A. Gopalsamy

发表

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Rajiv Chopra, Atul Agarwal, Boris Feld, 2006, Journal of medicinal chemistry.

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

R. Nilakantan, Roseann Petersen, A. Gopalsamy, 2008, Journal of medicinal chemistry.

Identification of Pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf Kinase Inhibitors.

D. Wojciechowicz, Steven C. Kim, L. Feldberg, 2009 .

Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.

D. Wojciechowicz, Steven C. Kim, L. Feldberg, 2009, Bioorganic & medicinal chemistry letters.

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Li Xing, Guoyun Bai, Atli Thorarensen, 2016, Scientific Reports.

Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.

Y. Ni, R. Denny, J. Telliez, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.

J. Levin, A. Gopalsamy, J. Ellingboe, 2009, Bioorganic & medicinal chemistry.

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.

D. L. Crandall, A. Gopalsamy, J. Ellingboe, 2004, Bioorganic & Medicinal Chemistry Letters.

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

A. Gopalsamy, G. Ciszewski, J. Ellingboe, 2006, Bioorganic & medicinal chemistry letters.

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.

D. Berger, M. Dutia, D. Powell, 2009, Bioorganic & medicinal chemistry letters.

Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.

D. Berger, D. Wojciechowicz, Steven C. Kim, 2009, Bioorganic & medicinal chemistry letters.

Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.

D. Berger, D. Wojciechowicz, Steven C. Kim, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.

A. Gopalsamy, G. Ciszewski, M. Shi, 2006, Bioorganic & medicinal chemistry letters.

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

A. Gopalsamy, Kitae Lim, J. Ellingboe, 2004, Bioorganic & medicinal chemistry letters.

B-Raf kinase inhibitors: hit enrichment through scaffold hopping.

Yongbo Hu, Robert Mallon, Larry Feldberg, 2010, Bioorganic & medicinal chemistry letters.

Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells.

Betsy S. Pierce, A. Gopalsamy, E. Hett, 2016, Organic & biomolecular chemistry.

Selectivity through Targeted Protein Degradation (TPD).

A. Gopalsamy, 2022, Journal of medicinal chemistry.

Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.

A. Narayanan, A. Gopalsamy, E. Hett, 2015, ACS chemical biology.

Lipophilic bis-arylsulfonates as inhibitors of the CD4-gp120 interaction

R. Patch, A. Gopalsamy, P. Pallai, 1996 .

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.

D. Powell, N. Zhang, S. Rabindran, 2007, Bioorganic & medicinal chemistry letters.

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

D. Powell, N. Zhang, S. Rabindran, 2005, Bioorganic & medicinal chemistry letters.

Discovery of indazoles as inhibitors of Tpl2 kinase.

David R. Anderson, Y. Ni, R. Denny, 2011, Bioorganic & medicinal chemistry letters.

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

J. Telliez, A. Gopalsamy, G. Ciszewski, 2005, Bioorganic & medicinal chemistry letters.

Identification of pyrimidine derivatives as hSMG-1 inhibitors.

A. Gopalsamy, J. Bard, Wei-guo Zhang, 2012, Bioorganic & medicinal chemistry letters.

Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A. Gopalsamy, J. Ellingboe, A. Howe, 2004, Antimicrobial Agents and Chemotherapy.

C Virus RNA-Dependent RNA Polymerase Novel Nonnucleoside Inhibitor of Hepatitis

A. Gopalsamy, J. Ellingboe, A. Howe, 2004 .

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.

A. Narayanan, A. Gopalsamy, E. Hett, 2015, Molecular bioSystems.

Parallel solid-phase synthesis of vitronectin receptor (αvβ3) inhibitors

A. Gopalsamy, J. Ellingboe, Hui-Yun Yang, 2000 .

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors

D. Joseph-McCarthy, J. McKew, A. Gopalsamy, 2006 .

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.

J. D. Clark, M. Hegen, Betsy S. Pierce, 2020, Bioorganic & medicinal chemistry.

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

A. Gopalsamy, E. Hett, L. R. Hoth, 2017, ACS chemical biology.

Neopentyl Ester Protecting Groups for Arylsulfonic Acids.

R. Patch, A. Gopalsamy, Huai Gao, 1997 .

Neopentyl ester protecting groups for arylsulfonic acids

R. Patch, A. Gopalsamy, Huai Gao, 1997 .

Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

D. Boschelli, R. Williamson, A. Gopalsamy, 2007, Journal of medicinal chemistry.

Combinatorial synthesis of heterocycles: Solid phase synthesis of 2-arylquinoline-4-carboxylic acid derivatives

A. Gopalsamy, P. Pallai, 1997 .

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Boris Feld, A. Gopalsamy, Kitae Lim, 2004, Journal of medicinal chemistry.

Combinatorial synthesis of heterocycles: solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives.

A. Gopalsamy, H. Yang, 2000, Journal of combinatorial chemistry.

Photoredox Catalysis: 1,4-Conjugate Addition of N-Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of N-Substituted Acetic Acids.

S. Tentarelli, A. Gopalsamy, H. Hatoum-Mokdad, 2020, Organic letters.

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region.

N. Zhang, D. Powell, S. Rabindran, 2005 .

Differing pharmacological activities of thiazolidinone analogs at the FSH receptor.

C. Holmes, R. Winneker, B. Arey, 2008, Biochemical and biophysical research communications.

Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors.

P. Bodine, J. Billiard, A. Gopalsamy, 2008, Journal of medicinal chemistry.

Facile acyl migration in 6-O-acylcastanospermine

A. Gopalsamy, W. Anderson, 1991 .

Synthesis of Pterocarpans by Means of a “Disfavored” 5‐endo‐trig Radical Cyclization Reaction

A. Gopalsamy, K. Balasubramanian, K. Santhosh, 2001 .

A facile selective acylation of castanospermine

A. Gopalsamy, T. Howe, R. A. Coburn, 1990 .

A Facile Selective Acylation of Castanospermine.

A. Gopalsamy, T. Howe, R. A. Coburn, 1990 .

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.

Roger M. Howard, S. Liras, K. Beaumont, 2020, Journal of medicinal chemistry.

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.

B. Komm, G. Welmaker, R. Bhat, 2009, Bone.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Li Xing, Eddine Saiah, David Lin, 2018, Journal of medicinal chemistry.

In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels

Timothy L. Foley, E. Androphy, Baohong Zhang, 2017, PloS one.

Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents.

A. Gopalsamy, W K Anderson, A Gopalsamy, 1994, Journal of medicinal chemistry.

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Timothy L. Foley, P. Loria, A. Narayanan, 2017, Journal of medicinal chemistry.

Radical cyclisation of 4-(o-bromophenoxy)-2H-1-benzopyrans; an efficient synthesis of pterocarpans

A. Gopalsamy, K. Balasubramanian, 1988 .

Radical Cyclization of 4-(o-Bromophenoxy)-2H-1-benzopyrans. An Efficient Synthesis of Pterocarpans.

A. Gopalsamy, K. Balasubramanian, 1988 .

Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors.

R. Bhat, P. Bodine, J. Billiard, 2009, Bioorganic & medicinal chemistry letters.

An efficient synthesis of dibenzo[c,f]-2,7 -naphthyridine ring system through design of experiments

R. Nilakantan, A. Gopalsamy, Mengxiao Shi, 2007 .

The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.

A. Gopalsamy, T. Herbertz, D. Young, 2010, Bioorganic & Medicinal Chemistry Letters.

Photocatalyzed Decarboxylative Addition of N-Substituted Acetic Acids to Aldehydes.

S. Tentarelli, A. Gopalsamy, Bo Peng, 2023, The Journal of organic chemistry.

Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

A. Gopalsamy, Mengxiao Shi, 2003, Organic letters.

Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.

F. Moy, A. Gopalsamy, Kitae Lim, 2004, Journal of medicinal chemistry.

Synthetic lethality: targeting SMARCA2 ATPase in SMARCA4-deficient tumors – a review of patent literature from 2019–30 June 2023

A. Gopalsamy, Kyle D Reichl, Esther C Y Lee, 2024, Expert opinion on therapeutic patents.