R. Rivero

发表

An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

G. Burton, R. Sarisky, Victor K. Johnston, 2006, Bioorganic & medicinal chemistry letters.

2-Aminomethyl piperidines as novel urotensin-II receptor antagonists.

L. Mcmillan, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.

H. Sarau, J. Foley, N. Aiyar, 2008, Bioorganic & medicinal chemistry letters.

N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists.

S. Douglas, Yonghui Wang, R. Rivero, 2008, Bioorganic & medicinal chemistry letters.

Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.

G. Warren, H. Sarau, J. Foley, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.

J. F. Mack, J. Luengo, Ramona N Plant, 2012, Bioorganic & medicinal chemistry letters.

Non-peptide Angiotensin Agonist

W. Greenlee, T. Schwartz, R. Rivero, 1995, The Journal of Biological Chemistry.

Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists.

K. Evans, R. Rivero, Hongshi Yu, 2010, Bioorganic & medicinal chemistry letters.

2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats.

D. H. Lee, R. Rivero, Boyu Zhao, 2003, Bioorganic & medicinal chemistry.

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

K. Evans, R. Rivero, R. Griffin, 2009, Journal of medicinal chemistry.

Synthesis and Structure—Activity Relationship of Novel Pyridyl Ethers for the Nicotinic Acetylcholine Receptor.

C. B. Davis, R. Shank, R. Rivero, 2000 .

A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

W. Greenlee, S. E. D. Laszlo, R. Rivero, 1997 .

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

E. Klann, R. Rivero, C. Gross, 2018, Neuropsychopharmacology.

The solid phase synthesis of complex propargylamines using the combination of sonogashira and mannich reactions

R. Rivero, A. B. Dyatkin, 1998 .

Synthesis and Structure—Activity Relationships of a Series of 3-Aryl-4-isoxazolecarboxamides as a New Class of TGR5 Agonists.

K. Evans, R. Rivero, Hongshi Yu, 2010 .

2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.

C. Langmead, I. Forbes, R. Rivero, 2010, Bioorganic & medicinal chemistry letters.

2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.

C. Langmead, J. Foley, I. Forbes, 2010, Bioorganic & medicinal chemistry letters.

M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.

Zehong Wan, Dwight M. Morrow, H. Sarau, 2009, Bioorganic & medicinal chemistry letters.

Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas.

Dwight M. Morrow, Wei-Chang Fu, H. Sarau, 2008, Bioorganic & medicinal chemistry letters.

The solid-phase synthesis of novel 14-membered macrocycles for high throughput screening

R. Rivero, J. Guiles, C. Lanter, 2004, Molecular Diversity.

Palladium-catalyzed intermolecular coupling of aryl chlorides and sulfonamides under microwave irradiation.

G. Burton, R. Rivero, Gang Li, 2003, Organic letters.

Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors.

J. F. Mack, J. Luengo, Ramona N Plant, 2012, ACS medicinal chemistry letters.

Abstract 2913: Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kα) for the treatment of PTEN deficient tumors

M. A. Hardwicke, R. Rivero, 2012 .

Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.

R. Rivero, J. Gunnet, K. Demarest, 2006, Bioorganic & medicinal chemistry letters.

Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II.

W. Greenlee, R. Chang, R. Rivero, 1995, American Journal of Physiology.

[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors.

J. Luengo, Ramona N Plant, K. Erhard, 2013, ACS medicinal chemistry letters.

Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors.

J. Luengo, Ramona N Plant, K. Erhard, 2012, Bioorganic & medicinal chemistry letters.

SOLID PHASE SYNTHESIS OF 3,4-DISUBSTITUTED-7-CARBAMOYL-1,2,3,4-TETRAHYDROQUINOXALIN-2-ONES

R. Rivero, W. Murray, Jung Lee, 1997 .

Total synthesis of (.+-.)-breynolide, an aglycon derivative of the orally active hypocholesterolemic agent breynin A

R. Rivero, Amos B. Smith, J. Duan, 1992 .

Total synthesis of (.+-.)-breynolide: an aglycon derivative of a potent, orally active hypocholesterolemic agent

R. Rivero, Amos B. Smith, J. Empfield, 1991 .

A convenient ‘catch and release’ synthesis of fused 2-alkylthio-pyrimidinones mediated by polymer-bound BEMP

G. Burton, T. Graybill, R. Rivero, 2003 .

The synthesis of novel macrocyclic inhibitors of human renin

W. Greenlee, R. Rivero, 1991 .

Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles

R. Rivero, D. Gauthier, Jung Lee, 1998 .

Solid-Phase Synthesis of 3,4,5-Substituted 1,5-Benzodiazepin-2-ones.

R. Rivero, D. Gauthier, Jung Lee, 1999, The Journal of organic chemistry.

Facile synthesis of 6-aryl 5-N-substituted pyridazinones: microwave-assisted Suzuki-Miyaura cross coupling of 6-chloropyridazinones.

G. Burton, R. Rivero, P. Cao, 2008, The Journal of organic chemistry.

Phyllanthoside-phyllanthostatin synthetic studies. 8. Total synthesis of (+)-phyllanthoside. Development of the Mitsunobu glycosyl ester protocol

R. Rivero, Amos B. Smith, K. Hale, 1991 .

Total Synthesis of (.+-.)-Breynolide: An Aglycon Derivative of a Potent, Orally Active Hypocholesterolemic Agent.

R. Rivero, Amos B. Smith, J. Empfield, 1991 .

An efficient synthesis of glycosyl esters exploiting the mitsunobu reaction.

R. Rivero, Amos B. Smith, K. Hale, 1987 .

Total Synthesis of (.+‐.)‐Breynolide, an Aglycon Derivative of the Orally Active Hypocholesterolemic Agent Breynin A.

R. Rivero, Amos B. Smith, J. Duan, 1993 .

Base-Promoted Solid-Phase Synthesis of Substituted Hydantoins and Thiohydantoins

R. Rivero, Jay M. Matthews, 1997 .

Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.

C. B. Davis, R. Shank, R. Rivero, 2000, Bioorganic & medicinal chemistry letters.

Phyllanthoside-Phyllanthostatin Synthetic Studies. Part 8. Total Synthesis of (+)-Phyllanthoside. Development of the Mitsunobu Glycosyl Ester Protocol.

R. Rivero, Amos B. Smith, K. Hale, 1991 .

Phyllanthoside-phyllanthostatin synthetic studies. 9. Total syntheses of (-)-phyllanthostatin 1, (+)-phyllanthostatin 2, and (+)-phyllanthostatin 3

R. Rivero, Amos B. Smith, K. Hale, 1991 .

Sulfones as peptide bond isosteres

W. Greenlee, R. Rivero, A. Patchett, 1991 .

Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions.

D. Holt, R. Rivero, A. Shu, 2020, Journal of medicinal chemistry.

Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.

Dwight M. Morrow, Wei-Chang Fu, H. Sarau, 2008, Journal of medicinal chemistry.

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Carl A. Brooks, D. Holt, D. Behm, 2018, Journal of medicinal chemistry.

Discovery of GSK3527497: A candidate for the inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Carl A. Brooks, D. Holt, D. Behm, 2019, Journal of medicinal chemistry.

Monoacylation of unprotected symmetrical diamines with resin-bound benzoic acids

Yonghui Wang, T. Graybill, R. Rivero, 2004 .

Structural model of antagonist and agonist binding to the angiotensin II, AT1 subtype, G protein coupled receptor.

K Prendergast, C. Strader, D. Underwood, 1994, Chemistry & biology.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

C. Murray, F. Holding, V. Berdini, 2016, Journal of medicinal chemistry.

Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745.

D. Holt, J. Briand, D. Behm, 2021, ACS medicinal chemistry letters.

Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.

R. Rivero, Jun Z. Xu, K. Demarest, 2004, Bioorganic & medicinal chemistry letters.

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.

Todd L Graybill, H. Sarau, J. Foley, 2009, Bioorganic & medicinal chemistry letters.

Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations.

W. Greenlee, T. Schwartz, R. Rivero, 1997, Molecular pharmacology.

Cell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce c-MYC Protein Levels in Cells.

J. F. Mack, L. Lafrance, R. Rivero, 2021, Journal of medicinal chemistry.

Oxazolidinones as novel human CCR8 antagonists.

Dwight M. Morrow, H. Sarau, J. Foley, 2007, Bioorganic & medicinal chemistry letters.

Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.

C. Langmead, I. Forbes, R. Rivero, 2010, ACS medicinal chemistry letters.

Discovery of substituted 8,9-dicarboxyldibenzo [2,3:5,6] bicyclo [5.2.0] nonan-4-ones with moderate binding affinity to the endothelin ETA and ETB receptors

David L. Williams, W. Greenlee, R. Rivero, 1995 .

L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes

W. Greenlee, R. Chang, R. Rivero, 1996 .

Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.

Zehong Wan, Dwight M. Morrow, H. Sarau, 2008, Journal of Medicinal Chemistry.

Total synthesis of (+)-phyllanthocindiol and (+)-phyllanthostatin 3

R. Rivero, Amos B. Smith, H. Vaccaro, 1989 .

Total synthesis of (+)-phyllanthoside

R. Rivero, Amos B. Smith, 1987 .

Design and synthesis of aminopyridine containing biaryls reducing c-MYC protein levels in cells.

J. F. Mack, Leanna E. Shuster, R. Rivero, 2023, Bioorganic & medicinal chemistry letters.