Thomas E Mahan

发表

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

D. Holtzman, K. Yanamandra, Najla Kfoury, 2013, Neuron.

Altered sleep and EEG power in the P301S Tau transgenic mouse model

David M. Holtzman, D. Holtzman, Thomas E Mahan, 2017, Annals of clinical and translational neurology.

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

D. Holtzman, K. Yanamandra, Hong Jiang, 2015, Annals of clinical and translational neurology.

Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis

Hong Jiang, Rebecca Betensky, David M Holtzman, 2014, The Journal of Neuroscience.

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

D. Holtzman, D. Holtzman, L. Lecea, 2014, The Journal of experimental medicine.

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

D. Holtzman, J. Grutzendler, M. Colonna, 2016, The Journal of experimental medicine.

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

D. Holtzman, G. Landreth, J. Ulrich, 2013, Molecular Neurodegeneration.

Proteopathic tau seeding predicts tauopathy in vivo

Nigel J. Cairns, David M. Holtzman, D. Holtzman, 2014, Proceedings of the National Academy of Sciences.

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

D. Holtzman, J. Ulrich, Thomas E Mahan, 2022, Molecular Neurodegeneration.

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo.

D. Holtzman, M. Raichle, Thomas E Mahan, 2015, The Journal of clinical investigation.

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

D. Holtzman, K. Yanamandra, Najla Kfoury, 2013, Neuron.

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

D. Holtzman, P. Fuller, Joel C Geerling, 2019, Science.

Neuronal activity regulates extracellular tau in vivo

D. Holtzman, E. Mandelkow, J. Cirrito, 2014, The Journal of experimental medicine.

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

D. Geschwind, D. Holtzman, J. Ulrich, 2021, Neuron.

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

D. Holtzman, R. Tanzi, J. Ulrich, 2019, Molecular Neurodegeneration.

ApoE facilitates the microglial response to amyloid plaque pathology

D. Holtzman, K. Nilsson, M. Colonna, 2018, The Journal of experimental medicine.

Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology

D. Holtzman, J. Culver, C. Nichols, 2021, bioRxiv.

Effects of growth hormone–releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model

D. Holtzman, Hong Jiang, Thomas E Mahan, 2015, Brain, Behavior, and Immunity.

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

D. Holtzman, J. Ulrich, Thomas E Mahan, 2022, Molecular Neurodegeneration.

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

D. Holtzman, T. Esparza, J. Ulrich, 2017, Neuron.

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

D. Holtzman, D. Holtzman, L. Lecea, 2014, The Journal of experimental medicine.

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

D. Holtzman, L. Piccio, M. Colonna, 2014, Molecular Neurodegeneration.

Analysis of in vivo turnover of tau in a mouse model of tauopathy

D. Holtzman, E. Mandelkow, Hong Jiang, 2015, Molecular Neurodegeneration.

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

D. Holtzman, R. Tanzi, J. Ulrich, 2019, Molecular Neurodegeneration.

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

D. Holtzman, M. Colonna, T. Golde, 2018, EMBO molecular medicine.

High affinity interactions and signal transduction between Aβ oligomers and TREM2

D. Holtzman, M. Colonna, T. Golde, 2018, bioRxiv.

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

D. Holtzman, Qingli Xiao, A. Shaw, 2015, Molecular Neurodegeneration.

Effects of CD 2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

D. Holtzman, Qingli Xiao, A. Shaw, 2018 .

Brief Definitive Report

D. Holtzman, B. J. Snider, M. Yanagisawa, 2003 .

Neuronal activity regulates extracellular tau in vivo.

D. Holtzman, E. Mandelkow, J. Cirrito, 2014, The Journal of experimental medicine.

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

D. Holtzman, L. Piccio, M. Colonna, 2014, Molecular Neurodegeneration.

Neuronal activity regulates extracellular tau in vivo

D. Holtzman, D. Holtzman, E. Mandelkow, 2014, The Journal of experimental medicine.

Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis

D. Holtzman, B. Hyman, J. Culver, 2014, The Journal of Neuroscience.