C. Glabe

发表

A specific amyloid-beta protein assembly in the brain impairs memory.

Michela Gallagher, M. Gallagher, K. Ashe, 2006, Nature.

Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid

Hans-Ulrich Demuth, Klaus Reymann, Brian J. Wiltgen, 2012, Nature.

The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein.

C. Glabe, N. Kamei, 2003, Genes & development.

A specific amyloid-β protein assembly in the brain impairs memory

M. Gallagher, K. Ashe, S. Lesné, 2006, Nature.

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

C. Glabe, E. Head, Jennifer L. Tomic, 2009, Neurobiology of Disease.

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

C. Glabe, 2006, Neurobiology of Aging.

Structural differences between amyloid beta oligomers.

V. Uversky, L. Breydo, I. Lednev, 2016, Biochemical and biophysical research communications.

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

C. Alberini, N. Relkin, Akinobu Suzuki, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Carl W. Cotman, Elizabeth Head, C. Cotman, 2003, Science.

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

G. Petsko, J. Buxbaum, D. Ringe, 2013, Molecular Psychiatry.

Structural Classification of Toxic Amyloid Oligomers*

C. Glabe, Charles G Glabe, 2008, Journal of Biological Chemistry.

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

C. Glabe, I. Bernstein, E. Funai, 2014, Science Translational Medicine.

Atomic View of a Toxic Amyloid Small Oligomer

David Eisenberg, Meytal Landau, Duilio Cascio, 2012, Science.

Chemical synthesis of biologically active tat trans-activating protein of human immunodeficiency virus type 1

H. Fan, C. Glabe, R. Chun, 1990, Journal of virology.

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo*

Fusheng Yang, G. Cole, S. Frautschy, 2005, Journal of Biological Chemistry.

Structure/function analysis of the sea urchin sperm adhesive protein bindin.

C. Glabe, A. Lopez, S. Miraglia, 1993, Developmental biology.

γ-Secretase Cleavage Is Distinct from Endoplasmic Reticulum Degradation of the Transmembrane Domain of the Amyloid Precursor Protein*

C. Glabe, W. L. Bunnell, H. V. Pham, 1998, The Journal of Biological Chemistry.

P1-172 Annular protofibrils, formation, stability and toxicity: new insights into the pore-like mechanism for amyloid toxicity

R. Kayed, C. Glabe, 2004, Neurobiology of Aging.

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

Carl W. Cotman, C. Cotman, C. Pike, 1991, Brain Research.

Toxicity of Pyroglutaminated Amyloid β‐Peptides 3(pE)‐40 and ‐42 Is Similar to That of Aβ1‐40 and ‐42

J. Geddes, C. Glabe, T. L. Tekirian, 1999 .

β-Amyloid protein promotes neuritic branching in hippocampal cultures

C. Cotman, C. Glabe, J. Whitson, 1990, Neuroscience Letters.

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.

C. Glabe, P. Butler, T. Gurlo, 2014, The Journal of clinical investigation.

Exercise reverses preamyloid oligomer and prolongs survival in αB-crystallin-based desmin-related cardiomyopathy

R. Kayed, C. Glabe, J. Robbins, 2007, Proceedings of the National Academy of Sciences.

Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.

R. Kayed, C. Glabe, H. Yamaguchi, 2005, Brain research.

Membrane Fusion Is Induced by a Distinct Peptide Sequence of the Sea Urchin Fertilization Protein Bindin*

C. Glabe, D. Hoekstra, A. Ulrich, 1998, The Journal of Biological Chemistry.

Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

C. Glabe, A. Tanoue, T. Endo, 2009, PloS one.

Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain

J. Helms, R. Kayed, C. Glabe, 2005, Brain Research.

Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples

K. Murray, S. Hoff, K. Wells, 2014, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

C. Masters, Xudong Huang, R. Tanzi, 1999, The Journal of Biological Chemistry.

Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion

V. Vacquier, C. Glabe, S. Rosen, 1982, The Journal of cell biology.

Isolation of a high molecular weight glycoconjugate derived from the surface of S purpuratus eggs that is implicated in sperm adhesion.

C. Glabe, W. Lennarz, 1981, Journal of supramolecular structure and cellular biochemistry.

Egg surface glycoprotein receptor for sea urchin sperm bindin.

V. Vacquier, C. Glabe, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Cultured cell and transgenic mouse models for tau pathology linked to β-amyloid

G. Bloom, C. Glabe, K. Ren, 2005 .

Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?

C. Glabe, 2000, Nature Medicine.

Glycosylation of Ovalbumin Nascent Chains

C. Glabe, W. Lennarz, John A. Hanoverg, 1980 .

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

D. Eisenberg, José A. Rodríguez, M. Sawaya, 2019, eLife.

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

C. Glabe, C. Glabe, B. Soreghan, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

M. Pomper, G. Tomaselli, J. V. Van Eyk, 2018, Circulation research.

Subtractive analysis of S. franciscanus and S. purpuratus ovary mRNA: what kinds of genes determine species-specificity?

C. Glabe, N. Kamei, 1999, Zygote.

Liposomes containing colloidal gold are a useful probe of liposome-cell interactions.

D. Friend, D. Papahadjopoulos, C. Glabe, 1983, Biochimica et biophysica acta.

Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.

J. Nowick, R. Woods, Pin-Nan Cheng, 2012, Journal of the American Chemical Society.

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Brian J Cummings, L. Thompson, P. Muchowski, 2012, Journal of Huntington's disease.

ASSESSMENT OF POSSIBLE ASSOCIATION BETWEEN ANTIOXIDANT LEVELS AND APOE GENE POLYMORPHISM IN DEMENTED SAUDI POPULATION

C. Glabe, T. Kumosani, A. Iyer, 2018 .

A Conformation Change in the Carboxyl Terminus of Alzheimer's Aβ(1–40) Accompanies the Transition from Dimer to Fibril as Revealed by Fluorescence Quenching Analysis*

David A. Johnson, C. Glabe, S. Milton, 2000, The Journal of Biological Chemistry.

Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide*

C. Glabe, A. Hatami, S. Milton, 2017, The Journal of Biological Chemistry.

PROFESSIONAL, RESEARCH, AND TEACHING EXPERIENCE:

P. Weigel, C. Glabe, P. DeAngelis, 2012 .

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.

K. Murray, K. Wells, O. Boutaud, 2015, Journal of molecular and cellular cardiology.

Hypertension Is Associated With Preamyloid Oligomers in Human Atrium: A Missing Link in Atrial Pathophysiology?

K. Murray, S. Hoff, K. Wells, 2014, Journal of the American Heart Association.

J. Saffitz, R. Kayed, C. Glabe, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

B. Teter, G. Cole, S. Frautschy, 2006, Journal of Neuroscience Research.

Identification of a 97-kDa heat shock protein from S. franciscanus ovaries with 94% amino acid identity to the S. purpuratus egg surface receptor for sperm.

C. Glabe, N. Kamei, D. Jaworski, 1997, Developmental biology.

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

R. Kayed, C. Glabe, Jeannie Chen, 2006, The Journal of clinical investigation.

Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome.

C. Cotman, C. Glabe, E. Head, 2001, Neurobiology of disease.

Improved synthesis and purification of Alzheimer's Aβ 1–42 and analogs

C. Glabe, S. Milton, R. C. Milton, 1999, Letters in Peptide Science.

Glycosylation of ovalbumin nascent chains. The spatial relationship between translation and glycosylation.

J. Hanover, C. Glabe, W. Lennarz, 1980, The Journal of biological chemistry.

Species specific agglutination of eggs by bindin isolated from sea urchin sperm

V. Vacquier, C. Glabe, 1977, Nature.

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein.

G. Lynch, B. Bahr, C. Glabe, 1998, The Journal of comparative neurology.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

M. Szyf, W. Klein, M. Ferretti, 2011, Current Alzheimer research.

Preparation and properties of fluorescent polysaccharides.

C. Glabe, S. Rosen, P. Harty, 1983, Analytical biochemistry.

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin

S. Potkin, T. V. van Erp, W. Chiu, 2015, Molecular Psychiatry.

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

R. Kayed, C. Glabe, Jeannie Chen, 2008, Molecular Neurodegeneration.

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

Pasko Rakic, Vladimir Kepe, P. Rakic, 2013, The Journal of Neuroscience.

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

Ian Parker, Angelo Demuro, R. Kayed, 2005, Journal of Biological Chemistry.

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

C. Glabe, M. Knauer, D. Burdick, 1997, Brain Research.

Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence.

C. Glabe, A. K. Yatsimirsky, W. Garzon-Rodriguez, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of Alzheimer's (1–42) Aβ-amyloid peptide with preformed Fmoc-aminoacyl fluorides

C. Glabe, S. Milton, R. C. Milton, 1997 .

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

Carl W. Cotman, C. Cotman, C. Pike, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

C. Masters, R. Tanzi, A. Bush, 1999, The Journal of biological chemistry.

Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semisynthetic aminoacyl-tRNAs.

M. Lyttle, C. Glabe, A. Chamberlin, 1991, Biochemistry.

Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide

C. Glabe, A. Chamberlin, T. Dix, 1989 .

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

D. Eisenberg, M. Sawaya, J. Nowick, 2012, Proceedings of the National Academy of Sciences.

Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice.

Zhikuan Yang, S. Schreiber, Z. Tan, 2009, The American journal of pathology.

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

F. LaFerla, C. Glabe, R. Albay, 2018, Molecular Neurodegeneration.

The contribution of orchid mycorrhizal fungi to seed germination: a speculative review.

C. Glabe, R. Ernst, T. Yam, 1990 .

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

Ralf Langen, S. Jayasinghe, Chia-yu Lin, 2006, American journal of physiology. Endocrinology and metabolism.

Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases*

R. Kayed, C. Glabe, B. Edmonds, 2004, Journal of Biological Chemistry.

Effect of Synthetic Aβ Peptide Oligomers and Fluorinated Solvents on Kv1.3 Channel Properties and Membrane Conductance

M. Lösche, C. Glabe, M. Alkire, 2012, PloS one.

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

R. Lerner, J. Nieva, J. Kelly, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion

V. Vacquier, C. Glabe, S. Rosen, 1982, The Journal of cell biology.

THE EFFECT OF SOLUBLE EGG JELLY ON THE FERTILIZABILITY OF ACID‐DEJELLIED SEA URCHIN EGGS *

V. Vacquier, C. Glabe, B. Brandriff, 1979, Development, growth & differentiation.

The sequence of the Arbacia punctulata bindin cDNA and implications for the structural basis of species-specific sperm adhesion and fertilization.

C. Glabe, D. Clark, 1991, Developmental biology.

Reversible disruption of cultured endothelial monolayers by sulphated fucans.

T. Yednock, C. Glabe, S. Rosen, 1983, Journal of cell science.

A fucan specific lectin on teratocarcinoma stem cells.

C. Glabe, G. Martin, S. Rosen, 1981, Biochemical and biophysical research communications.

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

C. Cotman, C. Pike, C. Glabe, 1995 .

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.

C. Cotman, C. Pike, C. Glabe, 1995, Journal of neurochemistry.

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.

P. S. St George-Hyslop, M. Vitek, D. Goldgaber, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A rapidly diverging EGF protein regulates species-specific signal transduction in early sea urchin development.

W. Swanson, C. Glabe, N. Kamei, 2000, Developmental biology.

Nonhuman Amyloid Oligomer Epitope Reduces Alzheimer’s-Like Neuropathology in 3xTg-AD Transgenic Mice

C. Glabe, H. Martínez-Coria, S. Rasool, 2013, Molecular Neurobiology.

Presenilin-1 Immunoreactivity Is Localized Intracellularly in Alzheimer's Disease Brain, but Not Detected in Amyloid Plaques

F. LaFerla, L. Weber, C. Glabe, 1997, Experimental Neurology.

Isolation and characterization of the vitelline layer of sea urchin eggs

V. Vacquier, C. Glabe, 1977, The Journal of cell biology.

Studies on the interactions of sperm with the surface of the sea urchin egg.

C. Glabe, W. Lennarz, M. Buchalter, 1981, Developmental biology.

SPERM‐EGG BINDING EVENTS DURING SEA URCHIN FERTILIZATION *

V. Vacquier, C. Glabe, W. Lennarz, 1982, Annals of the New York Academy of Sciences.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

C. Cotman, C. Glabe, D. Cribbs, 2008, Journal of Neuroinflammation.

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

K. Jeang, H. Fan, C. Glabe, 1993, Journal of virology.

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

C. Cotman, C. Glabe, A. Henschen, 1992, The Journal of biological chemistry.

Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.

J. Swanson, J. Kennedy, G. Lahoste, 1996, Molecular psychiatry.

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

Peter Güntert, Hiromi Arai, Joseph S. Wall, 2016, Proceedings of the National Academy of Sciences.

Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling*

Ralf Langen, R. Kayed, C. Glabe, 2002, The Journal of Biological Chemistry.

Soluble Amyloid Aβ-(1–40) Exists as a Stable Dimer at Low Concentrations*

C. Glabe, S. Milton, W. Garzon-Rodriguez, 1997, The Journal of Biological Chemistry.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Elizabeth Head, C. Cotman, L. Breydo, 2007, Molecular Neurodegeneration.

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

D. Eisenberg, D. Dickson, B. Ghetti, 2020, The Journal of Biological Chemistry.

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

D. Eisenberg, José A. Rodríguez, M. Sawaya, 2016, eLife.

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

R. Kayed, C. Glabe, Rakez Kayed, 2006, Neurology.

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-b

Brian J. Wiltgen, G. Bloom, B. Wiltgen, 2012 .

Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-β Peptides Aβ40 and Aβ42

Yun-Ru Chen, C. Glabe, 2006, Journal of Biological Chemistry.

Pore-Forming Proteins Share Structural and Functional Homology with Amyloid Oligomers

A. Takashima, R. Kayed, C. Glabe, 2007, Neuromolecular medicine.

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Bin Zhang, E. Schadt, J. Dudley, 2017, Acta Neuropathologica.

CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

P. Bickford, H. Hou, C. Glabe, 2011, The Journal of Neuroscience.

Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

L. Grinberg, W. Seeley, C. Glabe, 2021, Acta neuropathologica communications.

Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers.

H. Luecke, C. Glabe, H. Arai, 2012, Biochimica et biophysica acta.

Soluble Amyloid Oligomers Increase Bilayer Conductance by Altering Dielectric Structure

R. Kayed, C. Glabe, A. Chanturiya, 2006, The Journal of general physiology.

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer’s disease

C. Glabe, 2001, Journal of Molecular Neuroscience.

Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo

J. Troncoso, C. Glabe, Michael K. Lee, 2012, The Journal of Neuroscience.

43 – AN ENDOGENOUS BACTERIAL PROTEASE SPECIFICALLY CLEAVES A FUSION PROTEIN JUNCTION CONSISTING OF CONSECUTIVE BASIC AMINO ACIDS TO GENERATE A BIOLOGICALLY-ACTIVE EUKARYOTIC ADHESIVE PROTEIN, BINDIN1

C. Glabe, S. Brockman, L. Kennedy, 1989 .

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

C. Kawas, M. Corrada, C. Glabe, 2014, Neurobiology of Disease.

Acceleration of Amyloid Fibril Formation by Specific Binding of Aβ-(1–40) Peptide to Ganglioside-containing Membrane Vesicles*

L. Choo-Smith, W. Surewicz, C. Glabe, 1997, The Journal of Biological Chemistry.

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

R. Kayed, C. Glabe, J. Robbins, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome

C. Cotman, Julene K. Johnson, C. Glabe, 2001, Neurobiology of Disease.

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.

E. Teng, H. Vinters, C. Kawas, 2016, The American journal of pathology.

An “epitomic” analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies

C. Glabe, T. Kumosani, P. Felgner, 2020, bioRxiv.

Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain*♦

R. Kayed, C. Glabe, C. Lasagna-Reeves, 2011, The Journal of Biological Chemistry.

Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro.

R. Kayed, C. Glabe, C. Lasagna-Reeves, 2009, Journal of molecular biology.

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells (*)

C. Glabe, A. Yang, M. Knauer, 1995, The Journal of Biological Chemistry.

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

W. Klein, A. Attie, M. Ehrlich, 2016, Acta neuropathologica communications.

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

B. Hyman, P. McLean, C. Glabe, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct*

R. Kayed, C. Glabe, S. Milton, 2007, Journal of Biological Chemistry.

Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid.

G. Bloom, C. Glabe, K. Ren, 2005, Biochimica et biophysica acta.

G. Brewer, C. Glabe, J. M. Reyes-Ruiz, 2019, Journal of Alzheimer's disease : JAD.

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

C. Cotman, F. LaFerla, T. Golde, 2019, Scientific Reports.

Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation*

L. Breydo, Y. Kuznetsov, C. Glabe, 2009, The Journal of Biological Chemistry.

Anti-Aβ1–11 Antibody Binds to Different β-Amyloid Species, Inhibits Fibril Formation, and Disaggregates Preformed Fibrils but Not the Most Toxic Oligomers*

A. Kiyatkin, C. Glabe, D. Cribbs, 2007, Journal of Biological Chemistry.

Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease

W. Klein, M. Lambert, F. LaFerla, 2006, Journal of Biological Chemistry.

Conformation-dependent anti-amyloid oligomer antibodies.

R. Kayed, C. Glabe, 2006, Methods in enzymology.

Conformation-dependent antibodies target diseases of protein misfolding.

C. Glabe, 2004, Trends in biochemical sciences.

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

J. Marsh, L. Breydo, I. Canto, 2010, Molecular Neurodegeneration.

ERK1/2 Activation Mediates Aβ Oligomer-induced Neurotoxicity via Caspase-3 Activation and Tau Cleavage in Rat Organotypic Hippocampal Slice Cultures*

R. Kayed, C. Glabe, A. Tenner, 2006, Journal of Biological Chemistry.

Nonhuman Amyloid Oligomer Epitope Reduces Alzheimer’s-Like Neuropathology in 3xTg-AD Transgenic Mice

C. Glabe, H. Martínez-Coria, S. Rasool, 2013, Molecular Neurobiology.

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

L. Breydo, F. LaFerla, R. Kayed, 2012, Molecular Neurodegeneration.

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.

W. Klein, M. Lambert, F. LaFerla, 2006, The Journal of biological chemistry.

DISTINCT EARLY FOLDING AND AGGREGATION PROPERTIES OF ALZHEIMER AMYLOID-ß PEPTIDE Aß40 AND Aß42: STABLE TRIMER OR TETRAMER FORMATION BY Aß42.

Yun-Ru Chen, C. Glabe, 2006 .

Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42.

J. Geddes, C. Glabe, T. L. Tekirian, 1999, Journal of neurochemistry.

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

C. Cotman, N. Berchtold, M. Murphy, 2012, Neurobiology of Aging.

Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid

A. Erisir, G. Bloom, H. Kan, 2006, The Journal of cell biology.

Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer's Disease Mutation Carriers

J. Ringman, G. Coppola, D. Elashoff, 2012, Dementia and Geriatric Cognitive Disorders Extra.

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers*

C. Ross, A. Giese, H. Kretzschmar, 2008, Journal of Biological Chemistry.

Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

R. Kayed, C. Glabe, H. Yamaguchi, 2005, Brain Research.

Aβ Structure and Aggregation

A. Bush, C. Glabe, 2007 .

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

C. Cotman, C. Glabe, Haixiang Jiang, 1994, Journal of immunology.

Epitomic Characterization of the Specificity of the Anti-Amyloid Aβ Monoclonal Antibodies 6E10 and 4G8

C. Glabe, K. Abulnaja, J. M. Reyes-Ruiz, 2018, Journal of Alzheimer's disease : JAD.

Amyloid Oligomer Structures and Toxicity

C. Glabe, 2009 .

CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease

R. Dodel, R. Kayed, C. Glabe, 2008, The Journal of experimental medicine.

Soluble and mature amyloid fibrils in drusen deposits.

L. V. Johnson, R. Wetzel, R. Kayed, 2010, Investigative ophthalmology & visual science.

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer*

R. Kayed, C. Glabe, E. Head, 2009, Journal of Biological Chemistry.

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

E. Teng, G. Cole, S. Frautschy, 2015, Neurobiology of Disease.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

S. Potkin, D. Housman, L. Joachimiak, 2013, Proceedings of the National Academy of Sciences.

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle*

Shao-Yi Huang, L. Thompson, P. Muchowski, 2010, The Journal of Biological Chemistry.

Conformation-dependent anti-Aβ monoclonal antibody signatures of disease status and severity in urine of women with preeclampsia.

C. Glabe, C. Buhimschi, I. Buhimschi, 2022, Pregnancy hypertension.

Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

M. Ehrlich, C. Barlow, F. Gage, 2014, Molecular Psychiatry.

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

L. Breydo, R. Kayed, C. Glabe, 2007, Biochemistry.

Specific rosette formation between fibroblasts and erythrocytes.

C. Glabe, S. Rosen, M. Singer, 1981, Journal of cell science.

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.

H. Reber, O. Hines, C. Glabe, 2010, The American journal of pathology.

Toxic Human Islet Amyloid Polypeptide (h-IAPP) Oligomers Are Intracellular, and Vaccination to Induce Anti-Toxic Oligomer Antibodies Does Not Prevent h-IAPP–Induced β-Cell Apoptosis in h-IAPP Transgenic Mice

Chia-yu Lin, R. Kayed, C. Glabe, 2007, Diabetes.

C. Cotman, C. Pike, C. Glabe, 1991, European journal of pharmacology.

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

Yun-Ru Chen, C. Glabe, 2006, The Journal of biological chemistry.

Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models

S. Finkbeiner, J. Marsh, L. Thompson, 2012, The Journal of Neuroscience.

C1 activation by amyloid β fibrils. Evidence for a binding site for Aβ on the C1q globular regions

G. Arlaud, C. Glabe, A. Tenner, 2000 .

Toxic Human IAPP Oligomers are Intracellular , and Vaccination to Induce Anti-toxic Oligomer Antibodies Does not Prevent Human IAPP Induced Beta-Cell Apoptosis in Human IAPP Transgenic Mice

Chia-yu Lin, R. Kayed, C. Glabe, 2007 .

Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

R. Kayed, C. Glabe, D. Cribbs, 2005, Journal of Neuroinflammation.

Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.

H. Vinters, C. Kawas, M. Corrada, 2019, The American journal of pathology.

Dityrosine Cross-Linked Aβ Peptides: Fibrillar β-Structure in Aβ(1-40) Is Conducive to Formation of Dityrosine Cross-Links but a Dityrosine Cross-Link in Aβ(8-14) Does Not Induce β-Structure

J. Nowick, C. Glabe, Joshua C. Yoburn, 2003 .

Multivalent Binding of Complement Protein C1q to the Amyloid β-Peptide (Aβ) Promotes the Nucleation Phase of Aβ Aggregation

C. Glabe, J. Rogers, S. Webster, 1995 .

Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.

C. Glabe, B. Soreghan, J. Kosmoski, 1994, The Journal of biological chemistry.

Multivalent binding of complement protein C1Q to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation.

C. Glabe, J. Rogers, S. Webster, 1995, Biochemical and biophysical research communications.

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity.

C. Cotman, C. Pike, C. Glabe, 1991, Brain research.

Antibodies Against b-Amyloid Reduce Ab Oligomers, Glycogen Synthase Kinase-3b Activation and s Phosphorylation In Vivo and In Vitro

B. Teter, G. Cole, S. Frautschy, 2006 .

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers

T. Abel, A. Levey, W. Bilker, 2010, Annals of neurology.

Differentially Modulated by C1q -Peptide in Microglia Is b Amyloid Antibody-Mediated Phagocytosis of the

C. Glabe, S. Webster, E. Ferran, 2001 .

Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.

M. Murphy, R. Kayed, C. Glabe, 2010, Journal of Alzheimer's disease : JAD.

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

D. Eisenberg, José A. Rodríguez, M. Sawaya, 2017, The Journal of Biological Chemistry.

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

M. Staufenbiel, R. Kayed, C. Glabe, 2009, International journal of Alzheimer's disease.

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)

C. Glabe, R. Orlando, M. Knauer, 1996, Brain Research.

Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in Vitro and in Alzheimer Disease Brain*

C. Glabe, A. Hatami, S. Milton, 2014, The Journal of Biological Chemistry.

Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.

A. Kiyatkin, C. Glabe, D. Cribbs, 2007, The Journal of biological chemistry.

Amyloid β Immunotherapy

C. Glabe, S. Rasool, 2017 .

Amyloid Oligomer Structures and Toxicity~!2009-04-30~!2009-07-07~!2010-01-02~!

C. Glabe, 2010 .

In vitro study of the mechanism of intraneuronal β-amyloid aggregation in Alzheimer’s disease

C. Glabe, T. Kumosani, S. Moselhy, 2020, Archives of physiology and biochemistry.

Identification of amyloid antibodies for Alzheimer disease – immunotherapy

C. Glabe, T. Kumosani, S. Moselhy, 2020, Archives of physiology and biochemistry.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

C. Cotman, C. Glabe, D. Cribbs, 2022 .

Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

R. Kayed, C. Glabe, D. Cribbs, 2005 .

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

W. Klein, A. Attie, M. Ehrlich, 2016, Acta Neuropathologica Communications.

Cellular Membranes as Targets in Amyloid Oligomer Disease Pathogenesis

C. Glabe, E. Mina, 2008 .

The influence of the carboxyl terminus of the Alzheimer Aβ peptide on its conformation, aggregation, and neurotoxic properties

C. Cotman, C. Pike, R. Kayed, 2002, NeuroMolecular Medicine.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

C. Cotman, L. Breydo, R. Kayed, 2007, Molecular Neurodegeneration.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

S. Potkin, D. Housman, L. Joachimiak, 2013, Proceedings of the National Academy of Sciences.

Structural Classification of Toxic Amyloid Oligomers*

C. Glabe, 2008, Journal of Biological Chemistry.

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer*

R. Kayed, C. Glabe, E. Head, 2009, Journal of Biological Chemistry.

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers*

C. Ross, A. Giese, H. Kretzschmar, 2008, Journal of Biological Chemistry.

CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease

R. Dodel, R. Kayed, C. Glabe, 2008, The Journal of experimental medicine.

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

P. Rakic, V. Kepe, J. Barrio, 2013, The Journal of Neuroscience.

Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion

V. Vacquier, C. Glabe, S. Rosen, 1982, The Journal of cell biology.

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils

M. Sawaya, E. Pardon, J. Steyaert, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Thioflavin T In-gel Stain to Study Protein Misfolding in Frozen Tissue Specimens

J. Troncoso, C. Glabe, Irina Tchernyshyov, 2023, bioRxiv.

Abstract 16499: Preamyloid Oligomers are Present in Human Atrium and Are Associated With Post-Operative Atrial Fibrillation

K. Murray, S. Hoff, C. Glabe, 2011 .

Isolation and characterization of the vitelline layer of sea urchin eggs

V. Vacquier, C. Glabe, 1977, The Journal of cell biology.

Isolation of VLs from Unfertilized Eggs

V. Vacquier, C. Glabe, 2003 .

VITELLINE LAYER OF SEA URCHIN EGGS

V. Vacquier, C. Glabe, 1977 .

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

J. Marsh, L. Breydo, R. Kayed, 2010, Molecular Neurodegeneration.