L. Chan

发表

Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.

Darius Bilimoria, Lucille L'Heureux, R. Bethell, 2003, Journal of medicinal chemistry.

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.

Denis Labrecque, Darius Bilimoria, R. Bethell, 2004 .

Thiophene-based vitronectin receptor antagonists.

K. Meerovitch, L. Chan, G. Attardo, 2003, Bioorganic & medicinal chemistry letters.

A novel class of 1,3-oxathiolane nucleoside analogues having potent anti-HIV activity

L. Brasili, L. Chan, N. Nguyen-ba, 1993 .

Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors.

L. Chan, J. Bédard, H. Jin, 1999, Journal of medicinal chemistry.

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.

L. Chan, C. Yannopoulos, J. Bédard, 2005, Bioorganic & medicinal chemistry letters.

Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements.

L. Chan, H. Jin, T. Stefanac, 2000, Bioorganic & Medicinal Chemistry Letters.

Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors.

L. Chan, N. Turcotte, J. Bédard, 2000, Bioorganic & medicinal chemistry letters.

Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus

L. Chan, L. L'Heureux, J. Bédard, 2000, Antimicrobial Agents and Chemotherapy.

Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors.

L. Chan, J. Bédard, H. Jin, 1999, Bioorganic & medicinal chemistry letters.

A stereoselective route to bioactive nucleotide phosphonate analogs

L. Chan, G. Attardo, P. Préville, 2003 .

Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents.

L. Chan, N. Turcotte, N. Nguyen-ba, 1999, Nucleosides & nucleotides.

Comparative Study of the Anti-Human Cytomegalovirus Activities and Toxicities of a Tetrahydrofuran Phosphonate Analogue of Guanosine and Cidofovir

L. Chan, J. Bédard, R. Sidwell, 1999, Antimicrobial Agents and Chemotherapy.

Synthesis and antiviral activities of N-9-oxypurine 1,3-dioxolane and 1,3-oxathiolane nucleosides.

L. Chan, N. Nguyen-ba, B Zacharie, 2000, Bioorganic & medicinal chemistry letters.

Novel nucleotide phosphonate analogues with potent antitumor activity.

L. Chan, N. Nguyen-ba, G. Attardo, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV activity of 1,3-dithiolane nucleosides

L. Brasili, L. Chan, N. Nguyen-ba, 1999 .

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.

Darius Bilimoria, Lucille L'Heureux, R. Bethell, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of N-1-oxypyrimidine 1,3-dioxolane and 1,3-oxathiolane nucleosides

L. Chan, N. Nguyen-ba, B. Zacharie, 2000 .

A novel RGD antagonist that targets both αvβ3 and α5β1 induces apoptosis of angiogenic endothelial cells on type I collagen

K. Meerovitch, H. Gourdeau, B. Grouix, 2003 .

Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

Meitian Wang, M. James, K. Ng, 2003, The Journal of Biological Chemistry.

Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity.

L. Chan, N. Turcotte, J. Bédard, 1998, Bioorganic & medicinal chemistry letters.

935 IDENTIFICATION AND CHARACTERIZATION OF VCH-222, A NOVEL POTENT AND SELECTIVE NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR

L. Chan, L. L'Heureux, D. Bilimoria, 2009 .

Identification of Novel Nucleotide Phosphonate Analogues with Potent anti-HCMV Activity.

L. Chan, N. Turcotte, J. Bédard, 2010 .

A new approach to the synthesis of a dimeric fragment of the capsular polysaccharide of haemophilus influenzae type b

L. Chan, G. Just, 1988 .

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

B. G. Rao, G. Iyer, L. Chan, 2016, Journal of medicinal chemistry.

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.

Denis Labrecque, Darius Bilimoria, Lucille L'Heureux, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.

L. Chan, S. Das, Oswy Z. Pereira, 2015, Bioorganic & medicinal chemistry letters.

Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines.

L. Chan, J. Bédard, H. Jin, 2001, Bioorganic & medicinal chemistry letters.

Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.

Meitian Wang, Darius Bilimoria, M. James, 2006, Journal of molecular biology.

Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*

Meitian Wang, Darius Bilimoria, M. James, 2005, Journal of Biological Chemistry.

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.

L. Chan, M. Proulx, S. Das, 2003, Bioorganic & medicinal chemistry letters.

HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.

F. Ni, R. Bethell, L. Chan, 2004, Bioorganic & medicinal chemistry letters.

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors.

L. Chan, S. Das, L. L'Heureux, 2014, ACS medicinal chemistry letters.

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.

L. Chan, S. Das, L. L'Heureux, 2015, Bioorganic & medicinal chemistry letters.

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.

L. Chan, S. Das, L. L'Heureux, 2015, Bioorganic & medicinal chemistry letters.

Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Christopher R. Corbeil, Nicolas Moitessier, Pablo Englebienne, 2008, J. Chem. Inf. Model..

A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.

K. Meerovitch, H. Gourdeau, B. Grouix, 2003, Vascular pharmacology.

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

G. Iyer, L. Chan, C. Yannopoulos, 2016, Journal of medicinal chemistry.

Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.

L. Chan, S. Das, Oswy Z. Pereira, 2015, Bioorganic & medicinal chemistry letters.