B. Sweatman

发表

A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.

R. Cox, R. Salek, J. Griffin, 2007, Physiological genomics.

Pattern recognition analysis of high resolution 1H NMR spectra of urine. A nonlinear mapping approach to the classification of toxicological data

J C Lindon, C. Beddell, J. Nicholson, 1990, NMR in biomedicine.

An automatic data reduction and transfer method to aid pattern recognition analysis and classification of NMR spectra.

J C Lindon, J. Lindon, B. Sweatman, 1992, Journal of pharmaceutical and biomedical analysis.

Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states.

C. Beddell, M. Spraul, J. Lindon, 1994, Analytical biochemistry.

The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury.

Alexander Amberg, Philip Hewitt, Hans Gmuender, 2011, Toxicology and applied pharmacology.

Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development.

Robert S Plumb, Brian C Sweatman, Susan C Connor, 2002, Rapid communications in mass spectrometry : RCM.

Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.

E Holmes, J C Lindon, C. Beddell, 1992, Molecular pharmacology.

Assignment of the 1H, 19F, and 13C NMR spectra of 2-deoxy-2-fluoro-d-ribose and characterisation of the isomeric equilibrium

J. Lindon, B. Sweatman, R. Farrant, 1996 .

Tryptophan–NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation

J. Holder, M. Hodson, S. Connor, 2005, Archives of Toxicology.

The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.

B. Sweatman, J. Bridges, T. Fennell, 1980, Chemico-biological interactions.

SUBSTRATE-ELICITED DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME P-450 COMPLEX AND THE CONSEQUENTIAL REACTIVATION OF MONOOXYGENATION

B. Sweatman, J. Bridges, C. Elcombe, 1977 .

A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry

I. J. Fraser, B. Sweatman, R. Plumb, 1998 .

4,4-Dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA), a promising universal internal standard for NMR-based metabolic profiling studies of biofluids, including blood plasma and serum

S. Connor, B. Ubhi, B. Sweatman, 2008, Metabolomics.

NMR of biofluids: detection of 2H-acetate and 2H-formate in urine as an indicator of microbiological contamination.

J. Lindon, B. Sweatman, R. Farrant, 1993, Journal of pharmaceutical and biomedical analysis.

Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV).

J. Lindon, B. Sweatman, R. Farrant, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Observation of Separate J-Resolved 1H-NMR Spectra from CH, CH2, and CH3 Groups Using a Maximum-Quantum Filter

J. Lindon, J. Nicholson, B. Sweatman, 1995 .

Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS

B. Sweatman, R. Plumb, G. Dear, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Drug metabolism in the ferret: effects of age, sex and strain.

C. Ioannides, D. Parke, B. Sweatman, 1977, General pharmacology.

Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han Rats: Implications for biomarker discovery

Brian C Sweatman, Susan C Connor, S. Connor, 2004, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in dog, cynomolgus monkey and mini-pig.

B. Sweatman, R. Plumb, G. Dear, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy.

J C Lindon, J. Lindon, J. Nicholson, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography

Stephanie Ringeissen, Paul McGill, Brian C Sweatman, 2003, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns

M. Hodson, S. Connor, B. Sweatman, 2004, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

N-O glucuronidation: a major human metabolic pathway in the elimination of two novel anticonvulsant drug candidates

B. Sweatman, R. Plumb, J. Ayrton, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances.

J. Lindon, J. Nicholson, E. Holmes, 1993, Journal of pharmaceutical and biomedical analysis.

Use of directly coupled ion-exchange liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification.

J. Lindon, J. Nicholson, B. Sweatman, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine.

J C Lindon, C. Beddell, J. Lindon, 1994, Molecular pharmacology.

Optimisation of collection, storage and preparation of rat plasma for 1H NMR spectroscopic analysis in toxicology studies to determine inherent variation in biochemical profiles.

Brian C Sweatman, Susan C Connor, S. Connor, 2002, Journal of pharmaceutical and biomedical analysis.

A Metabolomic Study of Brain Tissues from Aged Mice with Low Expression of the Vesicular Monoamine Transporter 2 (VMAT2) Gene

P. Emson, R. Salek, J. Griffin, 2008, Neurochemical Research.

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling*

Kieran Clarke, Julian L Griffin, Brian C Sweatman, 2005, Journal of Biological Chemistry.

Quantitative structure-metabolism relationships for substituted benzoic acids in the rat. Computational chemistry, NMR spectroscopy and pattern recognition studies.

R. Glen, C. Beddell, I. Wilson, 1992, Biochemical pharmacology.

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

Reza M. Salek, Brian C. Sweatman, Julian L. Griffin, 2010, Neurochemistry International.

Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships.

C. Beddell, I. Wilson, J. Lindon, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry.

B. Sweatman, R. Plumb, J. Ayrton, 1999, Rapid communications in mass spectrometry : RCM.

Tandem mass spectrometry linked fraction collection for the isolation of drug metabolites from biological matrices.

B. Sweatman, R. Plumb, J. Ayrton, 1999, Rapid communications in mass spectrometry : RCM.

Automatic reduction of NMR spectroscopic data for statistical and pattern recognition classification of samples.

E Holmes, M. Spraul, J. Nicholson, 1994, Journal of pharmaceutical and biomedical analysis.

DRUGS AND METABOLITES | Liquid Chromatography–Nuclear Magnetic Resonance–Mass Spectrometry

B. Sweatman, R. Plumb, G. Dear, 2000 .

Peak Alignment of Urine NMR Spectra Using Fuzzy Warping

Wen Wu, Beata Walczak, Michael Daszykowski, 2006, J. Chem. Inf. Model..

Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes.

Kay S Tatsuoka, Brian C Sweatman, Susan C Connor, 2008, Molecular bioSystems.

Weighted least-squares deconvolution method for discovery of group differences between complex biofluid 1H NMR spectra.

Geoffrey T Gipson, Kay S Tatsuoka, Brian C Sweatman, 2006, Journal of magnetic resonance.

Mapping the biochemical trajectory of nephrotoxicity by pattern recognition of NMR urinanalysis

E Holmes, J C Lindon, C. Beddell, 1992, NMR in biomedicine.

Characterization of in vitro metabolites from human liver microsomes using directly coupled hplc-nmr: application to a phenoxathiin monoamine oxidase-A inhibitor.

J. Lindon, B. Sweatman, R. Farrant, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

NMR spectroscopy of human post mortem cerebrospinal fluid: Distinction of Alzheimer's disease from control using pattern recognition and statistics

J C Lindon, C. Beddell, N. Cairns, 1993, NMR in biomedicine.