Kazuhiro Ito

发表

Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7

Peter J. Barnes, Kazuhiro Ito, P. Barnes, 2011, Chest.

COPD as a disease of accelerated lung aging(a).

P. Barnes, Kazuhiro Ito, 2009, Revista portuguesa de pneumologia.

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients.

I. Adcock, P. Barnes, Kazuhiro Ito, 2004, The Journal of allergy and clinical immunology.

Does lung aging have an impact on chronic obstructive pulmonary disease

Kazuhiro Ito, 2007 .

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

N. Thomson, R. Chaudhuri, C. Charron, 2015, Pulmonary pharmacology & therapeutics.

Effect of theophylline plus beclometasone on lung function in smokers with asthma-a pilot study

N. Thomson, I. Adcock, R. Chaudhuri, 2009 .

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD

P. Barnes, L. Donnelly, Kazuhiro Ito, 2017, American journal of physiology. Lung cellular and molecular physiology.

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

I. Adcock, P. Barnes, S. Yamamura, 2006, The Journal of experimental medicine.

The role of antifungals in the management of patients with severe asthma

D. Denning, Kazuhiro Ito, Garth William Rapeport, 2020, Clinical and Translational Allergy.

Current approaches to the discovery of novel inhaled medicines.

Kazuhiro Ito, P. Strong, Garth William Rapeport, 2018, Drug discovery today.

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase

I. Adcock, P. Barnes, Kazuhiro Ito, 2004, The Lancet.

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.

Kazuhiro Ito, M. Lopes, R. Coletta, 2009, Brazilian oral research.

Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription

Y. Nasuhara, P. Barnes, J. Chivers, 2004, Journal of Biological Chemistry.

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

Kazuhiro Ito, T. Colley, N. Mercado, 2012, International journal of chronic obstructive pulmonary disease.

Desmoplastic reactions and epithelial-mesenchymal transition proteins in stages II and III colorectal cancer: association with and prognostic value for disease-free survival

T. Sugai, Kazuhiro Ito, Y. Kajiwara, 2022, Virchows Archiv.

Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ

P. Barnes, Kazuhiro Ito, Y. To, 2011, Journal of Pharmacology and Experimental Therapeutics.

Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells

Kazuhiro Ito, K. Midwood, W. S. To, 2015, British journal of pharmacology.

Faculty Opinions recommendation of Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

M. To, Kazuhiro Ito, 2011 .

Histone acetylation and histone deacetylation

I. Adcock, Kazuhiro Ito, 2002, Molecular biotechnology.

Reduced Denitration Activity in Peripheral Lung of Chronic Obstructive Pulmonary Disease

P. Barnes, J. Hogg, Kazuhiro Ito, 2012, Tanaffos.

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

I. Adcock, K. Chung, P. Barnes, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice.

T. Masuko, P. Barnes, Kazuhiro Ito, 2013, Chest.

ORMDL3 regulates poly I:C induced inflammatory responses in airway epithelial cells

W. Cookson, M. Moffatt, Kazuhiro Ito, 2021, BMC Pulmonary Medicine.

Fighting the Common Cold: ORMDL3 in the Crosshairs?

Kazuhiro Ito, Youming Zhang, 2020, American Journal of Respiratory Cell and Molecular Biology.

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

S. Biswal, P. Barnes, L. Donnelly, 2011, Biochemical and biophysical research communications.

Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages

I. Adcock, L. Tsaprouni, P. Barnes, 2004, The Journal of experimental medicine.

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

I. Adcock, K. Chung, L. Tsaprouni, 2011, Thorax.

Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-κB activation in COPD.

P. Barnes, M. To, K. Akashi, 2013, Chest.

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients

L. Fabbri, I. Adcock, K. Chung, 2009, Histopathology.

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

I. Adcock, K. Chung, P. Brun, 2005 .

Biomarkers in Lung Diseases : From Pathogenesis to Prediction to New Therapies Decreased phosphatase PTEN amplifies PI 3 K signaling and enhances proinflammatory cytokine release in COPD

P. Barnes, L. Donnelly, Kazuhiro Ito, 2017 .

A Retrospective Survey of Patients Undergoing Maintenance Hemodialysis vis-à-vis Cancer Prevalence

Kazuhiro Ito, K. Ina, Miho Tatematsu, 2020, Journal of Analytical Oncology.

5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene.

I. Adcock, P. Barnes, Kazuhiro Ito, 2005, Biochemical and biophysical research communications.

Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease.

S. Johnston, P. Barnes, Kazuhiro Ito, 2012, American journal of respiratory and critical care medicine.

Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer.

Kazuhiro Ito, H. Kuasne, R. Losi-Guembarovski, 2011, Urologic oncology.

The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia

Kazuhiro Ito, Katsunori Furuta, M. Shibasaki, 2013, Clinical interventions in aging.

Chapter 30 – Nitric Oxide

S. Kharitonov, Kazuhiro Ito, 2009 .

AMPK signalling regulates Nrf2 localization and activity via sirtuins in a monocytic cell line

Kazuhiro Ito, N. Mercado, Laura Núñez Naveira, 2011 .

Expression and activity of histone deacetylases in human asthmatic airways.

I. Adcock, K. Chung, P. Barnes, 2002, American journal of respiratory and critical care medicine.

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

S. Johnston, I. Adcock, P. Barnes, 2013, The Journal of allergy and clinical immunology.

Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients.

P. Barnes, S. Kharitonov, Kazuhiro Ito, 2011, Respiratory medicine.

Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity.

P. Barnes, S. Kharitonov, Kazuhiro Ito, 2007, Chest.

Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients.

P. Barnes, S. Kharitonov, Kazuhiro Ito, 2009, Chest.

p38 MAP kinase and MKK‐1 co‐operate in the generation of GM‐CSF from LPS‐stimulated human monocytes by an NF‐κB‐independent mechanism

Y. Nasuhara, M. Lindsay, P. Barnes, 2000, British journal of pharmacology.

Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers.

I. Adcock, K. Chung, P. Barnes, 2002, American journal of respiratory and critical care medicine.

Intraluminal Behavior of Various Transporter Substrates in the Rat Gastrointestinal Tract.

Kazuhiro Ito, S. Kasaoka, Yusuke Tanaka, 2021, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure

P. Barnes, L. Donnelly, Kazuhiro Ito, 2018, PloS one.

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

Christopher S. Stevenson, I. Adcock, C. Stevenson, 2009, American journal of respiratory and critical care medicine.

p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids

I. Adcock, P. Barnes, Kazuhiro Ito, 2001, The Journal of Biological Chemistry.

Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers.

P. Barnes, S. Kharitonov, Kazuhiro Ito, 2007, Chest.

Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway

Kazuhiro Ito, J. Davies, E. Alton, 2021, PloS one.

Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia.

S. Johnston, I. Adcock, Kazuhiro Ito, 2006, Current medicinal chemistry.

Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma

K. Chung, O. Usmani, P. Barnes, 2012, PloS one.

Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation.

P. Barnes, Kazuhiro Ito, A. Miller-Larsson, 2012, Pulmonary pharmacology & therapeutics.

Defects of Protein Phosphatase 2A Causes Corticosteroid Insensitivity in Severe Asthma

P. Barnes, Kazuhiro Ito, Yoshiki Kobayashi, 2011, PloS one.

p38 Mitogen-Activated Protein Kinase-γ Inhibition by Long-Acting β2 Adrenergic Agonists Reversed Steroid Insensitivity in Severe Asthma

I. Adcock, P. Barnes, Kazuhiro Ito, 2011, Molecular Pharmacology.

Prospects for PI3 Kinase Signaling Inhibition in Obstructive Airway Diseases

Kazuhiro Ito, N. Mercado, Nicolas Mercado, 2011 .

Therapeutic targets for new therapy for corticosteroid refractory asthma

Kazuhiro Ito, N. Mercado, Nicolas Mercado, 2009, Expert opinion on therapeutic targets.

Therapeutictargetsfornew therapyforcorticosteroid refractoryasthma

Kazuhiro Ito, N. Mercado, 2009 .

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

I. Adcock, Kazuhiro Ito, 2004, Current opinion in pharmacology.

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects

I. Adcock, K. Chung, P. Barnes, 2012, Journal of Inflammation.

Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.

I. Adcock, L. Tsaprouni, P. Barnes, 2005, Antioxidants & redox signaling.

Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of chronic obstructive pulmonary disease

A. Agustí, P. Barnes, Kazuhiro Ito, 2009 .

IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter.

I. Adcock, Kang-Yun Lee, P. Barnes, 2006, Journal of immunology.

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease.

I. Adcock, K. Chung, P. Brun, 2006, The Journal of allergy and clinical immunology.

Inhaled antifungal therapy: benefits, challenges, and clinical applications

Kazuhiro Ito, 2022, Expert opinion on drug delivery.

Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945.

M. Hows, Kazuhiro Ito, P. Strong, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection

D. Kelly, S. Kelly, A. Chowdhary, 2018, Antimicrobial Agents and Chemotherapy.

In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole,

D. Kelly, A. Chowdhary, Kazuhiro Ito, 2018 .

Title 1 In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole , 2 PC 1244 on Aspergillus fumigatus Infection 3 4

D. Kelly, A. Chowdhary, M. Fisher, 2018 .

In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice

Kazuhiro Ito, P. Strong, Garth William Rapeport, 2017, Antimicrobial Agents and Chemotherapy.

A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-κB Inhibition

P. Barnes, C. Rossios, Kazuhiro Ito, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway

T. Masuko, P. Barnes, Kazuhiro Ito, 2016, Biochemistry and biophysics reports.

LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD

E. Stoelben, J. Knobloch, Kazuhiro Ito, 2019, Journal of clinical medicine.

Superior anti‐inflammatory effects of narrow‐spectrum kinase inhibitors in airway smooth muscle cells from subjects with chronic obstructive pulmonary disease

E. Stoelben, J. Knobloch, C. Charron, 2017, The Journal of allergy and clinical immunology.

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

C. Brightling, P. Barnes, Kazuhiro Ito, 2016, The Journal of allergy and clinical immunology.

Proximal Promoter B Binding κ Differential Requirement for NF-) Expression : 2 AAdenosine Receptor ( A Regulation of the α and TNF-β IL-1

I. Adcock, Kang-Yun Lee, P. Barnes, 2006 .

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.

I. Adcock, K. Chung, P. Barnes, 2004, American journal of respiratory cell and molecular biology.

New insights into the molecular mechanisms of corticosteroids actions.

I. Adcock, Kazuhiro Ito, G. Caramori, 2006, Current drug targets.

Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription*

I. Adcock, P. Barnes, M. Griffiths, 2009, The Journal of Biological Chemistry.

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

I. Adcock, Kazuhiro Ito, E. Moilanen, 2010, Journal of Inflammation.

INHIBITION OF MTOR RESTORES CORTICOSTEROID SENSITIVITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

P. Barnes, Kazuhiro Ito, A. Mitani, 2015 .

Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?

N. Koulouris, S. Loukides, Kazuhiro Ito, 2020, Journal of clinical medicine.

HDAC6: A Neglected Player in Chronic Obstructive Pulmonary Disease?

Kazuhiro Ito, 2021, American Journal of Respiratory Cell and Molecular Biology.

Glucocorticoid suppression of nuclear factor-κB: a role for histone modifications

I. Adcock, Kazuhiro Ito, B. Cosío, 2001 .

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

C. Charron, Kazuhiro Ito, P. Murray, 2016, Journal of medicinal chemistry.

Effects Of RV1088, A Narrow Spectrum Kinase Inhibitor, On HRV16 Replication And Cytokine Production In Airway Epithelial Cells Obtained From COPD Patients

Kazuhiro Ito, M. Contoli, A. Papi, 2011, ATS 2011.

Oral administration of a T cell epitope inhibits symptoms and reactions of allergic rhinitis in Japanese cedar pollen allergen-sensitized mice.

M. Yamashita, Takako Murasugi, Y. Nakagami, 2005, European journal of pharmacology.

Activation of NF‐κB transcription factor in asthma death

A. Nicholson, I. Adcock, K. Chung, 2009, Histopathology.

Dual interleukin-17A/F deficiency protects against acute and chronic response to cigarette smoke exposure in mice

P. Barnes, Y. Iwakura, A. Kudo, 2021, Scientific Reports.

PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections

Kazuhiro Ito, P. Strong, D. Armstrong-James, 2020, Journal of fungi.

TRANSCRIPTION FACTORS | Overview

I. Adcock, Kazuhiro Ito, G. Caramori, 2006 .

Oxidative and nitrosative stress and histone deacetylase2 activity in exacerbations of Chronic Obstructive Pulmonary Disease

S. Johnston, I. Adcock, A. Durham, 2015 .

Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

Kazuhiro Ito, P. Strong, J. Ayrton, 2020, Pharmacology research & perspectives.

Superior Anti-inflammatory Effects Of A Novel Macrolide/fluoroketolide, CEM-101, In Monocytic Cells

P. Barnes, C. Rossios, Kazuhiro Ito, 2010, ATS 2010.

Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine.

Sergei Kharitonov, Kazuhiro Ito, Caterina Brindicci, 2009, Chest.

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis

Kazuhiro Ito, R. Thwaites, P. Openshaw, 2017, The Journal of infectious diseases.

A Novel Macrolide/fluoroketolide, CEM-101, Reverses Corticosteroid Insensitivity Under Oxidative Stress Via PI3K Pathway Inhibition

P. Barnes, C. Rossios, Kazuhiro Ito, 2010, ATS 2010.

Transcription factors in asthma and COPD.

I. Adcock, Kazuhiro Ito, G. Caramori, 2004, IDrugs : the investigational drugs journal.

Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection

Kazuhiro Ito, P. Strong, Garth William Rapeport, 2019, Scientific Reports.

A Male Case with ÃÂ²-Propeller Protein-Associated Neurodegeneration(BPAN) with Somatic Mosaic Mutation in WDR45

N. Matsumoto, Kazuhiro Ito, H. Saitsu, 2016 .

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

I. Adcock, P. Barnes, W. M. Elliott, 2005, The New England journal of medicine.

Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.

Kazuhiro Ito, M. Lopes, R. Coletta, 2009, Analytical and quantitative cytology and histology.

Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis

Hiromu Suzuki, T. Sugai, Kazuhiro Ito, 2022, Annals of Surgical Oncology.

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure

Kazuhiro Ito, R. Thwaites, P. Openshaw, 2018, American journal of respiratory and critical care medicine.

Anti-TIF1-γ antibody and cancer-associated myositis

A. Hida, S. Takeuchi, S. Tsuji, 2016, Neurology.

Anti-TIF1-&ggr; antibody and cancer-associated myositis: A clinicohistopathologic study

A. Hida, S. Takeuchi, S. Tsuji, 2016, Neurology.

Cigarette smoke impairs autophagic flux in bronchial epithelial cells

P. Barnes, Kazuhiro Ito, T. Colley, 2013 .

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

I. Adcock, P. Barnes, Kazuhiro Ito, 2000, Molecular and Cellular Biology.

IL-1 and TNF- Regulation of the Adenosine Receptor (A2A) Expression: Differential Requirement for NF- B Binding to the Proximal Promoter

S. Yamamura, Kazuhiro Ito, C. Cicala, 2006 .

Triamcinolone Acetonide and Dexamethasome Suppress TNF‐α‐Induced Histone H4 Acetylation on Lysine Residues 8 and 12 in Mononuclear Cells

I. Adcock, L. Tsaprouni, Kazuhiro Ito, 2002, Annals of the New York Academy of Sciences.

Modulation de l'histone deacetylase

I. Adcock, P. Barnes, Kazuhiro Ito, 2001 .

Late therapeutic intervention with a respiratory syncytial virus L‐protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium

M. Hows, Kazuhiro Ito, P. Strong, 2018, British journal of pharmacology.

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

I. Adcock, O. Usmani, P. Barnes, 2009, PLoS medicine.

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

I. Adcock, P. Barnes, W. M. Elliott, 2010, American journal of respiratory and critical care medicine.

Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice

Kazuhiro Ito, P. Strong, Garth William Rapeport, 2017, Mycoses.

Kinase inhibitors and airway inflammation.

Kazuhiro Ito, Ian M Adcock, I. Adcock, 2006, European journal of pharmacology.

Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus

A. Chowdhary, J. Meis, Kazuhiro Ito, 2019, The Journal of antimicrobial chemotherapy.

Activated protein phosphatase PP2A by formoterol enhances nuclear translocation of glucocorticoid receptor induced by budesonide

P. Barnes, Kazuhiro Ito, A. Miller-Larsson, 2011 .

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

D. Kelly, S. Kelly, Kazuhiro Ito, 2017, Antimicrobial Agents and Chemotherapy.

inhaled azole , 2 PC 945 , on Aspergillus fumigatus infection 3 4 5

D. Kelly, S. Kelly, Kazuhiro Ito, 2017 .

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

Malcolm Johnson, Kazuhiro Ito, Ian M Adcock, 2005, American journal of respiratory and critical care medicine.

Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease

I. Adcock, Kazuhiro Ito, G. Caramori, 2007, Journal of Pharmacology and Experimental Therapeutics.

Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study

Kazuhiro Ito, P. Strong, J. Devincenzo, 2020, The Journal of infectious diseases.

Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.

S. Hunt, Kazuhiro Ito, P. Strong, 2017, Bioorganic & medicinal chemistry letters.

Successful treatment of disseminated intravascular coagulation by recombinant human soluble thrombomodulin in patients with acute myeloid leukemia

H. Iwasaki, T. Yamauchi, Kazuhiro Ito, 2018, Medicine.

Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

Kazuhiro Ito, P. Strong, Y. Kizawa, 2021 .

Update on glucocorticoid action and resistance.

I. Adcock, Kazuhiro Ito, K. Chung, 2006, The Journal of allergy and clinical immunology.

In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris

Kazuhiro Ito, S. Rudramurthy, A. Chakrabarti, 2019, The Journal of antimicrobial chemotherapy.

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans-infected immunocompromised mice

Kazuhiro Ito, P. Strong, Y. Kizawa, 2020, bioRxiv.

Langerhans cells in human apocrine ducts

Kazuhiro Ito, A. Kawada, A. Kukita, 1976, Archives of Dermatological Research.

Journal of Occupational Medicine and Toxicology New Drugs Targeting Th2 Lymphocytes in Asthma

I. Adcock, D. Groneberg, Kazuhiro Ito, 2022 .

Aurones serve as probes of β-amyloid plaques in Alzheimer’s disease

Kazuhiro Ito, H. Mori, M. Haratake, 2007 .

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.

W. Klein, M. Lambert, Kazuhiro Ito, 2009, The American journal of pathology.

Histone Deacetylation: An Important Mechanism in Inflammatory Lung Diseases

I. Adcock, P. Barnes, Kazuhiro Ito, 2005, COPD.

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.

I. Adcock, K. Chung, P. Barnes, 2006, American journal of respiratory and critical care medicine.

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

R. Skinner, R. Mrak, L. J. Eldik, 1996, Neurobiology of Aging.

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

H. Peh, W. Wong, S. Johnston, 2016, Chest.

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

Kazuhiro Ito, Ian M Adcock, I. Adcock, 2009, Biochemical and biophysical research communications.

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation

Dave Singh, C. Charron, Kazuhiro Ito, 2017, European Respiratory Journal.

Telomere Shortening in Alveolar Macrophages of Smokers and COPD Patients~!2010-02-18~!2010-03-05~!2010-04-15~!

I. Adcock, P. Barnes, Kazuhiro Ito, 2010 .

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.

I. Adcock, K. Chung, P. Barnes, 2004, American journal of respiratory and critical care medicine.

Osteoprotegerin in sputum is a potential biomarker in COPD.

P. Barnes, S. Kharitonov, M. To, 2011, Chest.

Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells.

I. Adcock, P. Barnes, C. Rossios, 2011, European journal of pharmacology.

Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity

A. Kanda, P. Barnes, Kazuhiro Ito, 2017, Molecular Pharmacology.

MicroRNA-570 is a novel regulator of cellular senescence and inflammaging

P. Barnes, L. Donnelly, Kazuhiro Ito, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-31

Ian M. Adcock, Omar S. Usmani, Peter J. Barnes, 2007, The Journal of Immunology.

Effects of glucocorticoids on gene transcription.

I. Adcock, Kazuhiro Ito, H. Wada, 2004, European journal of pharmacology.

Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer

Kazuhiro Ito, Kazuhiro Ito, H. Kuasne, 2010, Cancer investigation.

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

P. Barnes, Kazuhiro Ito, A. Mitani, 2017, Experimental lung research.

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

P. Barnes, L. Donnelly, Kazuhiro Ito, 2004, American journal of physiology. Lung cellular and molecular physiology.

Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach

P. Barnes, Kazuhiro Ito, T. Homma, 2020, Journal of clinical medicine.

Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms*

I. Adcock, P. Evans, J. Dean, 2008, Journal of Biological Chemistry.

Mode of Glucocorticoid Actions in Airway Disease

C. Charron, Kazuhiro Ito, S. Getting, 2006, TheScientificWorldJournal.

Corticosteroid Resistance in COPD

I. Adcock, Kazuhiro Ito, 2005 .

Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation

S. Abe, M. To, Kazuhiro Ito, 2021, Scientific Reports.

Epigenetic regulation of airway inflammation.

I. Adcock, L. Tsaprouni, Kazuhiro Ito, 2007, Current opinion in immunology.

Targeting Th2 cells in asthmatic airways.

I. Adcock, Kazuhiro Ito, G. Caramori, 2004, Current drug targets. Inflammation and allergy.

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Jimmy D Bell, A. Boobis, M. El-Bahrawy, 2016, Oncotarget.

STOP accelerating lung aging for the treatment of COPD

Kazuhiro Ito, N. Mercado, Nicolas Mercado, 2014, Experimental Gerontology.

Anti‐Ageing Strategy of the Lung for Chronic Inflammatory Respiratory Disease – Targeting Protein Deacetylases

Kazuhiro Ito, N. Mercado, Nicolas Mercado, 2012 .

Translating Basic Research Into Clinical Practice COPD as a Disease of Accelerated Lung Aging *

Kazuhiro Ito, P. Barnes, Kazuhiro Ito, 2009 .

Oxidative stress modulates theophylline effects on steroid responsiveness.

Bernhard Kuster, Probir Chakravarty, Kazuhiro Ito, 2008, Biochemical and biophysical research communications.

Epigenetics and airways disease

I. Adcock, P. Barnes, Kazuhiro Ito, 2006, Respiratory research.

Decreased Serum Sirtuin-1 in COPD

P. Barnes, S. Loukides, Kazuhiro Ito, 2017, Chest.

Current perspectives Update on glucocorticoid action and resistance

I. Adcock, United Kingdom., Kazuhiro Ito, 2006 .

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

I. Adcock, O. Usmani, P. Barnes, 2009, PLoS medicine.

Cigarette Smoke Activates Human Monocytes by an Oxidant-AP-1 Signaling Pathway: Implications for Steroid Resistance

I. Adcock, J. Mitchell, M. Paul-Clark, 2005, Molecular Pharmacology.

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

I. Adcock, J. Marwick, P. Kirkham, 2007, Expert opinion on therapeutic targets.

IL-1β and TNF-α Regulation of the Adenosine Receptor (A2A) Expression: Differential Requirement for NF-κB Binding to the Proximal Promoter1

I. Adcock, P. Barnes, S. Yamamura, 2006, The Journal of Immunology.

Impact of protein acetylation in inflammatory lung diseases.

I. Adcock, C. Charron, Kazuhiro Ito, 2007, Pharmacology & therapeutics.

Interactions between long-acting β2-agonists and glucocorticoids

I. Adcock, Kazuhiro Ito, A. Papi, 2006 .

A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

Rie Teraoka, Kazuhiro Ito, Kenichi Ishibashi, 2010, The Journal of Neuroscience.

Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease.

P. Barnes, J. Hogg, S. Kharitonov, 2010, American journal of respiratory and critical care medicine.

Reduced HDAC2 in skeletal muscle of COPD patients

M. Polkey, P. Barnes, M. To, 2017, Respiratory Research.

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin.

P. Barnes, Kazuhiro Ito, A. Mitani, 2016, American journal of respiratory and critical care medicine.

Accelerated ageing of the lung in COPD: new concepts

P. Barnes, Kazuhiro Ito, N. Mercado, 2015, Thorax.

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9

P. Elliott, J. Hogg, C. Rossios, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

Kazuhiro Ito, Ian M Adcock, I. Adcock, 2005, Proceedings of the American Thoracic Society.

Decreased serum sirtuin-1 in chronic obstructive pulmonary disease

S. Loukides, Kazuhiro Ito, C. Vuppusetty, 2017 .

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD

K. Chung, Kang-Yun Lee, Kazuhiro Ito, 2022, Respiratory Research.

An impact of age on respiratory syncytial virus infection in air-liquid-interface culture bronchial epithelium

Kazuhiro Ito, M. Coates, Leah Daly, 2023, Frontiers in Medicine.

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

S. Hunt, Young-In Kim, Kazuhiro Ito, 2017, Antimicrobial Agents and Chemotherapy.

Cerebral blood flow abnormality in clinically diagnosed Alzheimer's disease patients with or without amyloid β accumulation on positron emission tomography

Yasuyoshi Watanabe, Kazuhiro Ito, Yasuhiro Wada, 2017 .

Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma.

Rakesh K. Kumar, P. Barnes, P. Foster, 2008, American journal of respiratory cell and molecular biology.

Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity

A. Kanda, P. Barnes, Kazuhiro Ito, 2016, Respiratory Research.

Establishment of Nontypeable Haemophilus influenzae airway infection murine model

Kazuhiro Ito, Y. Kizawa, Genki Kimura, 2020 .

Preclinical characterization of the inhaled small molecule respiratory syncytial virus L-1 protein polymerase inhibitor , PC 786 2 3 4

S. Hunt, Lauren, Young-In Kim, 2017 .

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

I. Adcock, O. Usmani, P. Barnes, 2009, PLoS medicine.

Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

I. Adcock, O. Usmani, P. Barnes, 2018, PLoS medicine.

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

Deepti Malhotra, Shyam Biswal, Kazuhiro Ito, 2011, The Journal of clinical investigation.

NF-κB and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1β-Induced TGF-β1 Gene Transcription1

I. Adcock, Kang-Yun Lee, P. Barnes, 2006, The Journal of Immunology.

NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription.

I. Adcock, Kang-Yun Lee, P. Barnes, 2006, Journal of immunology.

Recent Thymic Emigrants Do Not Account for the Increased Number of TCells Seen in the Lungs of Stable Chronic Obstructive Pulmonary Disease

I. Adcock, K. Chung, P. Barnes, 2008 .

Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma

P. Barnes, A. Bush, K. Akashi, 2013, Chest.

Faculty Opinions recommendation of The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens.

M. To, Kazuhiro Ito, 2012 .

Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-κB Repressing Factor1

I. Adcock, H. Kuo, Kang-Yun Lee, 2009, The Journal of Immunology.

Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure

P. Barnes, Kazuhiro Ito, S. Kamiya, 2015, Experimental lung research.

Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation

P. Barnes, M. To, Kazuhiro Ito, 2021, Scientific reports.

Adherence to Medication Regimens is an Effective Indicator of Cognitive Dysfunction in Elderly Individuals

Kazuhiro Ito, Katsunori Furuta, Fumihiro Mizokami, 2016, American journal of Alzheimer's disease and other dementias.

NF- B and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1 -Induced TGF- 1 Gene Transcription

Kazuhiro Ito, Kang-Yun Lee, I. Adcock, 2005 .

Histone acetylation and deacetylation: importance in inflammatory lung diseases

I. Adcock, P. Barnes, Kazuhiro Ito, 2005, European Respiratory Journal.

Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions.

K. Kostikas, C. Rossios, Kazuhiro Ito, 2013, Current drug targets.

Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

Yeping Xiong, P. Barnes, Kazuhiro Ito, 2014, PloS one.

Separate Evaluation of Fraction Absorbed and Intestinal Availability after Oral Administration of Drugs Based on the Measurement of Portal and Systemic Plasma Concentrations and Luminal Concentration.

Kazuhiro Ito, S. Kasaoka, Yusuke Tanaka, 2023, Molecular pharmaceutics.

P307 Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, fatty acid synthase and Ki-67

Kazuhiro Ito, M. Lopes, R. Coletta, 2007 .

Differential patterns of histone acetylation in inflammatory bowel diseases

I. Adcock, L. Tsaprouni, Kazuhiro Ito, 2011, Journal of Inflammation.

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

I. Adcock, Kazuhiro Ito, G. Caramori, 2004, Current opinion in investigational drugs.

GATA-3Phosphorylation of Regulation of Th2 Cytokine Genes by p38

Ian M. Adcock, Kang-Yun Lee, Omar S. Usmani, 2013 .

GATA-3 MAPK-Mediated Phosphorylation of Regulation of Th 2 Cytokine Genes by p 38 and

O. Usmani, Kang-Yun Lee, P. Barnes, 2007 .

Exhaled nitric oxide from lung periphery is increased in COPD

N. Pride, P. Barnes, O. Resta, 2005, European Respiratory Journal.

Accumulation of Bisphenol A in Hemodialysis Patients

S. Nakai, Y. Hiki, Kazuhiro Ito, 2007, Blood Purification.

Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD

A. Agustí, A. Agustí, P. Barnes, 2009, Thorax.

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.

I. Adcock, Kazuhiro Ito, Sam Lim, 2004, American journal of respiratory cell and molecular biology.

LATE-BREAKING ABSTRACT: Effects of a single treatment with PC786, a novel inhibitor of respiratory syncytial virus replication, on viral load and biomarkers in fully differentiated human bronchial epithelial cells

M. Hows, Kazuhiro Ito, P. Strong, 2016 .

Fluticasone Furoate, A Novel Enhanced-affinity Inhaled Corticosteroid (ICS), With Sustained Glucocorticoid Receptor Nuclear Translocation

I. Adcock, P. Barnes, C. Rossios, 2010, ATS 2010.

Chronic obstructive pulmonary disease Th1 cells display impaired response to endotoxin.

Kazuhiro Ito, J. Bengoechea, 2011, American journal of respiratory and critical care medicine.

Dasatinib attenuates airway inflammation of asthma exacerbation in mice induced by house dust mites and dsRNA

Kazuhiro Ito, Y. Kizawa, Tsubasa Yoshida, 2022, Biochemistry and Biophysics Reports.

Epigenetics and airways disease

Kazuhiro Ito, P. Ford, I. Adcock, 2006, Respiratory research.

[The Involvement of Src in Airway Inflammation Induced by Repeated Exposure to Lipopolysaccharide in Mice].

Kazuhiro Ito, H. Yasuda, Y. Kizawa, 2019, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

P. Barnes, L. Donnelly, Kazuhiro Ito, 2016, Scientific Reports.

New drugs targeting Th2 lymphocytes in asthma.

Kazuhiro Ito, A. Papi, G. Caramori, 2008, Journal of occupational medicine and toxicology.

A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

W. Klein, M. Lambert, Kazuhiro Ito, 2010, The Journal of Neuroscience.

p38 Mitogen-Activated Protein Kinase-γ Inhibition by Long-Acting β2 Adrenergic Agonists Reversed Steroid Insensitivity in Severe Asthma

I. Adcock, P. Barnes, Kazuhiro Ito, 2011, Molecular Pharmacology.

A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-κB Inhibition

P. Barnes, C. Rossios, Kazuhiro Ito, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease

I. Adcock, Kazuhiro Ito, G. Caramori, 2007, Journal of Pharmacology and Experimental Therapeutics.

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

I. Adcock, P. Barnes, Kazuhiro Ito, 2006, The Journal of experimental medicine.

Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ

P. Barnes, Kazuhiro Ito, Y. To, 2011, Journal of Pharmacology and Experimental Therapeutics.

Factor B Repressing κ Cells through Induction of NF-Synthesis in Human Airway Smooth Muscle Neutrophil Elastase Represses IL-8 / CXCL 8

I. Adcock, H. Kuo, Kang-Yun Lee, 2009 .

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation

Dave Singh, C. Charron, Kazuhiro Ito, 2017, European Respiratory Journal.

Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form.

Kazuhiro Ito, H. Mori, T. Tomiyama, 2009, Current Alzheimer research.