A. Holmes

发表

Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.

C. Stevenson, C. Hogaboam, Xiaoyan Tang, 2013, The American journal of pathology.

Connective Tissue Growth Factor Gene Regulation

D. Abraham, A. Holmes, A. Leask, 2003, The Journal of Biological Chemistry.

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

J. Pearson, C. Denton, A. Holmes, 2001, The Journal of investigative dermatology.

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

S. Sa, D. Abraham, A. Holmes, 2001, Molecular pathology : MP.

Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis.

S. Low, D. Abraham, A. Holmes, 2007, Rheumatology.

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.

D. Abraham, A. Holmes, G. Martin, 2001, The Journal of clinical investigation.

Constitutive Connective Tissue Growth Factor Expression in Scleroderma Fibroblasts Is Dependent on Sp1*

D. Abraham, C. Denton, A. Holmes, 2003, Journal of Biological Chemistry.

Response to Letter Regarding Article, “Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension”

R. Trembath, N. Morrell, D. Budd, 2011 .

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.

D. Budd, A. Holmes, D. Rodman, 2011, Blood.

Significance of plasma N-terminal pro-brain natriuretic peptide in patients with systemic sclerosis-related pulmonary arterial hypertension.

A. Holmes, C. Black, J. Coghlan, 2003, Respiratory medicine.

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

D. Pennington, R. D. du Bois, D. Abraham, 2000, Experimental cell research.

Evidence for the Involvement of Type I Interferon in Pulmonary Arterial Hypertension

M. Humbert, E. Fadel, J. Mitchell, 2014, Circulation research.

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

D. Budd, A. Holmes, L. Ciuclan, 2011, Blood.

Impaired bone morphogenetic protein receptor II signaling in a transforming growth factor-β-dependent mouse model of pulmonary hypertension and in systemic sclerosis.

C. Denton, A. Holmes, A. Gilbane, 2015, American journal of respiratory and critical care medicine.

Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.

Cerys Docx, C. Leblanc, N. Morrell, 2009, The American journal of pathology.

Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.

D. Abraham, C. Denton, A. Holmes, 2013, Arthritis and rheumatism.

Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

D. Abraham, A. Holmes, A. Leask, 2002, Current rheumatology reports.

Loss of protein kinase Cϵ results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2008, Journal of Cell Science.

Endothelins: effect on matrix biosynthesis and proliferation in normal and scleroderma fibroblasts.

D. Abraham, C. Denton, A. Holmes, 1998, Journal of cardiovascular pharmacology.

Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis

D. Abraham, C. Denton, A. Holmes, 2014, Arthritis & rheumatology.

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.

D. Abraham, C. Denton, A. Holmes, 2015, The American journal of pathology.

Elevated Levels Of Inflammatory Cytokines Are Strong Predictors Of Survival In Idiopathic And Familial Pulmonary Arterial Hypertension

N. Morrell, D. Budd, A. Holmes, 2010, ATS 2010.

Scleroderma and Related Disorders 379. SCORING THE SKIN EXTRACELLULAR MATRIX ORGANISATION IN SYSTEMIC SCLEROSIS – MODULATION OF THE TGF- (cid:3) SIGNALING PATHWAY

B. Griffiths, J. Isaacs, F. Verrecchia, 2006 .

Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin

D. Abraham, C. Denton, A. Holmes, 2011, Journal of Cell Communication and Signaling.

Loss of protein kinase C&egr; results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2014, Journal of Cell Science.

Molecular Mechanisms Regulating the Pulmonary Blood–Gas Barrier

D. Budd, A. Holmes, V. Burton, 2015 .

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

D. Abraham, C. Denton, A. Holmes, 2009, Arthritis and rheumatism.

Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK*

R. D. du Bois, J. Pearson, D. Abraham, 2004, Journal of Biological Chemistry.

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

C. Denton, A. Holmes, A. Gilbane, 2013, Arthritis Research & Therapy.

Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

R. D. du Bois, J. Pearson, D. Abraham, 2006, Molecular and Cellular Biology.

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

R. Trembath, N. Morrell, D. Budd, 2010, Circulation.

A novel murine model of severe pulmonary arterial hypertension.

J. Westwick, N. Morrell, A. Holmes, 2011, American journal of respiratory and critical care medicine.

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.

N. Morrell, D. Budd, A. Holmes, 2012, American journal of physiology. Lung cellular and molecular physiology.

A polymorphism in the CTGF promoter region associated with systemic sclerosis.

Paolo Spagnolo, Markella Ponticos, Patricia Leoni, 2007, The New England journal of medicine.

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

Yunliang Chen, D. Pennington, D. Abraham, 2002 .

Targeting TGFβ superfamily ligand accessory proteins as novel therapeutics for chronic lung disorders.

D. Budd, A. Holmes, 2012, Pharmacology & therapeutics.

Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension

D. Abraham, C. Denton, A. Holmes, 2021, The international journal of biochemistry & cell biology.

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

U. McDermott, F. Iorio, S. Barthorpe, 2018, eLife.

Platelet‐derived transforming growth factor‐β1 promotes keratinocyte proliferation in cutaneous wound healing

A. Holmes, C. Scotton, D. Chong, 2020, Journal of tissue engineering and regenerative medicine.

Inflammatory Cytokines Are Elevated In Patients With Operable Chronic Thromboembolic Pulmonary Hypertension And Predict Outcome Post-Endarterectomy

N. Morrell, D. Budd, A. Holmes, 2011, ATS 2011.

Analysis of a functional polymorphism in the CTGF/CCN2 promoter in Systemic Sclerosis.

D. Abraham, C. Denton, A. Holmes, 2005 .

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-β2 in fibroblasts. Vol. 278 (2003) 13008–13015

D. Abraham, A. Holmes, A. Leask, 2005 .

muscle cells: role of proinflammatory cytokines in pulmonary artery smooth β growth inhibition by TGF- BMP type II receptor deficiency confers resistance to

N. Morrell, D. Budd, A. Holmes, 2016 .

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

U. McDermott, F. Iorio, S. Barthorpe, 2018, eLife.

Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.

Carla M. T. Bauer, Christopher S. Stevenson, C. Hogaboam, 2013, The American journal of pathology.