Jada Lewis

发表

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

J. Hardy, D. Dickson, M. Hutton, 2001, Science.

Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles

Joshua M. Shulman, J. Shulman, M. Feany, 2001, Science.

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, 2000, Nature Genetics.

Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's Disease: linkage of poorer cognitive performance to tau pathology in forebrain

M. Hutton, R. Leighty, Jada Lewis, 2004, Brain Research.

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

J. Trojanowski, V. Lee, Ming-Rong Zhang, 2013, Neuron.

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

K. Ashe, G. Carlson, M. Hutton, 2005, The Journal of Neuroscience.

Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy

K. Ashe, M. Hutton, Z. Wszolek, 2007, The Journal of Neuroscience.

Naruhiko Sahara, Wen-Lang Lin, Dennis W. Dickson, 2014, Neurobiology of Aging.

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy.

D. Dickson, Jada Lewis, R. de Silva, 2009, The American journal of pathology.

In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures

M. Febo, Jada Lewis, N. Sahara, 2013, Molecular Neurodegeneration.

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

D. Borchelt, B. Giasson, Jada Lewis, 2018, Molecular neurodegeneration.

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

L. Petrucelli, D. Dickson, Jada Lewis, 2011, Molecular Neurodegeneration.

Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice.

D. Dickson, M. Hutton, Jada Lewis, 2003, The American journal of pathology.

ACCELERATED FILAMENT FORMATION FROM TAU PROTEIN WITH SPECIFIC FTDP-17 MISSENSE MUTATIONS

M. Hutton, J. Hackett, Jada Lewis, 1999 .

Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice.

P. Bickford, D. Diamond, M. Hutton, 2008, Journal of Alzheimer's disease : JAD.

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.

M. Staufenbiel, M. Hutton, M. Meyer-Luehmann, 2007, The American journal of pathology.

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

D. Dickson, M. King, M. Hutton, 2004, The American journal of pathology.

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

D. Borchelt, M. Swanson, Jada Lewis, 2018, Scientific Reports.

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

D. Borchelt, B. Giasson, Jada Lewis, 2018, Acta Neuropathologica.

Animal Models of Tauopathies

M. Hutton, Jada Lewis, 2005 .

CHAPTER I3 – Rodent Models of Tauopathies

Jada Lewis, E. McGowan, 2005 .

TRANSGENIC MICE EXPRESSING WILD-TYPE TAU TRANSGENES

M. Hutton, Jada Lewis, 2004 .

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.

D. Dickson, R. Tamargo, D. Krainc, 2013, Human molecular genetics.

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

L. Petrucelli, D. Dickson, M. Hutton, 2010, The Journal of Neuroscience.

Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility

D. Dickson, M. Hutton, Jada Lewis, 2002, Journal of neurochemistry.

Physiologically relevant factors influence tau phosphorylation by leucine‐rich repeat kinase 2

G. Shaw, B. Giasson, Jada Lewis, 2015, Journal of neuroscience research.

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

John Hardy, Dennis W. Dickson, Andrew Grover, 2004 .

Progranulin regulates neuronal outgrowth independent of Sortilin

L. Petrucelli, C. Link, J. Gass, 2012, Molecular Neurodegeneration.

Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions

M. Hutton, Jada Lewis, S. Yen, 2000, Brain Research.

Genomic Analysis of Stress Response against Arsenic in Caenorhabditis elegans

I. Patel, Jada Lewis, S. Bozdag, 2013, PloS one.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging

L. Petrucelli, D. Dickson, M. Nishihara, 2010, Alzheimer's & Dementia.

Generation of a new transgenic mouse model for assessment of tau gene silencing therapies

D. Borchelt, Jada Lewis, S. Fromholt, 2016, Alzheimer's Research & Therapy.

Genomic Analysis of Immune Response against Vibrio cholerae Hemolysin in Caenorhabditis elegans

J. E. Leclerc, I. Patel, Jada Lewis, 2012, PloS one.

Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis

Jada Lewis, M. Altshuler, Simon D’Alton, 2015, RNA.

Heterogeneity of Matrin 3 in the developing and aging murine central nervous system

D. Borchelt, Jada Lewis, Abigail R Hernandez, 2016, The Journal of comparative neurology.

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

D. Borchelt, Jada Lewis, Zoe B Siemienski, 2018, Acta Neuropathologica Communications.

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2017, Acta Neuropathologica Communications.

Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta Neuropathologica Communications.

Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (ADNP) in the Face of Tau Mutation

Jada Lewis, Y. Ophir, I. Gozes, 2014, PloS one.

Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice

D. Dickson, M. Hutton, Jada Lewis, 2006, Neuroscience Letters.

Tau Protein Is Cross-Linked by Transglutaminase in P301L Tau Transgenic Mice

M. Hutton, Jada Lewis, S. Frausto, 2005, The Journal of Neuroscience.

Tauopathy Mouse Models

B. Giasson, Jada Lewis, N. Sahara, 2015 .

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

D. Borchelt, Jada Lewis, C. Janus, 2015, PloS one.

Understanding the role of progranulin in Alzheimer's disease

Jada Lewis, Simon D’Alton, 2014, Nature Medicine.

Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage.

Katherine R. Smith, D. Dickson, S. Berkovic, 2012, American journal of human genetics.

TAPPing into the potential of inducible tau/APP transgenic mice

D. Borchelt, Jada Lewis, Guilian M. Xu, 2022, Neuropathology and applied neurobiology.

Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

M. Staufenbiel, M. Hutton, M. Meyer-Luehmann, 2007 .

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Dennis W. Dickson, D. Dickson, Jada Lewis, 2015, Acta Neuropathologica.

Rapid Genotyping of Mice with Hemoglobinopathies and Globin Transgenes

E. Rubin, W. Shehee, Jada Lewis, 1998, Biochemical Genetics.

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.

W. Noble, Jada Lewis, Vicki Olm, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tau promotes neurodegeneration through global chromatin relaxation

M. Hemberg, M. Feany, Jada Lewis, 2014, Nature Neuroscience.

Progranulin regulates neuronal outgrowth independent of Sortilin

L. Petrucelli, C. Link, J. Gass, 2012, Molecular Neurodegeneration.

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy

L. Petrucelli, D. Borchelt, D. Dickson, 2013, Acta Neuropathologica.

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Wen-Lang Lin, John Hardy, Peter Davies, 2000, Nature Genetics.

P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation

L. Petrucelli, M. Hutton, T. Dawson, 2004, Neurobiology of Aging.

The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms

Cory C. Funk, Hunter S. Futch, A. Levey, 2019, Molecular Neurodegeneration.

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

D. Borchelt, Jada Lewis, S. Fromholt, 2018, Acta neuropathologica communications.

Thinking laterally about neurodegenerative proteinopathies.

D. Borchelt, T. Golde, B. Giasson, 2013, The Journal of clinical investigation.

Therapeutic and diagnostic challenges for frontotemporal dementia

Jada Lewis, Simon D’Alton, 2014, Front. Aging Neurosci..

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions

D. Borchelt, T. Golde, P. Cruz, 2013, Brain Research.

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

L. Petrucelli, D. Dickson, C. Shaw, 2014, Nature Communications.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

L. Petrucelli, D. Dickson, M. Hutton, 2010, The American journal of pathology.

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

P. Davies, T. Golde, P. Cruz, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

M. Farrer, D. Dickson, B. Giasson, 2013, Acta Neuropathologica.

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

J. Rothstein, J. Troncoso, S. Subramony, 2013, Proceedings of the National Academy of Sciences.

Targeting Aβ and tau in Alzheimer's disease, an early interim report

Todd E. Golde, Leonard Petrucelli, L. Petrucelli, 2010, Experimental Neurology.

Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain.

D. Dickson, C. Volbracht, Jada Lewis, 2012, Journal of Alzheimer's disease : JAD.

Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy

A. Peters, J. Luebke, A. Rocher, 2011, Acta Neuropathologica.

Aging Is Not Associated with Proteasome Impairment in UPS Reporter Mice

L. Petrucelli, J. Gass, Jada Lewis, 2009, PloS one.

Nicotine Effect on Prepulse Inhibition and Prepulse Facilitation in Schizophrenia Patients

L. Hong, G. Thaker, Jada Lewis, 2008, Neuropsychopharmacology.

Transgenic Animal Models of Proteinopathies

Jada Lewis, N. Sahara, H. Melrose, 2011 .

Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy

D. Borchelt, T. Golde, P. Cruz, 2020, Molecular Neurobiology.

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.

N. Plesnila, D. Dickson, M. Hutton, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission

T. Golde, Paramita Chakrabarty, B. Giasson, 2015, Acta Neuropathologica.

Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study

Alan Peters, Jennifer I. Luebke, A. Peters, 2011, Brain Structure and Function.

Amyloid precursor protein and tau transgenic models of Alzheimer's disease: insights from the past and directions for the future.

Jada Lewis, N. Sahara, 2010, Future neurology.

Biologic models of neurodegenerative disorders.

Jada Lewis, C. Zehr, J. Eriksen, 2008, Handbook of clinical neurology.

Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.

Hunter S. Futch, D. Borchelt, T. Golde, 2021, Free neuropathology.

IFN‐γ promotes τ phosphorylation without affecting mature tangles

T. Golde, P. Cruz, Paramita Chakrabarty, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IFN- g promotes t phosphorylation without affecting mature tangles

T. Golde, P. Cruz, Paramita Chakrabarty, 2015 .

Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

D. Dickson, Jada Lewis, N. Sahara, 2014, Molecular Neurodegeneration.

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking

L. Kaczmarek, T. Golde, K. Wirdefeldt, 2017, PloS one.

Proteostasis and Secondary Proteinopathy in Alzheimer's Disease

D. Borchelt, L. Notterpek, Jada Lewis, 2014 .

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

M. Hutton, J. Hackett, Jada Lewis, 1999, FEBS letters.

Phosphorylated p38MAPK specific antibodies cross‐react with sarkosyl‐insoluble hyperphosphorylated tau proteins

Naruhiko Sahara, Irving E. Vega, Michael Hutton, 2004, Journal of neurochemistry.

Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.

D. Dickson, M. Hutton, Jada Lewis, 2003, The American journal of pathology.

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions

T. Golde, P. Cruz, B. Giasson, 2021, Acta Neuropathologica.

A novel calcium‐binding protein is associated with tau proteins in tauopathy

Irving E. Vega, D. Dickson, M. Hutton, 2008, Journal of neurochemistry.

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau

D. Dickson, M. Hutton, Jada Lewis, 2003, Journal of neurocytology.

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

T. Golde, P. Cruz, B. Giasson, 2013, Molecular Neurodegeneration.

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

T. Golde, P. Cruz, B. Giasson, 2013, Molecular Neurodegeneration.

Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling

L. Petrucelli, D. Dickson, Jada Lewis, 2014, PloS one.

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

Phillip B. Jones, B. Hyman, K. Ashe, 2008, The Journal of Neuroscience.

Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

D. Dickson, M. Hutton, Jada Lewis, 2004, Neurobiology of Disease.

Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis

B. Giasson, Jada Lewis, J. Howard, 2018, Molecular and Cellular Neuroscience.

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

L. Petrucelli, D. Dickson, Jada Lewis, 2012, Acta Neuropathologica.

Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta neuropathologica communications.

In vivo silencing of alpha-synuclein using naked siRNA

M. Farrer, S. Lincoln, D. Maraganore, 2008, Molecular neurodegeneration.

Effect of soluble interleukin‐10 receptor expression in mouse models of Alzheimer’s disease

Kristen R. Ibanez, Paramita Chakrabarty, Jada Lewis, 2020 .

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)

V. Pankratz, R. Petersen, S. Lincoln, 2013, PloS one.

Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy

D. Borchelt, T. Golde, P. Cruz, 2020, Molecular Neurobiology.

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics

M. Feany, Jada Lewis, Rachel M. Bailey, 2018, PLoS biology.

Designing antibodies against LRRK2-targeted tau epitopes

T. Golde, Y. Levites, B. Giasson, 2018, PloS one.

Sorting Out Frontotemporal Dementia?

T. Golde, Jada Lewis, 2010, Neuron.

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta neuropathologica communications.

Anti-Tau Antibodies: Hitting the Target

Nikolaus R. McFarland, T. Golde, Jada Lewis, 2013, Neuron.

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

D. Borchelt, B. Giasson, Jada Lewis, 2018, Molecular neurodegeneration.

In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures

M. Febo, Jada Lewis, N. Sahara, 2013, Molecular Neurodegeneration.

Generation of a new transgenic mouse model for assessment of tau gene silencing therapies

D. Borchelt, Jada Lewis, S. Fromholt, 2016, Alzheimer's Research & Therapy.

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

B. Hyman, K. Ashe, M. Kuskowski, 2005, Science.

The molecular genetics of the tauopathies

M. Hutton, Jada Lewis, M. Slegtenhorst, 2000, Experimental Gerontology.

Analysis of tauopathies with transgenic mice.

D. Dickson, M. Hutton, Jada Lewis, 2001, Trends in molecular medicine.

Pharmacokinetics of delta-9-tetrahydrocannabinol following acute cannabis smoke exposure in mice; effects of sex, age, and strain

B. Setlow, J. Bizon, Jada Lewis, 2023, Frontiers in pharmacology.

Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau

D. Dickson, M. Hutton, Jada Lewis, 2005, Journal of neurocytology.

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

D. Borchelt, T. Golde, Paramita Chakrabarty, 2020, Acta Neuropathologica Communications.

Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

J. Luebke, A. Rocher, Jada Lewis, 2010, Experimental Neurology.

Molecular Genetics and Transgenic Modeling of the Tauopathies

M. Hutton, M. Baker, Jada Lewis, 2002 .