.

Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids

J. Falck, J. Capdevila, Y. Jin, 1993 .

Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase.

J. Falck, J. Capdevila, 2000, Prostaglandins & other lipid mediators.

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

J. Falck, B. Hammock, J. Falck, 2009, Journal of medicinal chemistry.

Effect of phenobarbital and naphthalene on some of the components of the electron transport system and the hydroxylating activity of house fly microsomes.

J. Capdevila, M. Agosin, A. S. Perry, 1973, Biochemistry.

Some spectral properties of cytochrome P-450 from microsomes isolated from control, phenobarbital- and naphthalene-treated houseflies.

J. Capdevila, M. Agosin, A. S. Perry, 1973, Biochimica et biophysica acta.

Arachidonic acid epoxygenase

H. Jacobson, J. Falck, J. Capdevila, 1990, FEBS letters.

The metabolism of benzo(alpha)pyrene in isolated rat liver cells.

S. Orrenius, J. Capdevila, P. Moldéus, 1975, Cancer research.

A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).

V. Kishore, J. Falck, J. Capdevila, 1987, Biochemical and biophysical research communications.

Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells*

Jian-Kang Chen, R. Harris, J. Falck, 1998, The Journal of Biological Chemistry.

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases

J. Capdevila, 2007, Current opinion in nephrology and hypertension.

The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).

J. Morrow, R. DuBois, J. Falck, 1995, Biochemistry.

The existence of a benzo(a)pyrene-3,6-quinone reductase in rat liver microsomal fractions.

R. Estabrook, J. Capdevila, R. Prough, 1978, Biochemical and biophysical research communications.

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans

A. Pozzi, D. Wasserman, J. Capdevila, 2017, Diabetologia.

Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice

S. Joshi, S. Gupte, J. Capdevila, 2016, Pulmonary circulation.

Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension

B. Hammock, J. Capdevila, C. Morisseau, 2002, Hypertension.

Microsomal cytochrome P450 and eicosanoid metabolism

J. Falck, J. Capdevila, R.C. Harris, 2002, Cellular and Molecular Life Sciences CMLS.

Microsomal cytochrome P450 and eicosanoid metabolism.

J. Falck, J. Capdevila, R. Harris, 2002, Cellular and molecular life sciences : CMLS.

Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.

J. Falck, J. Capdevila, I. Blair, 1989, The Journal of biological chemistry.

Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.

K. Proctor, J. Falck, J. Capdevila, 1987, Circulation research.

20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice

Eric F. Johnson, F. Guengerich, J. Falck, 2016, The Journal of Biological Chemistry.

Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.

J. Falck, J. Capdevila, W. Campbell, 2014, Clinical science.

Development of Epoxyeicosatrienoic Acid Analogs with in Vivo Anti-Hypertensive Actions

J. Falck, J. Capdevila, K. Nithipatikom, 2010, Front. Physio..

Synthesis of epoxyeicosatrienoic acids and heteroatom analogs.

J. Falck, J. Capdevila, P. Yadagiri, 1990, Methods in enzymology.

Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3.

J. Capdevila, C. Helvig, E. Dishman, 1998, Biochemistry.

Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.

Wen‐Hui Wang, D. Lin, D. Zeldin, 2014, American journal of physiology. Renal physiology.

Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.

H. Jacobson, J. Falck, J. Capdevila, 1994, The Journal of clinical investigation.

Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.

D. Waxman, F. Guengerich, J. Falck, 1990, The Journal of biological chemistry.

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

D. Waxman, J. Falck, J. Capdevila, 1990, The Journal of biological chemistry.

Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation*

J. Morrow, A. Pozzi, R. Breyer, 2004, Journal of Biological Chemistry.

The renal antihypertensive endocrine function: its relation to cytochrome P-450.

L. W. Byers, J. Capdevila, J. Pitcock, 1989, Journal of hypertension.

Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

J. Capdevila, A. Kanetoshi, A. Rifkind, 1994, The Journal of biological chemistry.

Integrative Physiology 20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G q ) to Affect Vascular Function and Trigger Hypertension

D. Zeldin, A. Gruzdev, J. Falck, 2017 .

The microsomal metabolism of benzo(a) pyrene phenols.

R. Estabrook, J. Capdevila, R. Prough, 1978, Biochemical and biophysical research communications.

Cytochrome P450 Epoxygenase Metabolism of Arachidonic Acid Inhibits Apoptosis

Jian-Kang Chen, R. Harris, J. Capdevila, 2001, Molecular and Cellular Biology.

of Arachidonic Acid Inhibits Apoptosis Cytochrome P 450 Epoxygenase Metabolism

Jian-Kang Chen, R. Harris, J. Capdevila, 2001 .

The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance

J. Falck, J. Capdevila, 2018, Journal of Lipid Research.

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

Yan Ding, J. Falck, J. Capdevila, 2013, Journal of the American Society of Nephrology : JASN.

Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

M. Waterman, J. Capdevila, N. Brown, 2003, Archives of biochemistry and biophysics.

Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin

J. Falck, J. Capdevila, J. Imig, 2001, Journal of Vascular Research.

Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells

H. Jacobson, J. Capdevila, R. Harris, 1990, Journal of cellular physiology.

Vasoactivity of arachidonic acid epoxides.

J. Falck, J. Capdevila, M. Schwartzman, 1987, European journal of pharmacology.

Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.

H. Jacobson, F. Guengerich, R. DuBois, 1993, The Journal of biological chemistry.

Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells

Jian-Kang Chen, R. Harris, J. Capdevila, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Epoxyeicosatrienoic Acids Activate Transglutaminases in Situ and Induce Cornification of Epidermal Keratinocytes*

J. Capdevila, R. Mernaugh, Liping Du, 2003, Journal of Biological Chemistry.

Overexpression of C-terminal Src Kinase Blocks 14,15-Epoxyeicosatrienoic Acid-induced Tyrosine Phosphorylation and Mitogenesis*

Jian-Kang Chen, J. Capdevila, R. Harris, 2000, The Journal of Biological Chemistry.

Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule.

J. Capdevila, S. Wei, M. Breyer, 1995, The American journal of physiology.

Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.

H. Jacobson, F. Guengerich, R. DuBois, 1992, The Journal of biological chemistry.

Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.

H. Jacobson, J. Falck, J. Capdevila, 1989, The Journal of clinical investigation.

NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.

J. Falck, J. Capdevila, P. Mosset, 1988, Archives of biochemistry and biophysics.

20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor

Eric F. Johnson, F. Guengerich, J. Falck, 2016 .

Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.

J. Falck, J. Capdevila, B. Pramanik, 1987, Biochimica et biophysica acta.

Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence.

S. Ojeda, J. Falck, J. Capdevila, 1983, Endocrinology.

Preparation of l-α-phosphatidyl-d-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2)

J. Falck, J. Capdevila, U. M. Krishna, 2000 .

Intracellular second messengers synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate and analogs

J. Falck, J. Capdevila, K. K. Reddy, 1997 .

Cyp2c44 Epoxygenase Is Essential for Preventing the Renal Sodium Absorption During Increasing Dietary Potassium Intake

J. Antoun, Peng Sun, Wen‐Hui Wang, 2012, Hypertension.

Kidney Cyp 2 c 44 Epoxygenase Is Essential for Preventing the Renal Sodium Absorption During Increasing Dietary Potassium Intake

J. Antoun, Peng Sun, Wen‐Hui Wang, 2012 .

Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

J. Falck, J. Capdevila, Gang Zou, 2001 .

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

J. Falck, J. Falck, J. Capdevila, 2001, Journal of hypertension.

The Role of Arachidonic Acid and Its Metabolites in the Release of Neuropeptides a

S. Ojeda, M. Junier, H. Urbanski, 1989, Annals of the New York Academy of Sciences.

CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)*

E. Schuetz, D. Donner, D. Potter, 2011, The Journal of Biological Chemistry.

Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.

J. Falck, J. Capdevila, W. Campbell, 2006, American journal of physiology. Heart and circulatory physiology.

Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin.

S. Ojeda, M. Junier, J. Falck, 1990, Endocrinology.

Chiral α,β-Dialkoxy- and α-Alkoxy-β-aminostannanes: Preparation and Copper-Mediated Cross-Coupling

J. Falck, J. Capdevila, D. Barma, 2003 .

Epoxyeicosatrienoic Acids (EETs) Regulate Epithelial Sodium Channel Activity by Extracellular Signal-regulated Kinase 1/2 (ERK1/2)-mediated Phosphorylation*

Wen‐Hui Wang, R. Harris, J. Capdevila, 2013, The Journal of Biological Chemistry.

Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.

J. Falck, J. Capdevila, W. Campbell, 2006, Analytical biochemistry.

Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.

H. Jacobson, K. Badr, J. Falck, 1991, The American journal of physiology.

Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses.

H. Jacobson, K. Badr, J. Falck, 1990, The American journal of physiology.

Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.

J. Falck, J. Capdevila, R. Harris, 2000, Journal of lipid research.

7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement.

A. Brash, J. Capdevila, I. Blair, 1995, Archives of biochemistry and biophysics.

5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis.

H. Jacobson, J. Falck, J. Capdevila, 1995, The American journal of physiology.

Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450.

J. Capdevila, M. Orellana, L. Gil, 1989, Archives of biochemistry and biophysics.

Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

H. Jacobson, J. Falck, J. Capdevila, 1987, Journal of lipid research.

Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver.

J. Falck, J. Capdevila, B. Pramanik, 1984, Archives of biochemistry and biophysics.

Effects of epoxyicosatrienoic acids on ion transport in the rabbit cortical collecting tubule

H. Jacobson, J. Falck, J. Capdevila, 1984 .

Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid.

J. Falck, J. Capdevila, N. Chacos, 1982, Biochemical and biophysical research communications.

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

L. Marnett, R. Estabrook, J. Capdevila, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes.

J. Falck, J. Capdevila, I. Blair, 1992, Biochimica et biophysica acta.

Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary.

J. Falck, J. Capdevila, G. Snyder, 1985, Endocrinology.

Role of Cyp-epoxygenase in regulating renal membrane transport and hypertension

J. Capdevila, Wenhui Wang, 2014 .

Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension

Wen‐Hui Wang, J. Capdevila, 2013, Current opinion in nephrology and hypertension.

A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs)

J. Falck, J. Capdevila, V. R. Gopal, 2004 .

Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

H. Jacobson, J. Falck, J. Capdevila, 1988, The American journal of the medical sciences.

Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions

J. Falck, J. Capdevila, G.D. Snijder, 1984, FEBS letters.

Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.

D. Zeldin, J. Kobayashi, J. Falck, 1992, Analytical biochemistry.

Metabolism of benzo[a]pyrene‐3,6‐quinone by isolated hepatocytes

S. Orrenius, J. Capdevila, Sten Orrenius, 1980, FEBS letters.

Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues

J. Falck, J. Capdevila, K. Chauhan, 1994 .

Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

J. Falck, J. Capdevila, P. Yadagiri, 1989 .

Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids.

J. Falck, J. Capdevila, E. Dishman, 1991, Methods in enzymology.

Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.

J. Falck, J. Capdevila, I. Blair, 1989, Analytical biochemistry.

Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid

J. Falck, J. Capdevila, P. Mosset, 1986 .

Total synthesis of the cytochrome P-450 epoxygenase metabolites 5(R),6(S)-, 5(S),6(R)-, and 14(R),15(S)-epoxyeicosatrienoic acid (EET) and hydration products 5(R),6(R)- and 14(R),15(R)-dihydroxyeicosatrienoic acid (DHET)

J. Falck, J. Capdevila, Christine A. Moustakis, 1985 .

Effects of newly reported arachidonic acid metabolites on microsomal Ca++ binding, uptake and release.

J. Falck, J. Capdevila, G. Weiss, 1983, Prostaglandins.

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

Yan Ding, J. Falck, J. Capdevila, 2013, American journal of physiology. Renal physiology.

Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice

J. Capdevila, R. Quigley, J. Imig, 2009, Nephron Physiology.

Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450

H. Jacobson, R. Estabrook, J. Falck, 1984 .

Insulin second messengers : synthesis of 6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-chiro-inositol-1-phosphate

J. Falck, J. Capdevila, K. K. Reddy, 1993 .

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity.

J. Falck, J. Capdevila, L. Reddy, 2003, Bioorganic & medicinal chemistry letters.

Arachidonate epoxygenase: inhibitors and metabolite analogues

J. Falck, J. Capdevila, S. Manna, 1985 .

Differentiating Keratinocytes Express a Novel Cytochrome P450 Enzyme, CYP2B19, Having Arachidonate Monooxygenase Activity*

M. Waterman, J. Travers, J. Capdevila, 1998, The Journal of Biological Chemistry.

Cytochrome P450 and the arachidonate cascade 1

R. Estabrook, J. Falck, J. Capdevila, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Palladium mediated allylic mitsunobu displacement: stereocontrolled synthesis of hepoxilin A3 and trioxilin A3 methyl esters

J. Falck, J. Capdevila, A. Karara, 1992 .

Chiral cyclopropanes: Asymmetric synthesis of constanolactones A and B

J. Falck, J. Capdevila, N. Balu, 2002 .

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Elizabeth A Ambrose, E. Petricoin, Dafydd G. Thomas, 2017, Cell chemical biology.

Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks.

J. Falck, J. Capdevila, Bhavani Sangras, 2007, Bioorganic & medicinal chemistry.

Eicosanoid biosynthesis : Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

J. Falck, J. Capdevila, K. Reddy, 1997 .

THE METABOLISM OF POLYCYCLIC HYDROCARBONS AND ITS RELATIONSHIP TO CHEMICAL CARCINOGENESIS

S. Orrenius, J. Capdevila, J. Depierre, 1976 .

Concise syntheses of L-α-phosphatidyl-D-myo-inositol 3-phosphate (3- PIP), 5-phosphate (5-PIP), and 3,5-bisphosphate (3,5-PIP2)

J. Falck, J. Falck, J. Capdevila, 2000 .

Hepoxilins B3: Synthesis of all four stereoisomers and a glutathione adduct

J. Falck, J. Capdevila, Y. Belosludtsev, 1994 .

Chiral α,β‐Dialkoxy‐ and α‐Alkoxy‐β‐aminostannanes: Preparation and Copper‐Mediated Cross‐Coupling.

J. Falck, J. Capdevila, D. Barma, 2004 .

Synthesis of 14(R),15(S)- and 14(s),15(S)-dihydroxy-5,8-z-10,12-E - eicosatetraenoic acid

J. Falck, J. Capdevila, J. Buynak, 1983 .

DDT-dehydrochlorinase IV.—Further evidence on the lipoprotein nature of the enzyme

R. Maccioni, J. Capdevila, A. Ramírez, 1975 .

Cytochrome P-450 arachidonate oxygenase.

J. Falck, J. Capdevila, E. Dishman, 1990, Methods in enzymology.

The mechanistic plurality of cytochrome P-450 and its biological ramifications.

J. Falck, J. Capdevila, Y. Saeki, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.

R. Miller, D. Zeldin, J. Kobayashi, 1995, The Journal of clinical investigation.

Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450

D. Zeldin, J. Falck, J. Capdevila, 1996 .

Human cytochromes P450

P. Beaune, M. Waterman, R. Estabrook, 1999 .

Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.

J. Capdevila, M. Agosin, C. Náquira, 1976, Science.

Hemoproteins in Trypanosoma cruzi with emphasis on microsomal pigments

J. Capdevila, M. Agosin, C. Náquira, 1976 .

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.

L. Marnett, J. Falck, J. Capdevila, 1988, Archives of biochemistry and biophysics.

Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain.

J. Capdevila, M. Agosin, A. S. Perry, 1974, Chemico-biological interactions.

The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.

A. Pozzi, J. Capdevila, Shouzou Wei, 2009, Archives of biochemistry and biophysics.

CHIRAL ACETALS : STEREOCONTROLLED SYNTHESES OF 16-,17-, AND 18-HYDROXYEICOSATETRAENOIC ACIDS, CYTOCHROME P-450 ARACHIDONATE METABOLITES

J. Falck, J. Capdevila, C. Mioskowski, 1996 .

Transformation of 15-hete to 14,15-dihydroxyeicosatrienoic acid and 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acid

J. Falck, J. Capdevila, J. Buynak, 1983 .

Enantiospecific synthesis of methyl 11,12- and 14,15-epoxyeicosatrienoate

J. Falck, J. Capdevila, S. Manna, 1984 .

Synthesis of arachidonic acid metabolites produced by purified kidney cortex microsomal cytochrome P-450

J. Falck, J. Capdevila, S. Manna, 1983 .

Chiral Acetals: Stereocontrolled Syntheses of 16‐, 17‐, and 18‐ Hydroxyeicosatetraenoic Acids, Cytochrome P‐450 Arachidonate Metabolites.

J. Falck, J. Capdevila, C. Mioskowski, 2010 .

The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase.

R. Estabrook, B. Hammock, J. Falck, 1983, Archives of biochemistry and biophysics.

Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.

J. Falck, J. Capdevila, 2002, Prostaglandins & other lipid mediators.

A Synthesis of L‐α‐Phosphatidyl‐D‐myo‐inositol 4,5‐Bisphosphate (4,5‐PIP2) and Glyceryl Lipid Analogues.

J. Falck, J. Capdevila, U. M. Krishna, 2000 .

A synthesis of l-α-phosphatidyl-d-myo-inositol 4,5-bisphosphate (4,5-PIP2) and glyceryl lipid analogs

J. Falck, J. Capdevila, U. M. Krishna, 1999 .

Dimethylthiocarbamate (DMTC): an alcohol protecting group.

J. Falck, J. Capdevila, D. Barma, 2003, Organic letters.

PPARα Ligands as Antitumorigenic and Antiangiogenic Agents

A. Pozzi, J. Capdevila, 2008, PPAR research.

Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.

R. Harris, J. Capdevila, Shouzuo D. Wei, 2013, American journal of physiology. Renal physiology.

Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids

V. Holla, J. Falck, J. Capdevila, 2005 .

Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin.

J. Capdevila, R. Mernaugh, Liping Du, 2005, Archives of biochemistry and biophysics.

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

R. DuBois, D. Zeldin, J. Falck, 1995, Archives of biochemistry and biophysics.

Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids

J. Falck, D. Zeldin, J. Capdevila, 1995 .

15 – The Role of Cytochrome P-450 and the Microsomal Electron Transport System: The Oxidative Metabolism of Benzo[a]pyrene

R. Estabrook, J. Capdevila, R. Prough, 1978 .

The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.

V. Holla, J. Capdevila, P. Zaphiropoulos, 1999, The Journal of clinical investigation.

Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system

J. Falck, J. Capdevila, J R Falck, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.

Wen‐Hui Wang, J. Falck, J. Capdevila, 2015, Prostaglandins & other lipid mediators.

Cytochrome P-450-linked activation of 3-hydroxybenzo(a)pyrene

S. Orrenius, J. Capdevila, B. Jernström, 1975 .

20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension

J. Falck, D. Zeldin, A. Gruzdev, 2017, Circulation research.

The oxidative metabolism of arachidonic acid by purified cytochromes P-450.

R. Estabrook, B. Masters, J. Capdevila, 1981, Biochemical and biophysical research communications.

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

M. Waterman, A. Pozzi, V. Holla, 2006, The Journal of clinical investigation.

The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands*

Eric F. Johnson, J. Falck, J. Capdevila, 2002, The Journal of Biological Chemistry.

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

A. Pozzi, S. Hayward, J. Falck, 2015, Journal of the American Society of Nephrology : JASN.

Association of a CYP4A11 variant and blood pressure in black men.

M. Waterman, J. Capdevila, N. Brown, 2008, Journal of the American Society of Nephrology.

The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3*

J. Falck, J. Capdevila, S. Wei, 1996, The Journal of Biological Chemistry.

Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors*

Jian-Kang Chen, Jianchun Chen, R. Harris, 2008, Journal of Biological Chemistry.

The metabolic activation of benzo(a)pyrene and 9‐hydroxybenzo (a) pyrene by liver microsomal fractions

R. Lubet, J. Capdevila, Russell A. Prouoh, 1979, International journal of cancer.

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

J. Falck, J. Capdevila, W. Campbell, 2014, Journal of medicinal chemistry.

An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase*

J. Falck, J. Capdevila, S. Wei, 1997, The Journal of Biological Chemistry.

Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid.

K. Proctor, F. Fitzpatrick, J. Falck, 1989, Blood vessels.

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

J. Falck, J. Capdevila, J. Imig, 2007, Kidney international.

Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid.

J. Falck, J. Capdevila, V. R. Tuniki, 2006, Journal of labelled compounds & radiopharmaceuticals.

Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites

J. Falck, J. Capdevila, C. Mioskowski, 1992 .

Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids.

D. Zeldin, J. Capdevila, R. Rosenberg, 1999, Molecular pharmacology.

The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.

J. Falck, J. Capdevila, J. Falck, 2001, Biochemical and biophysical research communications.

Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.

J. Falck, J. Capdevila, E. Dishman, 1991, The Journal of biological chemistry.

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

R. Estabrook, J. Capdevila, R. Prough, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Solubilization and partial purification of cytochrome P-450 from rat lung microsomes.

S. Orrenius, J. Capdevila, S. Jakobsson, 1975, Biochemical and biophysical research communications.

Transfection of an Active Cytochrome P450 Arachidonic Acid Epoxygenase Indicates That 14,15-Epoxyeicosatrienoic Acid Functions as an Intracellular Second Messenger in Response to Epidermal Growth Factor*

Jian-Kang Chen, R. Harris, J. Falck, 1999, The Journal of Biological Chemistry.

The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension

M. Waterman, J. Capdevila, N. Brown, 2008, Hypertension.

Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.

S. Joshi, S. Gupte, J. Capdevila, 2017, American journal of physiology. Heart and circulatory physiology.

Cyp 2 c 44 gene disruption is associated with increased hematopoietic stem cells : implication in chronic hypoxia-induced pulmonary hypertension

S. Joshi, S. Gupte, J. Capdevila, 2017 .

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.

Scott M. Williams, A. Pozzi, F. Guengerich, 2018, Cancer research.

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.

Yan Ding, J. Falck, J. Capdevila, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450.

R. Estabrook, J. Capdevila, R. Prough, 1980, Archives of biochemistry and biophysics.

Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration.

H. Jacobson, K. Badr, J. Capdevila, 1993, Journal of the American Society of Nephrology : JASN.

Hydrogen peroxide-supported oxidation of benzo [a]pyrene by rat liver microsomal fractions.

R. Renneberg, R. Estabrook, J. Capdevila, 1981, Biochemical pharmacology.

Polycyclic hydrocarbon metabolism: a plethora of phenomena.

R. Estabrook, J. Capdevila, R. Prough, 1980, Advances in enzyme regulation.

Erratum: Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome P450 arachidonate metabolite (Molecular and Cellular Biology (2007) 27, 8, (3023-3034))

Jian-Kang Chen, Jianchun Chen, R. Harris, 2007 .

The metabolism of benzo[a]pyrene phenols by rat liver microsomal fractions.

J. Capdevila, R. Prough, Y. Saeki, 1981, Archives of biochemistry and biophysics.

MULTIPLE FORMS OF HOUSEFLY CYTOCHROME P-450

J. Capdevila, M. Agosin, 1977 .

Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

R. Murphy, J. Falck, J. Capdevila, 2001 .

Biochemical Considerations of the Enzymology Associated with Quinone and Tetrol Formation During Benzo(A)Pyrene Metabolism

R. Estabrook, J. Capdevila, R. Prough, 1980 .

20‐SOLA, a Novel Water Soluble 20‐HETE Antagonist, Reduces Blood Pressure Through Regulation of Vascular ACE Expression via an IKK Dependent Pathway

J. Falck, J. Capdevila, M. Schwartzman, 2015 .

produced by a cytochrome P450 monooxygenase Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites

K. Proctor, J. Falck, J. Capdevila, 2011 .

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

J. Falck, J. Capdevila, W. Campbell, 2014, Journal of Medicinal Chemistry.

Thematic Review Series: Living History of Lipids The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance

J. Falck, J. Capdevila, 2018, Journal of Lipid Research.

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

B. Hammock, J. Capdevila, W. Campbell, 2009, Journal of medicinal chemistry.