J. Goldstein

发表

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Joseph L Goldstein, J. Horton, J. Goldstein, 2002, The Journal of clinical investigation.

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1977, Cell.

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

D. Russell, M. Brown, J. Goldstein, 1985, Annual review of cell biology.

Surviving starvation: essential role of the ghrelin-growth hormone axis

M. Brown, J. Goldstein, Michael S. Brown, 2012, BMC Proceedings.

Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids*

J. Goldstein, Michael S. Brown, Tong-Jin Zhao, 2012, The Journal of Biological Chemistry.

Structure of the LDL Receptor Extracellular Domain at Endosomal pH

Joseph L. Goldstein, J. Deisenhofer, K. Henderson, 2002, Science.

Regulation of the mevalonate pathway

J. Goldstein, Michael S. Brown, 1990, Nature.

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Proceedings of the National Academy of Sciences of the United States of America.

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

J. Goldstein, Michael S. Brown, 1997, Cell.

Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.

M. Brown, J. Goldstein, Michael S. Brown, 1985, The Journal of biological chemistry.

A receptor-mediated pathway for cholesterol homeostasis.

M. Brown, J. Goldstein, M. Brown, 1986, Science.

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1994, Cell.

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M. Brown, J. Goldstein, M. Brown, 1980, Journal of lipid research.

The LDL receptor.

J. Goldstein, Michael S. Brown, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.

S. Armstrong, C. Slaughter, Y. Reiss, 1991, The Journal of biological chemistry.

PxF, a prenylated protein of peroxisomes.

M. Brown, J. Goldstein, R. G. Anderson, 1994, The Journal of biological chemistry.

Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection *

X. Hua, J. Goldstein, Michael S. Brown, 1995, The Journal of Biological Chemistry.

Transport-Dependent Proteolysis of SREBP Relocation of Site-1 Protease from Golgi to ER Obviates the Need for SREBP Transport to Golgi

P. Espenshade, J. Goldstein, Michael S. Brown, 1999, Cell.

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.

M. Brown, J. Goldstein, Michael S. Brown, 1999, Proceedings of the National Academy of Sciences of the United States of America.

5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription

T. Osborne, J. Goldstein, Michael S. Brown, 1985, Cell.

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

I. Shimomura, M. Brown, H. Shimano, 1997, The Journal of clinical investigation.

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Jean-Marc A. Lobaccaro, Joseph L. Goldstein, I. Shimomura, 2000 .

Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

J. Goldstein, Michael S. Brown, G. Liang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Protein Sensors for Membrane Sterols

Joseph L. Goldstein, J. Goldstein, Michael S. Brown, 2006, Cell.

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

Joseph L. Goldstein, Arun Radhakrishnan, Y. Ikeda, 2007, Proceedings of the National Academy of Sciences.

Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells

M. Brown, J. Goldstein, Michael S. Brown, 1975, Journal of cellular physiology.

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

J. Goldstein, Michael S. Brown, Jing Tian, 2016, Proceedings of the National Academy of Sciences.

The Cholesterol Quartet

Joseph L. Goldstein, J. Goldstein, Michael S. Brown, 2001, Science.

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands.

M. Brown, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

B. Shan, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Selective versus total insulin resistance: a pathogenic paradox.

J. Goldstein, Michael S. Brown, 2008, Cell metabolism.

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol.

M. Brown, J. Goldstein, M. Brown, 1974, The Journal of biological chemistry.

Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1974, The Journal of biological chemistry.

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

Joseph L. Goldstein, M. Brown, J. Goldstein, 1974, Proceedings of the National Academy of Sciences.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, Michael S. Brown, 1974, The Journal of biological chemistry.

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein

J. Goldstein, Michael S. Brown, 1976, Cell.

Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: Relation to low density lipoprotein receptor distribution

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1978, Cell.

Solubilization of the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

M. Brown, J. Goldstein, U. Beisiegel, 1981, The Journal of biological chemistry.

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

R. Cummings, S. Kornfeld, M. Brown, 1983, The Journal of biological chemistry.

Recycling receptors: The round-trip itinerary of migrant membrane proteins

Joseph L. Goldstein, Richard G. W. Anderson, J. Goldstein, 1983, Cell.

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

D. Russell, J. Goldstein, Michael S. Brown, 1984, Cell.

The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

Richard G. W. Anderson, D. Russell, J. Goldstein, 1986, Cell.

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.

T. Südhof, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.

D. Russell, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins.

D. Russell, M. Brown, J. Goldstein, 1989, The Journal of biological chemistry.

Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay.

M. Brown, J. Goldstein, I. V. van Driel, 1989, The Journal of biological chemistry.

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1990, The Journal of biological chemistry.

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

R. Hammer, M. Brown, J. Goldstein, 1992, The Journal of cell biology.

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.

J. McDonald, J. Goldstein, Michael S. Brown, 2008, Cell metabolism.

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.

A. Levinson, M. Brown, J. Goldstein, 1993, Science.

Scientific Side Trips: Six Excursions from the Beaten Path

J. Goldstein, Michael S. Brown, 2012, The Journal of Biological Chemistry.

Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells.

M. Brown, J. Goldstein, Michael S. Brown, 1995, Methods in enzymology.

CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB (*)

S. Armstrong, J. Goldstein, Michael S. Brown, 1995, The Journal of Biological Chemistry.

Peptidomimetic inhibitors of Ras farnesylation

J. Goldstein, Michael S. Brown, G. James, 1994 .

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.

M. Brown, J. Goldstein, I. Kaneko, 1978, The Journal of biological chemistry.

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, The Journal of biological chemistry.

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.

M. Brown, D. Andres, J. Goldstein, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

T. Südhof, M. Brown, J. Goldstein, 1992, The Journal of biological chemistry.

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.

M. Brown, J. Goldstein, Michael S. Brown, 1992, The Journal of biological chemistry.

Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product

T. Südhof, C. Slaughter, J. Goldstein, 1992, Cell.

Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme.

Y. Reiss, M. Brown, J. Goldstein, 1992, The Journal of biological chemistry.

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

M. Brown, K. Orth, T. Willnow, 1992, The Journal of biological chemistry.

Purification of an Interleukin-1 Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains (*)

C. Slaughter, X. Wang, M. Brown, 1995, The Journal of Biological Chemistry.

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

N. Maeda, M. Brown, J. Goldstein, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

J. R. Smith, T. Osborne, M. Brown, 1990, The Journal of biological chemistry.

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.

X. Wang, M. Brown, X. Hua, 1993, The Journal of biological chemistry.

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.

R. Mahley, M. Brown, J. Goldstein, 1980, Journal of lipid research.

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.

M. Brown, P. Kovanen, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice*

J. Goldstein, Michael S. Brown, G. Liang, 2009, The Journal of Biological Chemistry.

Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.

J. D. Wilson, P. Walsh, J. Goldstein, 1974, The New England journal of medicine.

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

R. Hammer, D. Russell, M. Brown, 1988, Science.

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

R. Hammer, Jingqing Yang, M. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

R. Havel, M. Brown, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1975, The American journal of medicine.

The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Current topics in cellular regulation.

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

M. Brown, J. Goldstein, S. Balasubramaniam, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.

M. Brown, J. Goldstein, U. Beisiegel, 1981, The Journal of biological chemistry.

Familial hypercholesterolemia in a large indred. Evidence for a monogenic mechanism.

A. Motulsky, W. Hazzard, J. Goldstein, 1972, Annals of internal medicine.

Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.

T. Kita, M. Brown, J. Goldstein, 1983, The New England journal of medicine.

Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein*

M. Brown, J. Goldstein, Michael S. Brown, 1999, The Journal of Biological Chemistry.

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

M. S. Brown, M. Brown, J. Goldstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes

P. Espenshade, J. Goldstein, Michael S. Brown, 2000, Cell.

Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.

M. Brown, J. Goldstein, Michael S. Brown, 1990, The Journal of biological chemistry.

Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.

T. Osborne, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

M. Brown, J. Goldstein, K. Luskey, 1989, The Journal of biological chemistry.

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.

J. Goldstein, Michael S. Brown, J. Feramisco, 2002, Molecular cell.

cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1 (*)

M. Brown, J. Goldstein, Ravindra Kumar Pathak, 1995, The Journal of Biological Chemistry.

Purified NPC1 Protein

Joseph L Goldstein, Arun Radhakrishnan, J. Dale, 2008, Journal of Biological Chemistry.

Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis*

J. Goldstein, Michael S. Brown, Yinxin Zhang, 2011, The Journal of Biological Chemistry.

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a potential step in cholesterol egress from lysosomes.*

J. Goldstein, Michael S. Brown, H. Kwon, 2009 .

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

M. Brown, J. Goldstein, S. E. Dana, 1975, The Journal of biological chemistry.

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of clinical investigation.

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper.

C. Slaughter, P. Dawson, N. Ridgway, 1989, The Journal of biological chemistry.

Purification of oxysterol binding protein from hamster liver cytosol.

P. Dawson, M. Brown, J. Goldstein, 1989, The Journal of biological chemistry.

Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs*

Christopher M. Adams, J. Goldstein, Michael S. Brown, 2004, Journal of Biological Chemistry.

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

J. Goldstein, Michael S. Brown, J. Seemann, 2007, Proceedings of the National Academy of Sciences.

Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦

J. Goldstein, Michael S. Brown, Li-ping Sun, 2005, Journal of Biological Chemistry.

Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER

R. Aebersold, P. Espenshade, J. Goldstein, 2002, Cell.

Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.

M. Brown, J. Goldstein, J. Faust, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Proteolytic processing of the 600 kd low density lipoprotein receptor‐related protein (LRP) occurs in a trans‐Golgi compartment.

M. S. Brown, M. Brown, J. Goldstein, 1990, The EMBO journal.

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

M. Brown, J. Goldstein, Michael S. Brown, 1989, Proceedings of the National Academy of Sciences of the United States of America.

History of Discovery The LDL Receptor

J. Goldstein, Michael S. Brown, 2009 .

Heart Attacks: Gone with the Century?

M. Brown, J. Goldstein, M. Brown, 1996, Science.

Receptor-mediated control of cholesterol metabolism.

M. Brown, J. Goldstein, M. Brown, 1976, Science.

Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1976, The New England journal of medicine.

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1983, Cell.

Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein

Joon-No Lee, Y. Ikeda, J. Goldstein, 2009, The Journal of Biological Chemistry.

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

M. Brown, J. Goldstein, J. Faust, 1975, The Journal of clinical investigation.

Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids.

A. Motulsky, W. Hazzard, J. Goldstein, 1974, American journal of human genetics.

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

M. S. Brown, M. Brown, J. Goldstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

M. Brown, H. Shimano, J. Horton, 1999, The Journal of clinical investigation.

Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.

D. Russell, S. Kornfeld, M. Brown, 1986, The Journal of biological chemistry.

Familial hypercholesterolemia: a genetic receptor disease.

M. Brown, J. Goldstein, M. Brown, 1985, Hospital practice.

Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1987, The New England journal of medicine.

RECEPTOR-MEDIATED ENDOCYTOSIS AS EXEMPLIFIED BY THE LOW DENSITY LIPOPROTEIN RECEPTOR

J. Goldstein, Michael S. Brown, 1983 .

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

J. Mendell, J. McDonald, J. Goldstein, 2020, Proceedings of the National Academy of Sciences.

LDL-receptor structure: Calcium cages, acid baths and recycling receptors

J. Goldstein, Michael S. Brown, J. Herz, 1997, Nature.

The Receptor Model for Transport of Cholesterol in Plasma a

M. Brown, J. Goldstein, Michael S. Brown, 1985, Annals of the New York Academy of Sciences.

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

J. Goldstein, Michael S. Brown, Akash Das, 2014, eLife.

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1.

M. Brown, J. Goldstein, Michael S. Brown, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex

R. Cummings, M. Brown, J. Goldstein, 1988, The Journal of cell biology.

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

Y. Chao, R. Havel, M. Brown, 1980, The Journal of biological chemistry.

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

M. Brown, P. Kovanen, J. Goldstein, 1979, The Journal of biological chemistry.

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.

R. Mahley, K. Weisgraber, M. Brown, 1990, The Journal of biological chemistry.

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

R. Havel, T. Kita, C. Hornick, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

R. Mahley, K. Weisgraber, M. Brown, 1990, The Journal of biological chemistry.

Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study.

L. Orci, M. Brown, J. Carpentier, 1979, Experimental cell research.

Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations.

M. Brown, J. Goldstein, M. Brown, 1975, Advances in internal medicine.

The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy.

M. Brown, J. Goldstein, Michael S. Brown, 1982, The Medical clinics of North America.

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

J. Goldstein, Michael S. Brown, H. Tolleshaug, 1983, Cell.

Retrospective on Cholesterol Homeostasis: The Central Role of Scap.

J. Goldstein, Michael S. Brown, A. Radhakrishnan, 2018, Annual review of biochemistry.

Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

R. Mahley, M. Brown, J. Goldstein, 1980, The Journal of biological chemistry.

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.

K., D. Bilheimer, M. Brown, 1978, The Journal of clinical investigation.

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are allelic

N. Stone, J. Goldstein, Michael S. Brown, 1977, Cell.

Atherosclerosis: the low-density lipoprotein receptor hypothesis.

M. Brown, J. Goldstein, M. Brown, 1977, Metabolism: clinical and experimental.

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

R. Hammer, I. Shimomura, J. Goldstein, 1999, Nature.

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

J. Horton, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

M. Cobb, M. Brown, J. Goldstein, 1994, The Journal of biological chemistry.

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

D. Bilheimer, M. Brown, P. Kovanen, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1979, The Journal of biological chemistry.

Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Archives of biochemistry and biophysics.

The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

J. Goldstein, Michael S. Brown, 1975, Cell.

Membrane Topology of S2P, a Protein Required for Intramembranous Cleavage of Sterol Regulatory Element-binding Proteins*

J. Goldstein, Michael S. Brown, R. B. Rawson, 1999, The Journal of Biological Chemistry.

Second-site Cleavage in Sterol Regulatory Element-binding Protein Occurs at Transmembrane Junction as Determined by Cysteine Panning*

M. Brown, J. Goldstein, Michael S. Brown, 1998, The Journal of Biological Chemistry.

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

R. Hammer, J. Goldstein, Michael S. Brown, 2012, Proceedings of the National Academy of Sciences.

Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein.

M. Krieger, M. Brown, J. Goldstein, 1981, Journal of molecular biology.

Familial hypercholesterolemia: pathogenesis of a receptor disease.

M. Brown, J. Goldstein, M. Brown, 1978, The Johns Hopkins medical journal.

Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.

R. Hammer, M. Brown, J. Goldstein, 1990, The Journal of clinical investigation.

Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.

M. Brown, J. Goldstein, Michael S. Brown, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1*

J. Goldstein, Michael S. Brown, R. B. Rawson, 1998, The Journal of Biological Chemistry.

Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2*

J. Goldstein, Michael S. Brown, J. Sakai, 1997, The Journal of Biological Chemistry.

Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

R. Hammer, M. Brown, J. Goldstein, 1990, The Journal of cell biology.

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors.

H. Hobbs, M. Brown, J. Goldstein, 1989, The Journal of clinical investigation.

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.

H. Hobbs, D. Russell, M. Brown, 1988, The Journal of clinical investigation.

Purification of the LDL receptor.

M. Brown, J. Goldstein, W. Schneider, 1985, Methods in enzymology.

The Ldl Receptor: Functional Studies And Partial Characterization

M. Brown, J. Goldstein, W. Schneider, 1984 .

Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.

M. Brown, J. Goldstein, Michael S. Brown, 1984, The Journal of clinical investigation.

Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells

Richard G. W. Anderson, L. Orci, L. Garcia-Segura, 1984, Cell.

Monoclonal Antibody as a Probe for Structural and Functional Studies of the LDL Receptor

J. Goldstein, Michael S. Brown, U. Beisiegel, 1983 .

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

D. Russell, C. Slaughter, M. Brown, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts

J. D. Capra, C. Slaughter, M. Brown, 1983, The Journal of cell biology.

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies

Richard G. W. Anderson, M. Brown, J. Goldstein, 1982, The Journal of cell biology.

Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein.

M. Brown, J. Goldstein, R. G. Anderson, 1982, Ciba Foundation symposium.

Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia

J. Goldstein, Michael S. Brown, W. Schneider, 1982, Cell.

Biologically active low density lipoprotein in human peripheral lymph.

M. Brown, J. Goldstein, N. B. Myant, 1978, The Journal of clinical investigation.

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.

R. Mahley, M. Brown, J. Goldstein, 1976, The Journal of biological chemistry.

Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells.

M. Brown, P. Kovanen, J. Goldstein, 1979, Endocrinology.

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

J. R. Smith, T. Osborne, M. Brown, 1988, The Journal of biological chemistry.

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

T. Südhof, D. Russell, M. Brown, 1987, The Journal of biological chemistry.

From fatty streak to fatty liver: 33 years of joint publications in the JCI.

J. Goldstein, Michael S. Brown, 2008, The Journal of clinical investigation.

Scavenging for receptors

J. Goldstein, Michael S. Brown, 1990, Nature.

Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue.

M. Brown, P. Kovanen, J. Goldstein, 1979, Endocrinology.

Stimulation of Cholesteryl Ester Synthesis in Macrophages by Extracts of Atherosclerotic Human Aortas and Complexes of Albumin/Cholesteryl Esters

M. Brown, J. Goldstein, Michael S. Brown, 1981, Arteriosclerosis.

Seventeenth Marabou Symposium on Diet and Genetic Interactions: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake

J. Goldstein, Michael S. Brown, 1998 .

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

R. Hammer, H. Kuriyama, J. Horton, 2004, The Journal of clinical investigation.

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, The Journal of biological chemistry.

Insulin Receptor Substrate-l ( IRS-l ) Expression in Rat Brain

David, Michael, J. Goldstein, 2001 .

On the origin and prevention of PAIDS (Paralyzed Academic Investigator's Disease Syndrome).

J. Goldstein, 1986, The Journal of clinical investigation.

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

M. Brown, J. Goldstein, M. Brown, 1983, The Journal of clinical investigation.

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

J. Goldstein, Michael S. Brown, S. Basu, 1976, Cell.

Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo.

M. Brown, P. Kovanen, J. Goldstein, 1979, The Journal of biological chemistry.

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.

D. Russell, M. Brown, J. Goldstein, 1986, Science.

Isoform 1 c of Sterol Regulatory Element Binding Protein Is Less Active Than Isoform 1 a in Livers of Transgenic Mice and in Cultured Cells

R. Hammer, I. Shimomura, H. Shimano, 2013 .

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

T. Südhof, P. Dawson, M. Brown, 1988, The Journal of biological chemistry.

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

M. Brown, M. Evans, J. Goldstein, 1994, The Journal of biological chemistry.

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.

M. Brown, J. Goldstein, J. Faust, 1980, The Journal of biological chemistry.

Koch's postulates for cholesterol

J. Goldstein, Michael S. Brown, 1992, Cell.

Hyperlipidemia inCoronary Heart Disease III.EVALUATION OF LIPOPROTEINPHENOTYPES OF 156 GENETICALLY DEFINED SURVIVORSOF MYOCARDIAL INFARCTION

W. Hazzard, J. Goldstein, R. Poole, 1973 .

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins

Richard G. W. Anderson, M. Krieger, M. Brown, 1979, The Journal of cell biology.

Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Nutrition reviews.

Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

J. Goldstein, Michael S. Brown, A. Radhakrishnan, 2009, Proceedings of the National Academy of Sciences.

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Jay D. Horton, Joseph L. Goldstein, J. Warrington, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.

Joon-No Lee, J. Goldstein, Michael S. Brown, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.

J. Goldstein, Michael S. Brown, R. B. Rawson, 2002, Archives of biochemistry and biophysics.

Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins*

J. Richardson, J. Shelton, J. Goldstein, 2003, Journal of Biological Chemistry.

Regulation of low density lipoprotein receptor gene expression in HepG 2 and Caco 2 cells by palmitate , oleate , and 25-hydroxycholestero 11 Rai

Michael, J. Goldstein, Brown, 2002 .

Elements regulateurs de sterol

T. Südhof, D. Russell, J. Goldstein, 1988 .

Direct Demonstration That Loop1 of Scap Binds to Loop7

N. Grishin, L. Kinch, D. Rosenbaum, 2016, The Journal of Biological Chemistry.

Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi*

J. Goldstein, Michael S. Brown, Yinxin Zhang, 2013, The Journal of Biological Chemistry.

Point Mutation in Luminal Loop 7 of Scap Blocks Interaction with Loop 1 and Abolishes Movement to Golgi *

J. Goldstein, Michael S. Brown, Yinxin Zhang, 2013 .

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

J. Richardson, J. Shelton, J. Goldstein, 2010, The Journal of investigative dermatology.

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

R. Hammer, H. Kuriyama, J. Horton, 2005, The Journal of clinical investigation.

SREPBs: Gene Regulation through Controlled Protein Trafficking

P. Espenshade, J. Goldstein, Michael S. Brown, 2003 .

Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins*

J. Goldstein, Michael S. Brown, O. Guryev, 1998, The Journal of Biological Chemistry.

Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

J. Goldstein, Michael S. Brown, Akash Das, 2013, Proceedings of the National Academy of Sciences.

Profiles in Cardiovascular Science

R. Bolli, J. Goldstein, Michael S. Brown, 2010 .

Reconstitution of Sterol-regulated Endoplasmic Reticulum-to-Golgi Transport of SREBP-2 in Insect Cells by Co-expression of Mammalian SCAP and Insigs*

J. Goldstein, Michael S. Brown, R. B. Rawson, 2003, Journal of Biological Chemistry.

Overexpression of Membrane Domain of SCAP Prevents Sterols from Inhibiting SCAP·SREBP Exit from Endoplasmic Reticulum*

J. Goldstein, Michael S. Brown, Tong Yang, 2000, The Journal of Biological Chemistry.

Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane (*)

X. Hua, J. Goldstein, Michael S. Brown, 1996, The Journal of Biological Chemistry.

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

M. Brown, X. Hua, J. Goldstein, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia.

M. Brown, J. Goldstein, Michael S. Brown, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis

J. Goldstein, Michael S. Brown, Yulian Zhou, 2017, The Journal of Biological Chemistry.

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change.

Y. Ikeda, J. Goldstein, Michael S. Brown, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Lipoprotein receptors and the genetic control of cholesterol metabolism in cultured human cells

M. Brown, J. Goldstein, M. Brown, 1975, Naturwissenschaften.

Heterozygous familial hypercholesterolemia: Failure of normal allele to compensate for mutant allele at a regulated genetic locus

J. Goldstein, Michael S. Brown, J. Faust, 1976, Cell.

Role of the LDL Receptor in the Regulation of Cholesterol and Lipoprotein Metabolism

J. Goldstein, Michael S. Brown, H. Bohmfalk, 1976 .

Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection.

M. Brown, J. Goldstein, Michael S. Brown, 1974, American journal of human genetics.

Biochemical and Morphologic Correlations

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 2003 .

Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex.

M. Brown, P. Kovanen, J. Goldstein, 1979, Recent progress in hormone research.

Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins.

M. Brown, J. Goldstein, Michael S. Brown, 1978, Journal of supramolecular structure.

M. Brown, J. Goldstein, R. Bradley, 1978, Journal of lipid research.

Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro.

M. Brown, J. Goldstein, R. G. Anderson, 1977, The Journal of clinical investigation.

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells.

M. Brown, J. Goldstein, R. G. Anderson, 1977, Journal of supramolecular structure.

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia

M. Brown, J. Goldstein, Y. Ho, 1976, The Journal of experimental medicine.

Hyperlipidemia in coronary heart disease: a biochemical genetic approach.

M. Brown, J. Goldstein, M. Brown, 1975, The Journal of laboratory and clinical medicine.

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

A. Beaudet, M. Brown, J. Goldstein, 1975, The Journal of biological chemistry.

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, The Journal of biological chemistry.

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

M. Brown, J. Goldstein, S. E. Dana, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1975, Advances in experimental medicine and biology.

Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Journal of lipid research.

EVOLUTION OF THE LDL RECEPTOR CONCEPT–FROM CULTURED CELLS TO INTACT ANIMALS *

M. Brown, P. Kovanen, J. Goldstein, 1980, Annals of the New York Academy of Sciences.

Concentration and Composition of Lipoproteins in Blood Plasma of the WHHL Rabbit

R. Havel, T. Kita, J. Kane, 1982, Arteriosclerosis.

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase.

P. Dawson, N. Ridgway, M. Brown, 1991, The Journal of biological chemistry.

PRENATAL DIAGNOSIS OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLÆMIA Expression of a Genetic Receptor Disease in Utero

J. Fryns, P. Kovanen, J. Goldstein, 1978, The Lancet.

Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads.

M. Brown, J. Goldstein, S. E. Dana, 1977, Biochemical and biophysical research communications.

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

M. Brown, J. Goldstein, U. Beisiegel, 1982, The Journal of biological chemistry.

Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.

M. Brown, J. Goldstein, U. Beisiegel, 1982, The Journal of biological chemistry.

Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.

D. Bilheimer, T. Kita, M. Brown, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Mutational Analysis of a Menabrane Protein

H. Hobbs, D. Russell, J. Goldstein, 1990 .

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.

M. Brown, P. Kovanen, J. Goldstein, 1980, The Journal of biological chemistry.

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

M. Krieger, M. Brown, J. Goldstein, 1978, The Journal of biological chemistry.

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

M. Brown, J. Goldstein, Michael S. Brown, 1977, The Journal of biological chemistry.

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

M. Brown, J. Goldstein, G. Y. Brunschede, 1977, The Journal of biological chemistry.

Complementation of Mutation in Acyl-CoA:Cholesterol Acyltransferase (ACAT) Fails to Restore Sterol Regulation in ACAT-defective Sterol-resistant Hamster Cells*

J. Goldstein, Michael S. Brown, Guoqing Cao, 1996, The Journal of Biological Chemistry.

Presentation of the Kober Medal Presentation of the Kober Medal to

J. Goldstein, Michael S. Brown, 2010 .

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.

C. Slaughter, M. Brown, J. Goldstein, 1986, The Journal of biological chemistry.

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

D. Russell, H. Okayama, J. Goldstein, 1984, Nature.

Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.

M. Brown, J. Goldstein, R. G. Anderson, 1983, The Journal of biological chemistry.

Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

P. Dawson, N. Ridgway, M. Brown, 1991, The Journal of biological chemistry.

Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts.

M. Brown, J. Goldstein, G. Y. Brunschede, 1976, The Journal of biological chemistry.

Co-localization of t 2 l-Epidermal Growth Factor and Ferritin-low Density Lipoprotein in Coated Pits : A Quantitative Electron Microscopic Study in Normal Mutant Human Fibroblasts and

Richard G. W. Anderson, L. Orci, J. Carpentier, 2003 .

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts

L. Orci, M. Brown, S. Cohen, 1982, The Journal of cell biology.

Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells

M. Brown, J. Goldstein, Michael S. Brown, 1981, The Journal of cell biology.

A tribute to Akira Endo, discoverer of a “Penicillin” for cholesterol

Michael S. Brown, J. Goldstein, 2004 .

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA

M. Brown, J. Goldstein, D. Chin, 1985 .

Lowering plasma cholesterol by raising LDL receptors.

M. Brown, J. Goldstein, Michael S. Brown, 1981, The New England journal of medicine.

The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis.

M. Brown, J. Goldstein, M. Brown, 1985, Current topics in cellular regulation.

THE LOW‐DENSITY LIPOPROTEIN PATHWAY IN HUMAN FIBROBLASTS: RELATION BETWEEN CELL SURFACE RECEPTOR BINDING AND ENDOCYTOSIS OF LOW‐DENSITY LIPOPROTEIN *

M. Brown, J. Goldstein, Michael S. Brown, 1976, Annals of the New York Academy of Sciences.

The low density lipoprotein pathway in human fibroblasts

J. Goldstein, Michael S. Brown, 1976 .

Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.

H. Hobbs, D. Russell, M. Brown, 1986, The Journal of biological chemistry.

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.

S. Grundy, T. Starzl, D. Bilheimer, 1984, The New England journal of medicine.

Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts.

M. Brown, J. Goldstein, R. G. Anderson, 1980, Journal of receptor research.

LDL receptors in coated vesicles isolated from bovine adrenal cortex: Binding sites unmasked by detergent treatment

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1980, Cell.

Visualization of lipoprotein receptors by ligand blotting.

M. Brown, J. Goldstein, W. Schneider, 1983, The Journal of biological chemistry.

Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.

M. Brown, J. Goldstein, T. Yamamoto, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.

T. Südhof, D. Bilheimer, M. Brown, 1986, Proceedings of the National Academy of Sciences of the United States of America.

mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.

D. Russell, M. Brown, J. Goldstein, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

M. Brown, J. Goldstein, Michael S. Brown, 1978, The Journal of biological chemistry.

Mad Bet for Rab

J. Goldstein, Michael S. Brown, 1993, Nature.

Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice

J. Goldstein, Michael S. Brown, G. Liang, 2019, Proceedings of the National Academy of Sciences.

Genetics of hyperlipidemia in coronary heart disease.

A. Motulsky, W. Hazzard, J. Goldstein, 1972, Transactions of the Association of American Physicians.

Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins.

S. Armstrong, M. Brown, J. Goldstein, 1995, Methods in enzymology.

Recycling of cell-surface receptors: observations from the LDL receptor system.

M. Brown, J. Goldstein, Michael S. Brown, 1982, Cold Spring Harbor symposia on quantitative biology.

The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.

T. Südhof, H. Hobbs, D. Russell, 1986, Cold Spring Harbor symposia on quantitative biology.

The LDL Receptor and the Regulation of Cellular Cholesterol Metabolism

M. Brown, J. Goldstein, Michael S. Brown, 1985, Journal of Cell Science.

Purification of ras farnesyl:Protein transferase

Y. Reiss, J. Goldstein, Michael S. Brown, 1990 .

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

M. Brown, J. Goldstein, D. Chin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar.

M. Brown, J. Goldstein, M. Brown, 1999, Proceedings of the Association of American Physicians.

Genetic and hormonal control of male sexual differentiation

J. Goldstein, Jean D. Wilson, 1975, Journal of cellular physiology.

Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization.

J. Wilson, J. Goldstein, 1972, The Journal of clinical investigation.

Familial incomplete male pseudohermaphroditism, type 1. Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome.

J. D. Wilson, J. Goldstein, P. Macdonald, 1974, The New England journal of medicine.

Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

M. Brown, J. Goldstein, Michael S. Brown, 1987, The Journal of cell biology.

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

M. Brown, J. Goldstein, D. Chin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role.

M. Brown, D. Andres, J. Goldstein, 1993, The Journal of biological chemistry.

Unexpected role for IGF-1 in starvation: Maintenance of blood glucose

J. Goldstein, Michael S. Brown, G. Liang, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Cystathionine synthase activity in human lymphocytes: induction by phytohemagglutinin.

J. Goldstein, S. Gartler, B. Campbell, 1972, Journal of Clinical Investigation.

Coated pits, coated vesicles, and receptor-mediated endocytosis

Joseph L. Goldstein, Richard G. W. Anderson, J. Goldstein, 1979, Nature.

Richard G.W. Anderson (1940–2011) and the birth of receptor-mediated endocytosis

J. Goldstein, Michael S. Brown, 2011, The Journal of cell biology.

The Low-Density Lipoprotein Receptor

J. Goldstein, Michael S. Brown, 1987 .

PICTORIAL ILLUSTRATIONS OF THE RECEPTOR-MEDIATED ENDOCYTOSIS OF LOW DENSITY LIPOPROTEIN VIA COATED REGIONS OF MEMBRANE

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1981 .

RECEPTOR-MEDIATED UPTAKE OF MACROMOLECULES AND THEIR DELIVERY TO LYSOSOMES IN HUMAN FIBROBLASTS

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1978 .

Familial hypercholesterolemia: model for genetic receptor disease.

M. Brown, J. Goldstein, 1979, Harvey lectures.

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

Joseph L. Goldstein, Mark A. Lehrman, Wolfgang J. Schneider, 1985, Cell.

LDL Receptor Mutations in Patients with Familial Hypercholesterolemia

H. Hobbs, D. Russell, J. Goldstein, 1987 .

Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia.

M. Brown, J. Goldstein, B. Kottke, 1982, Progress in clinical and biological research.

Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.

M. Brown, J. Goldstein, W. Schneider, 1983, Molecular biology & medicine.

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Akash Das, Joseph L. Goldstein, J. Goldstein, 2016, Proceedings of the National Academy of Sciences.

Surviving starvation: essential role of the ghrelin-growth hormone axis

J. Goldstein, Michael S. Brown, Tongjin Zhao, 2012, BMC Proceedings.

Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.

Joseph L. Goldstein, J. Goldstein, Michael S. Brown, 2010, Cell metabolism.

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

Miguel C. Seabra, Scott A. Armstrong, Joseph L. Goldstein, 1993, Cell.

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Joseph L. Goldstein, J. Deisenhofer, J. Goldstein, 2009, Cell.

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region.

M. Brown, J. Goldstein, Michael S. Brown, 1986, The Journal of biological chemistry.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

M. Brown, J. Goldstein, D. Chin, 1983, The Journal of biological chemistry.

Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain.

M. Brown, J. Goldstein, I. V. van Driel, 1987, The Journal of biological chemistry.

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

T. Kita, M. Brown, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Teaching old dogmas new tricks

J. Goldstein, Michael S. Brown, 1987, Nature.

Plasma lipoproteins: teaching old dogmas new tricks.

M. Brown, J. Goldstein, M. Brown, 1987, Nature.

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

M. Brown, P. Kovanen, J. Goldstein, 1978, The Journal of biological chemistry.

The low-density lipoprotein receptor-related protein: double agent or decoy?

J. Goldstein, Michael S. Brown, J. Herz, 1991 .

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.

U. Francke, M. Brown, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

M. Brown, J. Goldstein, J. Dietschy, 1979, The Journal of biological chemistry.

Hypercholesterolemia inLowDensity Lipoprotein Receptor Knockout MiceanditsReversal byAdenovirus-mediated GeneDelivery

M. Brown, J. Goldstein, 1993 .

The 1985 Nobel Prize Fu Medichse— Have Revolutionized Our Knowledge about Cholesterol Metabolisms and Heart Disease --- Number 38

E. Garfield, J. Goldstein, Michael S. Brown, 1986 .

Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

S. Grundy, D. Bilheimer, M. Brown, 1983, Transactions of the Association of American Physicians.

beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism.

M. Krieger, J. Kane, M. Brown, 1980, Biochemistry.

3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots.

M. Brown, J. Goldstein, P. Brannan, 1975, Journal of lipid research.

Regulation of cholesterol synthesis in normal and malignant tissue.

M. Brown, J. Goldstein, M. Siperstein, 1973, Federation proceedings.

Development of increased cytoplasmic binding of androgen in the submandibular gland of the mouse with testicular feminization.

J. Wilson, J. Dunn, J. Goldstein, 1973, The Journal of biological chemistry.

Protein prenylation. Mad bet for Rab.

M. Brown, J. Goldstein, M. Brown, 1993, Nature.

Visualization of acidic organelles in intact cells by electron microscopy.

M. Brown, J. Falck, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.

M. Brown, J. Goldstein, W. Schneider, 1980, The Journal of biological chemistry.

Complementation Cloning of S 2 P , a Gene Encoding a Putative Metalloprotease Required for Intramembrane

M. S. Brown, M. T. Hasan, J. Goldstein, 1997 .

Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

T. Osborne, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters.

J. R. Smith, M. Brown, J. Goldstein, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Lipoprotein receptors, cholesterol metabolism, and atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1975, Archives of pathology.

Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.

M. Brown, J. Goldstein, J. Faust, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for increased cytoplasmic androgen binding in the submandibular gland of the mouse with testicular feminization.

J. Goldstein, Jean D. Wilson, 1972, The Journal of biological chemistry.

The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor.

M. Brown, K. Mehta, J. Goldstein, 1991, The Journal of biological chemistry.

Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages.

M. Brown, J. Goldstein, Y. Ho, 1979, The Journal of biological chemistry.

Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice.

M. Krieger, M. Brown, J. Goldstein, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Gene therapy for cholesterol

R. Havel, D. Steinberg, J. Goldstein, 1994, Nature Genetics.

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.

M. Brown, J. Goldstein, M. Seabra, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture)

J. Goldstein, Michael S. Brown, 1986 .

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

M. Brown, D. Strickland, J. Goldstein, 1991, The Journal of biological chemistry.

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

M. Brown, J. Goldstein, Michael S. Brown, 2002, Science.

Genetic aspects of hyperlipidemia in coronary heart disease

J. Goldstein, 1973 .

Phosvitin kinase from the liver of the rooster. Purification and partial characterization.

J. Goldstein, M. Hasty, 1973, Journal of Biological Chemistry.

Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Methods in enzymology.

Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17a-ethinyl estradiol (SI nuclease assay/regulation of cell surface receptors/cholesterol metabolism)

J. Goldstein, Michael S. Brown, Tokuo T. Yamamoto, 2016 .

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.

P. Casey, Y. Reiss, M. Brown, 1991, Cell.

Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone

J. Goldstein, Michael S. Brown, Tong-Jin Zhao, 2015, Proceedings of the National Academy of Sciences.

Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation

Guoxun Chen, J. Goldstein, Michael S. Brown, 2022 .

cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.

U. Francke, T. Ozcelik, M. Brown, 1993, Genomics.

Atherosclerosis. Scavenging for receptors.

M. Brown, J. Goldstein, M. Brown, 1990, Nature.

Diet-induced hypercholesterolemia in mice

R. Hammer, J. Goldstein, Michael S. Brown, 1990 .

Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis.

D. Russell, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Molecular Characterization of Human Acetyl-CoA Synthetase, an Enzyme Regulated by Sterol Regulatory Element-binding Proteins*

J. Goldstein, Michael S. Brown, Voe C. Hannah, 2000, The Journal of Biological Chemistry.

The SREBP pathway in Drosophila: regulation by palmitate, not sterols.

J. Goldstein, Michael S. Brown, R. B. Rawson, 2002, Developmental cell.

How LDL receptors influence cholesterol and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1984, Scientific American.

Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.

J. Corbett, M. Brown, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

R. Mahley, R. Havel, J. Kane, 1981, The Journal of clinical investigation.

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.

R. Hammer, I. Shimomura, J. Richardson, 1998, Genes & development.

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

J. Goldstein, Michael S. Brown, H. Kwon, 2008, Proceedings of the National Academy of Sciences.

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.

R. Hammer, M. Matsuda, I. Shimomura, 2000, Molecular cell.

The low-density lipoprotein pathway and its relation to atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1977, Annual review of biochemistry.

The LDL receptor gene: a mosaic of exons shared with different proteins.

T. Südhof, D. Russell, M. Brown, 1985, Science.

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

D. Russell, J. Goldstein, Michael S. Brown, 1984, Cell.

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

J. Goldstein, Michael S. Brown, 2015, Cell.

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

X. Chen, M. Brown, R. Prywes, 2000, Molecular cell.

Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair Follicles

J. Goldstein, R. Sparkes, S. Gartler, 1971, Science.

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

M. Brown, J. Goldstein, M. Brown, 1983, Annual review of biochemistry.

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

D K Burns, D. Burns, M. Brown, 1994, The Journal of clinical investigation.

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

The clinical investigator: bewitched, bothered, and bewildered--but still beloved.

M. Brown, J. Goldstein, J L Goldstein, 1997, The Journal of clinical investigation.

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents.

M. Brown, J. Goldstein, Michael S. Brown, 1980, Journal of lipid research.

Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids.

M. Krieger, M. Brown, J. Goldstein, 1979, The Journal of biological chemistry.

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding

P. Dawson, N. Ridgway, M. Brown, 1992, The Journal of cell biology.

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

M. Brown, J. Goldstein, Michael S. Brown, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

M. Brown, J. Goldstein, R. G. Anderson, 1982, The Journal of biological chemistry.

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of biological chemistry.

Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone.

M. Brown, J. Goldstein, J. Faust, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol.

M. Brown, J. Goldstein, K. Luskey, 1974, The Journal of biological chemistry.

Expression of two X-linked genes in human hair follicles of double heterozygotes.

J. Goldstein, J. Marks, S. Gartler, 1971, Proceedings of the National Academy of Sciences of the United States of America.

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983.

S. Grundy, D. Bilheimer, J. Goldstein, 1983, Atherosclerosis. Supplements.

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

J. Goldstein, Michael S. Brown, D. Chin, 1985, Cell.

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.

M. Brown, J. Goldstein, Michael S. Brown, 1985, Molecular and cellular biology.

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.

M. Brown, J. Goldstein, M. Brown, 1984, Journal of lipid research.

HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions

T. Osborne, J. Goldstein, Michael S. Brown, 1984, Cell.

Regulation of plasma cholesterol by lipoprotein receptors.

M. Brown, P. Kovanen, J. Goldstein, 1981, Science.

The LDL receptor locus and the genetics of familial hypercholesterolemia.

M. Brown, J. Goldstein, J L Goldstein, 1979, Annual review of genetics.

Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells.

M. Krieger, A. Gotto, H. Pownall, 1979, Journal of supramolecular structure.

Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells.

M. Brown, J. Goldstein, Y. Ho, 1978, Blood.

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1981, Cell.

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

R. Hammer, M. Brown, J. Goldstein, 1993, The Journal of clinical investigation.

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

R J Havel, R. Mahley, R. Havel, 1982, Journal of lipid research.

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.

H. Hobbs, M. Brown, X. Hua, 1995, Genomics.

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

M. Nakanishi, M. Brown, J. Goldstein, 1988, The Journal of biological chemistry.

Targeted killing of cultured cells by receptor-dependent photosensitization.

M. Brown, J. Falck, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts.

M. Krieger, M. Brown, J. Goldstein, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

S. Grundy, D. Bilheimer, M. Brown, 1975, The Journal of clinical investigation.

The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages.

M. Brown, J. Falck, J. Goldstein, 1980, Journal of supramolecular structure.

Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.

A. Motulsky, W. Hazzard, J. Goldstein, 1973, The Journal of clinical investigation.

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication.

M. Gale, J. Goldstein, Michael S. Brown, 2005, Molecular cell.

Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta.

J. Goldstein, A. Damiano, E. Zotta, 2001, Placenta.

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.

Joseph L Goldstein, Jin Ye, J. Goldstein, 2006, Cell metabolism.

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.

I. Shimomura, M. Brown, H. Shimano, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

M. Brown, J. Goldstein, J L Goldstein, 1987, Circulation.

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

N. Grishin, J. Goldstein, Michael S. Brown, 2008, Cell.

Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to Humans

Joseph L Goldstein, Jin Ye, J. Goldstein, 2000, Cell.

Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing Domain*

J. Goldstein, Michael S. Brown, A. Nohturfft, 1998, The Journal of Biological Chemistry.

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains.

T. Südhof, D. Russell, M. Brown, 1985, Science.

Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia

D. Russell, J. Goldstein, Michael S. Brown, 1987, Cell.

Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides

P. Casey, Y. Reiss, J. Goldstein, 1990, Cell.

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

H. Hobbs, J. Goldstein, Michael S. Brown, 1992, Human mutation.

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man

J. Goldstein, Michael S. Brown, 1974, Science.

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.

R. Hammer, M. Brown, J. Goldstein, 1990, Science.

Cassette of eight exons shared by genes for LDL receptor and EGF precursor.

T. Südhof, D. Russell, G. Bell, 1985, Science.

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.

H. Hobbs, D. Russell, M. Brown, 1990, Annual review of genetics.

Hyperlipidemia in Coronary Heart Disease

Joseph L. Goldstein, J. Goldstein, E. Bierman, 1973 .

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.

M. Brown, J. Goldstein, Michael S. Brown, 1993, Science.

Lipoprotein receptors and the control of plasma LDL cholesterol levels.

M. Brown, J. Goldstein, M. Brown, 1992, European heart journal.

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

Shijie Li, J. Goldstein, Michael S. Brown, 2010, Proceedings of the National Academy of Sciences.

Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol*

Joseph L Goldstein, J. Goldstein, Michael S. Brown, 2003, Journal of Biological Chemistry.

Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells*

J. Goldstein, Michael S. Brown, J. Ou, 2001, The Journal of Biological Chemistry.

Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements.

C. Slaughter, M. Brown, K. Orth, 1989, The Journal of biological chemistry.

Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein

X. Hua, J. Goldstein, Michael S. Brown, 1996, Cell.

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

X. Hua, J. Goldstein, Michael S. Brown, 1994, Cell.

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

D. Russell, M. Brown, J. Goldstein, 1987, The Journal of biological chemistry.

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

M. Brown, J. Goldstein, J L Goldstein, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

X. Wang, M. Brown, J. Goldstein, 1996, The EMBO journal.

Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

M. Gale, R. Sumpter, J. Goldstein, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.

M. Brown, J. Goldstein, Michael S. Brown, 1993, The Journal of biological chemistry.

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.

P. Espenshade, M. Brown, J. Goldstein, 1998, Molecular cell.

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

J. Goldstein, Michael S. Brown, Akash Das, 2015, eLife.

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.

I. Shimomura, M. Brown, J. Horton, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*

R. Hammer, J. Horton, J. Goldstein, 2002, The Journal of Biological Chemistry.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

I. Shimomura, D. Mangelsdorf, J. Repa, 2000, Genes & development.

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

J. Goldstein, Michael S. Brown, D. Yabe, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.

D. Russell, M. Brown, J. Goldstein, 1986, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

S. Armstrong, T. Südhof, M. Brown, 1993, The Journal of biological chemistry.

The structure of human hemoglobin. VII. The digestion of the beta chain of human hemoglobin with pepsin.

W. Konigsberg, J. Goldstein, R. Hill, 1963, The Journal of biological chemistry.

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts

Richard G. W. Anderson, J. Goldstein, Michael S. Brown, 1977, Nature.

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.

U. Francke, P. Dawson, C. Hsieh, 1990, Genomics.

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

R. Hammer, I. Shimomura, M. Brown, 1996, The Journal of clinical investigation.

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

R. Hammer, M. Matsuda, I. Shimomura, 2001, Genes & development.

Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins*

P. Espenshade, J. Goldstein, Michael S. Brown, 1999, The Journal of Biological Chemistry.

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating Protein

J. Goldstein, Michael S. Brown, J. Sakai, 1998, The Journal of Biological Chemistry.

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

M. T. Hasan, J. Ye, M. Brown, 1997, Molecular cell.

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

R. Hammer, I. Shimomura, M. Brown, 1997, The Journal of clinical investigation.

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein*

J. Goldstein, Michael S. Brown, Y. Ho, 1997, The Journal of Biological Chemistry.

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

X. Hua, J. Goldstein, Michael S. Brown, 1996, Cell.

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

M. Brown, H. Otani, J. Goldstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

M. Brown, X. Hua, J. Wu, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

M. Brown, J. Goldstein, Michael S. Brown, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

P. Casey, Y. Reiss, J. Goldstein, 1991, Cell.

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro(*)

J. Goldstein, Michael S. Brown, G. James, 1995, The Journal of Biological Chemistry.

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Zhijian J. Chen, J. Goldstein, Michael S. Brown, 2018, eLife.

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

J. Richardson, J. Goldstein, Michael S. Brown, 2006, The Journal of clinical investigation.

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

M. Brown, J. Goldstein, Michael S. Brown, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A Golden Era of Nobel Laureates

J. Goldstein, Michael S. Brown, 2012, Science.

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

D. Russell, D. Andres, J. Goldstein, 1991, Cell.

Cellular Pathology of Progressive Atherosclerosis in the WHHL Rabbit: An Animal Model of Familial Hypercholesterolemia

T. Kita, J. Goldstein, Michael S. Brown, 1983, Arteriosclerosis.

Homocystinuria: heterozygote detection using phytohemagglutinin-stimulated lymphocytes.

J. Goldstein, S. Gartler, B. Campbell, 1973, The Journal of clinical investigation.

Lipoprotein receptors: therapeutic implications

J. Goldstein, Michael S. Brown, 1990, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size*

Joseph L Goldstein, J. Goldstein, Michael S. Brown, 2009, The Journal of Biological Chemistry.

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

H. Kuriyama, J. Horton, J. Goldstein, 2005, Cell metabolism.

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

T. Südhof, D. Russell, J. Goldstein, 1987, Cell.

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

M. Brown, J. Goldstein, D. Chin, 1983, The Journal of biological chemistry.

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet.

J. Goldstein, Michael S. Brown, Tong-Jin Zhao, 2014, Cell metabolism.

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain.

J. Goldstein, Michael S. Brown, H. Kwon, 2004, Molecular cell.

Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction.

A. Motulsky, W. Hazzard, J. Goldstein, 1973, The Journal of clinical investigation.

Purified NPC1 Protein

Lisa N Kinch, Nick V Grishin, Joseph L Goldstein, 2008, Journal of Biological Chemistry.

Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines

J. Goldstein, Michael S. Brown, Y. Ho, 1995, The Journal of Biological Chemistry.

Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages.

M. Brown, J. Goldstein, Michael S. Brown, 1983, Science.

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

S M Grundy, S. Grundy, D. Bilheimer, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

Richard G. W. Anderson, T. Südhof, D. Russell, 1987, Nature.

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching.

L Orci, L. Orci, M. Brown, 1978, Experimental cell research.

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

Joseph L Goldstein, J. Richardson, J. Shelton, 2011, Proceedings of the National Academy of Sciences.

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Proceedings of the National Academy of Sciences of the United States of America.

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

J. Goldstein, Michael S. Brown, Christopher M Adams, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Erratum: Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL (Journal of Lipid Research (2009) 50 (S15-S27))

J. Goldstein, Michael S. Brown, 2009 .

Molecular medicine. The cholesterol quartet.

M. Brown, J. Goldstein, M. Brown, 2001, Science.

Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol.

L. Orci, L. Garcia-Segura, M. Brown, 1983, Journal of cell science.

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

J. R. Smith, C. Slaughter, T. Osborne, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.

A. Motulsky, W. Hazzard, J. Goldstein, 1973, The Journal of clinical investigation.

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins*

C. Slaughter, P. Espenshade, J. Goldstein, 1999, The Journal of Biological Chemistry.

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

A. Murphy, G. Yancopoulos, M. Sleeman, 2010, Proceedings of the National Academy of Sciences.

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.

V. Koteliansky, J. Horton, J. Goldstein, 2012, Cell metabolism.

Lowering LDL--Not Only How Low, But How Long?

J. Goldstein, Michael S. Brown, 2006, Science.

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

J. Goldstein, Michael S. Brown, R. DeBose-Boyd, 2003, Molecular cell.

A case of genital self-amputation in which reconstruction was proposed.

J. Goldstein, D. Novins, J. E. Gerdis, 1990, General hospital psychiatry.

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

R. Stroud, J. Finer-Moore, M. Brown, 1985, The Journal of biological chemistry.

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol

J. McDonald, J. Goldstein, Michael S. Brown, 2022, Proceedings of the National Academy of Sciences.

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

T. Osborne, J. Goldstein, G. Gil, 1987, Proceedings of the National Academy of Sciences of the United States of America.

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

R. Cummings, J. Goldstein, R. G. Anderson, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice

I. Sakata, J. Zigman, J. Richardson, 2010, Proceedings of the National Academy of Sciences.

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides

J. Goldstein, Michael S. Brown, Tong-Jin Zhao, 2008, Proceedings of the National Academy of Sciences.

Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis*

J. Goldstein, Michael S. Brown, J. Feramisco, 2004, Journal of Biological Chemistry.

Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man.

J. Goldstein, M. Brown, 1974, Transactions of the Association of American Physicians.

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

M. S. Brown, N. Grishin, J. Goldstein, 2000, Proceedings of the National Academy of Sciences of the United States of America.

reply: Leptin and diabetes in lipoatrophic mice

Joseph L. Goldstein, R. Hammer, I. Shimomura, 2000, Nature.

Emerging Themes in Biology: Hints for the Future

D. Baltimore, P. Nurse, J. Goldstein, 2014, Cell.

The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking

P. Espenshade, J. Goldstein, Michael S. Brown, 2010 .

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

J. Goldstein, Michael S. Brown, R. Sato, 1994, Genes & development.

Familial pseudomembranous colitis and its relation to lincomycin therapy

J. Goldstein, Michael S. Brown, A. Weinberg, 1975, The American Journal of Digestive Diseases.

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

D. Rosenbaum, J. Goldstein, Michael S. Brown, 2021, Cell.

Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization.

L. Swanson, J. Goldstein, D. Simmons, 1988, Proceedings of the National Academy of Sciences of the United States of America.

REP-2, a Rab escort protein encoded by the choroideremia-like gene.

S. Armstrong, F. Cremers, J. Goldstein, 1994, The Journal of biological chemistry.

SREBPs: transcriptional mediators of lipid homeostasis.

J. Horton, J. Goldstein, Michael S. Brown, 2002, Cold Spring Harbor symposia on quantitative biology.

Classification of hereditary disorders of sexual development.

J. Goldstein, J. D. Wilson, 1975, Birth defects original article series.

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

J. Goldstein, Michael S. Brown, J. Seemann, 2018, eLife.

Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo.

J. Goldstein, U. Beisiegel, W. Schneider, 1981, The Journal of biological chemistry.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

B. Hawes, K. O'neill, J. Lisnock, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.

J. Goldstein, Michael S. Brown, R. Sato, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Genetic Heterogeneity in Familial Hyperc Different Mutations Affecting Functions o (cholesterol metabolism/atherosclerosis/hyperlipidemia/l

J. Goldstein, Michael S. Brown, S. E. Dana, 2016 .

Familial Hypercholesterolemia: Defective Cultured Fibroblasts Associated with Imp 3-Hydroxy-3-Methylglutaryl Coenzyme A (cholesterol synthesis/hyperlipidemia/atheroselerosis/en:

J. Goldstein, Michael S. Brown, 2016 .

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

D. Russell, J. Goldstein, R. G. Anderson, 1985, Annual review of cell biology.

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

R. Cummings, J. Goldstein, R. G. Anderson, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Regulated Intramembrane Proteolysis (Rip)

J. Goldstein, Michael S. Brown, Jin Ye, 2004 .

Linkage studies in a large kindred with familial hypercholesterolemia.

J. Ott, C. Falk, A. Motulsky, 1974, American journal of human genetics.

Atherosclerosis: Scavenger cell receptor shared

J. Goldstein, Michael S. Brown, 1985, Nature.

Scavenger cell receptor shared.

J. Goldstein, M. Brown, 1985, Nature.

Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins.

J. Goldstein, R. G. Anderson, Ravindra Kumar Pathak, 1989, The Journal of biological chemistry.

Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide.

J. Goldstein, C. Silberstein, C. Ibarra, 2002, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Starting out as a physician-scientist: the crucial first step on the ladder to success.

J. Goldstein, 2017, The Journal of clinical investigation.

Leptin and diabetes in lipoatrophic mice. Authors' reply

R. Hammer, L. Leon, M. Reitman, 2000 .

Suppression of 3 hydroxy 3 methylglutaryl coenzyme A reductase in familial hypercholesterolemia fibroblasts by cholesterol analogues

J. Goldstein, Michael S. Brown, 1974 .

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.

J. Goldstein, Michael S. Brown, J. Feramisco, 2002, Molecular cell.

Lowering plasma cholesterol by raising ldl receptors. 1981.

J. Goldstein, J L Goldstein, M S Brown, 2004, Atherosclerosis. Supplements.

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

J. Goldstein, Michael S. Brown, 2015, Cell.

HDL miR-ed Down by SREBP Introns

J. Goldstein, Michael S. Brown, Jin Ye, 2010, Science.

The amino acid sequence around the "reactive sulfhydryl" group of the beta chain from human hemoglobin.

W. Konigsberg, G. Guidotti, J. Goldstein, 1961, The Journal of biological chemistry.

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

J. Goldstein, Michael S. Brown, H. Kwon, 2008, Proceedings of the National Academy of Sciences.

Scientific Side Trips: Six Excursions from the Beaten Path

J. Goldstein, Michael S. Brown, 2012, The Journal of Biological Chemistry.

ERRATA

J. Goldstein, Michael S. Brown, 2009, Journal of Lipid Research.

New directions in human biochemical genetics: understanding the manifestations of receptor deficiency states.

J. Goldstein, M. Brown, 1976, Progress in medical genetics.

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.

J. Goldstein, D. Chin, L. Liscum, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Tetrapeptides Compete with p21(ras) for Farnesylation Catalyzed by Protein Farnesyltransferase

L. Gierasch, Y. Reiss, J. Goldstein, 1992 .

Biosynthesis of Cholesterol in Familial Hypercholesterolaemic Xanthomatosis

J. Fowler, J. Goldstein, C. Gray, 1959, British medical journal.

Presentation of the Kober Medal

J. Goldstein, Michael S. Brown, 2010 .