J. O'flaherty

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5-Oxo-eicosanoids and Hematopoietic Cytokines Cooperate in Stimulating Neutrophil Function and the Mitogen-activated Protein Kinase Pathway*

J. O'flaherty, M. Kuroki, A. Nixon, 1996, The Journal of Biological Chemistry.

In Vivo and in Vitro Regulation of Syndecan 1 in Prostate Cells by n-3 Polyunsaturated Fatty Acids*

J. Cline, J. O'flaherty, L. Rudel, 2008, Journal of Biological Chemistry.

Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.

J. O'flaherty, Haiguo Sun, I. Berquin, 2009, Neoplasia.

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.

J. O'flaherty, M. Kuroki, J. O’Flaherty, 1999, The Biochemical journal.

Omega-3 fatty acids and cancer risk.

J. Tooze, J. O'flaherty, L. Daniel, 2006, JAMA.

Fatty Acid Metabolites in Rapidly Proliferating Breast Cancer

S. Akman, L. Case, J. O'flaherty, 2013, PloS one.

Differential Effects of Delivery of Omega-3 Fatty Acids to Human Cancer Cells by Low-Density Lipoproteins versus Albumin

J. O'flaherty, R. Wykle, L. Daniel, 2004, Clinical Cancer Research.

15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells.

J. O'flaherty, Haiguo Sun, I. Edwards, 2013, Carcinogenesis.

ω-3 PUFAs: Interventional Trials for the Prevention and Treatment of Breast and Prostate Cancer

J. O'flaherty, I. Berquin, Yong Q. Chen, 2010 .

Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B4

J. O'flaherty, J. Redman, D. Jacobson, 1990, Journal of cellular physiology.

Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer.

Zhennan Gu, J. O'flaherty, Haiguo Sun, 2010, Neoplasia.

Protein kinase C blockers and neutrophil receptors for leukotriene B4.

J. O'flaherty, D. Jacobson, J. O’Flaherty, 1989, Biochemical and biophysical research communications.

Neutrophil aggregation and swelling induced by chemotactic agents.

P. Ward, J. O'flaherty, D. Kreutzer, 1977, Journal of immunology.

Protein Kinases C Translocation Responses to Low Concentrations of Arachidonic Acid*

Brad A. Chadwell, J. O'flaherty, L. Daniel, 2001, The Journal of Biological Chemistry.

15-Lipoxygenase Metabolites of Docosahexaenoic Acid Inhibit Prostate Cancer Cell Proliferation and Survival

J. O'flaherty, D. Horita, Haiguo Sun, 2012, PloS one.

Stimulus-dependent mobilization of protein kinase C.

L. Mcphail, J. O'flaherty, J. Nishihira, 1986, Biochemical and biophysical research communications.

Neutrophil degranulation responses to combinations of arachidonate metabolites and platelet-activating factor.

J. O'flaherty, R. Wykle, C. McCall, 1984, Research communications in chemical pathology and pharmacology.

Chemical and biological characterization of oxo-eicosatetraenoic acids.

J. O'flaherty, M. Thomas, S. L. Lee, 1994, Biochimica et biophysica acta.

Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist‐induced activation and retardation of apoptosis

C. Haslett, C. Ward, E. Chilvers, 2003, British journal of pharmacology.

Neutrophil degranulation: Evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet‐activating factor, and 5‐HETE

J. O'flaherty, J. O’Flaherty, 1985, Journal of cellular physiology.

5-Lipoxygenase Products Modulate the Activity of the 85-kDa Phospholipase A2 in Human Neutrophils (*)

J. O'flaherty, A. Nixon, J. Wijkander, 1995, The Journal of Biological Chemistry.

Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms.

J. O'flaherty, A. Rossi, J. Redman, 1990, The Journal of biological chemistry.

Stereospecific bioactions of 5‐hydroxyicosatetraenoate

J. O'flaherty, M. Thomas, A. Rossi, 1988, FEBS Letters.

The Coupling of 5-Oxo-Eicosanoid Receptors to Heterotrimeric G Proteins1

J. O'flaherty, M. Kuroki, Jennifer S. Taylor, 2000, The Journal of Immunology.

5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor.

J. O'flaherty, R. Wykle, C. McCall, 1983, Biochemical and biophysical research communications.

Roles of Ca2+ in human neutrophil responses to receptor agonists.

J. O'flaherty, A. Rossi, J. Redman, 1991, The Biochemical journal.

Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.

J. O'flaherty, R. Wykle, C. McCall, 1981, The American journal of pathology.

Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate.

J. O'flaherty, D. Jacobson, J. Redman, 1988, Journal of immunology.

5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism.

Brad A. Chadwell, S. Cramer, J. O'flaherty, 2002, Cancer research.

Receptors for the 5-Oxo Class of Eicosanoids in Neutrophils*

J. O'flaherty, Michael J. Thomas, Jennifer S. Taylor, 1998, The Journal of Biological Chemistry.

5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus.

J. O'flaherty, M. Thomas, J. Cordes, 1993, Biochemical and biophysical research communications.

5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism.

J. O'flaherty, A. Rossi, J. O’Flaherty, 1993, The Journal of biological chemistry.

Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3.

A. Mantovani, S. Bernasconi, S. Sozzani, 1996, Journal of immunology.

Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils.

J. O'flaherty, A. Nixon, J. Wijkander, 1996, Advances in experimental medicine and biology.

Effects of quercetin on magnesium-dependent adenosine triphosphatase and the metabolism of human polymorphonuclear leukocytes.

J. O'flaherty, C. McCall, D. Bass, 1981, Blood.

Interactions of arachidonate metabolism and protein kinase C in mediating neutrophil function.

J. Schmitt, J. O'flaherty, R. Wykle, 1985, Biochemical and biophysical research communications.

Phospholipid metabolism and stimulus-response coupling.

J. O'flaherty, J. O’Flaherty, Joseph T. O'Flaherty, 1987, Biochemical pharmacology.

Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors.

J. O'flaherty, M. Kuroki, J. O’Flaherty, 1997, Biochemical and biophysical research communications.

Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family.

J. O'flaherty, R. Wykle, D. Greene, 1994, Biochimica et biophysica acta.

Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids.

C. Piantadosi, J. O'flaherty, R. Wykle, 1987, Biochimica et biophysica acta.

1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187.

J. O'flaherty, R. Wykle, F. Chilton, 1983, Biochemical and biophysical research communications.

Chemotactic factors and the neutrophil.

P. Ward, J. O'flaherty, J. O’Flaherty, 1979, Seminars in hematology.

1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.

J. O'flaherty, R. Wykle, C. McCall, 1981, The American journal of pathology.

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

J. O'flaherty, R. Wykle, F. Chilton, 1982, The Journal of biological chemistry.

Binding and metabolism of platelet-activating factor by human neutrophils.

C. Piantadosi, J. O'flaherty, R. Wykle, 1986, The Journal of clinical investigation.

Biology and biochemistry of platelet-activating factor

J. O'flaherty, R. Wykle, J. O’Flaherty, 1983, Clinical reviews in allergy.

Bidirectional effects of protein kinase C activators. Studies with human neutrophils and platelet-activating factor.

J. O'flaherty, J. Redman, D. Jacobson, 1989, The Journal of biological chemistry.

Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate‐like mechanism

J. O'flaherty, R. Wykle, C. McCall, 1985, Journal of cellular physiology.

Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites.

J. O'flaherty, R. Wykle, T. Tessner, 1989, The Journal of biological chemistry.

The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils.

J. O'flaherty, R. Wykle, H. W. Mueller, 1984, The Journal of biological chemistry.

Platelet-activating factor effects on pulmonary ultrastructure in rabbits.

M. Bond, J. O'flaherty, R. Wykle, 1983, Experimental and molecular pathology.

Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative.

J. O'flaherty, R. Wykle, M. Thomas, 1986, Journal of immunology.

Effect of 15-lipoxygenase-derived arachidonate metabolites on human neutrophil degranulation.

J. O'flaherty, M. Thomas, J. O’Flaherty, 1985, Prostaglandins, leukotrienes, and medicine.

A possible role of arachidonic acid in human neutrophil aggregation and degranulation.

P. Ward, J. O'flaherty, H. Showell, 1979, The American journal of pathology.

5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.

J. O'flaherty, M. Kuroki, A. Nixon, 1996, Journal of immunology.

The Targeting of Leukocytes by 5-Oxo-Eicosanoids

S. Sozzani, J. O'flaherty, M. Kuroki, 1996 .

Neutrophil aggregation and degranulation. Effect of arachidonic acid.

P. Ward, J. O'flaherty, H. Showell, 1979, The American journal of pathology.

Stimulation of hexose uptake by human eosinophils with chemotactic factors.

E. Goetzl, J. O'flaherty, C. McCall, 1981, The Journal of infectious diseases.

Anaphylactic actions of platelet-activating factor.

J. O'flaherty, R. Wykle, C. McCall, 1981, The American journal of pathology.

Platelet activating factor (1‐O‐alkyl‐2‐O‐acetyl‐sn‐glycero‐3‐phosphocholine)

C. Piantadosi, J. O'flaherty, R. Wykle, 1982, FEBS letters.

Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils.

C. Piantadosi, J. Schmitt, J. Smith, 1981, Biochemical and biophysical research communications.

1-0-alkyl-2-N-methylcarbamyl-glycerophosphocholine: A biologically potent, non-metabolizable analog of platelet-activating factor

C. Piantadosi, J. Schmitt, J. O'flaherty, 1987 .

Platelet-Activating Factor: Mechanisms of Cellular Activation

J. O'flaherty, J. O’Flaherty, 1987 .

Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues.

J. O'flaherty, N. Stimler, J. O’Flaherty, 1983, The American journal of pathology.

Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.

J. O'flaherty, R. Wykle, F. Chilton, 1983, The Journal of biological chemistry.

[4] Platelet-activating factor

J. O'flaherty, R. Wykle, Michael J. Thomas, 1988 .

1-0-A lkyl-sn-glyceyl-3-phosphoycholines A Novel Class of Neutrophil Stimulants

J. O'flaherty, R. Wykle, C. McCall, 2007 .

Binding and metabolism of leukotriene B4 by neutrophils and their subcellular organelles

J. O'flaherty, J. Nishihira, S. Kosfeld, 1986, Journal of cellular physiology.

Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils.

J. O'flaherty, W. Salzer, C. McCall, 1982, The Journal of clinical investigation.

Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids.

J. O'flaherty, C. McCall, M. Thomas, 1981, The American journal of pathology.

Receptor‐independent metabolism of platelet‐activating factor by myelogenous cells

J. O'flaherty, R. Wykle, M. Chabot, 1989, FEBS letters.

Prostaglandin binding sites in human polymorphonuclear neutrophils.

J. O'flaherty, A. Rossi, J. O’Flaherty, 1989, Prostaglandins.

Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol.

J. O'flaherty, R. Wykle, R. Lumb, 1988, Biochimica et biophysica acta.

Tritiated hexadecyl platelet activating factor (PAF)

S. Wyrick, J. O'flaherty, R. Wykle, 1985 .

Phorbol myristate acetate receptors in human polymorphonuclear neutrophils.

J. O'flaherty, J. Nishihira, J. O’Flaherty, 1985, Journal of immunology.

Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain.

C. Piantadosi, F. Snyder, J. O'flaherty, 1985, Journal of medicinal chemistry.

Metabolic fate of platelet-activating factor in neutrophils.

J. O'flaherty, R. Wykle, F. Chilton, 1983, The Journal of biological chemistry.

Biosynthesis of platelet activating factor in rabbit polymorphonuclear neutrophils.

J. O'flaherty, R. Wykle, H. W. Mueller, 1983, The Journal of biological chemistry.

Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.

J. O'flaherty, R. Wykle, C. McCall, 1981, Journal of Immunology.

Role of Extracellular Calium in Neutrophil Degranu lation Responses to 1-0-a 1 kyl-2-- acetyl-sn-glycero-3-phosphocholine

J. O'flaherty, C. McCall, C. L. Swendsen, 2007 .

Neutrophil responses to platelet-activating factor

C. Miller, J. O'flaherty, R. Wykle, 1981, Inflammation.

Phorbol myristate acetate: in vivo effects upon neutrophils, platelets, and lung.

J. O'flaherty, C. McCall, D. Bass, 1980, The American journal of pathology.

Acetyl-CoA:1-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine Acetyltransferase Is Directly Activated by p38 Kinase*

J. O'flaherty, A. Nixon, R. Wykle, 1999, The Journal of Biological Chemistry.

ANIMAL MODEL OF HUMAN DISEASE

J. O'flaherty, C. McCall, R. Taylor, 2007 .

Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation.

J. O'flaherty, R. Wykle, C. McCall, 1981, Biochemical and biophysical research communications.

Platelet-activating factor.

J. O'flaherty, R. Wykle, M. Thomas, 1988, Methods in enzymology.

Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets.

C. Piantadosi, J. O'flaherty, R. Wykle, 1983, Research communications in chemical pathology and pharmacology.

Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

J. O'flaherty, C. McCall, C. Lees, 1981, The American journal of pathology.

Desensitization of the human neutrophil degranulation response: studies with 5,12-dihydroxy-6,8,10,14- eicosatetraenoic acid.

J. O'flaherty, R. Wykle, C. McCall, 1981, Biochemical and biophysical research communications.

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

J. O'flaherty, R. Wykle, H. W. Mueller, 1982, Lipids.

Role of arachidonic acid in stimulation of hexose transport by human polymorphonuclear leukocytes.

J. O'flaherty, C. McCall, D. Bass, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Role of arachidonic acid derivatives in neutrophil aggregation: a hypothesis.

P. Ward, J. O'flaherty, H. Showell, 1979, Prostaglandins.

Desensitization of the neutrophil aggregation response to chemotactic factors.

P. Ward, J. O'flaherty, D. Kreutzer, 1978, The American journal of pathology.

Chemotactic factor influences on the aggregation, swelling, and foreign surface adhesiveness of human leukocytes.

P. Ward, J. O'flaherty, D. Kreutzer, 1978, The American journal of pathology.

Influence of extracellular Ca2+ and Mg2+ on chemotactic factor-induced neutrophil aggregation

P. Ward, J. O'flaherty, H. Showell, 1977, Inflammation.

Influence of inhibitors of cellular function on chemotactic factor-induced neutrophil aggregation.

P. Ward, J. O'flaherty, D. Kreutzer, 1977, Journal of immunology.

Protein kinase C regulates leukotriene B4 receptors in human neutrophils

J. O'flaherty, J. Redman, D. Jacobson, 1986, FEBS letters.

Tumor necrosis factor-alpha regulates expression of receptors for formyl-methionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils.

J. O'flaherty, A. Rossi, J. Redman, 1991, Journal of immunology.

Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins.

C. Leslie, M. Willingham, J. O'flaherty, 2008, Biochimica et biophysica acta.

The effect of free radical derived hydroxyeicosatetraenoic acids on hexose transport in the human polymorphonuclear leukocyte.

J. O'flaherty, C. McCall, M. Thomas, 1982, Prostaglandins.

Neutropenia induced by systemic infusion of chemotactic factors.

P. Ward, J. O'flaherty, H. Showell, 1977, Journal of immunology.

Leukocyte aggregation induced by chemotactic factors

P. Ward, J. O'flaherty, J. O’Flaherty, 1978, Inflammation.

The influence of chemotactic factors on neutrophil adhesiveness

P. Ward, J. O'flaherty, D. Kreutzer, 1978, Inflammation.

Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils.

J. O'flaherty, J. Nishihira, J. O’Flaherty, 1987, Journal of immunology.

Pulmonary injury induced by phorbol myristate acetate following intravenous administration in rabbits. Acute respiratory distress followed by pulmonary interstitial pneumonitis and pulmonary fibrosis.

J. O'flaherty, C. McCall, R. Taylor, 1983, The American journal of pathology.

Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors.

P. Ward, J. O'flaherty, D. Kreutzer, 1978, Immunopharmacology.

Effect of prostaglandins E1, E2 and F2alpha on neutrophil aggregation.

P. Ward, J. O'flaherty, D. Kreutzer, 1979, Prostaglandins.