P. Gershkovich

发表

Characterisation of human saliva as a platform for oral dissolution medium development.

Clive J Roberts, C. Roberts, Sally Gittings, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Dissolution methodology for taste masked oral dosage forms.

C. Roberts, Sally Gittings, N. Turnbull, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Quantitative analysis of lab‐to‐lab variability in Caco‐2 permeability assays

Min Gi Kim, P. Fischer, P. Gershkovich, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

P. Gershkovich, E. Wasan, K. Wasan, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Proposing the Use of Partial AUC as an Adjunctive Measure in Establishing Bioequivalence Between Deltoid and Gluteal Administration of Long-Acting Injectable Antipsychotics

W. Honer, P. Gershkovich, A. Barr, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue.

T. Bradshaw, P. Gershkovich, B. Coyle, 2021, ACS applied materials & interfaces.

Is rat a good model for assessment of particulate-based taste-masked formulations?

C. Roberts, P. Gershkovich, M. Garnett, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability.

P. Gershkovich, A. Hoffman, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Strawberry Decreases Intraluminal and Intestinal Wall Hydrolysis of Testosterone Undecanoate

P. Fischer, P. Gershkovich, Jong Bong Lee, 2021, Molecules.

Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle

C. Constantinescu, P. Fischer, D. Barrett, 2021, Pharmaceutics.

Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.

C. Constantinescu, P. Fischer, D. Barrett, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations

E. Perucca, M. Bialer, P. Gershkovich, 2020, Clinical Pharmacokinetics.

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach.

Soyoung Shin, B. Shin, P. Gershkovich, 2019, Journal of pharmaceutical sciences.

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

C. Constantinescu, P. Fischer, D. Barrett, 2017, Scientific Reports.

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines.

C. Constantinescu, P. Fischer, D. Barrett, 2016, American journal of translational research.

Effect of hypertriglyceridemia on the pharmacokinetics and blood–brain barrier penetration of clozapine and norclozapine following administration to rats

P. Gershkovich, A. Barr, K. Wasan, 2010, European Neuropsychopharmacology.

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride‐rich lipoproteins: in‐silico prediction of uptake by chylomicrons

P. Gershkovich, A. Hoffman, S. Amselem, 2009 .

The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins.

P. Gershkovich, A. Hoffman, Daniel Shtainer, 2007, International journal of pharmaceutics.

Simple screening methods for prediction of intestinal lymphatic transport of lipophilic drugs

P. Gershkovich, A. Hoffman, 2006 .

Solid lipid nanoparticles self-assembled from spray dried microparticles.

Gareth R. Williams, A. Buanz, P. Gershkovich, 2019, International journal of pharmaceutics.

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents.

P. Fischer, Shudong Wang, F. Lam, 2021, European journal of medicinal chemistry.

Postprandial administration but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia.

P. Fischer, P. Gershkovich, H. Yun, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

P. Gershkovich, E. Wasan, K. Wasan, 2009, The Journal of antimicrobial chemotherapy.

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans.

P. Gershkovich, E. Wasan, K. Bartlett, 2009, International journal of pharmaceutics.

Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model.

P. Gershkovich, K. Wasan, Jinying Zhao, 2012, International journal of pharmaceutics.

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model.

P. Gershkovich, K. Wasan, O. Sivak, 2012, Journal of pharmaceutical sciences.

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

P. Gershkovich, P. Constantinides, K. Wasan, 2009, Lipids in Health and Disease.

Qazzaz, Mohannad E. and Raja, Vijay J. and Lim, Kuan- Hon and Kam, Toh-Seok and Lee, Jong Bong and Gershkovich, Pavel and Bradshaw, Tracey D. (2016) In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine

T. Bradshaw, P. Gershkovich, V. J. Raja, 2017 .

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

T. Bradshaw, P. Gershkovich, V. J. Raja, 2016, Cancer letters.

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols.

P. Gershkovich, E. Wasan, K. Wasan, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

P. Gershkovich, P. Constantinides, K. Wasan, 2009, Lipids in Health and Disease.

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

P. Fischer, D. Barrett, P. Gershkovich, 2019, Scientific Reports.

Benito-Gallo, Paloma and Marlow, Maria and Zann, Vanessa and Scholes, Peter and Gershkovich, Pavel (2016) Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic

P. Gershkovich, M. Marlow, P. Scholes, 2017 .

Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition

D. Mager, P. Gershkovich, K. Wasan, 2013, Pharmaceutical Research.

Physiologically Based Pharmacokinetic Model of Amphotericin B Disposition in Rats Following Administration of Deoxycholate Formulation (Fungizone®): Pooled Analysis of Published Data

D. Mager, P. Gershkovich, K. Wasan, 2011, The AAPS Journal.

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition.

T. Bradshaw, P. Gershkovich, M. Butler, 2019, Cancer letters.

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.

Min Gi Kim, P. Fischer, P. Gershkovich, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

I. Brown, J. Nguyen-Van-Tam, P. Gershkovich, 2021, Viruses.

Application of biorelevant saliva‐based dissolution for optimisation of orally disintegrating formulations of felodipine

C. Roberts, P. Gershkovich, M. Garnett, 2019, International journal of pharmaceutics.

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.

Shanshan He, P. Gershkovich, R. Brun, 2011, Bioorganic & medicinal chemistry.

Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered Testosterone Undecanoate

P. Gershkovich, Hyun‐moon Back, L. Kagan, 2020, Applied Sciences.

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study

P. Gershkovich, K. Wasan, Fady Ibrahim, 2014, Drug development and industrial pharmacy.

Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome

J. McNeill, P. Gershkovich, K. Wasan, 2015, Drugs in context.

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin

P. Gershkovich, C. Hayes, K. Mellits, 2021, Virulence.

Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site.

D. Scurr, P. Gershkovich, M. Marlow, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Inhibition of Cholesterol Absorption: Targeting the Intestine

P. Gershkovich, K. Wasan, Stephen D. Lee, 2012, Pharmaceutical Research.

Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release

S. Harding, P. Gershkovich, C. Ayed, 2018, Scientific Reports.

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

T. Bradshaw, P. Gershkovich, J. Segal, 2018, Molecular pharmaceutics.

Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis.

P. Gershkovich, M. Marlow, P. Scholes, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Simple and sensitive HPLC-UV method for determination of bexarotene in 1 rat plasma 2 3

Min Gi Kim, P. Gershkovich, S. Yoo, 2017 .

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma.

Peter M Fischer, Cris S Constantinescu, David A Barrett, 2015, Journal of pharmaceutical and biomedical analysis.

Smart Lipid-Based Drug Delivery Systems

P. Gershkovich, M. Marlow, K. Wasan, 2016 .

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice.

P. Gershkovich, E. Wasan, Xiaohua Zhu, 2010, The Journal of antimicrobial chemotherapy.

Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins.

P. Gershkovich, A. Hoffman, Pavel Gershkovich, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Highly effective oral amphotericin B formulation against murine visceral leishmaniasis.

P. Gershkovich, E. Wasan, Xiaohua Zhu, 2009, The Journal of infectious diseases.

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

P. Gershkovich, E. Wasan, K. Wasan, 2010, The Journal of antimicrobial chemotherapy.

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis.

P. Gershkovich, E. Wasan, K. Bartlett, 2012, International journal of pharmaceutics.

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

P. Gershkovich, E. Wasan, K. Wasan, 2011, Lipids in Health and Disease.

A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model

P. Gershkovich, E. Wasan, Xiaohua Zhu, 2010, PLoS neglected tropical diseases.

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

P. Gershkovich, E. Wasan, K. Wasan, 2013, Drug development and industrial pharmacy.

The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases

Fady Ibrahim, P. Gershkovich, K. Wasan, 2014, Drug development and industrial pharmacy.

Development of Cordycepin Formulations for Preclinical and Clinical Studies

P. Fischer, P. Gershkovich, C. D. de Moor, 2017, AAPS PharmSciTech.

The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model.

Leonid Kagan, P. Gershkovich, A. Hoffman, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines

P. Gershkovich, E. Wasan, K. Bartlett, 2011, Lipids in Health and Disease.

Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.

B. Ling, P. Fischer, P. Gershkovich, 2021, International journal of pharmaceutics.

Development and optimisation of simulated salivary fluid for biorelevant oral cavity dissolution.

C. Roberts, Sally Gittings, P. Gershkovich, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Development and validation of a cost-effective and sensitive bioanalytical HPLC-UV method for determination of lopinavir in rat and human plasma.

P. Fischer, P. Gershkovich, Sara Bettonte, 2020, Biomedical chromatography : BMC.

Delivery of temozolomide and N3-propargyl analog to brain tumors using an apoferritin nanocage.

M. Stevens, T. Bradshaw, P. Gershkovich, 2020, ACS applied materials & interfaces.

In search of effective therapies to overcome resistance to Temozolomide in brain tumours

M. Stevens, T. Bradshaw, P. Gershkovich, 2019, Cancer drug resistance.

[Expression of cytoskeleton genes in culture of human mesenchymal stromal cells in different periods of simulating the effects of microgravity].

P. Gershkovich, L. Buravkova, Iu G Gershkovich, 2011, Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine.

Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach.

P. Fischer, P. Gershkovich, Sijia He, 2020, Journal of controlled release : official journal of the Controlled Release Society.

The role of acid-base imbalance in statin-induced myotoxicity

D. Barrett, P. Gershkovich, C. D. de Moor, 2016, Translational research : the journal of laboratory and clinical medicine.

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols.

Katayoun Saatchi, U. Häfeli, P. Gershkovich, 2012, International journal of pharmaceutics.

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

P. Gershkovich, K. Wasan, K. Werbovetz, 2011, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer.

T. Bradshaw, P. Gershkovich, Michael J. Stocks, 2019, ACS medicinal chemistry letters.

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens.

Soyoung Shin, B. Shin, P. Gershkovich, 2019, Journal of pharmacological sciences.

Linking in Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations.

P. Gershkovich, M. Marlow, P. Scholes, 2016, Molecular pharmaceutics.

Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies.

D. Barrett, P. Gershkovich, C. D. de Moor, 2014, Translational research : the journal of laboratory and clinical medicine.

Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport.

P. Gershkovich, A. Hoffman, S. Amselem, 2009, Translational research : the journal of laboratory and clinical medicine.

Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220.

P. Gershkovich, A. Hoffman, S. Amselem, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin‐induced myotoxicity

R. Eckel, D. Barrett, P. Gershkovich, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment.

D. Harats, V. Meiner, P. Gershkovich, 2007, Biochimica et biophysica acta.

Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition

D. Mager, P. Gershkovich, K. Wasan, 2013, Pharmaceutical Research.

Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients

L. Marciani, P. Gellert, D. Scurr, 2021, Pharmaceutics.

Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers

L. Marciani, R. Spiller, C. Hoad, 2022, Pharmaceutics.

Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain.

T. Bradshaw, P. Gershkovich, J. Butler, 2023, International journal of pharmaceutics.

Lipophilic activated ester prodrug approach for drug delivery to the intestinal 1 lymphatic system 2 3

Fadi, Min Gi Kim, P. Fischer, 2018 .

Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue

P. Gershkovich, Atheer Zgair, J. C. Wong, 2016, Neuro-Immuno-Gastroenterology.

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature

P. Gershkovich, E. Wasan, K. Bartlett, 2015, Drug development and industrial pharmacy.

Distribution of a highly lipophilic drug cannabidiol into different lymph nodes following oral administration in lipidic vehicle.

P. Gellert, D. Scurr, P. Fischer, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer.

Amanda K. Pearce, P. Gershkovich, C. Alexander, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Is Oral Lipid-Based Delivery for Drug Targeting to the Brain Feasible?

T. Bradshaw, P. Gershkovich, J. Butler, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain.

P. Gershkovich, S. Woodhams, V. Chapman, 2023, Nanomedicine : nanotechnology, biology, and medicine.

Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport.

P. Gershkovich, Michael J. Stocks, Chaolong Qin, 2023, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Min Gi Kim, P. Fischer, B. Shin, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.

C. Constantinescu, D. Barrett, P. Gershkovich, 2022, International journal of pharmaceutics.

A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

P. Gershkovich, K. Wasan, Pavel Gershkovich, 2008, Critical reviews in therapeutic drug carrier systems.

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons.

Shimon Amselem, P. Gershkovich, A. Hoffman, 2009, The Journal of pharmacy and pharmacology.

Inhibition of Cholesterol Absorption: Targeting the Intestine

P. Gershkovich, K. Wasan, Stephen D. Lee, 2012, Pharmaceutical Research.

Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis.

P. Gershkovich, M. Marlow, P. Scholes, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.