M. Orlowski

发表

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Rajiv Chopra, Atul Agarwal, Boris Feld, 2006, Journal of medicinal chemistry.

A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags. Development and application of tag decode-assisted single bead LC/MS analysis.

W. Egan, J. Reader, M. Orlowski, 2000, Journal of combinatorial chemistry.

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

A. Gopalsamy, G. Ciszewski, J. Ellingboe, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.

A. Gopalsamy, G. Ciszewski, M. Shi, 2006, Bioorganic & medicinal chemistry letters.

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

A. Gopalsamy, Kitae Lim, J. Ellingboe, 2004, Bioorganic & medicinal chemistry letters.

Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A. Gopalsamy, J. Ellingboe, A. Howe, 2004, Antimicrobial Agents and Chemotherapy.

C Virus RNA-Dependent RNA Polymerase Novel Nonnucleoside Inhibitor of Hepatitis

A. Gopalsamy, J. Ellingboe, A. Howe, 2004 .

Occurrence of Tetracycline Resistance Genes among Escherichia coli Isolates from the Phase 3 Clinical Trials for Tigecycline

A. Howe, M. Orlowski, P. Bradford, 2007, Antimicrobial Agents and Chemotherapy.

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Boris Feld, A. Gopalsamy, Kitae Lim, 2004, Journal of medicinal chemistry.

Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.

I. Gluzman, D. Goldberg, M. Orlowski, 1998, Bioorganic & medicinal chemistry letters.

Diagnostic PCR Analysis of the Occurrence of Methicillin and Tetracycline Resistance Genes among Staphylococcus aureus Isolates from Phase 3 Clinical Trials of Tigecycline for Complicated Skin and Skin Structure Infections

A. Howe, M. Orlowski, P. Bradford, 2006, Antimicrobial Agents and Chemotherapy.

Identification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase.

Boris Feld, M. Orlowski, B. Feld, 2003, Virology.

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.

I. Gluzman, D. Goldberg, M. Orlowski, 1998, Bioorganic & medicinal chemistry letters.

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Rajiv Chopra, Atul Agarwal, Kevin Curran, 2007, Journal of medicinal chemistry.

Screening aspartyl proteases with combinatorial libraries.

M. Orlowski, C. Carroll, 1998, Advances in experimental medicine and biology.