J. Lowenson

发表

A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis

G. Giaever, C. Nislow, A. Baryshnikova, 2011, PLoS genetics.

Proteomic Identification of Novel Substrates of a Protein Isoaspartyl Methyltransferase Repair Enzyme*

D. Ray, S. Clarke, W. Carter, 2006, Journal of Biological Chemistry.

Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins.

Eric Z. Pang, S. Clarke, J. Lowenson, 2022, Biochemistry.

Chemical modifications of deposited amyloid-beta peptides.

S. Clarke, A. Roher, J. Lowenson, 1999, Methods in enzymology.

Structural elements affecting the recognition of L-isoaspartyl residues by the L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis.

S. Clarke, J. Lowenson, 1991, The Journal of biological chemistry.

An Arabidopsis ATP-Dependent, DEAD-Box RNA Helicase Loses Activity upon IsoAsp Formation but Is Restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE[C][W]

S. Clarke, S. E. Perry, P. Limbach, 2013, Plant Cell.

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt 1 2 / 2 Mice

S. Clarke, J. Lowenson, K. B. MacKay, 2012 .

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice

S. Clarke, J. Lowenson, K. B. MacKay, 2012, PloS one.

Deuteration protects asparagine residues against racemization

M. Shchepinov, S. Clarke, J. Lowenson, 2016, Amino Acids.

D-aspartate content of erythrocyte membrane proteins is decreased in uremia: implications for the repair of damaged proteins.

S. Clarke, J. Lowenson, A. D’Aniello, 1997, Journal of the American Society of Nephrology : JASN.

Synapsin I Is a Major Endogenous Substrate for Protein L-Isoaspartyl Methyltransferase in Mammalian Brain*

D. Aswad, K. Reissner, J. Lowenson, 2006, Journal of Biological Chemistry.

Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping.

S. Clarke, B. Karger, Shujia Dai, 2008, Analytical chemistry.

Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor.

J. Kuo, S. Clarke, J. Lowenson, 1990, Biochemistry.

Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation.

S. Clarke, J. Lowenson, 1991, Gerontology.

Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase.

S. Clarke, J. Lowenson, 1990, The Journal of biological chemistry.

Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.

S. Clarke, J. Lowenson, 1988, Blood cells.

Protein Repair L-Isoaspartyl Methyltransferase in Plants (Phylogenetic Distribution and the Accumulation of Substrate Proteins in Aged Barley Seeds)

S. Clarke, J. Lowenson, M. B. Mudgett, 1997, Plant physiology.

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

M J Ball, M. Ball, S. Clarke, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

M J Ball, M. Ball, I. Reardon, 1993, The Journal of biological chemistry.

Limited Accumulation of Damaged Proteins inl-Isoaspartyl (d-Aspartyl)O-Methyltransferase-deficient Mice*

Stephen G. Young, Steven Clarke, S. Young, 2001, The Journal of Biological Chemistry.

Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.

S. Young, S. Clarke, J. Lowenson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Phenotypic Analysis of Seizure-prone Mice Lacking l-Isoaspartate (d-Aspartate)O-Methyltransferase*

S. Young, S. Clarke, J. Lowenson, 1999, The Journal of Biological Chemistry.

Protein aging Extracellular amyloid formation and intracellular repair.

S. Clarke, A. Roher, J. Lowenson, 1994, Trends in cardiovascular medicine.

Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice.

R. Zubarev, S. Clarke, Hongqian Yang, 2013, Journal of proteome research.

Recognition of D-aspartyl residues in polypeptides by the erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis.

S. Clarke, J. Lowenson, S Clarke, 1992, The Journal of biological chemistry.

Intracellular protein modification associated with altered T cell functions in autoimmunity

D. Aswad, S. Clarke, J. Lowenson, 2006, The Journal of Immunology.

Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning*

S. Clarke, S. E. Perry, T. Rejtar, 2010, The Journal of Biological Chemistry.

Deuteration protects asparagine residues against racemization

M. Shchepinov, S. Clarke, J. Lowenson, 2016, Amino Acids.

Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity1

D. Aswad, S. Clarke, J. Lowenson, 2006, The Journal of Immunology.

Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.

S. Clarke, J. Perry, J. Lowenson, 2020, Journal of structural biology.