L. L'Heureux

发表

Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.

Darius Bilimoria, Lucille L'Heureux, R. Bethell, 2003, Journal of medicinal chemistry.

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.

Denis Labrecque, Darius Bilimoria, R. Bethell, 2004 .

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane.

M. Wainberg, L. L'Heureux, Z. Gu, 1999, Nucleosides & nucleotides.

Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus

L. Chan, L. L'Heureux, J. Bédard, 2000, Antimicrobial Agents and Chemotherapy.

Mechanism of Action and In Vitro Activity of 1′,3′-Dioxolanylpurine Nucleoside Analogues against Sensitive and Drug-Resistant Human Immunodeficiency Virus Type 1 Variants

M. Wainberg, L. L'Heureux, N. Nguyen-ba, 1999, Antimicrobial Agents and Chemotherapy.

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.

Darius Bilimoria, Lucille L'Heureux, R. Bethell, 2004, Bioorganic & medicinal chemistry letters.

935 IDENTIFICATION AND CHARACTERIZATION OF VCH-222, A NOVEL POTENT AND SELECTIVE NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR

L. Chan, L. L'Heureux, D. Bilimoria, 2009 .

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

B. G. Rao, G. Iyer, L. Chan, 2016, Journal of medicinal chemistry.

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.

Denis Labrecque, Darius Bilimoria, Lucille L'Heureux, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.

L. Chan, S. Das, Oswy Z. Pereira, 2015, Bioorganic & medicinal chemistry letters.

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.

L. Chan, M. Proulx, S. Das, 2003, Bioorganic & medicinal chemistry letters.

HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.

F. Ni, R. Bethell, L. Chan, 2004, Bioorganic & medicinal chemistry letters.

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors.

L. Chan, S. Das, L. L'Heureux, 2014, ACS medicinal chemistry letters.

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.

L. Chan, S. Das, L. L'Heureux, 2015, Bioorganic & medicinal chemistry letters.

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.

L. Chan, S. Das, L. L'Heureux, 2015, Bioorganic & medicinal chemistry letters.

Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Christopher R. Corbeil, Nicolas Moitessier, Pablo Englebienne, 2008, J. Chem. Inf. Model..

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

G. Iyer, L. Chan, C. Yannopoulos, 2016, Journal of medicinal chemistry.

Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.

L. Chan, S. Das, Oswy Z. Pereira, 2015, Bioorganic & medicinal chemistry letters.