Hiromasa Hashimoto

发表

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.

Satoru Ikeda, Takayoshi Suzuki, Takayoshi Suzuki, 2006, Journal of medicinal chemistry.

Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.

Hiromasa Hashimoto, T. Yamasaki, T. Adachi, 2019, Bioorganic & medicinal chemistry letters.

Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952.

Hiromasa Hashimoto, T. Yamasaki, Kazutaka Ikegashira, 2019, Bioorganic & medicinal chemistry letters.

Cyclopentane-annelated pyranosides: a new approach to chiral iridoid synthesis

Hiromasa Hashimoto, K. Furuichi, T. Miwa, 1987 .

Discovery of a potent and short-acting oral calcilytic with a pulsatile secretion of parathyroid hormone.

K. Fukuda, Hiromasa Hashimoto, Teruhiko Inoue, 2011, ACS medicinal chemistry letters.

New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists.

Hiromasa Hashimoto, Teruhiko Inoue, Takashi Nakagawa, 2010, Bioorganic & medicinal chemistry letters.

Claisen rearrangement of hexenopyranoside allyl ethers: A new approach to α-branched-chain dicarbonyl sugars

Hiromasa Hashimoto, K. Furuichi, T. Miwa, 1991 .

Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.

Takayoshi Suzuki, Hiromasa Hashimoto, Makoto Shiozaki, 2019, Journal of medicinal chemistry.

Self-association of 2',5'-linked deoxynucleotides : meta-DNA

Hiromasa Hashimoto, C. Switzer, 1992 .

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.

Takayoshi Suzuki, Shin‐ichi Hirashima, T. Ishida, 2006, Bioorganic & medicinal chemistry letters.

4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1).

Hiromasa Hashimoto, Hiromasa Hashimoto, Katsuaki Imamura, 2002, Journal of medicinal chemistry.

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.

Takayoshi Suzuki, Shin‐ichi Hirashima, T. Ishida, 2006, Bioorganic & medicinal chemistry letters.

Facile deprotonation of coordinated bis(diphenylphosphino)methane by an acetylacetonate anion

Hiromasa Hashimoto, S. Okeya, Yukio Nakamura, 1986 .

Reactions of Bis(β-diketonato)platinum(II) and -palladium(II) with Diphosphines Ph2PCHRPPh2 (R=H, Me): Unexpected Formation of the Homoleptic Bis(diphenylphosphino)methanido and Related Complexes

Hiromasa Hashimoto, S. Okeya, Yukio Nakamura, 1988 .

Consecutive Methylation and Protonation of the Carbanions in [Pt(Ph2PCHPPh2)2] Giving Rise to Ligand Scrambling

Hiromasa Hashimoto, S. Okeya, Yukio Nakamura, 1986 .

Facile Deprotonation of Coordinated Bis(diphenylphosphino)methane by an Acetylacetonate Anion.

Hiromasa Hashimoto, S. Okeya, Yukio Nakamura, 1987 .

Consecutive Methylation and Protonation of the Carbanions in (Pt(Ph2PCHPPh2)2) Giving Rise to Ligand Scrambling

Hiromasa Hashimoto, S. Okeya, Yukio Nakamura, 1987 .

Formation of chimeric duplexes between zwitterionic and natural DNA

Hiromasa Hashimoto, C. Switzer, M. G. Nelson, 1993 .

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Hiroshi Yamamoto, S. Noji, Hiromasa Hashimoto, 2020, Journal of medicinal chemistry.

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.

Shin‐ichi Hirashima, S. Noji, Izuru Ando, 2007, Bioorganic & medicinal chemistry letters.

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.

Satoru Ikeda, Toru Noguchi, Shin‐ichi Hirashima, 2006, Journal of medicinal chemistry.

SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.

R. Babine, Shin‐ichi Hirashima, Hiromasa Hashimoto, 2016, ACS medicinal chemistry letters.

4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.

Hiromasa Hashimoto, K. Wakitani, K. Maeda, 2002, Bioorganic & medicinal chemistry letters.

Inverted Motif for Oligonucleotide Triplexes: Adenosine-Pseudouridine-Adenosine (A-.PSI.-A)

Hiromasa Hashimoto, C. Switzer, R. Bandaru, 1995 .