Y. Bousquet

发表

Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Yves Bousquet, J. Gillard, P. Beaulieu, 2004, Journal of medicinal chemistry.

Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.

J. Duan, O. Hucke, M. Garneau, 2012, Bioorganic & medicinal chemistry letters.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

O. Hucke, P. Bonneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.

J. Duan, M. Garneau, P. Anderson, 2014, Journal of medicinal chemistry.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

M. Bös, J. Gillard, P. Beaulieu, 2004, Bioorganic & medicinal chemistry letters.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

S. LaPlante, M. Bös, J. Gillard, 2004, Bioorganic & medicinal chemistry letters.

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.

J. Duan, M. Garneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Preparation of (2S,4R)-4-Hydroxypipecolic Acid and Derivatives.

P. Beaulieu, Y. Bousquet, I. Guse, 1996 .

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Preparation of enantiopure 4-oxygenated pipecolic acid derivatives

Y. Bousquet, I. Guse, L. Grenier, 1997 .

Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

S. LaPlante, J. Gillard, A. Jakalian, 2004, Angewandte Chemie.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

J. Duan, O. Hucke, M. Garneau, 2013, Bioorganic & medicinal chemistry letters.

Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series

Jean-François Mercier, Yves Bousquet, J. Mercier, 2013, ChemMedChem.

Preparation of (2S,4R)-4-Hydroxypipecolic Acid and Derivatives

J. Gillard, P. Beaulieu, Y. Bousquet, 1996 .

Preparation of Enantiopure 4-Oxygenated Pipecolic Acid Derivatives.

Y. Bousquet, I. Guse, L. Grenier, 1998 .

PRACTICAL, STEREOSELECTIVE SYNTHESIS OF PALINAVIR, A POTENT HIV PROTEASE INHIBITOR

C. Yoakim, P. Anderson, J. Gillard, 1997 .

Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

M. Garneau, M. Bös, P. White, 2010, Journal of medicinal chemistry.

Multi-gram synthesis of a nucleotide-competing reverse transcriptase inhibitor

S. Morin, B. Thavonekham, Y. Bousquet, 2013 .

Practical, Stereoselective Synthesis of Palinavir, a Potent HIV Protease Inhibitor.

C. Yoakim, P. Anderson, J. Gillard, 2010 .

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Araz Jakalian, Sébastien Morin, Yves Bousquet, 2014, ACS medicinal chemistry letters.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Peptidomimetic inhibitors of the human cytomegalovirus protease.

P. Bonneau, C. Yoakim, C. Chabot, 1997, Journal of medicinal chemistry.

Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.

L. Tong, S. Pav, D. Lamarre, 1997, Journal of medicinal chemistry.