I. Vachier

发表

Lipoxins are potential endogenous antiinflammatory mediators in asthma.

J. Bousquet, P. Chanez, C. Bonnans, 2002, American journal of respiratory and critical care medicine.

Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound.

J. Bousquet, P. Chanez, C. Bonnans, 2005, The Journal of allergy and clinical immunology.

External Validity of Randomized Controlled Trials in Severe Asthma.

P. Chanez, I. Vachier, N. Molinari, 2015, American journal of respiratory and critical care medicine.

Impact of Rhinitis on Asthma Control in Children: Association With FeNO

P. Chanez, I. Vachier, P. Godard, 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

Leptin and leptin receptor expression in asthma.

P. Chanez, G. Chiappara, M. Profita, 2009, The Journal of allergy and clinical immunology.

Interference of psychological factors in difficult-to-control asthma.

P. Chanez, I. Vachier, P. Godard, 2007, Respiratory medicine.

Mise au pointAsthme difficileDifficult asthma

I. Vachier, P. Godard, A. Bourdin, 2006 .

Adherence in severe asthma

I. Vachier, P. Godard, A. Bourdin, 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Imaging reactive oxygen species in asthma.

P. Chanez, J. Nicolas, I. Vachier, 1994, Journal of bioluminescence and chemiluminescence.

Rising total costs and mortality rates associated with admissions due to COPD exacerbations

N. Roche, P. Chanez, I. Vachier, 2016, Respiratory Research.

Nonlinear weight and chronic obstructive pulmonary disease effect modeling to improve data fitting.

I. Vachier, N. Molinari, A. Bourdin, 2014, American journal of respiratory and critical care medicine.

Bimodal action of fatty acids on PMA-stimulated O2.- production in human adherent monocytes.

I. Vachier, C. Léger, B. Descomps, 1995, Journal of lipid mediators and cell signalling.

5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors

J. Bousquet, P. Chanez, I. Vachier, 1996, The Journal of experimental medicine.

Glucocorticoid receptor-binding characteristics in severe asthma

J. Bousquet, P. Chanez, C. Bonnans, 2003, European Respiratory Journal.

Epithelial ciliated beating cells essential for ex vivo ALI culture growth

P. Chanez, I. Vachier, N. Molinari, 2017, BMC Pulmonary Medicine.

Transbronchial cryobiopsy in the diagnosis of interstitial lung diseases: methodologies and perspectives from the Cryo-PID and COLDICE studies

I. Vachier, N. Molinari, A. Bourdin, 2020, Annals of translational medicine.

Poor Concordance between Sequential Transbronchial Lung Cryobiopsy and Surgical Lung Biopsy in the Diagnosis of Diffuse Interstitial Lung Diseases.

S. Nava, R. Trisolini, A. Cancellieri, 2019, American journal of respiratory and critical care medicine.

Exhaled breath condensate for lung cancer protein analysis : a review of methods and biomarkers

P. Chanez, I. Vachier, N. Molinari, 2016 .

Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate

P. Chanez, I. Vachier, N. Molinari, 2016, Journal of breath research.

High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma.

J. Bousquet, S. Dahlén, P. Chanez, 2003, Respiratory medicine.

Software-assisted Computed Tomography Quantification of Airway Remodeling in the Normal Aging Process.

I. Vachier, N. Molinari, A. Bourdin, 2017, American journal of respiratory and critical care medicine.

Club Cell Loss as a Feature of Bronchiolization in ILD

I. Vachier, A. Bourdin, S. Bommart, 2021, Frontiers in Immunology.

Careful consideration of the bleeding caused by transbronchial lung cryobiopsies

S. Nava, I. Vachier, N. Molinari, 2020, European Respiratory Journal.

Reply to Wand et al.: Role of Transbronchial Cryobiopsy in Interstitial Lung Diseases: An Ongoing Tale

T. Colby, I. Vachier, N. Molinari, 2020, American journal of respiratory and critical care medicine.

LAM is another small airway disease: lessons from microCT

I. Vachier, B. Crestani, A. Bourdin, 2020, European Respiratory Journal.

Glucocorticoid receptors in bronchial epithelial cells in asthma.

J. Bousquet, P. Chanez, G. Chiappara, 1998, American journal of respiratory and critical care medicine.

Modulation of cadherin and catenins expression by tumor necrosis factor-alpha and dexamethasone in human bronchial epithelial cells.

J. Bousquet, P. Chanez, I. Vachier, 2002, American journal of respiratory cell and molecular biology.

Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor.

P. Chanez, C. Bonnans, I. Vachier, 2009, American journal of physiology. Lung cellular and molecular physiology.

Regulation of CXCR/IL-8 in Human Airway Epithelial Cells

P. Chanez, I. Vachier, P. Godard, 2009, International Archives of Allergy and Immunology.

Endogenous anti-inflammatory mediators from arachidonate in human neutrophils.

J. Bousquet, P. Chanez, C. Bonnans, 2002, Biochemical and biophysical research communications.

Upper airway · 1: Allergic rhinitis and asthma: united disease through epithelial cells

P. Chanez, I. Vachier, D. Gras, 2009, Thorax.

Airway wall structural remodeling from endobronchial biopsies: what does it really mean?

P. Chanez, I. Vachier, P. Godard, 2009, The Journal of allergy and clinical immunology.

Airway lipoxin A4/formyl peptide receptor 2-lipoxin receptor levels in pediatric patients with severe asthma.

P. Chanez, R. Gagliardo, M. Profita, 2016, The Journal of allergy and clinical immunology.

Randomised controlled trials in severe asthma: selection by phenotype or stereotype

P. Chanez, I. Vachier, N. Molinari, 2019, European Respiratory Journal.

Eosinophilic inflammation in sputum of poorly controlled asthmatics

J. Bousquet, P. Chanez, I. Vachier, 2002, European Respiratory Journal.

Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients.

J. Bousquet, P. Chanez, I. Vachier, 1998, The European respiratory journal.

Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells.

P. Chanez, C. Bonnans, I. Vachier, 2007, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Effects of glucocorticoids on endogenous and transcellular metabolism of eicosanoids in asthma.

J. Bousquet, P. Chanez, I. Vachier, 2001, The Journal of allergy and clinical immunology.

15-lipoxygenase: a Janus enzyme?

P. Chanez, C. Bonnans, I. Vachier, 2002, American journal of respiratory cell and molecular biology.

An ex vivo model of severe asthma using reconstituted human bronchial epithelium.

P. Chanez, C. Bonnans, I. Vachier, 2012, The Journal of allergy and clinical immunology.

Generation of eicosanoids from 15(S)-hydroxyeicosatetraenoic acid in blood monocytes from steroid-dependent asthmatic patients.

J. Bousquet, P. Chanez, I. Vachier, 1998, Biochemical pharmacology.

Lipoxins and other arachidonate derived mediators in bronchial asthma

J. Bousquet, P. Chanez, I. Vachier, 2000, Thorax.

5-15-diHETE and lipoxins generated by neutrophils from endogenous arachidonic acid as asthma biomarkers.

J. Bousquet, P. Chanez, I. Vachier, 1995, Biochemical and biophysical research communications.

Human bronchial epithelium orchestrates dendritic cell activation in severe asthma

P. Chanez, I. Vachier, D. Gras, 2017, European Respiratory Journal.

Induced Pluripotent Stem Cells for Primary Ciliary Dyskinesia Modeling and Personalized Medicine

J. de Vos, J. Mianné, I. Vachier, 2018, American journal of respiratory cell and molecular biology.

Rheology predicts sputum eosinophilia in patients with muco-obstructive lung diseases.

É. Matzner-Lober, J. Vialaret, I. Vachier, 2022, Biochemical and biophysical research communications.

Safety and cellular assessment of bronchial brushing in airway diseases.

J. Bousquet, P. Chanez, A. Vignola, 1999, Respiratory medicine.

Goblet cell hyperplasia as a feature of neutrophilic asthma

P. Chanez, I. Vachier, D. Gras, 2019, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[Airway remodeling in asthma: clinical and functional correlates].

P. Chanez, I. Vachier, D. Gras, 2011, Medecine sciences : M/S.

Inflammatory features of nasal mucosa in smokers with and without COPD

J. Bousquet, P. Chanez, G. Chiappara, 2004, Thorax.

Effectiveness of bacteriophages in the sputum of cystic fibrosis patients.

I. Vachier, N. Molinari, I. Sermet, 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Asthma, COPD, and overlap in a national cohort: ACO on a gradient.

É. Matzner-Lober, P. Chanez, I. Vachier, 2018, The Journal of allergy and clinical immunology.

Enhancement o of rreactive o oxygen s species fformation iin s stable a and unstable a asthmatic p patients

P. Chanez, I. Vachier, P. Godard, 1994 .

[Aberrant expression of HLA-DR antigens of the MHC class II in bronchial epithelial cells in asthmatic patients].

I. Vachier, P. Godard, B. Descomps, 1990, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients.

P. Chanez, I. Vachier, P. Godard, 1994, The European respiratory journal.

Differentiation of Human Induced Pluripotent Stem Cells from Patients with Severe COPD into Functional Airway Epithelium

J. de Vos, J. Mianné, I. Vachier, 2022, Cells.

Increased oxygen species generation in blood monocytes of asthmatic patients.

P. Chanez, I. Vachier, P. Godard, 1992, The American review of respiratory disease.

Disease activated drugs: a new concept for the treatment of asthma.

K. Buchheit, B. Charpiot, R. Naef, 2001, Bioorganic & medicinal chemistry.

Glucocorticoids induced down‐regulation of glucocorticoid receptor mRNA expression in asthma

P. Chanez, J. Nicolas, I. Vachier, 1996, Clinical and experimental immunology.

Expression of the high-affinity receptor for IgE on bronchial epithelial cells of asthmatics.

J. Bousquet, P. Chanez, A. Vignola, 1998, American journal of respiratory cell and molecular biology.

IgE produces monocyte superoxide anion release: correlation with CD23 expression. Comparison of patients with asthma, patients with rhinitis, and normal subjects.

P. Demoly, I. Vachier, P. Godard, 1994, The Journal of allergy and clinical immunology.

Sputum eosinophilia in Churg-Strauss syndrome.

J. Bousquet, P. Chanez, I. Vachier, 2001, Respiratory medicine.

Reply to: Altered Calcium in Ciliary Dysfunction: Potential Role of ER Stress and Ciliophagy.

P. Chanez, I. Vachier, D. Gras, 2019, American journal of respiratory cell and molecular biology.

THE ROLE OF GLUCOCORTICOIDS IN THE MODULATION OF EICOSANOID METABOLISM IN ASTHMA

J. Bousquet, P. Chanez, I. Vachier, 1998 .

Generation of four severe early-onset chronic obstructive pulmonary disease (COPD) patient-derived induced pluripotent stem cell lines from peripheral blood mononuclear cells.

J. de Vos, J. Mianné, I. Vachier, 2021, Stem cell research.

Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD).

I. Vachier, A. Bourdin, A. Fort, 2022, Pharmacology & therapeutics.

Using intracellular SCGB1A1-sorted, formalin-fixed club cells for successful transcriptomic analysis.

V. Pantesco, P. Chanez, I. Vachier, 2022, Biochemical and biophysical research communications.

Cellular protein kinase C activity in asthma.

P. Chanez, I. Vachier, P. Godard, 1997, American journal of respiratory and critical care medicine.

Severe asthma in adults: what are the important questions?

W. Busse, L. Boulet, K. Rabe, 2007, The Journal of allergy and clinical immunology.

Online supplement methods and figures Human bronchial epithelium orchestrates dendritic cell activation in severe asthma. D.Gras

I. Vachier, D. Gras, J. Vitte, 2017 .

Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma

J. Bousquet, P. Demoly, P. Chanez, 2000 .

Prognostic value of cluster analysis of severe asthma phenotypes.

P. Chanez, I. Vachier, N. Molinari, 2014, The Journal of allergy and clinical immunology.

The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?

Nikolay A. Pavlov, Steven J. Smith, C. Janson, 2022, ERJ Open Research.

Comparison of anti‐interleukin‐5 therapies in patients with severe asthma: global and indirect meta‐analyses of randomized placebo‐controlled trials

I. Vachier, N. Molinari, A. Bourdin, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Generation of the induced pluripotent stem cell line UHOMi001-A from a patient with mutations in CCDC40 gene causing Primary Ciliary Dyskinesia (PCD).

J. de Vos, J. Mianné, I. Vachier, 2018, Stem cell research.

Specificity of basement membrane thickening in severe asthma.

P. Chanez, I. Vachier, P. Godard, 2007, The Journal of allergy and clinical immunology.

Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients.

P. Chanez, I. Vachier, N. Molinari, 2017, The Journal of allergy and clinical immunology.

Resolution of inflammation in asthma.

B. Levy, C. Serhan, I. Vachier, 2012, Clinics in chest medicine.

Methods of Sputum and Mucus Assessment for Muco-Obstructive Lung Diseases in 2022: Time to “Unplug” from Our Daily Routine!

I. Vachier, A. Bourdin, J. Charriot, 2022, Cells.

Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease

J. de Vos, C. Jorgensen, I. Vachier, 2021, Cells.

Lung development, regeneration and plasticity: From disease physiopathology to drug design using induced pluripotent stem cells

P. Chanez, J. de Vos, I. Vachier, 2017, Pharmacology & therapeutics.

DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

D. Caimmi, S. Leroy, L. Guillot, 2017, Clinical Epigenetics.

LIFE BEYOND LIFE – An Easy Way to Derive Lung Fibroblasts from Cadavers

I. Vachier, A. Bourdin, E. Baccino, 2017, Journal of forensic sciences.

Bronchial epithelium as a target for innovative treatments in asthma.

P. Chanez, I. Vachier, D. Gras, 2013, Pharmacology & therapeutics.

Regulation of E-cadherin expression by dexamethasone and tumour necrosis factor-α in nasal epithelium

J. Bousquet, P. Chanez, I. Vachier, 2002, European Respiratory Journal.

The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma

D. Postma, R. Pauwels, P. Howarth, 2003, European Respiratory Journal.

Future treatment for asthma

I. Vachier, A. Bourdin, L. Halimi, 2016, European Respiratory Review.

Differentiation of human induced pluripotent stem cells into functional airway epithelium

J. de Vos, J. Mianné, I. Vachier, 2020, bioRxiv.

Rhinosinusitis in severe asthma.

J. Bousquet, P. Chanez, I. Vachier, 2001, The Journal of allergy and clinical immunology.

I. Vachier, N. Molinari, A. Bourdin, 2021, ERJ Open Research.

Impact of psychological factors on the health-related quality of life of patients treated for pulmonary arterial hypertension.

I. Vachier, N. Molinari, A. Bourdin, 2018, Journal of psychosomatic research.

Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?

P. Chanez, I. Vachier, N. Molinari, 2020, BMC Medical Ethics.

Relationship between CT air trapping criteria and lung function in small airway impairment quantification

P. Chanez, I. Vachier, N. Molinari, 2014, BMC Pulmonary Medicine.

Asthma: treatment and prevention of pulmonary exacerbations

P. Chanez, I. Vachier, A. Bourdin, 2017 .

Supplementing defect in club cell secretory protein attenuates airway inflammation in COPD.

P. Chanez, I. Vachier, N. Molinari, 2015, Chest.

Distal Airway Impairment in Obese Normoreactive Women

P. Chanez, I. Vachier, N. Molinari, 2013, BioMed research international.

Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease.

J. Bousquet, P. Chanez, A. Vignola, 2004, Proceedings of the American Thoracic Society.

Bronchial Epithelial Calcium Metabolism Impairment in Smokers and COPD: Decreased ORAI3 Signaling.

P. Chanez, I. Vachier, D. Gras, 2019, American journal of respiratory cell and molecular biology.

Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma.

J. Bousquet, P. Demoly, P. Chanez, 2000, American journal of respiratory and critical care medicine.

CCSP G38A polymorphism environment interactions regulate CCSP levels differentially in COPD.

I. Vachier, N. Molinari, J. Varilh, 2016, American journal of physiology. Lung cellular and molecular physiology.

Obesity in women with asthma: Baseline disadvantage plus greater small‐airway responsiveness

I. Vachier, A. Bourdin, S. Bommart, 2022, Allergy.

Masitinib, a c‐kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid‐dependent asthmatics

A Magnan, I Vachier, M. Humbert, 2009, Allergy.

Human airway ex vivo models: new tools to study the airway epithelial cell response to SARS-CoV-2 infection

J. de Vos, I. Vachier, D. Muriaux, 2023, bioRxiv.

CCSP counterbalances airway epithelial-driven neutrophilic chemotaxis

P. Chanez, I. Vachier, N. Molinari, 2019, European Respiratory Journal.

Is generalization of exhaled CO assessment in primary care helpful for early diagnosis of COPD?

I. Vachier, N. Molinari, A. Bourdin, 2015, BMC Pulmonary Medicine.

Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory

P. Chanez, I. Vachier, D. Gras, 2023, European journal of immunology.

Complication and lung function impairment prediction using perfusion and computed tomography air trapping (CLIPPCAIR): protocol for the development and validation of a novel multivariable model for the prediction of post-resection lung function

I. Vachier, N. Molinari, A. Bourdin, 2021, Annals of translational medicine.

Mortality: a neglected outcome in OCS-treated severe asthma

P. Chanez, I. Vachier, N. Molinari, 2017, European Respiratory Journal.

Targeted therapy in eosinophilic chronic obstructive pulmonary disease

J. de Vos, I. Vachier, S. Assou, 2021, ERJ Open Research.

DNA Methylation at ATP11A cg11702988 Is a Biomarker of Lung Disease Severity in Cystic Fibrosis: A Longitudinal Study

D. Caimmi, M. Claustres, S. Taviaux, 2021, Genes.

Persistent severe hypereosinophilic asthma is not associated with airway remodeling.

P. Chanez, I. Vachier, N. Molinari, 2015, Respiratory medicine.

Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma.

Isabelle Vachier, J. Bousquet, P. Chanez, 2003, American journal of respiratory and critical care medicine.

Limited short-term steroid responsiveness is associated with thickening of bronchial basement membrane in severe asthma.

P. Chanez, I. Vachier, P. Godard, 2012, Chest.

Mucus from human bronchial epithelial cultures: rheology and adhesion across length scales

I. Vachier, C. Blanc, L. Casanellas, 2022, Interface Focus.

Mucus Microrheology Measured on Human Bronchial Epithelium Culture

I. Vachier, C. Blanc, L. Casanellas, 2019, Front. Phys..

Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?

P. Chanez, I. Vachier, N. Molinari, 2020, BMC medical ethics.

Non-Invasive Assessment of Small Airway Remodelling in Smokers

T. Kotsimbos, P. Chanez, I. Vachier, 2010, COPD.

k-Nearest Neighbor Curves in Imaging Data Classification

Nicolas Molinari, Yann Cabon, Isabelle Vachier, 2019, Front. Appl. Math. Stat..

Standard patient training versus Vik-Asthme chatbot-guided training: ‘AsthmaTrain’ – a protocol for a randomised controlled trial for patients with asthma

I. Vachier, N. Molinari, A. Bourdin, 2023, BMJ Open.

The HDAC inhibitor SAHA does not rescue CFTR membrane expression in Cystic Fibrosis.

M. Claustres, I. Vachier, N. Molinari, 2017, The international journal of biochemistry & cell biology.

Will the asthma revolution fostered by biologics also benefit adult ICU patients?

P. Chanez, I. Vachier, D. Gras, 2020, Allergy.

Mild asthma in overweight women: A new phenotype?

P. Sterk, P. Chanez, I. Vachier, 2010, Respiratory medicine.

Rhinovirus‐associated pulmonary exacerbations show a lack of FEV 1 improvement in children with cystic fibrosis

D. Caimmi, I. Vachier, N. Molinari, 2016, Influenza and other respiratory viruses.

The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2

J. de Vos, I. Vachier, D. Muriaux, 2023, International journal of molecular sciences.

Sputum-Rheology-Based Strategy for Guiding Azithromycin Prescription in COPD Patients with Frequent Exacerbations: A Randomized, Controlled Study (“COPD CARhE”)

I. Vachier, M. Zysman, N. Molinari, 2023, Biomedicines.

Hospitalizations for COPD Exacerbations: Trends and Determinants of Death

N. Roche, P. Chanez, I. Vachier, 2015, COPD.

Role of comorbid conditions in asthma hospitalizations in the south of France

P. Chanez, I. Vachier, P. Aubas, 2013, Allergy.

Upper airway · 1: Allergic rhinitis and asthma: united disease through epithelial cells

P. Chanez, I. Vachier, D. Gras, 2009, Thorax.