Hongjie Yuan

发表

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

R. Dingledine, F. Menniti, L. Wollmuth, 2010, Pharmacological Reviews.

Human GRIN2B variants in neurodevelopmental disorders

Scott J. Myers, Stephen F. Traynelis, S. Traynelis, 2016, Journal of pharmacological sciences.

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.

Stephen F Traynelis, David R Adams, Jing Zhang, 2016, American journal of human genetics.

Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy

Stephen F. Traynelis, S. Traynelis, Hongjie Yuan, 2017, Molecular Pharmacology.

Distinct roles of GRIN2A and GRIN2B variants in neurological conditions

Francis Chee Kuan Tan, Jing-Qiong Kang, S. Traynelis, 2019, F1000Research.

Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif

A. Gibb, S. Traynelis, Hongjie Yuan, 2020, The Journal of physiology.

GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function

J. Graham, M. Tagliati, T. Pierson, 2017, Journal of Human Genetics.

The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of the N-Methyl-d-aspartate Receptors*

Matthew T. Geballe, J. Snyder, M. Yepes, 2009, Journal of Biological Chemistry.

Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice.

D. Goldstein, Daniel K Krizay, W. Frankel, 2020, Brain : a journal of neurology.

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

Matthew T. Geballe, J. Snyder, J. McNamara, 2008, Journal of medicinal chemistry.

Negative allosteric modulation of GluN1/GluN3 NMDA receptors

D. Liotta, Zongjian Zhu, S. Traynelis, 2020, Neuropharmacology.

Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-d-Aspartate Receptor Antagonists

J. Snyder, Yuhong Du, S. Traynelis, 2010, Journal of Pharmacology and Experimental Therapeutics.

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

M. Regan, D. Liotta, Zongjian Zhu, 2019, Nature Communications.

Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders

S. Traynelis, Hongjie Yuan, Weiting Tang, 2020, Neuropharmacology.

Protective Role of ATP-Sensitive Potassium Channels in Hypoxia-Induced Generalized Seizure

S. Seino, Hongjie Yuan, T. Miki, 2001, Science.

Modeling and treating GRIN2A developmental and epileptic encephalopathy in mice

D. Goldstein, Daniel K Krizay, W. Frankel, 2019, bioRxiv.

The GluN2B‐Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand‐unbinding and domain opening

J. Snyder, D. Liotta, S. Traynelis, 2018, Proteins.

Mechanism for non-competitive inhibition by novel GluN2C/D NMDA receptor subunit-selective modulators

J. Snyder, D. Liotta, S. Traynelis, 2011 .

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells

S. Traynelis, K. Hansen, Hongjie Yuan, 2018, Neuron.

Implementation of a fluorescence-based screening assay identifies histamine H 3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective NMDA receptor antagonists

J. Snyder, Yuhong Du, Katie M Vance, 2010 .

Sympathetic Preganglionic Neurons Cyclase Activating Polypeptide in Neonatal Rat Potentiation of NMDA Currents by Pituitary Adenylate

Loren J. Martin, J. Roder, R. Dingledine, 2015 .

Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators

J. Snyder, D. Liotta, S. Traynelis, 2011, Molecular Pharmacology.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

J. Diamond, F. Menniti, L. Wollmuth, 2021, Pharmacological Reviews.

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007, Molecular Pharmacology.

Subunit-Specific Agonist Activity at NR 2 A-, NR 2 B-, NR 2 C-, and NR 2 D-Containing N-Methyl-D-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007 .

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009, The Journal of Neuroscience.

GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine

Stephen F Traynelis, William A Gahl, David R Adams, 2014, Annals of clinical and translational neurology.

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects

Anup D. Patel, Ethan M. Goldberg, I. Scheffer, 2017, Journal of Medical Genetics.

Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions

M. Quirk, A. Robichaud, S. Traynelis, 2023, Cellular and Molecular Life Sciences.

De Novo Mutations and Rare Variants Occurring in NMDA Receptors.

Hongjie Yuan, Yuwu Jiang, Wenshu XiangWei, 2018, Current opinion in physiology.

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

A. Cohen, S. Petrovski, S. Traynelis, 2017, PLoS genetics.

Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.

K. F. Fajardo, J. Snyder, D. Kerr, 2014, Molecular genetics and metabolism.

Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs

S. Traynelis, Hongjie Yuan, T. Benke, 2021, Neuropharmacology.

Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors

S. Traynelis, Hongjie Yuan, S. J. Myers, 2022, The Journal of Pharmacology and Experimental Therapeutics.

De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

L. Wollmuth, S. Petrovski, W. Wilcox, 2019, Human mutation.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density

K. Roche, W. Lu, M. Vieira, 2017, The Journal of Neuroscience.

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

S. Traynelis, Kevin K Ogden, K. Hansen, 2014, Neuron.

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

H. Mefford, A. Fry, D. Pilz, 2018, Brain : a journal of neurology.

The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

D. Liotta, S. Traynelis, Hongjie Yuan, 2021, Molecular Pharmacology.

Biased modulators of NMDA receptors control channel opening and ion selectivity

D. Liotta, S. Traynelis, Hongjie Yuan, 2019, Nature Chemical Biology.

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases

A. Jenkins, S. Traynelis, Hongjie Yuan, 2015, Molecular Pharmacology.

Conserved Structural and Functional Control of N-Methyl-d-aspartate Receptor Gating by Transmembrane Domain M3*

S. Dravid, S. Traynelis, Hongjie Yuan, 2005, Journal of Biological Chemistry.

A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia

S. Traynelis, Hongjie Yuan, Yuwu Jiang, 2017, PloS one.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Marni J. Falk, H. Hakonarson, R. Chiavacci, 2016, American journal of human genetics.

Functional Analysis of a De Novo GRIN2A Missense Mutation Associated with Early-onset Epileptic Encephalopathy

D. Adams, T. Pierson, C. Boerkoel, 2014, Nature Communications.

A de novo GRIN1 Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology

W. Dobyns, S. Traynelis, Hongjie Yuan, 2021, Frontiers in Genetics.

A novel missense mutation in GRIN 2 A causes a non-epileptic neurodevelopmental disorder

S. Traynelis, Hongjie Yuan, S. J. Myers, 2022 .

Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling

Matthew T. Geballe, J. Snyder, A. Johnston, 2005, Molecular Pharmacology.

Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.

S. Traynelis, Hongjie Yuan, S. J. Myers, 2019, Brain : a journal of neurology.

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder

S. Traynelis, Hongjie Yuan, S. J. Myers, 2018, Movement disorders : official journal of the Movement Disorder Society.

Plasmin Potentiates Synaptic N-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1*

M. Yepes, S. Traynelis, Hongjie Yuan, 2008, Journal of Biological Chemistry.

Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons

I. Helbig, C. McBain, S. Traynelis, 2021, bioRxiv.

Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block

S. Dravid, T. F. Murray, S. Traynelis, 2007, The Journal of physiology.

block Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel

S. Dravid, T. F. Murray, S. Traynelis, 2007 .

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

J. Snyder, D. Liotta, S. Traynelis, 2015, Neuron.

Astrocytic control of synaptic NMDA receptors

C. J. Lee, Stephen F Traynelis, C Justin Lee, 2007, The Journal of physiology.

Structure and Function of the NMDA Receptor

Matthew T. Geballe, S. Traynelis, K. Hansen, 2008 .

GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy.

Hongjie Yuan, Chad R. Camp, 2019, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.

Steven H. Liang, L. Josephson, J. Daunais, 2019, ACS chemical neuroscience.

AMPA receptors: Molecular biology and pharmacology

S. Dravid, S. Traynelis, Hongjie Yuan, 2009 .

Functional effects of disease-associated variants reveal that the S1–M1 linker of the NMDA receptor critically controls channel opening

L. Armengol, T. Pierson, P. Sanchez-Lara, 2023, Cellular and Molecular Life Sciences.

The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus

J. Chelly, S. Traynelis, Hongjie Yuan, 2020, Movement disorders : official journal of the Movement Disorder Society.

Structural aspects of AMPA receptor activation, desensitization and deactivation

S. Traynelis, K. Hansen, Hongjie Yuan, 2007, Current Opinion in Neurobiology.

Mapping the Binding of GluN2B-Selective N-Methyl-d-aspartate Receptor Negative Allosteric Modulators

Matthew T. Geballe, J. Snyder, D. Liotta, 2012, Molecular Pharmacology.

Control of N-methyl-D-aspartate Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009 .

Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson's Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1

G. Miller, S. Traynelis, Hongjie Yuan, 2007, Molecular Pharmacology.

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

D. Liotta, S. Traynelis, Katie M Vance, 2010, Nature Communications.

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

R. Dingledine, D. Liotta, M. Yepes, 2009, Bioorganic & medicinal chemistry.

Recurrent seizure‐related GRIN1 variant: Molecular mechanism and targeted therapy

Daniel W. Shrey, S. Traynelis, Hongjie Yuan, 2021, Annals of clinical and translational neurology.

Loss of Grin2a Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null GRIN2A Variants

I. Helbig, C. McBain, S. Traynelis, 2023, bioRxiv.

Glutamate Clearance Receptors at Thalamocortical Synapses: Role of Kinetics and Activation of Postsynaptic Kainate

S. Sherman, J. Isaac, R. Dingledine, 2015 .

Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry

F. Menniti, S. Traynelis, Hongjie Yuan, 2023, Neuropsychopharmacology.

Protective Role of ATP-Sensitive Potassium Channels in Hypoxia-Induced Generalized Seizure

S. Seino, Hongjie Yuan, T. Miki, 2001, Science.

Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B

D. Baralle, A. Laquérriere, S. Mansour, 2022, Journal of Medical Genetics.

Distinct roles of GRIN2A and GRIN2B variants in neurological conditions

S. Traynelis, Hongjie Yuan, S. J. Myers, 2019, F1000Research.

Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor

N. Burnashev, Jing Zhang, S. Traynelis, 2023, ACS chemical neuroscience.

Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-d-Aspartate Receptor Antagonists

J. Snyder, Yuhong Du, S. Traynelis, 2010, Journal of Pharmacology and Experimental Therapeutics.

A novel class of negative allosteric modulators of NMDA receptor function.

D. Liotta, S. Traynelis, Hongjie Yuan, 2015, Bioorganic & medicinal chemistry letters.

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

S. Traynelis, Katie M Vance, Kevin K Ogden, 2009, The Journal of Neuroscience.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density

K. Roche, W. Lu, M. Vieira, 2017, The Journal of Neuroscience.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Marni J. Falk, H. Hakonarson, R. Chiavacci, 2016, American journal of human genetics.

Clinical and functional consequences of GRIA variants in patients with neurological diseases

S. Traynelis, Hongjie Yuan, S. J. Myers, 2023, Cellular and Molecular Life Sciences.

Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function

S. Traynelis, Hongjie Yuan, S. J. Myers, 2023, Human molecular genetics.

Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy

S. Traynelis, Hongjie Yuan, Wenjuan Chen, 2017, Molecular Pharmacology.

GRIN1 Mutations in Early-Onset Epileptic Encephalopathy

Hongjie Yuan, Wenjuan Chen, 2015, Pediatric Neurology Briefs.

Human Mutation

L. Wollmuth, S. Petrovski, S. Traynelis, 2019 .

Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.

Steven H. Liang, S. Traynelis, Hongjie Yuan, 2023, Journal of neurochemistry.

The Negative Allosteric Modulator EU1794-4 Reduces Single Channel Conductance and Ca2+ Permeability of GluN1/GluN2A NMDA Receptors

D. Liotta, S. Traynelis, Hongjie Yuan, 2021 .