B. Maddux

发表

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.

Joseph L Evans, I. Goldfine, B. Maddux, 2002, Endocrine reviews.

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

Joseph L Evans, I. Goldfine, B. Maddux, 2003, Diabetes.

Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity

U. Masharani, D. Hessler, J. Youngren, 2012, BMC Endocrine Disorders.

Are Oxidative StressActivated Signaling Pathways Mediators of Insulin Resistance and -Cell

I. Goldfine, B. Maddux, G. Grodsky, 2003 .

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF‐1 receptor and androgen dependent growth of LAPC‐4 prostate cancer cells

J. Youngren, I. Goldfine, B. Maddux, 2008, The Prostate.

A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities.

E. Ferrannini, R. Vigneri, B. Maddux, 1999, The Journal of clinical endocrinology and metabolism.

Regulating Insulin-Receptor-Gene Expression by Differentiation and Hormones

A. Brunetti, I. Goldfine, B. Maddux, 1990, Diabetes Care.

Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels.

A. Brunetti, I. Goldfine, B. Maddux, 1989, The Journal of clinical investigation.

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.

C. Yip, I. Goldfine, B. Maddux, 1988, Biochemical and biophysical research communications.

Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.

J. Youngren, I. Goldfine, B. Maddux, 2005, Metabolism: clinical and experimental.

Mechanisms of Insulin-Induced Insulin-Receptor Downregulation: Decrease of Receptor Biosynthesis and mRNA Levels

I. Goldfine, B. Maddux, C. Logsdon, 1989, Diabetes.

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

R. Roth, I. Goldfine, B. Maddux, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.

A. Costantino, A. Belfiore, R. Vigneri, 1991, Molecular endocrinology.

Production of Inhibitor of Insulin-Receptor Tyrosine Kinase in Fibroblasts From Patient With Insulin Resistance and NIDDM

G. Reaven, I. Goldfine, B. Maddux, 1991, Diabetes.

Insulin‐cholera toxin binding unit conjugate: A hybrid molecule with insulin biological activity and cholera toxin binding specificity

R. Roth, B. Maddux, 1983, Journal of cellular physiology.

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

Joseph L Evans, J. Youngren, I. Goldfine, 2002, The Journal of clinical endocrinology and metabolism.

Regulation of Insulin Receptor Function by a Small Molecule Insulin Receptor Activator*

Joseph L Evans, J. Youngren, I. Goldfine, 2002, The Journal of Biological Chemistry.

Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

B. Zhang, J. Youngren, I. Goldfine, 2001, Diabetes.

IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance

L. Mandarino, I. Goldfine, B. Maddux, 2007, Diabetes Care.

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

I. Goldfine, B. Maddux, 2000, Diabetes.

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.

Y. Fujita-Yamaguchi, I. Goldfine, B. Maddux, 1993, Biochemistry.

Sequence and Analysis of Promoter Region of Human Insulin-Receptor Gene

I. Goldfine, B. Maddux, A. McDonald, 1988, Diabetes.

Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.

I. Goldfine, B. Maddux, E. Verspohl, 1988, The Journal of clinical endocrinology and metabolism.

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

I. Goldfine, B. Maddux, A. Montemurro, 1987, The Journal of biological chemistry.

Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity.

P. Vigneri, A. Costantino, A. Belfiore, 1996, Molecular endocrinology.

Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist.

R. Roth, I. Goldfine, B. Maddux, 1983, Biochemical and biophysical research communications.

Insulin-ricin B chain conjugate. A hybrid molecule with ricin-binding activity and insulin biological activity.

Y. Iwamoto, R. Roth, I. Goldfine, 1981, The Journal of biological chemistry.

Human insulin receptor radioimmunoassay: applicability to insulin-resistant states.

R. Vigneri, A. Brunetti, V. Papa, 1989, The American journal of physiology.

Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.

A. Brunetti, R. Yamamoto-Honda, I. Goldfine, 1992, Biochemistry.

Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.

G. Reaven, D. Moller, I. Goldfine, 1993, The Journal of clinical endocrinology and metabolism.

Biosynthesis and Processing of the Human Insulin Receptor

I. Goldfine, B. Maddux, J. Forsayeth, 1986, Diabetes.

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

I. Goldfine, B. Maddux, M. Sinha, 1987, Proceedings of the National Academy of Sciences of the United States of America.

in is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.

U. Masharani, J. Youngren, I. Goldfine, 2011 .

Regulation of Insulin-Receptor mRNA Levels by Glucocorticoids

I. Goldfine, B. Maddux, C. Logsdon, 1987, Diabetes.

Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.

A. Brunetti, C. Sung, I. Goldfine, 1991, Biochemical and biophysical research communications.

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

I. Goldfine, B. Maddux, 1991, The Journal of biological chemistry.

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase.

G. Firestone, A. Brunetti, I. Goldfine, 1989, The Journal of biological chemistry.

PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.

P. Schauerte, R. Terkeltaub, I. Goldfine, 2001, The American journal of pathology.

Tissue-specific Antibodies Against the Fibroblast Insulin Receptor in a Patient with Lupus Nephritis and Hypoglycemia

I. Testa, C. Martinis, A. Festa, 1985, Diabetes.

Erratum: IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance (Diabetes Care (2006) 29, (1535-1537))

L. Mandarino, I. Goldfine, B. Maddux, 2006 .

Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.

V. Papa, I. Goldfine, B. Maddux, 1991, Molecular endocrinology.

Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors.

I. Goldfine, C. Sung, B. Maddux, 1989, The Journal of biological chemistry.

Nordihydroguaiaretic acid inhibits insulin‐like growth factor signaling, growth, and survival in human neuroblastoma cells

K. Matthay, W. Weiss, J. Youngren, 2007, Journal of cellular biochemistry.

Production of antibodies that inhibit the binding of insulin to its receptor.

R. Roth, I. Goldfine, B. Maddux, 1981, Biochemical and biophysical research communications.

Human autoantibodies directed against the human, but not the rat, insulin receptor.

S. Gammeltoft, R. Lauro, L. Rossetti, 1985, The Journal of clinical endocrinology and metabolism.

Effect of amiodarone on L-triiodothyronine stimulation of [3H] thymidine incorporation into GH3 cells

K. Woeber, I. Goldfine, B. Maddux, 1982, Journal of endocrinological investigation.

Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors.

D. Styne, R. Roth, I. Goldfine, 1983, Endocrinology.

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF‐1 receptor tyrosine kinases, blocks the growth of HER2‐overexpressing human breast cancer cells

P. Kushner, L. Hodges, J. Youngren, 2008, Journal of cellular biochemistry.

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

S. Schow, J. Youngren, I. Goldfine, 2006, Molecular Cancer Therapeutics.

Nordihydroguaiaretic Acid (NDGA) Inhibits the IGF-1 and c-erbB2/HER2/neu Receptors and Suppresses Growth in Breast Cancer Cells

J. Youngren, I. Goldfine, B. Maddux, 2005, Breast Cancer Research and Treatment.

Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.

S. Rosewicz, I. Goldfine, I. Goldfine, 1988, The Journal of biological chemistry.

The molecular basis for oxidative stress-induced insulin resistance.

Joseph L Evans, I. Goldfine, B. Maddux, 2005, Antioxidants & redox signaling.

Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

S. Watson, I. Goldfine, B. Maddux, 2014, PloS one.

High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.

R. Vigneri, C. Yip, G. Milazzo, 1992, The Journal of clinical investigation.

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

G. Reaven, A. Grupe, J. Youngren, 1995, Nature.

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

D. Accili, G. Reaven, R. Vigneri, 2008, Endocrine reviews.

The Potential of a Diatom-Based Photosynthetic Biorefinery for Biofuels and Valued Co-Products

Debra K. Gale, B. Maddux, G. Rorrer, 2016 .

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

K. Clément, C. Dina, P. Boutin, 2005, Nature Genetics.

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

D. Accili, O. McGuinness, J. Youngren, 2006, American journal of physiology. Endocrinology and metabolism.

Insulin Resistance Induced by Hyperinsulinemia Coincides with a Persistent Alteration at the Insulin Receptor Tyrosine Kinase Domain

J. Youngren, I. Goldfine, F. Schaufele, 2014, PloS one.

Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.

J. Lawrence, I. Goldfine, B. Maddux, 2001, Diabetes.

Thyroid hormone binding in nonthyroid illness.

K. Woeber, B. Maddux, 1981, Metabolism: clinical and experimental.

Regulation of the insulin receptor by a monoclonal anti-receptor antibody. Evidence that receptor down regulation can be independent of insulin action.

R. Roth, I. Goldfine, B. Maddux, 1983, The Journal of biological chemistry.

Chloroquine stimulation of insulin binding to IM-9 lymphocytes: evidence for action at a nonlysosomal site.

Y. Iwamoto, I. Goldfine, B. Maddux, 1981, Biochemical and biophysical research communications.

Membrane glycoprotein PC-1 and insulin resistance

G. Dohm, J. Youngren, I. Goldfine, 1998, Molecular and Cellular Biochemistry.

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase.

A. Brunetti, C. Sung, I. Goldfine, 1989, Biochemical and biophysical research communications.

Insulin-ricin B chain conjugate has enhanced biological activity in insulin-insensitive cells.

Y. Iwamoto, R. Roth, I. Goldfine, 1983, Endocrinology.

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

R. Terkeltaub, D. Accili, Kristen Johnson, 2005, Diabetes.

PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity

R. Vigneri, J. Youngren, I. Goldfine, 1996, Diabetologia.

Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.

R. Guy, J. Youngren, I. Goldfine, 2006, Journal of combinatorial chemistry.

XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes

A. Mirza, I. Goldfine, B. Maddux, 2013, Obesity.

Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.

B. Maddux, M. K. Carter, 1974, Toxicology and applied pharmacology.

Role of PC‐1 in The Etiology of Insulin Resistance

J. Youngren, I. Goldfine, B. Maddux, 1999, Annals of the New York Academy of Sciences.

Membrane Glycoprotein PC1 Inhibition of Insulin Receptor Function Occurs Via Direct Interaction With the Receptor-Subunit

B. Maddux, Ira D. Goldfin, 1999 .

Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle

Xiaojuan Li, M. Schambelan, U. Masharani, 2011, PloS one.

Overexpression of membrane glycoprotein PC‐1 can influence insulin action at a post‐receptor site

C. Sung, B. Maddux, S. Kumakura, 1998, Journal of cellular biochemistry.

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

S. Watson, I. Goldfine, B. Maddux, 2012, Diabetes.

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody

S. Watson, I. Goldfine, B. Maddux, 2013, mAbs.

The effect of phenformin and other adenosine triphosphate (ATP)‐lowering agents on insulin binding to IM‐9 human cultured lymphocytes

R. Vigneri, I. Goldfine, B. Maddux, 1984, Journal of cellular biochemistry.

S-4: Insulin receptor inhibitors as a cause of insulin resistance

G. Dohm, J. Youngren, I. Goldfine, 2009 .

Skeletal Muscle Content of Membrane Glycoprotein PC-1 in Obesity: Relationship to Muscle Glucose Transport

G. Dohm, J. Youngren, I. Goldfine, 1996, Diabetes.

Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

J. Youngren, I. Goldfine, B. Maddux, 2001, Diabetes.