F. Narjes

发表

Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase

S. Harper, L. Pacini, R. De Francesco, 2003, Journal of Virology.

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.

Michael Rowley, Frank Narjes, Giovanni Migliaccio, 2005, Journal of medicinal chemistry.

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Michael Rowley, Frank Narjes, Giovanni Migliaccio, 2005 .

Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

S. Harper, F. Narjes, M. Rowley, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.

U. Koch, R. De Francesco, P. Baiocco, 2011, Journal of medicinal chemistry.

Bacteriohopanetetrol from chemical degradation of an oil shale kerogen

F. Narjes, W. Michaelis, B. Mycke, 1987, Nature.

Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.

R. Bazzo, U. Koch, S. Altamura, 2009, European journal of medicinal chemistry.

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.

A. Urbani, R. Francesco, R. De Francesco, 1996, Analytical biochemistry.

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.

R. Pehrson, Yafeng Xue, F. Narjes, 2021, Journal of medicinal chemistry.

Synthesis of Indolo[2,1-a][2]benzazepineand Indolo[2,1-a][2]-benzazocine

F. Narjes, M. R. Ferreira, J. Habermann, 2009 .

Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase

U. Koch, F. Narjes, N. Gennari, 2009, ChemMedChem.

Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase.

U. Koch, F. Narjes, E. Capitò, 2009, Bioorganic & medicinal chemistry letters.

Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase.

U. Koch, F. Narjes, I. Stansfield, 2006, Bioorganic & medicinal chemistry letters.

Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.

S. Harper, M. Maccoss, F. Narjes, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.

F. Narjes, M. Rowley, R. Laufer, 2009, Bioorganic & medicinal chemistry letters.

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

K. Koehler, U. Koch, R. De Francesco, 2002, Bioorganic & medicinal chemistry letters.

Improved modular synthesis of thieno[3,2-b]pyrroles and thieno[2,3-b]pyrroles

J. I. Hernando, F. Narjes, J. Ontoria, 2009 .

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.

J. Evenäs, F. Narjes, M. Lepistö, 2014, Bioorganic & medicinal chemistry letters.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Uwe Koch, Steven Thomas, Frank Narjes, 2006, Journal of medicinal chemistry.

Application of intramolecular Heck reactions to the preparation of steroid and terpene intermediates having cis A-B ring fusions. Model studies for the total synthesis of complex cardenolides.

L. Overman, S. Laschat, F. Narjes, 1994 .

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

E. H. Rydberg, U. Koch, R. De Francesco, 2009, Journal of medicinal chemistry.

Synthesis of vinylcyclopropanes by intramolecular epoxide ring opening. Application for an enantioselective synthesis of dictyopterene A

F. Narjes, E. Schaumann, D. Icheln, 1993 .

Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase.

U. Koch, F. Narjes, N. Gennari, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of (+)‐Artemeseole

F. Narjes, E. Schaumann, 1993 .

Synthesis of vinylcyclopropanes from epoxides

A. Kirschning, F. Narjes, E. Schaumann, 1991 .

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

L. Pacini, U. Koch, R. De Francesco, 2003, Journal of Virology.

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease.

U. Koch, R. De Francesco, F. Narjes, 2000, Biochemistry.

Allosteric inhibition of the hepatitis C virus NS5B RNA dependent RNA polymerase.

Uwe Koch, Frank Narjes, U. Koch, 2006, Infectious disorders drug targets.

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

R. De Francesco, F. Narjes, J. Deval, 2009, Antimicrobial Agents and Chemotherapy.

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Michael Rowley, Frank Narjes, Giovanni Migliaccio, 2005, Journal of medicinal chemistry.

Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.

Yafeng Xue, F. Narjes, Marie Brännström, 2019, ACS medicinal chemistry letters.

Hepatitis C Virus Serine Protease Inhibitors: Current Progress and Future Challenges

F. Narjes, V. Matassa, Christian Steinkulher, 2001 .

Hepatitis C virus protease inhibitors: current progress and future challenges.

U. Koch, F. Narjes, V. Matassa, 2001, Current medicinal chemistry.

Emerging modes-of-action in drug discovery.

Eric Valeur, Frank Narjes, Christian Ottmann, 2019, MedChemComm.

Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.

R. Bazzo, U. Koch, M. Bottomley, 2009, Journal of molecular biology.

Substrate Specificity of the Hepatitis C Virus Serine Protease NS3*

A Tramontano, A. Tramontano, A. Urbani, 1997, The Journal of Biological Chemistry.

Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase.

U. Koch, F. Narjes, E. Capitò, 2009, Bioorganic & medicinal chemistry letters.

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

S. Grzesiek, R. Bazzo, R. De Francesco, 2000, The EMBO journal.

Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.

F. Narjes, C. Tyrchan, Stefan Schiesser, 2021, Journal of Medicinal Chemistry.

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Yafeng Xue, F. Narjes, Elisabeth Bäck, 2018, Journal of medicinal chemistry.

Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (TH17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ

Yafeng Xue, F. Narjes, A. Aagaard, 2016, ChemMedChem.

Characterization of the Hepatitis C Virus NS2/3 Processing Reaction by Using a Purified Precursor Protein

C. Nardella, F. Narjes, Laura Orsatti, 2001, Journal of Virology.

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.

R. Lewis, F. Narjes, C. Tyrchan, 2018, Journal of inorganic biochemistry.

Recent developments in the discovery of hepatitis C virus serine protease inhibitors – towards a new class of antiviral agents?

U. Koch, F. Narjes, C. Steinkühler, 2003, Expert opinion on investigational drugs.

Probing the Active Site of the Hepatitis C Virus Serine Protease by Fluorescence Resonance Energy Transfer*

A. Urbani, R. De Francesco, F. Narjes, 2000, The Journal of Biological Chemistry.

Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease.

U. Koch, F. Narjes, V. Matassa, 2004, Bioorganic & medicinal chemistry letters.

Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.

U. Koch, F. Narjes, I. Stansfield, 2002, Bioorganic & medicinal chemistry letters.

Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.

Michael Rowley, Frank Narjes, Giovanni Migliaccio, 2007, Bioorganic & medicinal chemistry letters.

2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.

S. Harper, L. Pacini, U. Koch, 2009, Bioorganic & medicinal chemistry letters.

Active Site Inhibitors of HCV NS5B Polymerase. The Development and Pharmacophore of 2‐Thienyl‐5,6‐dihydroxypyrimidine‐4‐carboxylic Acid.

S. Harper, F. Narjes, N. Gennari, 2005 .

Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.

S. Harper, F. Narjes, N. Gennari, 2004, Bioorganic & medicinal chemistry letters.

SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease.

F. Narjes, I. Stansfield, V. Matassa, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture.

U. Koch, R. De Francesco, S. Altamura, 2009, Bioorganic & medicinal chemistry letters.

Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site*

Uwe Koch, Michael Rowley, Frank Narjes, 2005, Journal of Biological Chemistry.

Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Uwe Koch, Frank Narjes, U. Koch, 2007, Current topics in medicinal chemistry.

Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (TH17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ

Yafeng Xue, F. Narjes, A. Aagaard, 2016, ChemMedChem.

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Yafeng Xue, F. Narjes, Elisabeth Bäck, 2018, Journal of medicinal chemistry.

Enhancement of intestinal absorption of 2-methyl cytidine prodrugs

F. Narjes, M. Rowley, R. Laufer, 2010, Drug delivery.

Inhibition of the Hepatitis C Virus NS3/4A Protease

R. De Francesco, M. Rizzi, F. Narjes, 2000, The Journal of Biological Chemistry.

Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation.

L. De Maria, F. Narjes, Werngard Czechtizky, 2021, Journal of pharmaceutical and biomedical analysis.

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

L. Pacini, U. Koch, S. Altamura, 2003, Journal of Virology.

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

F. Narjes, J. Deval, Megan H. Powdrill, 2009, Antimicrobial Agents and Chemotherapy.