J. Horowitz

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Mechanisms for the Resolution of Organ Fibrosis.

J. Horowitz, V. Thannickal, 2019, Physiology.

Extracellular matrix in lung development, homeostasis and disease.

L. Niklason, N. Ambalavanan, A. Engler, 2018, Matrix biology : journal of the International Society for Matrix Biology.

Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute.

R. Wells, C. Henke, E. White, 2014, The American journal of pathology.

Idiopathic Pulmonary Fibrosis

J. Horowitz, V. Thannickal, 2006, Treatments in respiratory medicine.

Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis

D. Tschumperlin, J. Horowitz, T. Sisson, 2019, Thrombosis and Haemostasis.

Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury.

F. Martinez, T. Standiford, J. Horowitz, 2005, The American journal of pathology.

The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis.

J. Horowitz, T. Sisson, M. Agarwal, 2016, American journal of physiology. Lung cellular and molecular physiology.

Fibroblast biology in idiopathic pulmonary fibrosis

J. Horowitz, V. Thannickal, 2015 .

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

J. Horowitz, E. Canalis, Kevin K. Kim, 2014, American journal of physiology. Lung cellular and molecular physiology.

and Paracrine Secretion of Connective Tissue Growth Factor

J. Horowitz, E. Canalis, Kevin K. Kim, 2014 .

Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top‐Down” approach to intestinal fibrosis in mice

A. Luke, P. Higgins, L. Johnson, 2012, Inflammatory bowel diseases.

Stress in the ER (endoplasmic reticulum): a matter of life and death for epithelial cells.

J. Horowitz, A. Limper, 2008, American journal of respiratory and critical care medicine.

Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.

Shaomeng Wang, C. Duckett, J. Horowitz, 2016, American journal of respiratory cell and molecular biology.

Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

J. Horowitz, V. Thannickal, G. Toews, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts

J. Horowitz, V. Thannickal, Y. Sanders, 2019, American journal of respiratory cell and molecular biology.

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

R. Neubig, V. Keshamouni, P. Higgins, 2015, The American journal of pathology.

Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome.

T. Standiford, T. Moore, J. Horowitz, 2006, American journal of physiology. Lung cellular and molecular physiology.

Mesenchymal Cell Fate and Phenotypes in the Pathogenesis of Emphysema

F. Martinez, J. Horowitz, V. Thannickal, 2009, COPD.

IDIOPATHIC PULMONARY FIBROSIS: NEW CONCEPTS IN PATHOGENESIS AND IMPLICATIONS FOR DRUG THERAPY

J. Horowitz, V. Thannickal, 2008 .

Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis

Hui Liu, J. Horowitz, V. Thannickal, 2016, Scientific Reports.

Pulmonary fibrosis induced by γ-herpesvirus in aged mice is associated with increased fibroblast responsiveness to transforming growth factor-β.

T. Moore, J. Horowitz, B. Moore, 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

Endobronchial biopsy of an intrapulmonary arterial mass.

J. Horowitz, D. Arenberg, Kathryn R Kleaveland, 2013, Journal of bronchology & interventional pulmonology.

SMAD-Independent Down-Regulation of Caveolin-1 by TGF-β: Effects on Proliferation and Survival of Myofibroblasts

J. Horowitz, V. Thannickal, Y. Sanders, 2015, PloS one.

Blood 1 J U L Y 2 0 1 0 I V O L U M E 1 1 5 , N U M B E R 2 6

S. Chanock, J. Horowitz, Katayama, 2022 .

Interleukin 6 gene expression in normal and neoplastic B cells.

G. Freeman, A. Freedman, L. Nadler, 1989, The Journal of clinical investigation.

Pathogenesis of pneumonia and acute lung injury.

R. Mallampalli, J. Horowitz, M. E. Long, 2022, Clinical science.

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.

T. Koh, D. Lawrence, J. Horowitz, 2011, Blood.

Epithelium from Oxidant-Mediated Death Lung Injury by Protecting the Alveolar TLR Signaling Prevents Hyperoxia-Induced

R. Flavell, D. Pinsky, Xianying Zeng, 2012 .

TLR Signaling Prevents Hyperoxia-Induced Lung Injury by Protecting the Alveolar Epithelium from Oxidant-Mediated Death

T. Standiford, R. Flavell, D. Pinsky, 2012, The Journal of Immunology.

Endobronchial Ultrasound-guided Biopsy of an Intrapulmonary Arterial Mass

J. Horowitz, 2013 .

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Steven K. Huang, D. Tschumperlin, J. Horowitz, 2018, Respiratory Research.

Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.

David S. Rogers, P. Higgins, Steven K. Huang, 2012, The international journal of biochemistry & cell biology.

Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt

E. White, J. Horowitz, M. Agarwal, 2018, American journal of respiratory cell and molecular biology.

Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.

David S. Rogers, J. Horowitz, V. Thannickal, 2008, American journal of respiratory cell and molecular biology.

PAI‐1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury

D. Lawrence, M. Olszewski, J. Horowitz, 2012, The Journal of pathology.

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report

C. E. Perlman, S. Matalon, J. Bates, 2022, American journal of respiratory cell and molecular biology.

Fibroblast growth factors and pulmonary fibrosis: it's more complex than it sounds

J. Horowitz, T. Sisson, Kevin K. Kim, 2017, The Journal of pathology.

Fibroblast Growth Factors and Pulmonary Fibrosis : It ’ s more complex than it sounds † Running Title : Pleiotropic actions of FGFs in lung fibrosis

J. Horowitz, T. Sisson, Kevin K. Kim, 2016 .

Outstaying their Welcome: The Persistent Myofibroblast

J. Horowitz, 2014 .

Outstaying their Welcome: The Persistent Myofibroblast in IPF.

Steven K. Huang, J. Horowitz, Steven K. Huang, 2014, Austin journal of pulmonary and respiratory medicine.

Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation.

David S. Rogers, J. Horowitz, V. Thannickal, 2009, American journal of respiratory cell and molecular biology.

Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β.

J. Horowitz, V. Thannickal, Q. Ding, 2017, American journal of physiology. Lung cellular and molecular physiology.

Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia

J. Horowitz, J. Jennings, M. Lazar, 2022, Journal of intensive care medicine.

Normal cellular counterparts of B cell chronic lymphocytic leukemia.

F. Bieber, D. N. Levy, A. Freedman, 1987, Blood.

Expression of B cell activation antigens on normal and malignant B cells.

A. Berrebi, D. N. Levy, A. Freedman, 1987, Leukemia.

Studies of the in vitro activation and differentiation of human B lymphocytes. II. Optimization of activation by anti-immunoglobulin antibody bound to beads: analysis of the role of autocrine effects on B-cell proliferation and of T-cell help in B-cell differentiation.

A. Freedman, D. Fisher, A. Boyd, 1986, Cellular immunology.

B7, a B-cell-restricted antigen that identifies preactivated B cells.

G. Freeman, A. Freedman, L. Nadler, 1987, Journal of immunology.

Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis.

Heather Wang, Yutong Zhao, J. Horowitz, 2022, Translational research : the journal of laboratory and clinical medicine.

Phenotypic Changes Occurring during in vitro Activation of Human Splenic B Lymphocytes

A. Freedman, D. Fisher, A. Boyd, 1986 .

How a fibroblast ages: a role for bone morphogenetic protein 4 in protecting lung fibroblasts from senescence in pulmonary fibrosis

L. Farkas, J. Horowitz, A. Mora, 2022, European Respiratory Journal.

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Philip D. Blood, Matthew A. Wyczalkowski, Andrew C. Nelson, 2022, Nature aging.

Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.

David S. Rogers, E. White, J. Horowitz, 2007, Cellular signalling.

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor*

V. Keshamouni, J. Horowitz, V. Thannickal, 2004, Journal of Biological Chemistry.

NADPH Oxidase-4 Mediates Myofibroblast Activation and Fibrogenic Responses to Lung Injury

F. Martinez, J. Horowitz, V. Thannickal, 2009, Nature Medicine.

Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts

P. Higgins, L. Johnson, D. Tschumperlin, 2013, Inflammatory bowel diseases.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Lauren E. Stopfer, X. Varelas, D. Tschumperlin, 2015 .

Evolving concepts of apoptosis in idiopathic pulmonary fibrosis.

J. Horowitz, V. Thannickal, 2006, Proceedings of the American Thoracic Society.

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

J. Horowitz, V. Thannickal, Victor Thannickal1, 2006, Seminars in respiratory and critical care medicine.

Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways

E. White, M. Peters-Golden, J. Horowitz, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

“Scar-cinoma”: viewing the fibrotic lung mesenchymal cell in the context of cancer biology

J. Horowitz, J. Osterholzer, G. Stathopoulos, 2016, European Respiratory Journal.

X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis.

P. Higgins, E. White, J. E. King, 2013, American journal of respiratory cell and molecular biology.

Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases

J. Horowitz, V. Thannickal, B. Moore, 2007, Journal of Pharmacology and Experimental Therapeutics.

Increased survivin expression contributes to apoptosis-resistance in IPF fibroblasts.

P. Higgins, E. White, J. E. King, 2012, Advances in Bioscience and Biotechnology.

Idiopathic Pulmonary Fibrosis

J. Horowitz, V. Thannickal, 2006, Treatments in respiratory medicine.

Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation.

Kevin Weiss, Laura E Niklason, Thomas H Barker, 2012, American journal of respiratory and critical care medicine.

Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase*

R. Day, E. White, J. Horowitz, 2003, The Journal of Biological Chemistry.

Ultrasound strain measurements for evaluating local pulmonary ventilation

J. Rubin, Kang Kim, J. Horowitz, 2015, IUS.

Antipneumococcal effects of C-reactive protein and monoclonal antibodies to pneumococcal cell wall and capsular antigens

L. McDaniel, J. Volanakis, J. Horowitz, 1989, Infection and immunity.

Genetic control of the susceptibility to pneumococcal infection.

L. McDaniel, J. Horowitz, D. Briles, 1986, Current topics in microbiology and immunology.

A role for Toll-like receptor 3 in lung vascular remodeling associated with SARS-CoV-2 infection

L. Farkas, R. Nho, R. Mallampalli, 2023, bioRxiv.

Implicating Exudate Macrophages and Ly-6Chigh Monocytes in CCR2-Dependent Lung Fibrosis following Gene-Targeted Alveolar Injury

M. Olszewski, J. Horowitz, J. Erb-Downward, 2013, The Journal of Immunology.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

H. Collard, K. Anstrom, F. Martinez, 2014, American journal of respiratory and critical care medicine.

Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury

J. Horowitz, T. Sisson, P. Christensen, 2018, Physiological reports.

Biomechanical Force and Cellular Stiffness in Lung Fibrosis.

S. Ghadiali, R. Nho, J. Horowitz, 2022, The American journal of pathology.

Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts

E. White, M. Peters-Golden, J. Horowitz, 2013, Cell Death and Disease.

Smoking history, and not depression, is related to deficits in detection of happy and sad faces.

Natania A. Crane, S. Langenecker, J. Zubieta, 2015, Addictive behaviors.

Prostaglandin E2's new trick: "decider" of differential alveolar cell life and death.

M. Peters-Golden, J. Horowitz, 2010, American journal of respiratory and critical care medicine.

Phlegmasia cerulea dolens: a rare cause of shock

J. Horowitz, M. Hensley, Alexander S Taylor, 2019, Respirology case reports.

Investigating Matrix-Fibroblast Regulation of MicroRNAs. A Dice(r)y Proposition.

J. Horowitz, 2018, American journal of respiratory and critical care medicine.

Idiopathic pulmonary fibrosis: What primary care physicians need to know

B. Southern, J. Horowitz, D. Culver, 2018, Cleveland Clinic Journal of Medicine.

Antipneumococcal Effects ofC-Reactive Protein andMonoclonal Antibodies toPneumococcal CellWallandCapsular Antigens

L. McDaniel, J. Volanakis, J. Horowitz, 1989 .

Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

L. Farkas, R. Nho, J. Horowitz, 2023, Physiological reports.

Plakoglobin expression in fibroblasts and its role in idiopathic pulmonary fibrosis

E. White, J. Horowitz, Stephanie A. Matthes, 2015, BMC Pulmonary Medicine.

The aged extracellular matrix and the pro-fibrotic role of senescence -associated secretory phenotype (SASP).

R. Nho, Y. Mebratu, J. Horowitz, 2023, American Journal of Physiology - Cell Physiology.

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

L. Farkas, D. Eckmann, R. Mallampalli, 2023, bioRxiv.

Fibroblast Activating Protein: Skimming the Surface of Molecular Imaging to Assess Fibrotic Disease Activity

J. Horowitz, S. Montesi, 2022, American journal of respiratory and critical care medicine.