S. Traynelis

S. Traynelis, R. Mckeon, P. Lyuboslavsky, 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.

A. Scimemi, Arun Singh, A. Jenkins, 2018, Cell reports.

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

Eric J Miller, Eric J. Miller, D. Liotta, 2018, Molecular Pharmacology.

Allosteric Regulation and Spatial Distribution of Kainate Receptors Bound to Ancillary Proteins

G. D. Lange, S. Traynelis, D. Bowie, 2003, The Journal of physiology.

Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.

S. Traynelis, J. Hepler, K. Mccoy, 2012, Cellular signalling.

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

M. Regan, D. Liotta, Zongjian Zhu, 2019, Nature Communications.

Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus

S. Traynelis, C. J. Lee, Jaekwang Lee, 2011, Molecular Brain.

Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders

S. Traynelis, Hongjie Yuan, Weiting Tang, 2020, Neuropharmacology.

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.

T. Lovenberg, N. Carruthers, S. Traynelis, 2019, ACS medicinal chemistry letters.

AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise

S. Traynelis, T. Benke, 2018, Neurochemical Research.

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis

R. Huganir, S. Snyder, S. Traynelis, 2012, Proceedings of the National Academy of Sciences.

Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones.

S. Cull-Candy, S. Traynelis, S. Cull‐Candy, 1991, The Journal of physiology.

Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B

D. Baralle, A. Laquérriere, S. Mansour, 2022, Journal of Medical Genetics.

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors.

D. Liotta, S. Traynelis, Kevin K Ogden, 2020, ACS chemical neuroscience.

PAR1 and PAR2 Couple to Overlapping and Distinct Sets of G Proteins and Linked Signaling Pathways to Differentially Regulate Cell Physiology

S. Traynelis, J. Hepler, K. Mccoy, 2010, Molecular Pharmacology.

Modeling and treating GRIN2A developmental and epileptic encephalopathy in mice

D. Goldstein, Daniel K Krizay, W. Frankel, 2019, bioRxiv.

The GluN2B‐Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand‐unbinding and domain opening

J. Snyder, D. Liotta, S. Traynelis, 2018, Proteins.

MOL094516 548..560

J. Snyder, S. Zimmerman, D. Liotta, 2014 .

A roadmap for precision medicine in the epilepsies

I. Scheffer, H. Mefford, S. Berkovic, 2015, The Lancet Neurology.

Mechanism for non-competitive inhibition by novel GluN2C/D NMDA receptor subunit-selective modulators

J. Snyder, D. Liotta, S. Traynelis, 2011 .

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes

D. Brat, J. Olson, C.Justin Lee, 2004, Experimental Neurology.

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells

S. Traynelis, K. Hansen, Hongjie Yuan, 2018, Neuron.

Is tissue plasminogen activator a threat to neurons?

S. Lipton, S. Traynelis, 2001, Nature Medicine.

PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance

S. Traynelis, Meagan A. Jenkins, 2012, Channels.

Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

S. Traynelis, C. J. Lee, J. Hepler, 2003, Molecular pharmacology.

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.

M. Pomper, A. Horti, S. Traynelis, 2016, Journal of medicinal chemistry.

Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.

S. Traynelis, Hiro Furukawa, Hyunook Kang, 2022, Molecular cell.

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors

S. Traynelis, Subhrajit Bhattacharya , 2018, Journal of experimental neuroscience.

Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

H. Mefford, M. Rogawski, K. Staley, 2020, Epilepsy currents.

Compound‐heterozygous GRIN2A null variants associated with severe developmental and epileptic encephalopathy

S. Traynelis, S. J. Myers, J. Lemke, 2022, Epilepsia.

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

J. Kehr, S. Thompson, T. Gould, 2019, Proceedings of the National Academy of Sciences.

The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas.

J. Olson, S. Traynelis, S. Swanger, 2016, Annals of translational medicine.

NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate

Stephen F Traynelis, Thomas Wichmann, Annalisa Scimemi, 2018, Journal of neuroscience research.

Sympathetic Preganglionic Neurons Cyclase Activating Polypeptide in Neonatal Rat Potentiation of NMDA Currents by Pituitary Adenylate

Loren J. Martin, J. Roder, R. Dingledine, 2015 .

Open probability of homomeric murine 5‐HT3A serotonin receptors depends on subunit occupancy

S. Traynelis, K. Erreger, T. Banke, 2001, The Journal of physiology.

NMDA Receptors in the Central Nervous System.

F. Menniti, S. Traynelis, K. Hansen, 2017, Methods in molecular biology.

Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation

F. Noubary, S. Moss, S. Traynelis, 2019, The Journal of Neuroscience.

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

C. Bundgaard, S. Zimmerman, D. Liotta, 2017, ACS chemical neuroscience.

Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators

J. Snyder, D. Liotta, S. Traynelis, 2011, Molecular Pharmacology.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

J. Diamond, F. Menniti, L. Wollmuth, 2021, Pharmacological Reviews.

Zinc inhibition of rat NR1/NR2A N‐methyl‐d‐aspartate receptors

S. Traynelis, K. Erreger, 2008, The Journal of physiology.

Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies

Matthew T. Geballe, J. Snyder, S. Traynelis, 2008, Molecular Brain.

Activation of NR1/NR2B NMDA receptors

S. Traynelis, T. Banke, 2003, Nature Neuroscience.

Structure, function, and allosteric modulation of NMDA receptors

L. Wollmuth, A. Gibb, S. Traynelis, 2018, The Journal of general physiology.

EXCITATORY AMINO ACID RECEPTOR CHANNELS IN RAT

S. Cull-Candy, S. Traynelis, 2005 .

Glutamate receptor gating.

S. Traynelis, K. Erreger, D. Wyllie, 2004, Critical reviews in neurobiology.

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007, Molecular Pharmacology.

Selective RNA editing and subunit assembly of native glutamate receptors

J. Morrison, R. Puchalski, S. Heinemann, 1994, Neuron.

Subunit-Specific Agonist Activity at NR 2 A-, NR 2 B-, NR 2 C-, and NR 2 D-Containing N-Methyl-D-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007 .

Potentiation of NMDA receptor currents by arachidonic acid

D. Attwell, S. Traynelis, M. Sarantis, 1992, Nature.

Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition

S. Traynelis, P. Conn, F. Zheng, 1998, Nature Neuroscience.

Proton Release as a Modulator of Presynaptic Function

M. Chesler, S. Traynelis, 2001, Neuron.

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

S. Cull-Candy, S. Traynelis, 1990, Nature.

Mechanism of CaMKII regulation of AMPA receptor gating

R. Huganir, A. Schousboe, S. Traynelis, 2011, Nature Neuroscience.

Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain

S. Traynelis, K. Hansen, Hiro Furukawa, 2010, Molecular Pharmacology.

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009, The Journal of Neuroscience.

New advances in NMDA receptor pharmacology.

S. Traynelis, Kevin K Ogden, 2011, Trends in pharmacological sciences.

Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin

S. Traynelis, P. Wahl, S F Traynelis, 1997, The Journal of physiology.

Potentiation of NMDA Receptor Function by the Serine Protease Thrombin

S. Traynelis, P. Lyuboslavsky, M. B. Gingrich, 2000, The Journal of Neuroscience.

P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2

Y. Smith, C. Yun, S. Traynelis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function

S. Traynelis, P. Conn, O. Valenti, 2001, The Journal of Neuroscience.

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors*

S. Traynelis, Stefka Gyoneva, 2013, The Journal of Biological Chemistry.

Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.

D. Brat, S. Traynelis, R. Mckeon, 2005, Clinical neurosurgery.

Stereocontrolled Synthesis and Pharmacological Evaluation of Azetidine‐2,3‐Dicarboxylic Acids at NMDA Receptors

S. Traynelis, K. Hansen, L. Bunch, 2009, ChemMedChem.

GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine

Stephen F Traynelis, William A Gahl, David R Adams, 2014, Annals of clinical and translational neurology.

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects

Anup D. Patel, Ethan M. Goldberg, I. Scheffer, 2017, Journal of Medical Genetics.

Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions

M. Quirk, A. Robichaud, S. Traynelis, 2023, Cellular and Molecular Life Sciences.

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

A. Cohen, S. Petrovski, S. Traynelis, 2017, PLoS genetics.

Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.

K. F. Fajardo, J. Snyder, D. Kerr, 2014, Molecular genetics and metabolism.

Novel NMDA receptor modulators: an update

S. Zimmerman, D. Liotta, S. Traynelis, 2012, Expert opinion on therapeutic patents.

Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs

S. Traynelis, Hongjie Yuan, T. Benke, 2021, Neuropharmacology.

Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors

S. Traynelis, Hongjie Yuan, S. J. Myers, 2022, The Journal of Pharmacology and Experimental Therapeutics.

De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

L. Wollmuth, S. Petrovski, W. Wilcox, 2019, Human mutation.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density

K. Roche, W. Lu, M. Vieira, 2017, The Journal of Neuroscience.

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

S. Traynelis, Kevin K Ogden, K. Hansen, 2014, Neuron.

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

H. Mefford, A. Fry, D. Pilz, 2018, Brain : a journal of neurology.

Structural Determinants and Mechanism of Action of a Glun2c- Selective Nmda Receptor Positive Allosteric Modulator Running Title: Analysis of a Glun2c Nmdar Positive Allosteric Modulator

J. Snyder, S. Zimmerman, D. Liotta, 2022 .

Potentiation of GluN2C/D NMDA Receptor Subtypes in the Amygdala Facilitates the Retention of Fear and Extinction Learning in Mice

S. Traynelis, Kevin K Ogden, S. Heldt, 2014, Neuropsychopharmacology.

The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

D. Liotta, S. Traynelis, Hongjie Yuan, 2021, Molecular Pharmacology.

Biased modulators of NMDA receptors control channel opening and ion selectivity

D. Liotta, S. Traynelis, Hongjie Yuan, 2019, Nature Chemical Biology.

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

D. Liotta, S. Traynelis, P. Burger, 2018, eLife.

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases

A. Jenkins, S. Traynelis, Hongjie Yuan, 2015, Molecular Pharmacology.

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-d-Aspartate Receptors

S. Traynelis, Katie M Vance, Kevin K Ogden, 2013, Molecular Pharmacology.

Contribution of the M1 Transmembrane Helix and Pre-M1 Region to Positive Allosteric Modulation and Gating of N-Methyl-d-Aspartate Receptors

S. Traynelis, Kevin K Ogden, 2013, Molecular Pharmacology.

Molecular pharmacology of human NMDA receptors

S. Traynelis, K. Hansen, H. Bräuner‐Osborne, 2012, Neurochemistry International.

Conserved Structural and Functional Control of N-Methyl-d-aspartate Receptor Gating by Transmembrane Domain M3*

S. Dravid, S. Traynelis, Hongjie Yuan, 2005, Journal of Biological Chemistry.

Getting the most out of noise in the central nervous system

Stephen F. Traynelis, Fernan Jaramillo, S. Traynelis, 1998, Trends in Neurosciences.

Control of Voltage-independent Zinc Inhibition of Nmda Receptors by the Nr1 Subunit

S. Traynelis, F. Zheng, P. Lyuboslavsky, 2022 .

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

P. Krogsgaard‐Larsen, S. Traynelis, P. Wahl, 1998, Molecular pharmacology.

A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia

S. Traynelis, Hongjie Yuan, Yuwu Jiang, 2017, PloS one.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Marni J. Falk, H. Hakonarson, R. Chiavacci, 2016, American journal of human genetics.

Functional Analysis of a De Novo GRIN2A Missense Mutation Associated with Early-onset Epileptic Encephalopathy

D. Adams, T. Pierson, C. Boerkoel, 2014, Nature Communications.

Ionotropic glutamate-like receptor δ2 binds d-serine and glycine

P. Naur, B. Vestergaard, L. Olsen, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.

P. Naur, B. Vestergaard, L. Olsen, 2007, Proceedings of the National Academy of Sciences of the United States of America.

A de novo GRIN1 Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology

W. Dobyns, S. Traynelis, Hongjie Yuan, 2021, Frontiers in Genetics.

A novel missense mutation in GRIN 2 A causes a non-epileptic neurodevelopmental disorder

S. Traynelis, Hongjie Yuan, S. J. Myers, 2022 .

Protease-activated receptor signaling: new roles and regulatory mechanisms

J. Trejo, S. Traynelis, 2007, Current opinion in hematology.

Activation of Protease-Activated Receptor-1 Triggers Astrogliosis after Brain Injury

Stephen F Traynelis, Olivier Nicole, S. Traynelis, 2005, The Journal of Neuroscience.

Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.

D. Liotta, S. Traynelis, Kevin K Ogden, 2013, Journal of medicinal chemistry.

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Matthew T. Geballe, J. Snyder, S. Traynelis, 2008, The Journal of physiology.

Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling

Matthew T. Geballe, J. Snyder, A. Johnston, 2005, Molecular Pharmacology.

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor

S. Lipton, S. Heinemann, S. Traynelis, 1994, Neuron.

Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.

S. Traynelis, L. Petch, G. L. Waldo, 1985, The Journal of biological chemistry.

Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.

S. Traynelis, Hongjie Yuan, S. J. Myers, 2019, Brain : a journal of neurology.

Different responses of CA1 and CA3 regions to hypoxia in rat hippocampal slice.

R. Dingledine, K. Kawasaki, S. Traynelis, 1990, Journal of neurophysiology.

Structural Mechanism of F unctional Modulation by Gene Splicing in NMDA Receptors Highlights

N. Grigorieff, M. Regan, S. Traynelis, 2018 .

Three-dimensional missense tolerance ratio analysis

S. Traynelis, A. Kristensen, P. Lyuboslavsky, 2021, Genome research.

Plasmin Potentiates Synaptic N-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1*

M. Yepes, S. Traynelis, Hongjie Yuan, 2008, Journal of Biological Chemistry.

The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor.

D. Liotta, Zongjian Zhu, S. Traynelis, 2020, Journal of medicinal chemistry.

Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons

I. Helbig, C. McBain, S. Traynelis, 2021, bioRxiv.

Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

S. Traynelis, J. Hepler, Suneela Ramineni, 2022, Molecular Pharmacology.

Distinct Functional Roles of the Metabotropic Glutamate Receptors 1 and 5 in the Rat Globus Pallidus

Y. Smith, S. Traynelis, P. Conn, 2003, The Journal of Neuroscience.

Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis

S. Oh, S. Traynelis, C. J. Lee, 2012, Molecular Brain.

Bestrophin-1 Encodes for the Ca2+-Activated Anion Channel in Hippocampal Astrocytes

S. Traynelis, C. J. Lee, Soo-Jin Oh, 2009, The Journal of Neuroscience.

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.

D. Liotta, S. Traynelis, K. Hansen, 2010, Journal of medicinal chemistry.

Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block

S. Dravid, T. F. Murray, S. Traynelis, 2007, The Journal of physiology.

block Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel

S. Dravid, T. F. Murray, S. Traynelis, 2007 .

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

D. Liotta, S. Traynelis, J. Bacsa, 2017, Journal of medicinal chemistry.

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.

J. Snyder, D. Liotta, S. Traynelis, 2013, Journal of medicinal chemistry.

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

J. Snyder, D. Liotta, S. Traynelis, 2015, Neuron.

The PDZ Scaffold NHERF-2 Interacts with mGluR5 and Regulates Receptor Activity*

Y. Smith, H. Inuzuka, C. Yun, 2006, Journal of Biological Chemistry.

Serine proteases and brain damage – is there a link?

S. Traynelis, M. B. Gingrich, 2000, Trends in Neurosciences.

RESEARCH Open Access Activation of protease activated receptor

S. Traynelis, C. J. Lee, Jaekwang Lee, 2022 .

Systemic inflammation regulates microglial responses to tissue damage in vivo

Francis Loth, Stephen F Traynelis, Katerina Akassoglou, 2014, Glia.

Structure-based discovery of antagonists for GluN3-containing N-methyl-d-aspartate receptors

J. Greenwood, S. Traynelis, K. Hansen, 2013, Neuropharmacology.

Structure and Function of the NMDA Receptor

Matthew T. Geballe, S. Traynelis, K. Hansen, 2008 .

Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A

S. Traynelis, P. Conn, K. Erreger, 2001, Nature Neuroscience.

Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines.

S. Heinemann, M. Hartley, S. Traynelis, 1995, Science.

causes desensitization of NMDA receptors Allosteric interaction between zinc and glutamate binding domains on NR2A

S. Traynelis, K. Erreger, 2008 .

Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors

S. Traynelis, K. Erreger, 2005, The Journal of physiology.

Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors

Matthew T. Geballe, J. Snyder, S. Dravid, 2010, The Journal of Neuroscience.

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors

Y. Bae, R. Berlinguer-Palmini, S. Dravid, 2015, Molecular Brain.

Structural Correlates of Ionotropic Glutamate Receptor Function

L. Wollmuth, S. Traynelis, K. Hansen, 2008 .

Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.

Steven H. Liang, L. Josephson, J. Daunais, 2019, ACS chemical neuroscience.

Binding of ArgTX-636 in the NMDA receptor ion channel.

S. Traynelis, K. Hansen, Jacob Andersen, 2015, Journal of molecular biology.

Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model

R. Dingledine, M. Regan, S. Traynelis, 2023, ACS chemical neuroscience.

Astrocytic control of synaptic NMDA receptors

C. J. Lee, Stephen F Traynelis, C Justin Lee, 2007, The Journal of physiology.

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

R. Dingledine, S. Traynelis, J. Doherty, 1998, Nature Neuroscience.

AMPA receptors: Molecular biology and pharmacology

S. Dravid, S. Traynelis, Hongjie Yuan, 2009 .

GPR37L1 controls maturation and organization of cortical astrocytes during development

S. Sloan, S. Traynelis, R. Hall, 2023, Glia.

Learning and memory deficits in mice lacking protease activated receptor-1

K. Ressler, J. Sweatt, J. Chhatwal, 2007, Neurobiology of Learning and Memory.

Functional effects of disease-associated variants reveal that the S1–M1 linker of the NMDA receptor critically controls channel opening

L. Armengol, T. Pierson, P. Sanchez-Lara, 2023, Cellular and Molecular Life Sciences.

Conserved patterns across ion channels correlate with variant pathogenicity and clinical phenotypes

P. May, M. Nothnagel, S. Schorge, 2022, bioRxiv.

The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus

J. Chelly, S. Traynelis, Hongjie Yuan, 2020, Movement disorders : official journal of the Movement Disorder Society.

Differential regulation of microglial motility by ATP/ADP and adenosine.

S. Traynelis, Anna G. Orr, Stefka Gyoneva, 2009, Parkinsonism & related disorders.

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

R. Huganir, A. Schousboe, S. Traynelis, 2011, Nature Neuroscience.

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder

S. Traynelis, Hongjie Yuan, S. J. Myers, 2018, Movement disorders : official journal of the Movement Disorder Society.

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

Y. Smith, G. Miller, S. Traynelis, 2014, Neurobiology of Disease.

Structural aspects of AMPA receptor activation, desensitization and deactivation

S. Traynelis, K. Hansen, Hongjie Yuan, 2007, Current Opinion in Neurobiology.

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors

Y. Bae, R. Berlinguer-Palmini, S. Dravid, 2015, Molecular Brain.

Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival.

D. Brat, S. Paek, S. Kang, 2010, Cancer research.

AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise

S. Traynelis, T. Benke, 2019, Neurochemical Research.

Expression and characterization of soluble amino‐terminal domain of NR2B subunit of N‐methyl‐d‐aspartate receptor

S. Traynelis, F. Ng, L. Lim, 2005, Protein science : a publication of the Protein Society.

Amino acid receptors and uptake systems in the mammalian central nervous system.

N. L. Chamberlin, R. Dingledine, K. Kawasaki, 1988, Critical reviews in neurobiology.

Identification of Amino Acid Residues in GluR1 Responsible for Ligand Binding and Desensitization

T. Liljefors, A. Schousboe, J. Greenwood, 2001, The Journal of Neuroscience.

Altered motility of plaque-associated microglia in a model of Alzheimer’s disease

S. Traynelis, D. Weinshenker, S. Swanger, 2016, Neuroscience.

Adenosine A(2A) receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

G. Miller, S. Traynelis, Lauren P. Shapiro, 2022 .

Regulation of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Function by Protein Kinase C at Serine-818 and Threonine-840

J. Snyder, R. Huganir, A. Jenkins, 2014, Molecular Pharmacology.

Mapping the Binding of GluN2B-Selective N-Methyl-d-aspartate Receptor Negative Allosteric Modulators

Matthew T. Geballe, J. Snyder, D. Liotta, 2012, Molecular Pharmacology.

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors.

S. Traynelis, F. Zheng, C. Low, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Control of N-methyl-D-aspartate Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009 .

Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating.

William H. Thiel, William H Thiel, K. Williams, 2003, Molecular pharmacology.

6.2 Structure-Function Correlates of Glutamate-Gated Ion Channels

L. Wollmuth, S. Traynelis, K. Hansen, 2012 .

Protons Trap NR1/NR2B NMDA Receptors in a Nonconducting State

S. Dravid, S. Traynelis, T. Banke, 2005, The Journal of Neuroscience.

Molecular Protons Trap NR 1 / NR 2 B NMDA Receptors in a Nonconducting State

S. Dravid, S. Traynelis, G. Banke, 2004 .

NMDA receptor modulators: an updated patent review (2013 – 2014)

D. Liotta, S. Traynelis, K. Strong, 2014, Expert opinion on therapeutic patents.

A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2

Matthew T. Geballe, P. Naur, B. Vestergaard, 2005, Journal of Biological Chemistry.

Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.

J. Kastrup, S. Traynelis, J. Egebjerg, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Contribution of the M 1 Transmembrane Helix and PreM 1 Region to Positive Allosteric Modulation and Gating of N-Methyl-D-Aspartate Receptors s

S. Traynelis, Kevin K Ogden, 2013 .

Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson's Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1

G. Miller, S. Traynelis, Hongjie Yuan, 2007, Molecular Pharmacology.

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Y. Smith, C. McBain, D. Liotta, 2016, Molecular Pharmacology.

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

D. Liotta, S. Traynelis, Katie M Vance, 2010, Nature Communications.

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-d-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site*

J. Greenwood, J. Kastrup, M. Gajhede, 2013, The Journal of Biological Chemistry.

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

R. Dingledine, D. Liotta, M. Yepes, 2009, Bioorganic & medicinal chemistry.

Molecular Mechanism of a Novel GluN 1 Glycine-Site Antagonist ! " ! ! Crystal Structure and Pharmacological Characterization of a Novel NMDA Receptor Antagonist at the GluN 1 Glycine Binding Site

J. Greenwood, J. Kastrup, M. Gajhede, 2013 .

Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

S. Traynelis, K. Hansen, C. Thompson, 2019, The Journal of physiology.

Recurrent seizure‐related GRIN1 variant: Molecular mechanism and targeted therapy

Daniel W. Shrey, S. Traynelis, Hongjie Yuan, 2021, Annals of clinical and translational neurology.

Mechanism of Partial Agonism at NMDA Receptors for a Conformationally Restricted Glutamate Analog

Matthew T. Geballe, J. Snyder, S. Dravid, 2005, The Journal of Neuroscience.

Modulation of the Dimer Interface at Ionotropic Glutamate-Like Receptor δ2 by d-Serine and Extracellular Calcium

P. Naur, J. Kastrup, M. Gajhede, 2009, The Journal of Neuroscience.

Properties of AMPA Receptor Channel During Long-Term Depression in Rat Cerebellar Purkinje Cells

Kazuhisa Ichikawa, Tohru Yoshioka, T. Yoshioka, 2000 .

Activation of recombinant NR1/NR2C NMDA receptors

S. Dravid, S. Traynelis, A. Prakash, 2008, The Journal of physiology.

Synaptic Receptor Diversity Revealed Across Space and Time

S. Traynelis, S. Swanger, Sharon A. Swanger, 2018, Trends in Neurosciences.

Software-based correction of single compartment series resistance errors

Stephen F Traynelis, S. Traynelis, 1998, Journal of Neuroscience Methods.

How Glutamate Receptor Subunits Mix and Match: Details Uncovered

S. Traynelis, K. Hansen, 2011, Neuron.

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

S. Traynelis, Kevin K Ogden, K. Hansen, 2012, The Journal of Neuroscience.

Differential binding properties of [H-3]dextrorphan and [H-3]MK-801 in heterologously expressed NMDA receptors

T. F. Murray, S. Traynelis, C. Low, 2022 .

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

S. Traynelis, Katie M Vance, K. Hansen, 2012, The Journal of physiology.

Modification of potassium-induced interictal bursts and electrographic seizures by divalent cations

R. Dingledine, S. Traynelis, 1989, Neuroscience Letters.

Malevolent lurkers no more: NMDA receptors come of age

C. McBain, S. Traynelis, 2006, The Journal of physiology.

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.

S. Traynelis, Katie M Vance, Hiro Furukawa, 2011, Nature communications.

NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus

Y. Smith, S. Traynelis, Katie M Vance, 2015, The Journal of Neuroscience.

Molecular NMDA Receptors Containing the GluN 2 D Subunit Control Neuronal Function in the Subthalamic Nucleus

Y. Smith, S. Traynelis, Katie M Vance, 2022 .

Role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures.

R. Dingledine, S. Traynelis, 1989, Journal of neurophysiology.

Phase 1 Clinical Results for NP10679, a pH‐sensitive GluN2B‐selective N‐methyl‐d‐aspartate Receptor Inhibitor

R. Dingledine, S. Traynelis, D. Laskowitz, 2023, Clinical pharmacology in drug development.

Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke

S. Wolf, A. Butler, M. LaPlaca, 2015, Rehabilitation research and practice.

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor.

D. Liotta, Zongjian Zhu, S. Traynelis, 2019, ACS Medicinal Chemistry Letters.

Loss of Grin2a Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null GRIN2A Variants

I. Helbig, C. McBain, S. Traynelis, 2023, bioRxiv.

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

P. Naur, L. Olsen, J. Kastrup, 2016, Molecular Pharmacology.

GluD2: GluD2 receptors containing the lurcher mutation iGluRs: Ionotropic glutamate receptors ITC: Isothermal titration calorimetry LBD: Ligand binding domain LTP: Long-term potentiation LTD: Long-term depression NMDA: N-methyl-D-aspartate NMDAR: NMDA receptor PSD: Postsynaptic density SAR: Structur

P. Naur, M. Gajhede, S. Traynelis, 2015 .

Glutamate Clearance Receptors at Thalamocortical Synapses: Role of Kinetics and Activation of Postsynaptic Kainate

S. Sherman, J. Isaac, R. Dingledine, 2015 .

NMDA receptor permeation: a light in the tunnel

S. Traynelis, D. Wyllie, 2012, Nature Neuroscience.

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors

S. Traynelis, K. Hansen, 2011, The Journal of Neuroscience.

Neuroscience: Excitatory view of a receptor

L. Wollmuth, S. Traynelis, 2009, Nature.

Response to Gibb: NMDA receptor subunit gating – uncovered

S. Traynelis, T. Banke, 2004, Trends in Neurosciences.

Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry

F. Menniti, S. Traynelis, Hongjie Yuan, 2023, Neuropsychopharmacology.

Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.

S. Traynelis, K. Hansen, F. Yi, 2017, Methods in molecular biology.

Activation of recombinant NR 1 / NR 2 C NMDA receptors

S. Dravid, S. Traynelis, A. Prakash, 2008 .

Multiple non-NMDA glutamate receptors in rat cerebellar granule neurones in explant culture

S. Cull-Candy, S. Traynelis, D. Wyllie, 1992 .

Faculty Opinions recommendation of GRIN2A mutations cause epilepsy-aphasia spectrum disorders.

S. Traynelis, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Additional Depth to the NMDA Receptor Hypofunction and Parvalbumin Cell Dysfunction Hypotheses of Schizophrenia

S. Traynelis, Chad R. Camp, 2023, Biological Psychiatry.

Distinct roles of GRIN2A and GRIN2B variants in neurological conditions

S. Traynelis, Hongjie Yuan, S. J. Myers, 2019, F1000Research.

Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.

D. Brat, S. Traynelis, R. Mckeon, 2005, Clinical neurosurgery.

Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor

N. Burnashev, Jing Zhang, S. Traynelis, 2023, ACS chemical neuroscience.

Assembly and cell surface presentation of NMDA receptors

S. Traynelis, Subhrajit Bhattacharya, Chad R. Camp, 2019, Reactome - a curated knowledgebase of biological pathways.

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors*

S. Traynelis, Stefka Gyoneva, 2013, The Journal of Biological Chemistry.

Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival.

S. Traynelis, Sung-Hye Park, Jae-Yong Park, 2010, Cancer research.

Modal gating of GluN1/GluN2D NMDA receptors

S. Traynelis, Katie M Vance, K. Hansen, 2013, Neuropharmacology.

Regulation of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Function by Protein Kinase C at Serine-818 and Threonine-840

J. Snyder, R. Huganir, A. Jenkins, 2014, Molecular Pharmacology.

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis

R. Huganir, S. Traynelis, Meagan A. Jenkins, 2012, Proceedings of the National Academy of Sciences of the United States of America.

Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-d-Aspartate Receptor Antagonists

J. Snyder, Yuhong Du, S. Traynelis, 2010, Journal of Pharmacology and Experimental Therapeutics.

A novel class of negative allosteric modulators of NMDA receptor function.

D. Liotta, S. Traynelis, Hongjie Yuan, 2015, Bioorganic & medicinal chemistry letters.

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009, The Journal of Neuroscience.

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit

S. Traynelis, F. Zheng, P. Lyuboslavsky, 1998, The Journal of Neuroscience.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density

K. Roche, W. Lu, M. Vieira, 2017, The Journal of Neuroscience.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Marni J. Falk, H. Hakonarson, R. Chiavacci, 2016, American journal of human genetics.

Clinical and functional consequences of GRIA variants in patients with neurological diseases

S. Traynelis, Hongjie Yuan, S. J. Myers, 2023, Cellular and Molecular Life Sciences.

Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function

S. Traynelis, Hongjie Yuan, S. J. Myers, 2023, Human molecular genetics.

Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy

S. Traynelis, Hongjie Yuan, Wenjuan Chen, 2017, Molecular Pharmacology.

Human Mutation

L. Wollmuth, S. Petrovski, S. Traynelis, 2019 .

Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.

Steven H. Liang, S. Traynelis, Hongjie Yuan, 2023, Journal of neurochemistry.

Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator

J. Snyder, S. Zimmerman, D. Liotta, 2014, Molecular Pharmacology.

Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors.

D. Liotta, S. Traynelis, Kevin K Ogden, 2014, Journal of medicinal chemistry.

Epilepsy: High potassium-induced synchronous bursts and electrographic seizures

R. Dingledine, C. McBain, S. Traynelis, 1993 .

A GluN2B-selective inhibitor of NMDA receptor function with enhanced potency at acidic pH and oral bioavailability for clinical use

Polina, R. Dingledine, D. Liotta, 2021 .

The Negative Allosteric Modulator EU1794-4 Reduces Single Channel Conductance and Ca2+ Permeability of GluN1/GluN2A NMDA Receptors

D. Liotta, S. Traynelis, Hongjie Yuan, 2021 .

Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.

S. Dravid, S. Traynelis, Elizabeth N. Krizman, 2024, Glia.

GluN2D-containing NMDA receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity

Y. Smith, S. Traynelis, Kevin K Ogden, 2016 .

The GluN2A Subunit of the NMDA Receptor Modulates the Rate of Functional Maturation in Parvalbumin‐positive Interneurons

S. Traynelis, K. Pelkey, A. Escayg, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural Determinants and Mechanism of Action of a Glun2c- Selective Nmda Receptor Positive Allosteric Modulator Running Title: Analysis of a Glun2c Nmdar Positive Allosteric Modulator

S. Traynelis, Hiro Furukawa, E. Karakas, 2022 .