Yongfeng Jiang

发表

Cutting Edge: Interleukin 4-Dependent Mast Cell Proliferation Requires Autocrine/Intracrine Cysteinyl Leukotriene-Induced Signaling1

Yongfeng Jiang, Y. Kanaoka, Chunli Feng, 2006, The Journal of Immunology.

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor

S. Paruchuri, W. Xing, Yongfeng Jiang, 2009, The Journal of experimental medicine.

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

S. Milstein, K. G. Rajeev, M. Manoharan, 2015, Nature Medicine.

Leukotriene E 4 – induced pulmonary inflammation is mediated by the P 2 Y 12 receptor

S. Paruchuri, W. Xing, Yongfeng Jiang, 2009 .

Leukotriene E4 Activates Peroxisome Proliferator-activated Receptor γ and Induces Prostaglandin D2 Generation by Human Mast Cells*

J. Plutzky, S. Paruchuri, Yongfeng Jiang, 2008, Journal of Biological Chemistry.

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

S. Milstein, M. Manoharan, S. Chong, 2022, Nature Biotechnology.

cysteinyl leukotriene-dependent mitogenic responses of mast cells CysLT2 receptors interact with CysLT1 receptors and down-modulate

B. Bacskai, Yongfeng Jiang, Y. Kanaoka, 2013 .

Protein Kinase C (PKC) Phosphorylation of the Ca2+ o -sensing Receptor (CaR) Modulates Functional Interaction of G Proteins with the CaR Cytoplasmic Tail*

S. Quinn, Yongfeng Jiang, O. Kifor, 2002, The Journal of Biological Chemistry.

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

A. Akinc, Yongfeng Jiang, June Qin, 2014, Molecular therapy. Nucleic acids.

From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization

S. Milstein, M. Manoharan, P. Haslett, 2022, Nucleic acids research.

Receptors Interact with CysLT 1 Receptors and Down-Modulate Cysteinyl Leukotriene-Dependent Mitogenic Responses of Mast Cells

B. Bacskai, Yongfeng Jiang, Y. Kanaoka, 2007 .

Leukotriene-Induced Signaling Autocrine / Intracrine Cysteinyl Cell Proliferation Requires Cutting Edge : Interleukin 4-Dependent

Yongfeng Jiang, Y. Kanaoka, Chunli Feng, 2006 .

Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects

M. Manoharan, M. Egli, K. Charissé, 2022, Journal of the American Chemical Society.

Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates

S. Milstein, M. Manoharan, S. Chong, 2021 .

Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates

K. G. Rajeev, M. Manoharan, A. Akinc, 2019, Nucleic acids research.

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs

M. Manoharan, M. Egli, Yongfeng Jiang, 2021, Nucleic acids research.

P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells1

B. Bacskai, Yongfeng Jiang, Y. Kanaoka, 2009, The Journal of Immunology.

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.

B. Bacskai, Yongfeng Jiang, Y. Kanaoka, 2007, Blood.

Association of Peripheral Blood Levels of Cytokines With Autism Spectrum Disorder: A Meta-Analysis

Yongfeng Jiang, Junwei Gao, Hongqi Zhang, 2021, Frontiers in Psychiatry.

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease

M. Manoharan, P. Herdewijn, M. Egli, 2020, Nucleic acids research.

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

K. G. Rajeev, M. Manoharan, Huilei Xu, 2018, Nature Communications.

Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity.

Yongfeng Jiang, Maja M. Janas, S. Kuchimanchi, 2017, Nucleic acid therapeutics.

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

K. G. Rajeev, M. Manoharan, Huilei Xu, 2018, Nature Communications.

Leukotriene E 4 Activates Peroxisome Proliferator-activated Receptor and Induces Prostaglandin D 2 Generation by

J. Plutzky, S. Paruchuri, Yongfeng Jiang, 2008 .

Exposure to siRNA-GalNAc Conjugates in Systems of the Standard Test Battery for Genotoxicity.

Yongfeng Jiang, Maja M. Janas, Pia V Kasperkovitz, 2016, Nucleic acid therapeutics.

l-Phenylalanine and NPS R-467 Synergistically Potentiate the Function of the Extracellular Calcium-sensing Receptor through Distinct Sites*

S. Quinn, Yongfeng Jiang, E. Nemeth, 2002, The Journal of Biological Chemistry.

Modulation of Interprotomer Relationships Is Important for Activation of Dimeric Calcium-sensing Receptor*

P. Silver, Yongfeng Jiang, E. Minet, 2004, Journal of Biological Chemistry.

Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

K. G. Rajeev, M. Manoharan, M. Egli, 2023, Journal of the American Chemical Society.