J. Söderholm

Å. Keita, J. Söderholm, Åsa V. Keita, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

The role of microbiota and probiotics in stress-induced gastro-intestinal damage.

J. Söderholm, L. Akkermans, F. Lutgendorff, 2008, Current molecular medicine.

Atrophic Gastritis Is Associated with Increased Sucrose Permeability Related to Chronic Inflammation

J. Söderholm, U. Hannestad, L. Franzén, 2005, Digestion.

Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis.

M. Jönsson, J. Söderholm, Javier Santos, 2011, Gastroenterology.

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

P. Artursson, K. Magnusson, J. Söderholm, 2008, Laboratory Investigation.

ER-stress mobilization of death-associated protein kinase-1–dependent xenophagy counteracts mitochondria stress–induced epithelial barrier dysfunction

J. Rho, D. Philpott, S. Girardin, 2018, The Journal of Biological Chemistry.

Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission

A. Öst, K. Magnusson, J. Söderholm, 2011, Alimentary pharmacology & therapeutics.

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate†

J. Söderholm, D. McKay, P. Sherman, 2010, Inflammatory bowel diseases.

Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease

K. H. Peterson, J. Söderholm, L. Franzén, 2002, Gut.

Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis

Å. Keita, J. Söderholm, O. Yakymenko, 2013, Scandinavian journal of gastroenterology.

Release of Satiety Hormones in Response to Specific Dietary Proteins Is Different between Human and Murine Small Intestinal Mucosa

W. Saris, J. Söderholm, R. Brummer, 2010, Annals of Nutrition and Metabolism.

A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models.

V. Théodorou, Å. Keita, J. Söderholm, 2018, Inflammatory Bowel Diseases.

Bidirectional supply of glutamine maintains enterocyte ATP content in the in vitro Ussing chamber model

J. Permert, J. Larsson, J. Söderholm, 2000, International Journal of Colorectal Disease.

Glutamine effects on permeability and ATP content of jejunal mucosa in starved rats.

J. Permert, J. Larsson, J. Söderholm, 1999, Clinical nutrition.

Increased uptake of non‐pathogenic E. coli via the follicle‐associated epithelium in longstanding ileal Crohn's disease

P. Söderkvist, K. Magnusson, Å. Keita, 2008, The Journal of pathology.

Peyer's Patches and M Cells as Potential Sites of the Inflammatory Onset in Crohn's Disease

J. Söderholm, E. Gullberg, 2006, Annals of the New York Academy of Sciences.

Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α

C. Streutker, J. Söderholm, D. McKay, 2004, Gut.

Relationship between bile salts, bacterial translocation, and duodenal mucosal integrity in functional dyspepsia

J. Tack, Å. Keita, J. Söderholm, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn’s Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability

Å. Keita, J. Söderholm, D. McKay, 2019, Journal of Crohn's & colitis.

Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate

P. Artursson, J. Söderholm, G. Alván, 1997, Pharmaceutical Research.

Dynamics of mucosal permeability and inflammation in collagenous colitis before, during, and after loop ileostomy

A. Öst, J. Söderholm, G. Olaison, 2005, Gut.

Colonic paracellular permeability and circulating zonulin-related proteins

Å. Keita, J. Söderholm, S. Walter, 2021, Scandinavian journal of gastroenterology.

Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies

J. Söderholm, M. Ström, A. Münch, 2007, Scandinavian journal of gastroenterology.

Epithelia under metabolic stress perceive commensal bacteria as a threat.

J. Söderholm, D. McKay, Ping-Chang Yang, 2004, The American journal of pathology.

Systemic inflammation in pre-clinical ulcerative colitis.

S. Heath, H. Drummond, C. Lees, 2021, Gastroenterology.

Increased expression of protease-activated receptor-2 in mucosal mast cells in Crohn's ileitis.

Å. Keita, J. Söderholm, Ulrika Christerson, 2009, Journal of Crohn's & colitis.

Increased CD9 and β1-integrin expression in human follicle associated epithelium is linked with selective transport into human Peyer´s patches

P. Artursson, Å. Keita, J. Söderholm, 2005 .

Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis

L. Öhman, D. Repsilber, M. D’Amato, 2022, Clinical and experimental gastroenterology.

CEG_A_368040 129..144

L. Öhman, D. Repsilber, M. D’Amato, 2022 .

Dendritic Cells and Toll-Like Receptors 2 and 4 in the Ileum of Crohn's Disease Patients

J. Söderholm, S. Salim, M. Perdue, 2008, Digestive Diseases and Sciences.

Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats

Å. Keita, J. Söderholm, I. Sjöholm, 2007, Journal of Neuroimmunology.

Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum

P. Artursson, Å. Keita, J. Söderholm, 2006, Laboratory Investigation.

INFLAMMATION AND INFLAMMATORY BOWEL DISEASE Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn’s disease

K. H. Peterson, J. Söderholm, L. Franzén, 2002 .

Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber.

P. Artursson, J. Permert, J. Larsson, 1998, Acta physiologica Scandinavica.

Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease – associations with disease phenotype, treatment, and outcome

J. Satsangi, M. Vatn, J. Jahnsen, 2019, Clinical and experimental gastroenterology.

Dietary Supplementation with Soluble Plantain Non-Starch Polysaccharides Inhibits Intestinal Invasion of Salmonella Typhimurium in the Chicken

A. Watson, Å. Keita, J. Söderholm, 2014, PloS one.

Ileorectal anastomosis in comparison with ileal pouch anal anastomosis in reconstructive surgery for ulcerative colitis--a single institution experience.

J. Söderholm, P. Myrelid, P. Andersson, 2014, Journal of Crohn's & colitis.

Split stoma in resectional surgery of high‐risk patients with ileocolonic Crohn’s disease

J. Söderholm, G. Olaison, R. Sjödahl, 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

Anorectal Function After Ileo-Rectal Anastomosis Is Better than Pelvic Pouch in Selected Ulcerative Colitis Patients

J. Söderholm, R. Andersson, M. Olsson, 2019, Digestive Diseases and Sciences.

Commentary: the effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis – authors' reply

J. Söderholm, M. Persborn, 2013, Alimentary pharmacology & therapeutics.

The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis

J. Söderholm, L. Akkermans, J. Gerritsen, 2013, Alimentary pharmacology & therapeutics.

Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells

Å. Keita, J. Söderholm, E. Shankar, 2020, eLife.

Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C.

J. Söderholm, I. Schoultz, D. McKay, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Effects of starvation and bowel resection on paracellular permeability in rat small-bowel mucosa in vitro.

J. Permert, J. Larsson, J. Söderholm, 1999, Scandinavian journal of gastroenterology.

Edinburgh Explorer Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in inflammatory bowel disease

J. Jahnsen, J. Söderholm, J. Halfvarson, 2020 .

Long-term Endoscopic Remission of Crohn Disease after Autologous Stem Cell Transplantation for Acute Myeloid Leukaemia

G. Juliusson, J. Söderholm, R. Sjödahl, 2002, Scandinavian journal of gastroenterology.

Anal and rectal cancer in Crohn's disease

J. Söderholm, R. Sjödahl, P. Myrelid, 2003, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

International Organization for the Study of IBD Recommendations for Surgery in Patients With IBD During the Coronavirus Disease 2019 Pandemic

W. Bemelman, F. Remzi, J. Söderholm, 2020 .

Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers

J. Söderholm, S. Walter, Javier Santos, 2022, United European gastroenterology journal.

Mucosal permeability and mast cells as targets for functional gastrointestinal disorders

Å. Keita, J. Söderholm, 2018, Current opinion in pharmacology.

Increased Colonic Epithelial Permeability and Mucosal Eosinophilia in Ulcerative Colitis in Remission Compared With Irritable Bowel Syndrome and Health

Å. Keita, J. Söderholm, S. Walter, 2020, Inflammatory bowel diseases.

Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.

J. Söderholm, D. McKay, Ping-Chang Yang, 2006, The American journal of pathology.

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

J. Tack, Å. Keita, J. Söderholm, 2013, Gut.

Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro

Å. Keita, J. Söderholm, D. McKay, 2007, Gut.

Surgery in Ulcerative Colitis: Indication and Timing

J. Söderholm, P. Andersson, 2009, Digestive Diseases.

Gut immunology: Nanoparticles ferry gut antigens.

J. Söderholm, 2015, Nature nanotechnology.

Effects of Stress on Intestinal Mucosal Functions

J. Söderholm, 2012 .

CHAPTER 28 – Effect of Stress on Intestinal Mucosal Function

J. Söderholm, 2006 .

Presence of eubacteria in biopsies from Crohn's disease inflammatory lesions as determined by 16S rRNA gene-based PCR.

J. Söderholm, J. Jonasson, G. Olaison, 1999, Journal of medical microbiology.

Stress and gastrointestinal tract. II. Stress and intestinal barrier function.

J. Söderholm, M. Perdue, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Early response of ornithine decarboxylase activity and energy metabolism to postsurgery refeeding in rat small intestine.

J. Permert, J. Larsson, J. Söderholm, 1998, Clinical nutrition.

Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

J. Söderholm, M. Perdue, J. Santos, 2001, Gut.

Dextran sodium sulphate‐induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport

J. Söderholm, D. McKay, Jun Lu, 2002, British journal of pharmacology.

J. Söderholm, 2007, Gut.

Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

H. Gooszen, K. Magnusson, J. Söderholm, 2009, PloS one.

Barrier dysfunction and bacterial uptake in the follicle‐associated epithelium of ileal Crohn's disease

J. Söderholm, Å. Keita, 2012, Annals of the New York Academy of Sciences.

Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogens

Å. Keita, J. Söderholm, M. Prorok-Hamon, 2013, The Journal of nutritional biochemistry.

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

M. Fredrikson, P. Söderkvist, J. Söderholm, 2009, The American Journal of Gastroenterology.

TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation

G. Meroni, J. Söderholm, I. Schoultz, 2012, PloS one.

On‐table endoscopy to define strictures and resection margins: experience from 178 operations for Crohn’s disease using intraoperative endoscopy

J. Söderholm, G. Olaison, R. Sjödahl, 2001 .

CD45RA+CD62L− ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

Å. Keita, J. Söderholm, R. Pandey, 2022, Science Immunology.

Stress‐induced barrier disruption of rat follicle‐associated epithelium involves corticotropin‐releasing hormone, acetylcholine, substance P, and mast cells

J. Söderholm, A. Ericson, Å. Keita, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress.

G. MacQueen, J. Söderholm, Ping-Chang Yang, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Corticotropin‐Releasing Hormone and Mast Cells in the Regulation of Mucosal Barrier Function in the Human Colon

J. Söderholm, C. Wallon, 2009, Annals of the New York Academy of Sciences.

Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

W. MacNaughton, Å. Keita, J. Söderholm, 2014, The American journal of pathology.

Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine.

J. Söderholm, R. Riddell, Ping-Chang Yang, 2002, Gastroenterology.

Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis.

H. Gooszen, J. Söderholm, L. Akkermans, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Smoking and intestinal absorption of oral polyethylene glycols in Crohn's disease.

J. Söderholm, G. Olaison, R. Sjödahl, 1993, Scandinavian journal of gastroenterology.

Intestinal permeability to polyethylene glycols in monozygotic twins with Crohn's disease.

E. Lindberg, J. Söderholm, G. Järnerot, 1995, Scandinavian journal of gastroenterology.

Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in inflammatory bowel disease.

J. Satsangi, A. Ivens, J. Jahnsen, 2020, Journal of Crohn's & colitis.

Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

S. Duncan, Å. Keita, J. Söderholm, 2010, Gut.

Epithelial and Mesenchymal Cell Biology CD 83 CCR 7 Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB 101 in the Peyer ’ s Patches of Ileal Crohn ’ s Disease

K. Magnusson, Å. Keita, J. Söderholm, 2010 .

Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis

S. Melgar, J. Söderholm, S. Salim, 2015, Scandinavian journal of gastroenterology.

Editorial: what is normal function of a pelvic pouch?

J. Söderholm, P. Myrelid, 2022, Alimentary pharmacology & therapeutics.

Potential role of protease-activated receptor-2-stimulated activation of cytosolic phospholipase A(2) in intestinal myofibroblast proliferation: Implications for stricture formation in Crohn's disease.

Å. Keita, J. Söderholm, Ulrika Christerson, 2009, Journal of Crohn's & colitis.

Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle‐associated epithelium and during stress in rats

Å. Keita, J. Söderholm, D. McKay, 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells

Son Thanh Nguyen, Jeff E. Mold, A. Bergquist, 2021, Science Translational Medicine.

Crohn’s Disease Pathobiont Adherent-Invasive E coli Disrupts Epithelial Mitochondrial Networks With Implications for Gut Permeability

J. Shearer, Å. Keita, J. Söderholm, 2020, Cellular and molecular gastroenterology and hepatology.

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae.

J. Hugot, J. Söderholm, C. Neut, 2011, The Journal of clinical investigation.

Increased Numbers of Enteric Glial Cells in the Peyer’s Patches and Enhanced Intestinal Permeability by Glial Cell Mediators in Patients with Ileal Crohn’s Disease

Å. Keita, J. Söderholm, M. E. Winberg, 2022, Cells.

Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations

F. Azpiroz, J. Söderholm, Javier Santos, 2014, Gut.

Epigenetic Alterations at Diagnosis Predict Susceptibility, Prognosis and Treatment Escalation in Inflammatory Bowel Disease and IBD Character

E. Nimmo, J. Satsangi, M. Vatn, 2017 .

The Swedish Crohn Trial: A Prematurely Terminated Randomized Controlled Trial of Thiopurines or Open Surgery for Primary Treatment of Ileocaecal Crohn's Disease.

J. Söderholm, A. Eriksson, G. Olaison, 2016, Journal of Crohn's & colitis.

Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways.

J. Söderholm, M. Perdue, D. Yates, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease

J. Satsangi, D. Repsilber, M. D’Amato, 2020, bioRxiv.

Possible Involvement of Intracellular Calcium-Independent Phospholipase A2 in the Release of Secretory Phospholipases from Mast Cells—Increased Expression in Ileal Mast Cells of Crohn’s Disease

Å. Keita, J. Söderholm, Ulrika Christerson, 2019, Cells.

Mast Cells and Mastocytosis

J. Söderholm, 2010, Digestive Diseases.

Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)

J. Satsangi, M. Vatn, J. Jahnsen, 2020, Scandinavian journal of gastroenterology.

Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn’s disease via effects on epithelial lipid rafts

Å. Keita, J. Söderholm, I. Schoultz, 2018, Scandinavian journal of gastroenterology.

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations.

H. Tilg, A. Forbes, C. O'Morain, 2010, Journal of Crohn's & colitis.

Duodenal low-grade inflammation and impaired mucosal integrity in functional dyspepsia patients

J. Tack, J. Söderholm, R. Farré, 2012 .

Effects of analgesic and surgical modality on immune response in colorectal cancer surgery.

Å. Keita, J. Söderholm, P. Myrelid, 2021, Surgical oncology.

Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis

Å. Keita, J. Söderholm, P. Myrelid, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients

S. Heath, H. Drummond, C. Lees, 2018, Scientific Reports.

Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

J. Söderholm, D. McKay, J. Jury, 2006 .

Inflammation and inflammatory bowel disease

C. Mathew, J. Söderholm, M. Wirén, 2005 .

Ultrastructural injury to interstitial cells of Cajal and communication with mast cells in Crohn's disease

L. W. Liu, Louis W C Liu, J. Huizinga, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

S. Duncan, Å. Keita, J. Söderholm, 2010, Gut.

Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?

E. Lindberg, J. Söderholm, G. Järnerot, 1999, Gut.

Increased uptake of non‐pathogenic E. coli via the follicle‐associated epithelium in longstanding ileal Crohn's disease

J. Söderholm, P-C Yang, Peter Söderkvist, 2008, The Journal of pathology.

INFLAMMATION AND INFLAMMATORY BOWEL DISEASE Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn’s disease

K. H. Peterson, J. Söderholm, L. Franzén, 2002 .

Å. Keita, J. Söderholm, Ulrika Christerson, 2009, Journal of Crohn's & colitis.

Falk Symposium Series

Claudio Fiocchi, Peter L. Lakatos, Ashwin N. Ananthakrishnan, 2009, Digestive Diseases.

Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3

J. Söderholm, T. Shutt, Armaan Mohan, 2023, Gut microbes.

Surgery in Ulcerative Colitis: Indication and Timing

J. Söderholm, P. Andersson, 2009, Digestive Diseases.