N. McElvaney

发表

MicroRNAs in inflammatory lung disease - master regulators or target practice?

I. Oglesby, N. McElvaney, C. Greene, 2010, Respiratory research.

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis

N. McElvaney, S. O’Neill, K. Hurley, 2013, Journal of inflammation research.

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

S. Cullen, Seamus J. Martin, J. Medema, 2011, Molecular cell.

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency

N. McElvaney, C. Greene, T. Hassan, 2011, Expert review of respiratory medicine.

Gain of Function Effects of Z Alpha-1 Antitrypsin

N. McElvaney, C. Greene, T. Carroll, 2010 .

Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis.

N. McElvaney, S. O’Neill, R. Coakley, 2002, Blood.

and Stability of IL-18 in Cystic Fibrosis IL-8 Dictates Glycosaminoglycan Binding

N. McElvaney, P. Greally, S. O’Neill, 2013 .

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

N. McElvaney, R. O'Kennedy, P. Greally, 2009, The Journal of Immunology.

Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide

N. McElvaney, C. Greene, S. O’Neill, 2005, Respiratory research.

Anti-apoptotic effects of Z α1-antitrypsin in human bronchial epithelial cells

I. Oglesby, N. McElvaney, C. Greene, 2009, European Respiratory Journal.

Elafin Prevents Lipopolysaccharide-induced AP-1 and NF-κB Activation via an Effect on the Ubiquitin-Proteasome Pathway*

M. Butler, N. McElvaney, C. Greene, 2006, Journal of Biological Chemistry.

Prone positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients

J. Laffey, B. McNicholas, N. McElvaney, 2021, BMC research notes.

Cathepsin B, L, and S Cleave and Inactivate Secretory Leucoprotease Inhibitor*

R. Levine, N. McElvaney, C. Greene, 2001, The Journal of Biological Chemistry.

Title Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency : safety , tolerability , and patient outcomes

N. McElvaney, S. Chotirmall, M. Al-Alawi, 2019 .

Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes

N. McElvaney, S. Chotirmall, M. Al-Alawi, 2015, Therapeutics and clinical risk management.

α-1 antitrypsin deficiency: current and future treatment options

N. McElvaney, O. McElvaney, Abdelhaleem Bella., 2015 .

Alpha-1 Antitrypsin Deficiency — A Missed Opportunity in COPD?

N. McElvaney, K. Molloy, T. Carroll, 2014 .

Alpha-1 Antitrypsin Deficiency – A Genetic Risk Factor for COPD

N. McElvaney, E. Reeves, T. Carroll, 2012 .

The role of proteases , endoplasmic reticulum stress and SERPINA 1 heterozygosity in lung disease in alpha-1 antitrypsin deficiency

N. McElvaney, C. Greene, K. Molloy, 2011 .

The prevalence of alpha-1 antitrypsin deficiency in Ireland

B. Dimitrov, N. McElvaney, D. Kelleher, 2011, Respiratory research.

Alpha-1 antitrypsin deficiency.

N. McElvaney, C. Greene, S. O’Neill, 2010, Respiratory medicine.

New Strategies in Drug Development Focusing on the Anti-Protease- Protease Balance in Alpha-1 Antitrypsin Deficiency

N. McElvaney, C. Greene, D. Bergin, 2010 .

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency

N. McElvaney, C. Greene, C. McLean, 2009, Biologics : targets & therapy.

Priorities for the alpha-1 community: The physicians perspective

N. McElvaney, S. Chotirmall, T. Carroll, 2009 .

Alpha-1-Antitrypsin Deficiency: Current Concepts

N. McElvaney, A. Mulgrew, C. Taggart, 2007, Lung.

Alpha-1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestations

N. McElvaney, C. Greene, M. Lawless, 2008, Journal of Inherited Metabolic Disease.

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha‐1 antitrypsin via inhibition of bad

N. McElvaney, C. Greene, M. Lawless, 2007, Hepatology.

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant.

N. McElvaney, C. Greene, M. Lawless, 2004, Chest.

The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions.

M. Wormald, P. Rudd, N. McElvaney, 2014, Journal of proteome research.

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

N. McElvaney, C. Greene, S. O’Neill, 2005, American journal of respiratory and critical care medicine.

Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study

P. Gilligan, M. Wolfgang, N. McElvaney, 2018, European Respiratory Journal.

Anaerobic bacteria cultured from CF airways correlate to milder disease-a multisite study

P. Gilligan, M. Wolfgang, N. McElvaney, 2018 .

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19

M. Cho, D. Qiao, B. Hobbs, 2020, EBioMedicine.

Rare manifestations of AATD

N. McElvaney, T. Carroll, A. Franciosi, 2019, α1-Antitrypsin Deficiency.

Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages.

N. McElvaney, C. Greene, S. Cryan, 2014, Molecular pharmaceutics.

Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway*

N. McElvaney, C. Greene, S. Chotirmall, 2010, The Journal of Biological Chemistry.

Alpha-1 Antitrypsin Augmentation Therapy Corrects Accelerated Neutrophil Apoptosis in Deficient Individuals

N. McElvaney, C. O’Dwyer, K. Hurley, 2014, The Journal of Immunology.

Alpha-1 Antitrypsin: A Potent Anti-Inflammatory and Potential Novel Therapeutic Agent

N. McElvaney, K. Hurley, D. Bergin, 2012, Archivum Immunologiae et Therapiae Experimentalis.

Toll-like receptors as therapeutic targets in cystic fibrosis

N. McElvaney, C. Greene, P. Branagan, 2008, Expert opinion on therapeutic targets.

Toll-like receptors as therapeutic targets in cystic fibrosis

N. McElvaney, C. Greene, P. Branagan, 2008 .

Toll-like receptors as therapeutic targets in cystic fibrosis.

N. McElvaney, C. Greene, P. Branagan, 2008, Expert opinion on therapeutic targets.

Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

F. Malone, N. McElvaney, P. Dicker, 2013, The Journal of clinical endocrinology and metabolism.

Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).

M. Sanak, J. Ficker, N. Seersholm, 2017, The Lancet. Respiratory medicine.

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.

E. Silverman, C. Hersh, N. McElvaney, 2014, American journal of respiratory and critical care medicine.

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.

N. McElvaney, C. Greene, S. O’Neill, 2010, American journal of respiratory and critical care medicine.

A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19

J. Laffey, N. McElvaney, I. Martín-Loeches, 2022, Med.

Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease

N. McElvaney, E. Reeves, M. Williamson, 2022, International journal of molecular sciences.

Characterization of the Inflammatory Response to Severe COVID-19 Illness

N. McElvaney, R. Costello, K. Hurley, 2020, American journal of respiratory and critical care medicine.

Measurement of the unfolded protein response (UPR) in monocytes.

N. McElvaney, C. Greene, T. Carroll, 2011, Methods in enzymology.

The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.

N. McElvaney, C. McCarthy, E. Reeves, 2016, Annals of the American Thoracic Society.

The efficacy and safety of inhaled human α-1 antitrypsin in people with α-1 antitrypsin deficiency-related emphysema

N. McElvaney, C. McCarthy, A. Franciosi, 2015, Expert review of respiratory medicine.

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling

M. Wormald, N. McElvaney, C. O’Dwyer, 2015, The Journal of Immunology.

Safety of biweekly α1-antitrypsin treatment in the RAPID programme

T. Greulich, C. Vogelmeier, N. McElvaney, 2018, European Respiratory Journal.

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.

M. Henry, P. Meleady, M. Clynes, 2010, The Journal of clinical investigation.

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

M. Fisher, N. McElvaney, R. Barton, 2022, Nature Microbiology.

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.

M. Henry, P. Meleady, M. Clynes, 2014, Journal of proteome research.

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals

N. McElvaney, E. Reeves, T. McEnery, 2018, Journal of inflammation research.

Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway*

N. McElvaney, C. Greene, S. O’Neill, 2008, Journal of Biological Chemistry.

Interactions between infection and inflammation in the cystic fibrosis airway

N. McElvaney, S. Chotirmall, K. Molloy, 2015 .

Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency

M. Henry, P. Meleady, N. McElvaney, 2020, Thorax.

Alpha-one antitrypsin aerosolized augmentation abrogates neutrophil elastase induced expression of Cathepsin B and Matrix Metalloprotease 2 in vivo and in vitro

N. McElvaney, C. Greene, M. Rogan, 2008 .

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

N. McElvaney, C. Greene, M. Rogan, 2008, Thorax.

Elastolytic Cathepsins -Defensins 2 and 3 by b Inactivation of Human

R. Levine, N. McElvaney, C. Greene, 2003 .

Secretory Leucoprotease Inhibitor Prevents Lipopolysaccharide-induced IκBα Degradation without Affecting Phosphorylation or Ubiquitination*

N. McElvaney, C. Greene, S. O’Neill, 2002, The Journal of Biological Chemistry.

Brief Report: Genetic Variation of the α1‐Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis

N. McElvaney, D. Veale, G. Mccarthy, 2017, Arthritis & rheumatology.

α1-Antitrypsin Deficiency: Biological Answers to Clinical Questions

N. McElvaney, S. O’Neill, R. Coakley, 2001 .

Alpha-1 Antitrypsin Deficiency Associated Panniculitis.

C. Gulmann, N. McElvaney, T. Carroll, 2021, Journal of the American Academy of Dermatology.

α1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome?

N. McElvaney, G. Curley, T. Carroll, 2021, Anesthesiology.

α1-Antitrypsin activates protein phosphatase 2A to counter lung inflammatory responses.

M. Campos, N. McElvaney, R. Foronjy, 2014, American journal of respiratory and critical care medicine.

The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus

N. McElvaney, K. Kavanagh, E. Reeves, 2018, Infection and Immunity.

Pulmonary Infl ammation in Cystic Fibrosis: Impact of Innate Immunity and Estrogen

B. Harvey, N. McElvaney, C. Greene, 2011 .

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.

W. Thomas, B. Harvey, I. Oglesby, 2010, American journal of respiratory and critical care medicine.

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline1

N. McElvaney, C. Greene, P. Greally, 2009, The Journal of Immunology.

The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis

N. McElvaney, D. Bergin, E. Reeves, 2011, TheScientificWorldJournal.

The Basophil Surface Marker CD 203 c Identifies Aspergillus Sensitization in 1 Cystic Fibrosis

Ahmed Abdul Azim, N. McElvaney, C. Greene, 2018 .

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.

Ahmed Abdul Azim, N. McElvaney, C. Greene, 2016, The Journal of allergy and clinical immunology.

Elafin, an Elastase-specific Inhibitor, Is Cleaved by Its Cognate Enzyme Neutrophil Elastase in Sputum from Individuals with Cystic Fibrosis*

M. Butler, R. Levine, N. McElvaney, 2008, Journal of Biological Chemistry.

Proteases and antiproteases in chronic neutrophilic lung disease – relevance to drug discovery

N. McElvaney, C. Greene, 2009, British journal of pharmacology.

Molecular characterization of a glycosylphosphatidylinositol-linked ADP- ribosyltransferase from lymphocytes

J. Moss, N. McElvaney, E. Lesma, 1996 .

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases

M. Butler, R. Levine, N. McElvaney, 2010, Biological chemistry.

Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin De ﬁ ciency in

E. Silverman, C. Hersh, B. Hobbs, 2020 .

Pitfalls and caveats in α1-antitrypsin deficiency testing: a guide for clinicians.

N. McElvaney, T. Carroll, A. Franciosi, 2019, The Lancet. Respiratory medicine.

Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction

Q. Hamid, R. Olivenstein, B. Wallaert, 2004, European Respiratory Journal.

Increased Expression of Interleukin‐9, Interleukin‐9 Receptor, and the Calcium‐Activated Chloride Channel hCLCA1 in the Upper Airways of Patients With Cystic Fibrosis

Q. Hamid, N. McElvaney, K. Holroyd, 2003, The Laryngoscope.

miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency.

P. Buckley, R. Cummins, N. McElvaney, 2014, American journal of respiratory and critical care medicine.

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.

N. McElvaney, C. Greene, S. O’Neill, 2002, The Journal of biological chemistry.

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.

N. McElvaney, S. O’Neill, R. Coakley, 2001, American journal of respiratory cell and molecular biology.

Quantification and Evaluation of the Role of Antielastin Autoantibodies in the Emphysematous Lung

N. McElvaney, C. Greene, S. O’Neill, 2011, Pulmonary medicine.

Attitudes Towards Vaccination Against Coronavirus Disease 2019 in Patients with Severe Alpha-1 Antitrypsin Deficiency

N. McElvaney, B. Cleary, T. Carroll, 2022, Chronic obstructive pulmonary diseases.

Alpha-1 Antitrypsin Deficiency and Tobacco Smoking: Exploring Risk Factors and Smoking Cessation in a Registry Population

N. McElvaney, T. Carroll, L. Fee, 2020, COPD.

SZ alpha-1 antitrypsin deficiency and pulmonary disease: more like MZ, not like ZZ

N. McElvaney, T. Carroll, A. Franciosi, 2020, Thorax.

N. McElvaney, D. Veale, U. Fearon, 2017, Arthritis & rheumatology.

Autoantibody production in rheumatoid arthritis associated with alpha‐1‐antitrypsin deficiency is complex and likely driven by inflammation and neutrophil dysfunction

N. McElvaney, D. Veale, U. Fearon, 2017 .

Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation

A. Dabo, N. McElvaney, G. Turino, 2019, ERJ Open Research.

Diagnosing α1-antitrypsin deficiency: how to improve the current algorithm

N. McElvaney, 2015, European Respiratory Review.

In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin

M. Henry, P. Meleady, N. McElvaney, 2021, ERJ open research.

Unusual Acute Sequelae of α1-Antitrypsin Deficiency: A Myriad of Symptoms With One Common Cure.

N. McElvaney, C. McCarthy, T. Carroll, 2015, Chest.

Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression1

N. McElvaney, C. Greene, M. Rogan, 2007, The Journal of Immunology.

A Dry Powder Formulation of Liposome-Encapsulated Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) for Inhalation: Preparation and Characterisation

N. McElvaney, S. Cryan, A. Gibbons, 2010, AAPS PharmSciTech.

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

N. McElvaney, S. Cryan, C. Taggart, 2009, Journal of microencapsulation.

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses.

N. McElvaney, S. Weldon, N. McGarry, 2007, Biochemical Society transactions.

Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis.

N. McElvaney, P. Greally, S. O’Neill, 2011, American journal of respiratory and critical care medicine.

Alpha-1 Antitrypsin Deficiency: Recent Developments in Gene Therapy Research

N. McElvaney, C. Greene, 2011 .

Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels

B. Fischer, N. McElvaney, A. Ghio, 2009, Clinical and translational science.

Alpha-1 antitrypsin for cystic fibrosis complicated by severe cytokinemic COVID-19

N. McElvaney, G. Curley, J. O'Rourke, 2020, Journal of Cystic Fibrosis.

Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.

N. McElvaney, M. Griese, J. Riethmüller, 2016, The Journal of allergy and clinical immunology.

Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

N. McElvaney, S. O’Neill, K. Pohl, 2013, BioMed research international.

Be Restored by Hypertonic Saline Inhibits Antimicrobial Activity, Which Can Glycosaminoglycans in Cystic Fibrosis Lungs LL-37 Complexation with

N. McElvaney, C. Greene, P. Greally, 2009 .

Activation of Endoplasmic Reticulum-Specific Stress Responses Associated with the Conformational Disease Z α1-Antitrypsin Deficiency1

N. McElvaney, C. Greene, M. Lawless, 2004, The Journal of Immunology.

miR-199 a-5 p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α 1-antitrypsin deficiency

P. Buckley, R. Cummins, N. McElvaney, 2016 .

TLR-Induced Inflammation in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cells1

N. McElvaney, C. Greene, S. O’Neill, 2005, The Journal of Immunology.

The Cystic Fibrosis ‘Gender Gap’: Past Observations Present Understanding and Future Directions

B. Harvey, N. McElvaney, C. Greene, 2012 .

In Vitro Activities of Synthetic Host Defense Propeptides Processed by Neutrophil Elastase against Cystic Fibrosis Pathogens

N. McElvaney, C. Greene, S. Cryan, 2011, Antimicrobial Agents and Chemotherapy.

in the Cystic Fibrosis AirwaysGalectin-9 Pathway - Dysregulation of TIM-3

T. Niki, M. Hirashima, N. McElvaney, 2011 .

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

B. Dimitrov, N. McElvaney, C. Greene, 2010, Thorax.

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis.

M. Uskoković, L. Adorini, N. McElvaney, 2011, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity

N. McElvaney, C. Greene, C. Taggart, 2015, Journal of immunology research.

Secretory Leucoprotease Inhibitor Impairs Toll-Like Receptor 2- and 4-Mediated Responses in Monocytic Cells

N. McElvaney, C. Greene, S. O’Neill, 2004, Infection and Immunity.

5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency

T. Flotte, B. Trapnell, James M. Wilson, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis1

N. McElvaney, C. Greene, S. O’Neill, 2000, The Journal of Immunology.

Activation in Sarcoidosis T Lymphocyte + Role of IL-18 in CD4

N. McElvaney, C. Greene, G. Meachery, 2022 .

Neutrophil Elastase UpRegulates Cathepsin B and Matrix Metalloprotease-2 Expression 1

N. McElvaney, C. Greene, M. Rogan, 2007 .

Viral Inhibition of IL-1- and Neutrophil Elastase-Induced Inflammatory Responses in Bronchial Epithelial Cells1

A. Bowie, N. McElvaney, C. Greene, 2005, The Journal of Immunology.

Bronchial Epithelial Cells Elastase-Induced Inflammatory Responses in Viral Inhibition of IL-1- and Neutrophil

A. Bowie, N. McElvaney, C. Greene, 2005 .

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial

Berend C Stoel, B. Stoel, N. Seersholm, 2015, The Lancet.

Ataluren, a New Therapeutic for Alpha‐1 Antitrypsin‐Deficient Individuals with Nonsense Mutations

M. Wormald, N. McElvaney, C. O’Dwyer, 2018, American journal of respiratory and critical care medicine.

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression

R. Stallings, I. Oglesby, N. McElvaney, 2010, The Journal of Immunology.

miR-224-5p and miR-545-5p Levels Relate to Exacerbations and Lung Function in a Pilot Study of X-Linked MicroRNA Expression in Cystic Fibrosis Monocytes

N. McElvaney, C. Greene, A. Glasgow, 2021, Frontiers in Genetics.

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6

I. Oglesby, N. McElvaney, C. Greene, 2015, Molecular and Cellular Pediatrics.

Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes.

H. J. Kim, J. Moss, N. McElvaney, 1996, Blood.

Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

A. Borczuk, L. Thorne, M. Wolfgang, 2022, eBioMedicine.

Respiratory Research BioMed Central Review

W. Timens, N. McElvaney, C. Greene, 2004 .

3 The Cystic Fibrosis ‘ Gender Gap ’ : Past Observations Present Understanding and Future Directions

B. Harvey, N. McElvaney, C. Greene, 2018 .

Immunoevasive Aspergillus Virulence Factors

N. McElvaney, S. Chotirmall, Bojana Mirković, 2014, Mycopathologia.

Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis.

K. Bennett, N. McElvaney, S. O’Neill, 2010, Chest.

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.

Seamus J. Martin, N. McElvaney, E. Lavelle, 2018, Cell reports.

Extracellular Neutrophil P roteases Are Efficient Regulators of IL-1 , IL-33 , and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing Graphical

Seamus J. Martin, N. McElvaney, E. Lavelle, 2018 .

The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

K. Bennett, N. McElvaney, C. Greene, 2012, American journal of respiratory and critical care medicine.

Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency

T. Flotte, B. Trapnell, James M. Wilson, 2017 .

AB0115 Phenotypic Variations of Alpha-One Anti-Trypsin Are Associated with Higher Titres of Ana

N. McElvaney, U. Fearon, C. McCarthy, 2015 .

Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis

S. Wallenstein, L. Herzenberg, N. McElvaney, 2015, European Respiratory Journal.

Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis

N. McElvaney, C. Greene, S. Chotirmall, 2012, Expert review of respiratory medicine.

Ivacaftor: from bench to bedside... and back again.

N. McElvaney, K. Molloy, 2014, American journal of respiratory and critical care medicine.

Reply to Blot et al. and to Inoue et al.

N. McElvaney, G. Curley, N. McEvoy, 2020, American journal of respiratory and critical care medicine.

Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin‐8 secretion in human neutrophils

N. McElvaney, C. Greene, S. O’Neill, 2002, Journal of leukocyte biology.

Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.

N. McElvaney, 2016, Annals of the American Thoracic Society.

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications

N. McElvaney, K. Chapman, I. Ferrarotti, 2018, International journal of chronic obstructive pulmonary disease.

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity

Pauline M. Rudd, Derek C. Liberti, Darrell N. Kotton, 2019, The Journal of Immunology.

interleukin-8 concentrations cystic fibrosis are associated with high bronchoalveolar lavage fluid from children with High concentrations of pepsin in http : / / thorax

B. Dimitrov, N. McElvaney, C. Greene, 2010 .

Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response

N. McElvaney, C. Greene, S. Chotirmall, 2013, BioMed research international.

Candida species in cystic fibrosis: A road less travelled.

N. McElvaney, C. Greene, S. Chotirmall, 2010, Medical mycology.

Fungi in the cystic fibrosis lung: bystanders or pathogens?

N. McElvaney, S. Chotirmall, Noel G McElvaney, 2014, The international journal of biochemistry & cell biology.

The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model

N. McElvaney, S. Cryan, A. Hickey, 2011, Pharmaceutical Research.

Tracing patterns of evolution and acquisition of drug resistant Aspergillus fumigatus infection from the environment using population genomics

M. Fisher, N. McElvaney, R. Barton, 2021, bioRxiv.

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

N. McElvaney, E. Reeves, N. Browne, 2016, BioMed research international.

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium.

N. McElvaney, C. Greene, S. Cryan, 2014, The international journal of biochemistry & cell biology.

Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in ΔF508 Cystic Fibrosis Airway Epithelium

I. Oglesby, N. McElvaney, C. Greene, 2013, The Journal of Immunology.

Targeting neutrophil elastase in cystic fibrosis

N. McElvaney, C. Greene, E. Kelly, 2008 .

The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes

I. Adcock, A. Durham, N. McElvaney, 2019, Journal of Innate Immunity.

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique

I. Oglesby, N. McElvaney, C. Greene, 2013, Nucleic acids research.

Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation1

Paul McNally, R. Levine, N. McElvaney, 2009, The Journal of Immunology.

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.

N. McElvaney, C. Greene, S. O’Neill, 2003, The Journal of infectious diseases.

New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity

N. McElvaney, K. Hurley, E. Reeves, 2015 .

TLR3 Sensing of Viral Infection

N. McElvaney, C. Greene, F. Dunlevy, 2010 .

Evidence for Unfolded Protein Response Activation in Monocytes from Individuals with α-1 Antitrypsin Deficiency

N. McElvaney, C. Greene, S. O’Neill, 2010, The Journal of Immunology.

Interleukin-1, Neutrophil Elastase, and Lipopolysaccharide: Key Pro- Inflammatory Stimuli Regulating Inflammation in Cystic Fibrosis

N. McElvaney, C. Greene, S. O’Neill, 2005 .

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

S. Rose-John, N. McElvaney, G. Curley, 2021, The Lancet Respiratory Medicine.

Therapeutic modulation of microRNA for the treatment of pro-inflammatory disorders

N. McElvaney, S. Cryan, T. Hassan, 2019 .

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases

N. McElvaney, C. Greene, S. Cryan, 2012, Expert review of anti-infective therapy.

Targeting airway inflammation in cystic fibrosis

N. McElvaney, E. Reeves, M. Murphy, 2019, Expert review of respiratory medicine.

SLPI and inflammatory lung disease in females.

N. McElvaney, C. Greene, P. McKiernan, 2011, Biochemical Society transactions.

Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity.

J. Moss, R. Levine, N. McElvaney, 2000, The Journal of biological chemistry.

Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis.

N. McElvaney, P. Greally, S. O’Neill, 2000, American journal of physiology. Lung cellular and molecular physiology.

X Chromosome-encoded MicroRNAs Are Functionally Increased in Cystic Fibrosis Monocytes.

N. McElvaney, C. Greene, S. Cryan, 2017, American journal of respiratory and critical care medicine.

Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung

V. Kuchroo, M. Hirashima, N. McElvaney, 2014, The Journal of Immunology.

Dysregulation of TIM-3–Galectin-9 Pathway in the Cystic Fibrosis Airways

T. Niki, M. Hirashima, N. McElvaney, 2011, The Journal of Immunology.

This information is current as Abrogated within the Cystic Fibrosis Lung Gram-Negative Bacterial Killing: An Effect Involved in Neutrophil-Mediated Galectin-9 Signaling through TIM-3 Is

V. Kuchroo, M. Hirashima, N. McElvaney, 2014 .

Tumor Necrosis Factor– a –Converting Enzyme: Its Role in Community-Acquired Pneumonia

N. McElvaney, C. Greene, S. O’Neill, 2002 .

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.

N. McElvaney, C. Greene, S. O’Neill, 2002, The Journal of infectious diseases.

Outcome in patients with cystic fibrosis liver disease.

N. McElvaney, P. Greally, C. Gallagher, 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis.

N. McElvaney, C. Greene, S. O’Neill, 2005, American journal of respiratory and critical care medicine.

Supplementary Methods and Results

M. Henry, P. Meleady, M. Clynes, 2015 .

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

R. Crystal, S. Brody, C. Chu, 1994, Nature Genetics.

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway.

Ahmed Abdul Azim, M. Wolfgang, N. McElvaney, 2015, American journal of respiratory and critical care medicine.

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia

N. McElvaney, C. Greene, S. O’Neill, 2003, Thorax.

The facilitating effect of hypertonic saline on resolution of airway inflammation in cystic fibrosis.

N. McElvaney, E. Reeves, 2012, American journal of respiratory and critical care medicine.

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

M. Henry, P. Meleady, M. Clynes, 2014, Blood.

Fibrosis and Non-Cystic Fibrosis Airway TLR-Induced Inflammation in Cystic

N. McElvaney, Stephen G. J. Smith, M. Greene, 2013 .

Toll-like receptor expression and function in airway epithelial cells.

N. McElvaney, C. Greene, 2005, Archivum immunologiae et therapiae experimentalis.

Neutrophil elastase up‐regulates interleukin‐8 via toll‐like receptor 4

N. McElvaney, C. Greene, S. O’Neill, 2003, FEBS letters.

Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics

G. Cagney, N. McElvaney, C. Greene, 2020, Frontiers in Immunology.

Characterisation of the Major Extracellular Proteases of Stenotrophomonas maltophilia and Their Effects on Pulmonary Antiproteases

G. Cagney, N. McElvaney, C. Greene, 2019, Pathogens.

Effect of pro‐inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor

N. McElvaney, C. Greene, S. O’Neill, 2007, Cellular microbiology.

A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application

M. Wormald, N. McElvaney, C. McCarthy, 2022, International journal of molecular sciences.

Emerging pharmacotherapies in cystic fibrosis

N. McElvaney, E. Reeves, O. McElvaney, 2018, Expert review of respiratory medicine.

A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.

N. McElvaney, E. Reeves, O. McElvaney, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis.

E. Gulbins, N. McElvaney, E. Pålsson-McDermott, 2019, American journal of respiratory and critical care medicine.

Glycosylation Repurposes Alpha‐1 Antitrypsin for Resolution of Community‐acquired Pneumonia

M. Henry, P. Meleady, P. Rudd, 2017, American journal of respiratory and critical care medicine.

Interleukin-8 Up-regulation by Neutrophil Elastase Is Mediated by MyD88/IRAK/TRAF-6 in Human Bronchial Epithelium*

N. McElvaney, C. Greene, S. O’Neill, 2001, The Journal of Biological Chemistry.

miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production

I. Oglesby, N. McElvaney, C. Greene, 2015, European Respiratory Journal.

The Circulating Proteinase Inhibitor α-1 Antitrypsin Regulates Neutrophil Degranulation and Autoimmunity

N. McElvaney, K. Hurley, D. Bergin, 2014, Science Translational Medicine.

Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis

N. McElvaney, E. Reeves, M. Williamson, 2021, Expert review of respiratory medicine.

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

N. McElvaney, C. Greene, M. Rogan, 2004, The Journal of infectious diseases.

Trikafta Rescues CFTR and Lowers Monocyte P2X7R-Induced Inflammasome Activation in Cystic Fibrosis.

N. McElvaney, E. Marron, E. Reeves, 2022, American journal of respiratory and critical care medicine.

The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell

N. McElvaney, K. Pohl, E. Reeves, 2011, Archivum Immunologiae et Therapiae Experimentalis.

C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

A. Hopkins, N. McElvaney, E. Reeves, 2021, Biomedicines.

Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients

N. McElvaney, F. Palmas, Esteban A Gomez, 2021, PloS one.

Targeting neutrophil elastase in cystic fibrosis.

N. McElvaney, C. Greene, E. Kelly, 2008, Expert opinion on therapeutic targets.

Alpha-1 Antitrypsin Therapy Modifies Neutrophil Adhesion in Patients with Obstructive Lung Disease.

P. Meleady, N. McElvaney, Orla Coleman, 2022, American journal of respiratory cell and molecular biology.

Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment

N. McElvaney, K. Hurley, E. Reeves, 2016, Expert review of respiratory medicine.

Protein misfolding and obstructive lung disease.

N. McElvaney, C. Greene, 2010, Proceedings of the American Thoracic Society.

Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

N. McElvaney, K. Pohl, E. Reeves, 2012, TheScientificWorldJournal.

Assessment of stability and fluctuations of cultured lower airway bacterial communities in people with cystic fibrosis.

N. McElvaney, M. Tunney, J. Elborn, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Alpha-1 antitrypsin deficiency: current therapy and emerging targets

N. McElvaney, T. Carroll, O. McElvaney, 2023, Expert review of respiratory medicine.

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

N. McElvaney, C. Greene, S. O’Neill, 2007, Respiratory research.

Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding

N. McElvaney, C. Greene, S. Cryan, 2005, The Journal of experimental medicine.

Inactivation of Human β-Defensins 2 and 3 by Elastolytic Cathepsins1

R. Levine, N. McElvaney, C. Greene, 2003, The Journal of Immunology.

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.

R. Levine, N. McElvaney, C. Greene, 2003, Journal of immunology.

Community‐acquired pneumonia in older patients: Does age influence systemic cytokine levels in community‐acquired pneumonia?

N. McElvaney, C. Greene, S. O’Neill, 2009, Respirology.

Chapter 4 Antiproteases as Therapeutics to Target Inflammation in Chronic Obstructive Pulmonary Disease

N. McElvaney, C. O’Dwyer, C. McCarthy, 2017 .

Antiproteases as Therapeutics to Target Inflammation in Chronic Obstructive Pulmonary Disease

N. McElvaney, C. O’Dwyer, C. McCarthy, 2014 .

A platelet dense‐granule secretion defect may lead to a muted inflammatory cell mobilization response in cystic fibrosis patients

N. McElvaney, N. Moran, K. Molloy, 2013, Journal of thrombosis and haemostasis : JTH.

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.

I. Oglesby, N. McElvaney, C. Greene, 2014, American journal of respiratory and critical care medicine.

The Impact of Smoke Exposure on the Clinical Phenotype of Alpha-1 Antitrypsin Deficiency in Ireland: Exploiting a National Registry to Understand a Rare Disease

N. McElvaney, Jonathan Shum, E. Reeves, 2015, COPD.

Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor

N. McElvaney, C. Greene, S. O’Neill, 2010, Mediators of inflammation.

Hermansky-Pudlak syndrome with a novel genetic variant in HPS1 and subsequent accelerated pulmonary fibrosis: significance for phenocopy diseases

W. Gahl, M. Huizing, N. McElvaney, 2018, Thorax.

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.

M. Henry, P. Meleady, M. Clynes, 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.

N. McElvaney, K. Pohl, C. McCarthy, 2015, Molecular immunology.

Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function.

N. McElvaney, K. Pohl, C. McCarthy, 2015, World journal of critical care medicine.

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

N. McElvaney, E. Reeves, M. Murphy, 2021, Medicina.

Clarifying the Risk of Lung Disease in SZ α1-antitrypsin Deficiency.

E. Silverman, C. Hersh, B. Hobbs, 2020, American journal of respiratory and critical care medicine.

α1 Antitrypsin therapy modulates the neutrophil membrane proteome and secretome

M. Henry, P. Meleady, N. McElvaney, 2020, European Respiratory Journal.

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB

N. McElvaney, C. Greene, C. Mooney, 2017, Scientific Reports.

Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives.

N. McElvaney, S. O’Neill, David Smith, 2010, Journal of critical care.

miR-CATCH: microRNA capture affinity technology.

N. McElvaney, C. Greene, Stephen G. J. Smith, 2015, Methods in molecular biology.

Is There a Therapeutic Role for Selenium in Alpha-1 Antitrypsin Deficiency?

N. McElvaney, C. Greene, R. Chhabra, 2013, Nutrients.

Selenoprotein S/SEPS1 Modifies Endoplasmic Reticulum Stress in Z Variant α1-Antitrypsin Deficiency*

N. McElvaney, C. Greene, S. O’Neill, 2009, The Journal of Biological Chemistry.

Immunoevasive Aspergillus Virulence Factors

N. McElvaney, S. Chotirmall, Bojana Mirković, 2014, Mycopathologia.

Reply: interactions and clarifying group-specific estimates by using stratification.

C. Hersh, N. McElvaney, J. Lasky-Su, 2014, American journal of respiratory and critical care medicine.

The Prevalence of Alpha-1 Antitrypsin Deficiency in Ireland.

N. McElvaney, S. O’Neill, R. Costello, 2009, ATS 2009.

Secretory Leucocyte Protease Inhibitor Inhibits Interferon-γ-induced Cathepsin S Expression*

N. McElvaney, C. Greene, S. O’Neill, 2007, Journal of Biological Chemistry.

Alpha-1 Antitrypsin: A Potent Anti-Inflammatory and Potential Novel Therapeutic Agent

N. McElvaney, K. Hurley, D. Bergin, 2012, Archivum Immunologiae et Therapiae Experimentalis.

Targeting IL-8 in Cystic Fibrosis: Enough but Not Too Much.

N. McElvaney, O. McElvaney, 2018, American journal of respiratory cell and molecular biology.

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

M. Henry, P. Meleady, M. Clynes, 2017, EBioMedicine.

Cystic Fibrosis Airway Epithelium ∆ MicroRNA-145 ,-223 , and-494 Is Altered in Transmembrane Conductance Regulator by Regulation of Cystic Fibrosis and

I. Oglesby, N. McElvaney, C. Greene, 2013 .

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8.

N. McElvaney, P. Greally, S. O’Neill, 2000, American journal of physiology. Lung cellular and molecular physiology.

The role of TIM-containing molecules in airway disease and their potential as therapeutic targets

N. McElvaney, E. Reeves, I. Vega-Carrascal, 2012, Journal of inflammation research.

Serendipitous detection of α1-antitrypsin deficiency: a single institution’s experience over a 32 month period

N. McElvaney, T. Cronin, T. Carroll, 2021, Clinical chemistry and laboratory medicine.

Consequences of Abrupt Cessation of Alpha1-Antitrypsin Replacement Therapy.

B. Hobbs, N. McElvaney, E. Reeves, 2020, The New England journal of medicine.

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

N. McElvaney, K. McQuillan, K. Pohl, 2020, Frontiers in Immunology.

Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency.

N. McElvaney, E. Reeves, M. Murphy, 2020, Chronic obstructive pulmonary diseases.

Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis

N. McElvaney, S. O’Neill, T. Hassan, 2014, BMC Immunology.

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

N. McElvaney, C. Greene, J. Elborn, 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Alpha 1-antitrypsin deficiency.

N. McElvaney, S. O’Neill, R. Coakley, 1999, Irish medical journal.

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response.

N. McElvaney, C. Greene, 2010, World journal of gastrointestinal pharmacology and therapeutics.

Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.

R. Crystal, N. McElvaney, N. McElvaney, 1992, The Journal of clinical investigation.

A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis.

R. Crystal, S. Shak, N. McElvaney, 1992, The New England journal of medicine.

Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS)

Derek C. Dorris, M. Woodward, R. Stallings, 2016, BMC Proceedings.

Alpha-1 antitrypsin deficiency: clarifying the role of the putative protective threshold

N. McElvaney, T. Carroll, A. Franciosi, 2021, European Respiratory Journal.

Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis.

R. Crystal, N. McElvaney, N. McElvaney, 1993, The American review of respiratory disease.

α1-Antitrypsin deficiency

D. Lomas, J. Stoller, N. McElvaney, 2016, Nature Reviews Disease Primers.

Supplementary Methods and Results

Jonathan H. Chan, S. Scherer, D. Merico, 2015 .

Is gene therapy in cystic fibrosis a realistic expectation?

N. McElvaney, 1996, Current opinion in pulmonary medicine.

Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function.

N. McElvaney, K. Pohl, C. McCarthy, 2015, World journal of critical care medicine.

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway.

Ahmed Abdul Azim, M. Wolfgang, N. McElvaney, 2015, American journal of respiratory and critical care medicine.

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations

N. McElvaney, P. Greally, M. Shields, 2010, Thorax.

High Concentrations of Pepsin in Bronchoalveolar Lavage Fluid from Children with Cystic Fibrosis Are Associated with High Interleukin-8 Concentrations

N. McElvaney, P. Greally, E. Ervine, 2010 .

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis

N. McElvaney, K. McQuillan, E. Reeves, 2020, Frontiers in Pharmacology.

A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.

N. McElvaney, E. Reeves, O. McElvaney, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Community‐acquired pneumonia in older patients: Does age influence systemic cytokine levels in community‐acquired pneumonia?

N. McElvaney, C. Greene, S. O’Neill, 2009, Respirology.

Antimicrobial proteins and polypeptides in pulmonary innate defence

N. McElvaney, C. Greene, M. Rogan, 2006, Respiratory research.

Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

F. Malone, N. McElvaney, P. Dicker, 2013, The Journal of clinical endocrinology and metabolism.

Dysregulation of TIM-3–Galectin-9 Pathway in the Cystic Fibrosis Airways

T. Niki, M. Hirashima, N. McElvaney, 2011, The Journal of Immunology.

Neutrophil elastase up‐regulates human β‐defensin‐2 expression in human bronchial epithelial cells

Shane O'Neill, N. McElvaney, C. Greene, 2003, FEBS letters.

Normal values and ranges for ventilation and breathing pattern at maximal exercise.

N J Morrison, N. McElvaney, M. Fairbarn, 1991, Chest.

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

N. McElvaney, S. Cryan, C. Taggart, 2009, Journal of microencapsulation.

THEMED SECTION: MEDIATORS AND RECEPTORS IN THE RESOLUTION OF INFLAMMATION REVIEW Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

N. McElvaney, C. Greene, 2009 .

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.

Ahmed Abdul Azim, N. McElvaney, C. Greene, 2016, The Journal of allergy and clinical immunology.

Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding

N. McElvaney, C. Greene, S. Cryan, 2005, The Journal of experimental medicine.

Alpha-1 antitrypsin regulates neutrophil reactive oxygen species production via inhibition of key players of the respiratory burst oxidase system

N. McElvaney, D. Bergin, E. Reeves, 2013, BMC Proceedings.