Alessandro Bonifazi

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Strategic Environmental Assessment And The Democratisation Of Spatial Planning

C. Rega, Alessandro Bonifazi, P. Gazzola, 2011 .

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.

J. Deschamps, Lei Shi, J. Javitch, 2017, Journal of medicinal chemistry.

The Rise of Resilience in Spatial Planning: A Journey through Disciplinary Boundaries and Contested Practices

C. Rega, Alessandro Bonifazi, 2020 .

Evaluating Sustainability and Democracy in the Development of Industrial Port Cities: Some Italian Cases

C. Torre, Alessandro Bonifazi, Raffaele Attardi, 2012 .

Strategic Environmental Assessment and spatial planning in Italy: sustainability, integration and democracy

Alessandro Bonifazi, Carlo Rega, C. Rega, 2014 .

The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes.

A. Cilia, R. Matucci, G. Vistoli, 2017, European journal of medicinal chemistry.

Land Use Change and Habitat Degradation: A Case Study from Tomar (Portugal)

B. Murgante, A. Pilogallo, Alessandro Bonifazi, 2020 .

Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring.

G. Vistoli, G. Santoni, C. Amantini, 2015, Journal of medicinal chemistry.

Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.

R. Matucci, G. Vistoli, Alessandro Bonifazi, 2017, European journal of medicinal chemistry.

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.

RES and Habitat Quality: Ecosystem Services Evidence Based Analysis in Basilicata Area

B. Murgante, A. Pilogallo, Alessandro Bonifazi, 2020 .

Best Practices of Agro-Food Sector in Basilicata Region (Italy): Evidences from INNOVAGRO Project

B. Murgante, A. Pilogallo, Alessandro Bonifazi, 2020 .

Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.

Amy S. Billing, N. Volkow, M. Michaelides, 2019, The Journal of clinical investigation.

The highly selective dopamine D 3 R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

Z. Xi, A. Newman, C. Jordan, 2019, Neuropharmacology.

Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).

R. Matucci, G. Vistoli, S. Ferré, 2014, Journal of medicinal chemistry.

Evaluation and the environmental democracy of cities: Strategic Environmental Assessment of urban plans in Italy.

C. Torre, C. Rega, Alessandro Bonifazi, 2008 .

1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.

R. Matucci, Alessandro Bonifazi, M. Camalli, 2012, Journal of medicinal chemistry.

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B‐Selective NMDA Receptor Antagonists with a Benzo[7]annulen‐7‐amine Scaffold

W. Sippl, G. Seebohm, Alessandro Bonifazi, 2017, ChemMedChem.

Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.

Alessandro Bonifazi, B. Wünsch, D. Schepmann, 2014, Bioorganic & medicinal chemistry.

Pharmacological targeting of G protein-coupled receptor heteromers.

L. Pardo, Z. Xi, S. Ferré, 2022, Pharmacological research.

Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane.

G. Vistoli, Alessandro Bonifazi, C. Cifani, 2019, ACS chemical neuroscience.

Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives in α1-adrenergic and 5-HT1A receptor binding sites recognition.

G. Santoni, C. Amantini, Alessandro Bonifazi, 2013, Journal of medicinal chemistry.

Highly Potent and Selective Dopamine D4 Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma

L. Ricci-Vitiani, R. Pallini, G. Vistoli, 2022, Journal of medicinal chemistry.

Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer.

L. Pardo, S. Ferré, Alessandro Bonifazi, 2022, Pharmacological research.

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells.

G. Santoni, C. Amantini, Alessandro Bonifazi, 2019, ACS medicinal chemistry letters.

Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.

R. Matucci, G. Vistoli, Alessandro Bonifazi, 2014, Bioorganic & medicinal chemistry letters.

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

T. Hummel, A. Newman, M. Freissmuth, 2020, bioRxiv.

Methodology and Feasibility of Sustainability Impact Assessment. Case: Federal Policy-making Processes

Edwin Zaccai, Thomas Bauler, Alessandro Bonifazi, 2006 .

Everyday People Evaluating Everyday Landscapes: A Participatory Application of Landscape Character Assessment to Peri-urban Countryside

Alessandro Bonifazi, R. Grittani, A. Tassinari, 2014 .

Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus

R. Matucci, G. Vistoli, M. Sabbieti, 2020, Journal of medicinal chemistry.

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

D. Sibley, A. Janowsky, Lei Shi, 2016, Journal of Medicinal Chemistry.

Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability.

A. Newman, Alessandro Bonifazi, C. Loland, 2019, Journal of Medicinal Chemistry.

Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.

J. Deschamps, A. Newman, Alessandro Bonifazi, 2015, Bioorganic & medicinal chemistry.

Defining off-label and unlicensed use of medicines for children: results of a Delphi survey.

C. Giaquinto, M. Sturkenboom, Alessandro Bonifazi, 2008, Pharmacological research.

Off-label and unlicensed use of medicines for children

Ick Wong, Alessandro Bonifazi, Antje Neubert, 2009 .

Novel and Potent Dopamine D2 Receptor Go-Protein Biased Agonists

A. Hoffman, C. Lupica, Lei Shi, 2019, ACS pharmacology & translational science.

A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter.

Ara M. Abramyan, J. Deschamps, Lei Shi, 2019, ACS chemical neuroscience.

Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells.

A. Cilia, G. Vistoli, G. Santoni, 2019, European journal of medicinal chemistry.

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands.

Lei Shi, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.

A. Hudson, Alessandro Bonifazi, L. Mattioli, 2012, Bioorganic & medicinal chemistry.

Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

D. Sibley, Chun Wu, A. Newman, 2019, Journal of medicinal chemistry.

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.

Z. Xi, A. Newman, C. Jordan, 2021, Annual review of pharmacology and toxicology.

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

G. Vistoli, Alessandro Bonifazi, C. Cifani, 2020, ACS chemical neuroscience.

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

Ara M. Abramyan, Lei Shi, A. Newman, 2018, Neuropharmacology.

Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.

A. Newman, Alessandro Bonifazi, G. Tanda, 2020, European journal of medicinal chemistry.

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

T. Hummel, A. Newman, M. Freissmuth, 2020, ACS pharmacology & translational science.

2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-protein Coupled Receptors - The Whole is Greater Than the Sum of its Parts.

A. Newman, Alessandro Bonifazi, Francisco O. Battiti, 2019, Journal of medicinal chemistry.

Investigation of novel primary and secondary pharmacophores, and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine D3 receptor antagonists and partial agonists.

Z. Xi, A. Newman, Alessandro Bonifazi, 2019, Journal of medicinal chemistry.

Pollination and the Integration of Ecosystem Services in Landscape Planning and Rural Development

Pasquale Balena, Alessandro Bonifazi, Carlo Rega, 2017, ICCSA.

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.

A. Newman, Alessandro Bonifazi, Gregory H. Imler, 2019, Journal of medicinal chemistry.

Countryside vs City: A User-Centered Approach to Open Spatial Indicators of Urban Sprawl

Carmelo Maria Torre, Raffaele Attardi, Valentina Sannicandro, 2016, ICCSA.

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

J. Javitch, Brian T DeVree, J. Grimm, 2020, ACS chemical neuroscience.

Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation

Alessandro Piergentili, Wilma Quaglia, Alessandro Bonifazi, 2014, BMC Cancer.

Social Value of Nature Amenities: WTP for the Use of Public Seasides

Carmelo Maria Torre, Pasquale Balena, Alessandro Bonifazi, 2019, ICCSA.

Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders

Alessandro Bonifazi, C. Cifani, M. V. Micioni Di Bonaventura, 2023, Medicinal research reviews.

Mapping power relations in SEA – The role of statutory environmental consultees. An Italian case-study

Alessandro Bonifazi, P. Gazzola, A. Rinaldi, 2020 .

Polycentrism and Effective Territorial Structures: Basilicata Region Case Study

Lucia Saganeiti, Francesco Scorza, Alessandro Bonifazi, 2020 .

Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.

J. R. Lane, Z. Xi, A. Newman, 2023, Journal of medicinal chemistry.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Zheng-Xiong Xi, Alessandro Bonifazi, Rana Rais, 2016, Journal of medicinal chemistry.

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism.

Lei Shi, A. Newman, Alessandro Bonifazi, 2017, Journal of medicinal chemistry.

Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

Z. Xi, A. Newman, Alessandro Bonifazi, 2016, Journal of medicinal chemistry.

Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist

S. Ferré, A. Newman, Alessandro Bonifazi, 2016, Molecular Pharmacology.

Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.

S. Franchini, A. Cilia, A. Newman, 2019, ACS chemical neuroscience.

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

D. Sibley, J. R. Lane, Lei Shi, 2017, Journal of medicinal chemistry.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Antonina L. Nazarova, V. Katritch, J. R. Lane, 2023, Journal of medicinal chemistry.

Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor.

D. Sibley, J. R. Lane, Lei Shi, 2020, ACS chemical neuroscience.

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Lei Shi, A. Newman, Alessandro Bonifazi, 2021, Biomolecules.

Energy community innovations and regional policy diversification in Italy: a preliminary analysis

Alessandro Bonifazi, Monica Bolognesi, Franco Sala, 2022, 2022 AEIT International Annual Conference (AEIT).

Sustainable Local Development and Smart Specialisation Strategies: Recent Developments in Agri-food Research and Innovation Partnerships in Puglia, Italy

Carmelo Maria Torre, Pasquale Balena, Alessandro Bonifazi, 2020, ICCSA.

From Cost Benefit Analysis to Spatial Indicators: The Use of CO2 Segregation and Carbon Footprint for the Evaluation of Sustainable Land Use Transitions

Carmelo Maria Torre, Pasquale Balena, Alessandro Bonifazi, 2021, ICCSA.

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.

W. Sippl, Alessandro Bonifazi, B. Wünsch, 2015, Bioorganic & medicinal chemistry letters.

GluN2B‐Selective N‐Methyl‐d‐aspartate (NMDA) Receptor Antagonists Derived from 3‐Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen‐7‐amines

O. Shoji, Alessandro Bonifazi, C. Shirataki, 2014, ChemMedChem.

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3 Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders

G. Vistoli, A. Newman, Alessandro Bonifazi, 2021, ACS chemical neuroscience.

A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus

S. Ferré, A. Newman, Alessandro Bonifazi, 2016, ChemMedChem.

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.

Amy S. Billing, N. Volkow, M. Michaelides, 2019, The Journal of clinical investigation.

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

A. Newman, Alessandro Bonifazi, S. Hemby, 2023, Journal of medicinal chemistry.

Cycling Infrastructures and Community Based Management Model for the Lagonegro-Rotonda Cycling Route: ECO-CICLE Perspectives

Beniamino Murgante, Francesco Scorza, Alessandro Bonifazi, 2020 .

Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket

Antonina L. Nazarova, V. Katritch, Alessandro Bonifazi, 2023, Research square.

Making Sense of Spatial Relationships Trough Local Knowledge Discovery in Social Media

Dino Borri, Pasquale Balena, Alessandro Bonifazi, 2017, ICCSA.

Smart Communities Meet Urban Management: Harnessing the Potential of Open Data and Public/Private Partnerships through Innovative E-Governance Applications

Giovanna Mangialardi, Pasquale Balena, Alessandro Bonifazi, 2013, ICCSA.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

Alessandro Bonifazi, Francisco O. Battiti, Kuo-Hao Lee, 2024, bioRxiv.

Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats

Alessandro Bonifazi, Guo-hua Bi, Francisco O. Battiti, 2024, Neuropharmacology.

The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior.

Alessandro Bonifazi, C. Cifani, G. Giorgioni, 2023, Pharmacological research.