M. Nonnemacher

发表

Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase*

Ricardo Macarron, Dashyant Dhanak, Adam T. Gates, 2002, The Journal of Biological Chemistry.

Molecular evidence for Acanthocephala as a subtaxon of Rotifera

S. Nadler, M. Nonnemacher, J. Garey, 1996, Journal of Molecular Evolution.

Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathway.

M. Nonnemacher, B. Wigdahl, A. Banerjee, 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Co-culture model consisting of human brain microvascular endothelial and peripheral blood mononuclear cells

M. Nonnemacher, B. Wigdahl, Marianne Strazza, 2016, Journal of Neuroscience Methods.

Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival

M. Nonnemacher, B. Wigdahl, Adriano Ferrucci, 2013, Journal of NeuroVirology.

Bioinformatic analysis of HIV-1 entry and pathogenesis.

M. Nonnemacher, B. Wigdahl, W. Dampier, 2014, Current HIV research.

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

M. Nonnemacher, B. Wigdahl, S. Dahiya, 2012, The Journal of general virology.

HIV-1 cure strategies: why CRISPR?

E. Haddad, M. Nonnemacher, B. Wigdahl, 2020, Expert opinion on biological therapy.

Mortality among HIV-Infected Patients in Resource Limited Settings: A Case Controlled Analysis of Inpatients at a Community Care Center.

M. Nonnemacher, B. Wigdahl, J. Jacobson, 2009, American journal of infectious diseases.

HIV- Bidirectional Encoder Representations From Transformers: A Set of Pretrained Transformers for Accelerating HIV Deep Learning Tasks

M. Nonnemacher, J. Earl, B. Wigdahl, 2022, Frontiers in Virology.

Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir.

M. Nonnemacher, É. Cohen, B. Wigdahl, 2012, Virus research.

Substance abuse, HIV-1 and hepatitis.

M. Nonnemacher, B. Wigdahl, T. Block, 2012, Current HIV research.

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity

Sonia Shah, B. Moldover, Adam P. Wojno, 2016, PloS one.

HIV-Quasipore: A Suite of HIV-1-Specific Nanopore Basecallers Designed to Enhance Viral Quasispecies Detection

M. Nonnemacher, B. Wigdahl, C. Chung, 2022, Frontiers in Virology.

Computational Analysis Concerning the Impact of DNA Accessibility on CRISPR-Cas9 Cleavage Efficiency.

M. Nonnemacher, B. Wigdahl, C. Chung, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localization

M. Nonnemacher, B. Wigdahl, Adriano Ferrucci, 2011, Virology Journal.

Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 Infection.

Sonia Shah, Yujie Liu, M. Nonnemacher, 2014, MOJ immunology.

HIV-1 infection of bone marrow stromal cells , changes in the Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 Infection

Sonia Shah, Yujie Liu, M. Nonnemacher, 2014 .

Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis

O. Meucci, M. Nonnemacher, B. Wigdahl, 2011, Journal of NeuroVirology.

Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-κB Binding Sites

M. Nonnemacher, B. Wigdahl, C. Chung, 2020, Molecular therapy. Nucleic acids.

Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND

M. Nonnemacher, B. Wigdahl, Jamie Marino, 2020, Frontiers in Aging Neuroscience.

HIV-1 Tat Length: Comparative and Functional Considerations

M. Nonnemacher, B. Wigdahl, W. Dampier, 2020, Frontiers in Microbiology.

CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation.

M. Nonnemacher, B. Wigdahl, Devanshi Pandya, 2006, Virology.

Novel gRNA design pipeline to develop broad-spectrum CRISPR/Cas9 gRNAs for safe targeting of the HIV-1 quasispecies in patients

J. Mell, M. Nonnemacher, G. Ehrlich, 2019, Scientific Reports.

Myelomonocytic Cell Lines in Modeling HIV-1 Infection of the Bone Marrow

M. Nonnemacher, B. Wigdahl, V. Pirrone, 2017 .

Cocaine Alters Cytokine Profiles in HIV-1–Infected African American Individuals in the DrexelMed HIV/AIDS Genetic Analysis Cohort

M. Nonnemacher, B. Wigdahl, J. Jacobson, 2014, Journal of acquired immune deficiency syndromes.

HIV-1 Latency and Eradication: Past, Present and Future.

K. Khalili, P. Datta, M. Nonnemacher, 2016, Current HIV research.

Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants

J. Mell, M. Nonnemacher, B. Wigdahl, 2017, Scientific Reports.

Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood–Brain Barrier

P. Couraud, M. Nonnemacher, B. Wigdahl, 2016, International journal of molecular sciences.

Altered recruitment of Sp isoforms to HIV-1 long terminal repeat between differentiated monoblastic cell lines and primary monocyte-derived macrophages

T. Burdo, M. Nonnemacher, B. Wigdahl, 2022, Frontiers in Virology.

Genetic variation and function of the HIV-1 Tat protein

M. Nonnemacher, B. Wigdahl, A. Mele, 2019, Medical Microbiology and Immunology.

Coinfection with Hepatitis C Virus among HIV-1-Infected Individuals Increases Proinflammatory Cytokines and HIV-1 Disease Severity

M. Nonnemacher, B. Wigdahl, J. Jacobson, 2016 .

AP‐1‐directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation

M. Nonnemacher, B. Wigdahl, A. Alexaki, 2006, Journal of leukocyte biology.

Impact of age on markers of HIV-1 disease.

D. Libon, M. Nonnemacher, B. Wigdahl, 2013, Future virology.

Chronic Low Dose Morphine Does Not Alter Two In Vitro BBB Models

M. Nonnemacher, B. Wigdahl, Monique E. Maubert, 2022, Brain sciences.

Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes

Z. Klase, L. Sardo, M. Nonnemacher, 2020, PloS one.

Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease

M. Nonnemacher, B. Wigdahl, V. Pirrone, 2016, Front. Microbiol..

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

Sonia Shah, M. Nonnemacher, B. Wigdahl, 2009, Retrovirology.

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III.

Joel D Martin, E. Harhaj, M. Nonnemacher, 2006, DNA and cell biology.

Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy

M. Nonnemacher, I. Sariyer, B. Wigdahl, 2022, Frontiers in Immunology.

CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.

Yujie Liu, M. Nonnemacher, B. Wigdahl, 2009, Future microbiology.

Defining Differential Genetic Signatures in CXCR4- and the CCR5-Utilizing HIV-1 Co-Linear Sequences

Sonia Shah, T. Ivanova, B. Moldover, 2014, PloS one.

Genetic variation and function of the HIV-1 Tat protein

M. Nonnemacher, B. Wigdahl, A. Mele, 2019, Medical Microbiology and Immunology.

Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site

Yujie Liu, M. Nonnemacher, B. Wigdahl, 2017, Clinical medicine insights. Pathology.

Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review.

S. Rahman, M. Nonnemacher, B. Wigdahl, 2009, American journal of infectious diseases.

Impact of Naturally Occurring Genetic Variation in the HIV-1 LTR TAR Region and Sp Binding Sites on Tat- Mediated Transcription

B. Moldover, M. Nonnemacher, B. Wigdahl, 2015 .

Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease

M. Nonnemacher, B. Wigdahl, V. Pirrone, 2014 .

Impact of Tat Genetic Variation on HIV-1 Disease

S. Kortagere, M. Nonnemacher, B. Wigdahl, 2012, Advances in virology.

HIV Latency and Reactivation: Role in Neuropathogenesis

M. Nonnemacher, B. Wigdahl, A. Banerjee, 2010 .

CCAAT Enhancer Binding Protein and Nuclear Factor of Activated T Cells Regulate HIV-1 LTR via a Novel Conserved Downstream Site in Cells of the Monocyte-Macrophage Lineage

Yujie Liu, M. Nonnemacher, B. Wigdahl, 2014, PloS one.

Genetic variation and HIV-associated neurologic disease.

M. Nonnemacher, B. Wigdahl, S. Dahiya, 2013, Advances in virus research.

Investigating the distribution of HIV-1 Tat lengths present in the Drexel Medicine CARES cohort.

M. Nonnemacher, B. Wigdahl, J. Jacobson, 2019, Virus research.

HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients

J. Mell, M. Nonnemacher, J. Earl, 2016, PloS one.

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection

K. Khalili, M. Nonnemacher, B. Wigdahl, 2018, Front. Microbiol..

Role of Downstream Elements in Transcriptional Regulation of the HIV-1 Promoter

Yujie Liu, M. Nonnemacher, B. Wigdahl, 2014 .

Impact of Viral Activators and Epigenetic Regulators on HIV-1 LTRs Containing Naturally Occurring Single Nucleotide Polymorphisms

Sonia Shah, M. Nonnemacher, B. Wigdahl, 2015, BioMed research international.

Innate and Adaptive Factors Regulating Human Immunodeficiency Virus Type 1 Genomic Activation

Sonia Shah, M. Nonnemacher, B. Wigdahl, 2010, Journal of Neuroimmune Pharmacology.

Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND

M. Nonnemacher, B. Wigdahl, Monique E. Maubert, 2020, Cellular and Molecular Life Sciences.

Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR.

Yujie Liu, Devin L. Stauff, M. Nonnemacher, 2010, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Identification of binding sites for members of the CCAAT/enhancer binding protein transcription factor family in the simian immunodeficiency virus long terminal repeat.

F. Krebs, M. Nonnemacher, B. Wigdahl, 2003, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human Immunodeficiency Virus Type 1 Transcription in Cells of the Monocyte/Macrophage Lineage

M. Nonnemacher, B. Wigdahl, H. Ross, 2001, Journal of Virology.

Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy

M. Nonnemacher, I. Sariyer, B. Wigdahl, 2021, Frontiers in Genome Editing.

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I

Sonia Shah, M. Nonnemacher, B. Wigdahl, 2014, Virology Journal.

Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status

F. Krebs, T. Giovannetti, D. Libon, 2016, Journal of NeuroVirology.

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I

M. Nonnemacher, B. Wigdahl, A. Alexaki, 2014, Virology Journal.

Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier

M. Nonnemacher, B. Wigdahl, Marianne Strazza, 2011, Brain Research.

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment

D. Kolson, B. Moldover, Adam P. Wojno, 2011, Journal of NeuroVirology.

PMA-induced differentiation of a bone marrow progenitor cell line activates HIV-1 LTR-driven transcription.

Yujie Liu, M. Nonnemacher, B. Wigdahl, 2007, DNA and cell biology.

Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression

Yujie Liu, Michael R. Nonnemacher, Brian Wigdahl, 2004, Journal of Neuroimmunology.

High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia.

F. Krebs, T. Burdo, M. Nonnemacher, 2004, DNA and cell biology.

HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific.

F. Krebs, M. Nonnemacher, B. Wigdahl, 2003, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Prediction of Human Immunodeficiency Virus Type 1 Subtype-Specific Off-Target Effects Arising from CRISPR-Cas9 Gene Editing Therapy.

M. Nonnemacher, B. Wigdahl, W. Dampier, 2018, The CRISPR journal.

Defining the molecular mechanisms of HIV‐1 Tat secretion: PtdIns(4,5)P2 at the epicenter

Z. Klase, C. Janetopoulos, M. Nonnemacher, 2018, Traffic.

Opinion: Inhibition of Blood-Brain Barrier Repair as a Mechanism in HIV-1 Disease

M. Nonnemacher, B. Wigdahl, Monique E. Maubert, 2017, Front. Neurosci..

Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis.

M. Nonnemacher, B. Wigdahl, Adriano Ferrucci, 2011, Advances in virus research.

CRSeek: a Python module for facilitating complicated CRISPR design strategies

Will Dampier, Cheng-Han Chung, Neil T. Sullivan, 2018 .

Integrated Human Immunodeficiency Virus Type 1 Sequence in J-Lat 10.6

M. Nonnemacher, B. Wigdahl, C. Chung, 2020, Microbiology Resource Announcements.

Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants

J. Mell, M. Nonnemacher, B. Wigdahl, 2017, Scientific Reports.

Epigenetics, Drugs of Abuse, and the Retroviral Promoter

Sonia Shah, M. Nonnemacher, B. Wigdahl, 2013, Journal of Neuroimmune Pharmacology.

Human Immunodeficiency Virus Type 1 Cellular Entry and Exit in the T Lymphocytic and Monocytic Compartments: Mechanisms and Target Opportunities During Viral Disease.

M. Nonnemacher, B. Wigdahl, V. Pirrone, 2015, Advances in virus research.

Roles of neuropathology-associated reactive astrocytes: a systematic review

M. Nonnemacher, B. Wigdahl, J. Lawrence, 2023, Acta Neuropathologica Communications.

Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing

Will Dampier, Cheng-Han Chung, Neil T. Sullivan, 2020, Frontiers in Microbiology.

Broad-Spectrum and Personalized Guide RNAs for CRISPR/Cas9 HIV-1 Therapeutics.

J. Mell, K. Khalili, M. Nonnemacher, 2018, AIDS research and human retroviruses.

Effect of μ-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells

O. Meucci, M. Nonnemacher, B. Wigdahl, 2014, BMC Research Notes.

Computational Design of gRNAs Targeting Genetic Variants Across HIV-1 Subtypes for CRISPR-Mediated Antiviral Therapy

M. Nonnemacher, B. Wigdahl, C. Chung, 2021, Frontiers in Cellular and Infection Microbiology.

Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals

J. Mell, T. Giovannetti, D. Libon, 2016, PloS one.

Effect of μ-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells

O. Meucci, M. Nonnemacher, B. Wigdahl, 2014, BMC Research Notes.

Defining the roles for Vpr in HIV-1-associated neuropathogenesis

F. Krebs, M. Nonnemacher, B. Wigdahl, 2016, Journal of NeuroVirology.

Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival

M. Nonnemacher, B. Wigdahl, Adriano Ferrucci, 2013, Journal of NeuroVirology.

Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences

F. Krebs, M. Nonnemacher, B. Wigdahl, 2017, International journal of genomics.

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures

Gregory W. Schwartz, Uri Hershberg, F. Krebs, 2016, Retrovirology.

Assessment of anti-HIV-1 guide RNA efficacy in cells containing the viral target sequence, corresponding gRNA, and CRISPR/Cas9

M. Nonnemacher, B. Wigdahl, C. Chung, 2023, Frontiers in Genome Editing.

HIV Excision Utilizing CRISPR/Cas9 Technology: Attacking the Proviral Quasispecies in Reservoirs to Achieve a Cure.

M. Nonnemacher, B. Wigdahl, J. Jacobson, 2014, MOJ immunology.

Immunomodulatory Effects of Non-Thermal Plasma in a Model for Latent HIV-1 Infection: Implications for an HIV-1-Specific Immunotherapy

E. Haddad, M. Nonnemacher, Vandana Miller, 2023, Biomedicines.

Molecular Characterization and Functional Analysis of a secA Gene Homolog in Actinobacillus actinomycetemcomitans

M. Nonnemacher, K. F. Novak, Jaleh Pourhamidi, 2000, Microbiology and immunology.

cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells

F. Krebs, M. Nonnemacher, B. Wigdahl, 2017, Clinical medicine insights. Pathology.

Genetic variation and HIV-associated neurologic disease.

M. Nonnemacher, B. Wigdahl, Bryan P Irish, 2013, Advances in virus research.

Delivering CRISPR to the HIV-1 reservoirs

M. Nonnemacher, I. Sariyer, B. Wigdahl, 2024, Frontiers in Microbiology.