D. Ouwens

发表

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

J. Kaufman, P. Arner, D. Lamers, 2011, Diabetes.

Secretome profiling of primary human skeletal muscle cells.

M. D. de Angelis, M. Irmler, J. Beckers, 2014, Biochimica et biophysica acta.

Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes

D. Ouwens, H. Sips, J. Maassen, 1994, Molecular and cellular biology.

The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system

H. Pijl, J. Romijn, D. Ouwens, 2013, British journal of pharmacology.

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice[S]

H. Pijl, J. Romijn, L. Havekes, 2011, Journal of Lipid Research.

Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production.

J. Romijn, T. Derks, A. Grefhorst, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification

D. Ouwens, S. Coort, M. Diamant, 2007, Diabetologia.

Hyperosmotic stress activates the insulin receptor in CHO cells.

D. Ouwens, J. Dekker, D. S. Gomes de Mesquita, 2001, Biochimica et biophysica acta.

Glucocorticoids alter Subcutaneous Adipose Tissue Function and Adipokine Levels in vivo in Healthy Men

S. Lehr, D. Ouwens, M. Diamant, 2012 .

Effect of a 2-day very low-energy diet on skeletal muscle insulin sensitivity in obese type 2 diabetic patients on insulin therapy.

H. Pijl, D. Ouwens, A. Meinders, 2005, Metabolism: clinical and experimental.

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

W. Alkema, W. Fleuren, D. Ouwens, 2013, Archives of physiology and biochemistry.

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study.

W. Rathmann, C. Meisinger, M. Carstensen, 2015, European journal of endocrinology.

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice Published, JLR Papers in Press, August 16, 2003. DOI 10.1194/jlr.M300143-JLR200

B. Teusink, J. Romijn, L. Havekes, 2003, Journal of Lipid Research.

Heat Shock Protein 60 as a Mediator of Adipose Tissue In fl ammation and Insulin Resistance

M. Roden, Tina Märker, P. Pattyn, 2012 .

Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance

M. Roden, Tina Märker, P. Pattyn, 2012, Diabetes.

Chapter 3 Dietary fat-induced hepatic insulin resistance with regard to VLDL production in rats

J. Romijn, A. Meijer, D. Ouwens, 2002 .

Anti‐inflammatory cytokines and risk of type 2 diabetes

M. Carstensen, C. Herder, D. Ouwens, 2013, Diabetes, obesity & metabolism.

Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats

R. Heine, J. Maassen, D. Ouwens, 2005, Diabetologia.

Determinants of testosterone levels in human male obesity

J. Kaufman, D. Ouwens, J. Ruige, 2015, Endocrine.

Secretory Products From Epicardial Adipose Tissue of Patients With Type 2 Diabetes Mellitus Induce Cardiomyocyte Dysfunction

D. Ouwens, J. Ruige, J. Eckel, 2012, Circulation.

Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin

J. Bos, D. Ouwens, J. Dorrestijn, 1996, Diabetologia.

Combined Gene and Protein Expression of Hormone-Sensitive Lipase and Adipose Triglyceride Lipase, Mitochondrial Content, and Adipocyte Size in Subcutaneous and Visceral Adipose Tissue of Morbidly Obese Men

J. Kaufman, L. T. ’t Hart, P. Pattyn, 2011, Obesity Facts.

Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans

D. Ouwens, M. Diamant, R. E. van Genugten, 2011, Diabetes Care.

Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.

B. Teusink, J. Romijn, R. Zechner, 2003, Endocrinology.

Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function

D. Langin, D. Ouwens, J. Eckel, 2011, Journal of cellular and molecular medicine.

Cellular and Molecular Life Sciences REVIEW Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes

R. Schwenk, D. Ouwens, M. Diamant, 2022 .

Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats

J. Eckel, D. Ouwens, M. Diamant, 2006, Diabetes.

Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.

R. Schwenk, A. Bonen, D. Ouwens, 2009, The Journal of endocrinology.

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

J. Heitman, C. Alarcón, M. Cárdenas, 1997, Biochemical and biophysical research communications.

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.

T. Kuhn, H. Vogel, A. Schürmann, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

N. Tennagels, J. Eckel, Nina Wronkowitz, 2016, Cardiovascular Diabetology.

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes*

D. Lamers, S. Famulla, S. Hartwig, 2011, Molecular & Cellular Proteomics.

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.

G. H. Thoresen, B. Knebel, D. Müller-Wieland, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Endogenous IL-10 Protects Against Hepatic Steatosis, but Does Not Improve Insulin Sensitivity During High Fat Feeding in Mice

J. Romijn, L. Havekes, D. Ouwens, 2006 .

Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice.

J. Romijn, E. Korsheninnikova, L. Havekes, 2006, Endocrinology.

Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity.

D. Ouwens, B. Lapauw, Y. Van Nieuwenhove, 2021, Cytokine.

Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E

M. Roden, C. Herder, D. Ouwens, 2019, PloS one.

The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease

D. Ouwens, H. Sell, J. Eckel, 2010, Journal of cellular and molecular medicine.

Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy

W. Rathmann, C. Meisinger, M. Roden, 2015, Diabetic medicine : a journal of the British Diabetic Association.

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

J. Romijn, A. Grefhorst, E. Korsheninnikova, 2006, Diabetologia.

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes.

P. J. Simons, M. V. van Zandvoort, K. Douma, 2012, The Biochemical journal.

Differential regulation of cardiac glucose and fatty acid uptake by endosomal pH and actin filaments.

R. Schwenk, A. Bonen, D. Ouwens, 2010, American journal of physiology. Cell physiology.

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid

G. H. Thoresen, D. Ouwens, E. T. Kase, 2018, PloS one.

Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

M. Bazuine, D. Ouwens, J. Maassen, 2003, European journal of biochemistry.

High intensity interval training is associated with greater impact on physical fitness, insulin sensitivity and muscle mitochondrial content in males with overweight/obesity, as opposed to continuous endurance training: a randomized controlled trial

D. Hansen, D. Ouwens, C. Tonoli, 2018, Journal of musculoskeletal & neuronal interactions.

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity

J. Kaufman, A. Geerts, D. Ouwens, 2016, Obesity.

in the liver in mice

B. Teusink, J. Romijn, L. Havekes, 2003 .

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.

A. Kessler, I. Uphues, D. Ouwens, 2001, American journal of physiology. Endocrinology and metabolism.

Diversification of cardiac insulin signaling involves the p85α/β subunits of phosphatidylinositol 3-kinase

A. Kessler, I. Uphues, D. Ouwens, 2001 .

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography

M. Lubberink, A. Lammertsma, D. Ouwens, 2009, Cardiovascular diabetology.

Molecular mechanisms of contraction-regulated cardiac glucose transport.

A. Kessler, J. Eckel, D. Ouwens, 2000, The Biochemical journal.

The role of JNK, p38 and ERK MAP-kinases in insulin-induced Thr69 and Thr71-phosphorylation of transcription factor ATF2

D. Ouwens, J. Maassen, G. C. Zon, 2009 .

The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells

D. Ouwens, J. Maassen, G. C. Zon, 2009, Molecular and Cellular Endocrinology.

Transcription Factor 2 Kinase in Insulin-Induced Thr69 and Thr71 Phosphorylation of Activating The Role of c-Jun N-Terminal Kinase, p38, and Extracellular Signal-Regulated

D. Ouwens, J. Maassen, G. C. Zon, 2006 .

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

H. van Dam, D. Ouwens, J. Maassen, 2006, Molecular endocrinology.

CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health

B. Knebel, J. Kotzka, S. Lehr, 2018, International Journal of Obesity.

Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity

F. Klauschen, D. Ouwens, N. Rudovich, 2021, Cells.

SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status

J. Beckmann, A. Smit, J. Hillebrands, 2007, Molecular and Cellular Neuroscience.

The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal gamma delta T cells

C. Esser, D. Ouwens, K. Hochrath, 2020, EXCLI journal.

Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin–angiotensin system and induction of miR-208a

D. Ouwens, J. Ruige, P. Akhyari, 2016, Basic Research in Cardiology.

Effects of dipeptidyl peptidase‐4 inhibitor linagliptin versus sulphonylurea glimepiride on systemic haemodynamics in overweight patients with type 2 diabetes: A secondary analysis of an 8‐week, randomized, controlled, double‐blind trial

D. Ouwens, M. Kramer, D. V. van Raalte, 2020, Diabetes, obesity & metabolism.

Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese men.

J. Kaufman, P. Pattyn, T. Fiers, 2012, The Journal of clinical endocrinology and metabolism.

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

C. Kahn, J. Maassen, J. Bos, 1994, The Journal of biological chemistry.

Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes

G. H. Thoresen, D. Ouwens, V. Aas, 2019, Cells.

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

J. Kaufman, D. De Bacquer, T. Fiers, 2012, Heart.

Soluble CD14 inhibits contractile function and insulin action in primary adult rat cardiomyocytes.

D. Ouwens, P. Akhyari, B. Maxhera, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Postprandial renal haemodynamic effects of the dipeptidyl peptidase‐4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS): A predefined substudy of a randomized, double‐blind trial

J. Holst, B. Hartmann, D. Ouwens, 2021, Diabetes, obesity & metabolism.

The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes

O. Kuss, A. Pfeiffer, A. Schürmann, 2018, Diabetologia.

Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF‐I and secrete more IGFBP‐3

A. Zwinderman, J. Wit, D. Ouwens, 2002, Clinical endocrinology.

Diversiﬁcation of cardiac insulin signaling involves the p85 a / b subunits of phosphatidylinositol 3-kinase

A. Kessler, I. Uphues, J. Eckel, 2000 .

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

D. Ouwens, M. Diamant, B. Guigas, 2010, Cellular signalling.

Effect of Sfrp5 on Cytokine Release and Insulin Action in Primary Human Adipocytes and Skeletal Muscle Cells

M. Carstensen, M. Roden, C. Herder, 2014, PloS one.

Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity

H. Boeing, M. Weickert, D. Ouwens, 2018, Journal of Cell Communication and Signaling.

Role of PRAS40 in Akt and mTOR signaling in health and disease.

D. Ouwens, E. Nascimento, C. Wiza, 2012, American journal of physiology. Endocrinology and metabolism.

Interactive contribution of hyperinsulinemia, hyperglycemia, and mammalian target of rapamycin signaling to valvular interstitial cell differentiation and matrix remodeling

A. Lichtenberg, M. Barth, D. Ouwens, 2022, Frontiers in Cardiovascular Medicine.

Adding exercise to a 16-week very low calorie diet in obese, insulin-dependent type 2 diabetes mellitus patients improves metabolic flexibility, VO 2max and mitochondrial copy number in skeletal muscle

J. Romijn, A. Gastaldelli, M. Hesselink, 2011 .

Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact.

D. Ouwens, J. Dorrestijn, J. Maassen, 1996, Biochemistry.

Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial

J. Holst, B. Hartmann, D. Ouwens, 2020, Diabetes Care.

Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?

D. Ouwens, M. Diamant, D. V. van Raalte, 2009, European journal of clinical investigation.

Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle

A. Schürmann, D. Ouwens, H. Al-Hasani, 2014, Archives of physiology and biochemistry.

Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D.

A. Ullrich, M. Stein-Gerlach, D. Ouwens, 1996, The Biochemical journal.

Signaling by insulin receptors and related protein tyrosine kinases

D. Ouwens, J. Maassen, 1996 .

Growth factors can activate ATF2 via a two‐step mechanism: phosphorylation of Thr71 through the Ras–MEK–ERK pathway and of Thr69 through RalGDS–Src–p38

K. Kooistra, A. Carter, J. Bos, 2002, The EMBO journal.

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

P. Schrauwen, D. Ouwens, Esther Moonen-Kornips, 2012, Diabetes.

VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells: Depot-Specific Release from Visceral and Perivascular Adipose Tissue

A. Lichtenberg, W. Knoefel, J. Eckel, 2013, Mediators of inflammation.

Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes

G. Shulman, M. Roden, J. Szendroedi, 2014, Diabetes.

PRAS40: Target or modulator of mTORC1 signalling and insulin action?

D. Ouwens, E. Nascimento, 2009, Archives of physiology and biochemistry.

CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells

Wei Zhang, Tao Jiang, H. Steiger, 2017, British Journal of Cancer.

Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment—Impact on Aortic Valve Remodeling

A. Lichtenberg, M. Barth, D. Ouwens, 2021, International journal of molecular sciences.

SIGNALING BY INSULIN RECEPTORS AND RELATED PROTEIN

D. Ouwens, J. Maassen, 1996 .

The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.

H. Pijl, J. Romijn, L. Havekes, 2010, Biochemical pharmacology.

MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease

J. H. van Bockel, J. Bernhagen, L. Leng, 2009, Circulation research.

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients

H. Pijl, J. Maassen, J. Romijn, 2007, Diabetologia.

Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143.

D. Ouwens, J. Ruige, P. Akhyari, 2013, Cardiovascular research.

Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.

M. Heymans, P. Pouwels, A. Mari, 2014, European journal of endocrinology.

Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6

K. Stühler, B. Knebel, J. Kotzka, 2014, Archives of physiology and biochemistry.

Beneficial and adverse effects of testosterone on the cardiovascular system in men.

J. Kaufman, D. Ouwens, J. Ruige, 2013, The Journal of clinical endocrinology and metabolism.

Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy

D. Ouwens, M. Diamant, 2007, Archives of physiology and biochemistry.

Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.

M. J. Wagner, H. Westerhoff, R. Heine, 2007, Biochimica et biophysica acta.

Glucose Intolerance and the Amount of Visceral Adipose Tissue Contribute to an Increase in Circulating Triglyceride Concentrations in Caucasian Obese Females

J. Kaufman, L. V. Van Gaal, D. Ouwens, 2012, PloS one.

Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

Nina Wronkowitz, D. Ouwens, H. Sell, 2014, Biochimica et biophysica acta.

Regulation of Sarcolemmal Transport of Substrates in the Healthy and Diseased Heart

A. Bonen, D. Ouwens, J. Glatz, 2006, Cardiovascular Drugs and Therapy.

Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice

P. Schrauwen, D. Ouwens, S. Paglialunga, 2012, Diabetologia.

Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men

B. Knebel, D. Müller-Wieland, J. Kotzka, 2020, International journal of molecular sciences.

Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice

J A Romijn, J. Romijn, E. Korsheninnikova, 2007, Archives of physiology and biochemistry.

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells

S. Lehr, D. Ouwens, H. Al-Hasani, 2013, Diabetologia.

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes

J. Maassen, L. T. ’t Hart, D. Ouwens, 2007, Current opinion in clinical nutrition and metabolic care.

Activation of overexpressed receptors for insulin and epidermal growth factor interferes in mitogenic signaling without affecting the activation of p21ras.

R. Medema, D. Ouwens, W. Möller, 1994, Biochemistry.

Cardioprotective Properties of Omentin-1 in Type 2 Diabetes: Evidence from Clinical and In Vitro Studies

Jeroen J. Bax, H. Lamb, A. Lichtenberg, 2013, PloS one.

Intracerebroventricular Administration of Neuropeptide Y Induces Hepatic Insulin Resistance via Sympathetic Innervation

H. Pijl, A. Kalsbeek, J. Romijn, 2008, Diabetes.

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

K. Meijer, G. Shulman, M. Hopman, 2020, Diabetologia.

Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome

J. Kaufman, S. Hartwig, S. Lehr, 2012, Archives of physiology and biochemistry.

Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis

B. Knebel, J. Kotzka, S. Hartwig, 2020, Scientific Reports.

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells.

W. Alkema, D. Ouwens, M. Diamant, 2011, Cellular signalling.

Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice.

D. Ouwens, M. Diamant, A. Chabowski, 2011, American journal of physiology. Endocrinology and metabolism.

Cerebrospinal fluid levels of Alzheimer’s disease biomarkers in middle-aged patients with type 1 diabetes

P. Scheltens, F. Barkhof, A. Moll, 2014, Diabetologia.

Role of PRAS 40 in Akt and mTOR signaling in health and disease

D. Ouwens, E. Nascimento, C. Wiza, 2012 .

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice

F. Bosch, G. H. Thoresen, A. Pujol, 2018, Endocrinology.

Proline-rich Akt substrate of 40-kDa contains a nuclear export signal.

F. Carlotti, D. Ouwens, M. Diamant, 2013, Cellular signalling.

Glucocorticoid treatment impairs microvascular function in healthy men in association with its adverse effects on glucose metabolism and blood pressure: a randomised controlled trial

D. Ouwens, R. IJzerman, M. Diamant, 2013, Diabetologia.

Glucocorticoid Treatment Impairs Microvascular Function in Healthy Males, in Association with its Adverse Effects on Glucose Metabolism and Blood Pressure

D. Ouwens, R. IJzerman, M. Diamant, 2012 .

Activin a is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes

H. Lamb, A. Roos, M. Lubberink, 2013, Cardiovascular Diabetology.

Effects of adding exercise to a 16-week very low-calorie diet in obese, insulin-dependent type 2 diabetes mellitus patients.

H. Pijl, J. Romijn, A. Gastaldelli, 2012, The Journal of clinical endocrinology and metabolism.

Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells - A link between aortic heart valve degeneration and type 2 diabetes.

A. Lichtenberg, J. Fischer, M. Barth, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography

M. Lubberink, A. Lammertsma, D. Ouwens, 2009 .

Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

B. Viollet, L. Bertrand, M. Foretz, 2013, Journal of molecular and cellular cardiology.