T. Mansour

发表

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Rajiv Chopra, Atul Agarwal, Boris Feld, 2006, Journal of medicinal chemistry.

3,5-Dioxopyrazolidines, Novel Inhibitors of UDP-N- Acetylenolpyruvylglucosamine Reductase (MurB) with Activity against Gram-Positive Bacteria

R. Chopra, K. Svenson, G. Krishnamurthy, 2006, Antimicrobial Agents and Chemotherapy.

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.

A. Moretto, D. Joseph-McCarthy, T. Mansour, 2007, Journal of medicinal chemistry.

Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

N. Brooijmans, A. Wissner, T. Mansour, 2009 .

Kinase domain mutations in cancer: implications for small molecule drug design strategies.

Allan Wissner, Natasja Brooijmans, N. Brooijmans, 2009, Journal of medicinal chemistry.

Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of their derivatives.

T. Mansour, Youjun Yang, Guy Singh, 2002, Bioorganic & medicinal chemistry letters.

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.

T. Mansour, Guy Singh, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

Application of the INEPT technique to 13C NMR assignments in polynuclear aromatic nitrogeneous heterocycles; 6H‐pyrido[4,3‐b]‐5,11‐dimethylcarbazole (ellipticine)

T. Mansour, T. C. Wong, E. Kaiser, 1983 .

An efficient direct amination of cyclic amides and cyclic ureas.

T. Mansour, Zhao‐Kui Wan, E. Binnun, 2006, Organic letters.

Inhibition of OXA-1 β-Lactamase by Penems

R. Bonomo, K. Hujer, A. Hujer, 2008, Antimicrobial Agents and Chemotherapy.

Recent Developments in β-Lactamases and Inhibitors

T. Mansour, P. Bradford, A. Venkatesan, 2008 .

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.

A. Agarwal, T. Mansour, Youjun Yang, 2008, Bioorganic & medicinal chemistry.

Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489

T. Mansour, P. Bradford, S. Projan, 2008, Antimicrobial Agents and Chemotherapy.

On the Absolute Configuration in 1,4‐Dihydrothiazepine Covalent Complexes Derived from Inhibition of Class A and C β‐Lactamases with 6‐Methylidene Penems

A. Agarwal, T. Mansour, Youjun Yang, 2007, ChemMedChem.

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

Nancy Torres, T. Mansour, E. Graziani, 2003, Bioorganic & medicinal chemistry letters.

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic.

Nancy Torres, T. Mansour, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

S. Lang, Nancy Torres, T. Mansour, 2004, Journal of medicinal chemistry.

Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2012, Journal of medicinal chemistry.

Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.

K. Svenson, J. Bard, T. Mansour, 2009, Journal of medicinal chemistry.

ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.

R. Abraham, N. Brooijmans, J. Gibbons, 2009, Journal of medicinal chemistry.

Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796

R. Chopra, J. Bard, G. Krishnamurthy, 2008, Antimicrobial Agents and Chemotherapy.

Neuroprotective Profile of Novel Src Kinase Inhibitors in Rodent Models of Cerebral Ischemia

M. Pangalos, D. Boschelli, P. Frost, 2009, Journal of Pharmacology and Experimental Therapeutics.

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

Kevin Curran, Judy Lucas, John Ellingboe, 2009, Cancer research.

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).

N. Brooijmans, L. Toral-Barza, J. Bard, 2010, Bioorganic & medicinal chemistry letters.

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

R. Abraham, P. Cai, J. Levin, 2007, Molecular Cancer Therapeutics.

PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors

P. Frost, J. Skotnicki, P. Cai, 2005, Cancer biology & therapy.

Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016.

T. Mansour, J. Xiang, E. Saiah, 2011, The Journal of organic chemistry.

Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.

J. Gibbons, J. Lucas, Jianxin Gu, 2010, Journal of medicinal chemistry.

Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.

J. Skotnicki, P. Cai, J. Gibbons, 2006, Journal of medicinal chemistry.

Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A. Gopalsamy, J. Ellingboe, A. Howe, 2004, Antimicrobial Agents and Chemotherapy.

C Virus RNA-Dependent RNA Polymerase Novel Nonnucleoside Inhibitor of Hepatitis

A. Gopalsamy, J. Ellingboe, A. Howe, 2004 .

Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.

K. Svenson, J. Bard, T. Mansour, 2013, ACS medicinal chemistry letters.

Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine and their 5-fluoro analogues in vitro.

M. Wainberg, H. Salomón, T. Mansour, 1995, Journal of medicinal chemistry.

Immunomodulatory and Antiviral Activities of 2′,3′-Dideoxy-β-L-Cytidine and 2′,3′-Dideoxy-β-l-5-Fluorocytidine

T. Mansour, N. Cammack, L. Yuen, 1995 .

Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor

R. Abraham, N. Brooijmans, L. Feldberg, 2010 .

Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.

N. Brooijmans, L. Toral-Barza, J. Lucas, 2009, Journal of medicinal chemistry.

Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2014, Journal of medicinal chemistry.

Oxidative palladium catalysis in S(N)Ar reactions leading to heteroaryl ethers from pyridotriazol-1-yloxy heterocycles with aryl boronic acids.

T. Mansour, K. Tabei, Zhao‐Kui Wan, 2009, Journal of the American Chemical Society.

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Wei Li, Xin Xu, Paul Morgan, 2009, Journal of medicinal chemistry.

Structure-Activity Relationship of Pyrimidine Heterosubstituted Nucleoside Analogues

N. Nguyen-ba, T. Mansour, M. Siddiqui, 1997 .

N-Protected α-Aminomethylketone Analogues of C-Terminal p-Nitrobenzyl-3-Ketoesters of N-Protected Amino Acids

T. Mansour, C. Evans, 1989 .

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

R. Bonomo, A. Hujer, A. Agarwal, 2004, Journal of medicinal chemistry.

Acidity measurements in THF. V: Heteroaromatic compounds containing 5-membered rings

R. R. Fraser, T. Mansour, S. Savard, 1985 .

Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.

N. Brooijmans, L. Feldberg, R. Mallon, 2010, Journal of medicinal chemistry.

Hunig's base-magnesium chloride mediated carbon alkylation and oxygen acylation of benzoylacetonitrile

T. Mansour, 1988 .

Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.

S. Rabindran, T. Mansour, H. Tsou, 2009, Journal of medicinal chemistry.

Diastereoselective Synthesis of the Potent Antiviral Agent (-)-2'-Deoxy-3'-thiacytidine and Its Enantiomer

P. Ravenscroft, T. Mansour, M. Siddiqui, 1995 .

Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.

J. Bédard, T. Mansour, H. Jin, 1998, Bioorganic & medicinal chemistry letters.

Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone

R. Williamson, T. Mansour, Youjun Yang, 2003 .

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.

T. Mansour, Youjun Yang, Guy Singh, 2004, Bioorganic & medicinal chemistry letters.

The Scope and Mechanism of Phosphonium-Mediated SNAr Reactions in Heterocyclic Amides and Ureas.

T. Mansour, C. Levins, K. Tabei, 2008 .

The scope and mechanism of phosphonium-mediated S(N)Ar reactions in heterocyclic amides and ureas.

T. Mansour, C. Levins, K. Tabei, 2007, The Journal of organic chemistry.

Acidity measurements on pyridines in tetrahydrofuran using lithiated silylamines

R. R. Fraser, T. Mansour, S. Savard, 1985 .

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Boris Feld, A. Gopalsamy, Kitae Lim, 2004, Journal of medicinal chemistry.

Ortho lithiation of monosubstituted benzenes: a quantitative determination of pKa values in tetrahydrofuran

R. R. Fraser, T. Mansour, Monique Bresse, 1983 .

pKa Measurements in tetrahydrofuran

R. R. Fraser, T. Mansour, Monique Bresse, 1983 .

Use of bis-(chiral alpha-methylbenzyl)glycine esters for synthesis of enantiopure beta-hydroxyamino esters.

R. Williamson, T. Mansour, A. Yamashita, 2003, Organic letters.

Oxygen transfer from sulfoxide: formation of aromatic aldehydes from dihalomethylarenes

T. Mansour, Jianchang Li, Wei Li, 2004 .

Additions and Corrections - Acidity Measurements with Lithiated Amines: Steric Reduction and Electronic Enhancement of Acidity.

R. R. Fraser, T. Mansour, 1984 .

Crystal Structure of E. Coli Mur B bound to a Naphthyl Tetronic Acid inihibitor

R. Chopra, K. Svenson, J. Bard, 2007 .

Unexpected effects of Lewis acids in the synthesis of optically pure 2′-deoxy-3′-oxacytidine nucleoside analogues

P. Ravenscroft, T. Mansour, J. Payne, 1993 .

Diastereocontrol in glycosylation reactions: Synthesis of β-D and β-L dideoxycytidine analogues

T. Mansour, A. Tse, 1995 .

(1′R,2′S,5′R)-Menthyl-(5R)-acetoxy-1,3-oxathiolan-(2R)-carboxylate: Synthesis and isomeric purity determination by HPLC

T. Mansour, M. Siddiqui, Haolun Jin, 1994 .

Expeditious preparation of (−)-2′-deoxy-3′-thiacytidine (3TC)

T. Mansour, J. Payne, Haolun Jin, 1992 .

Design and Synthesis of Monocyclic β‐Lactams as Mechanism‐Based Inhibitors of Human Cytomegalovirus Protease.

J. Bédard, T. Mansour, H. Jin, 1998 .

Novel imidazole substituted 6-methylidene-penems as broad-spectrum beta-lactamase inhibitors.

A. Agarwal, T. Mansour, J. Ryan, 2004, Bioorganic & medicinal chemistry.

Decarboxylative Carbon Acylation of Malonates with Aminoacylimidazolides Mediated by Lewis Acids

T. Mansour, C. Evans, 1990 .

Dipeptide Analogues: Synthesis of C-Terminal p-Nitrobenzyl-3-ketoesters of N-Protected Amino Acids

T. Mansour, 1989 .

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

A. Agarwal, T. Mansour, J. Knox, 2006, Journal of medicinal chemistry.

Carboxyl-modified amino acids and peptides. I: An efficient method for the synthesis of monofunctionalized enamines and monofunctionalized methyl ketone derivatives from thioamides via episulfides and thioiminium salts

T. Mansour, P. Lachance, G. Sauvé, 1988 .

The effect of additives on organolithiums

R. R. Fraser, T. Mansour, 1986 .

Selective Carbon Formylation of Cyandacetanilides

T. Mansour, 1987 .

An efficient synthesis of Ecopladib

T. Mansour, Jianchang Li, Wei Li, 2008 .

In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors

J. O'Connell, T. Mansour, P. Bradford, 2004, Antimicrobial Agents and Chemotherapy.

2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis.

J. Skotnicki, T. Mansour, Youjun Yang, 2003, Bioorganic & medicinal chemistry letters.

Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids

T. Mansour, K. Tabei, Zhao‐Kui Wan, 2009 .

Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

R. Abraham, N. Brooijmans, L. Feldberg, 2010, Journal of medicinal chemistry.

β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

J. McKew, T. Mansour, J. Xiang, 2007 .

Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.

D. Powell, J. Levin, L. Toral-Barza, 2009, Journal of medicinal chemistry.

Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics.

Nancy Torres, T. Mansour, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

On The Conversion of Arabino- and Ribofuranosyl Methyl Glycosides to Their 1-O-Acetyl Derivatives

T. Mansour, T. Breining, A. Cimpoia, 1994 .

Antiviral optically pure dioxolane purine nucleosides analogues

N. Nguyen-ba, T. Mansour, J. Cameron, 1993 .

Stereochemical Aspects of the anti-HCMV Activity of Cytidine Nucleoside Analogues

J. Gillard, T. Mansour, J. Coates, 1995 .

Oxidative degradation of L-ascorbic acid acetals to 2′,3′-dideoxy-3′-oxaribofuranosides. Synthesis of enantiomerically pure 2′,3′-dideoxy-3′-oxacytidine stereoisomers as potential antiviral agents

T. Mansour, B. Belleau, D. Dixit, 1992 .

Synthesis of (+/−)–1′-Aza-carbocyclic-pyrimidine-2′,3′-dideoxynucleoside analogues as potential anti-HIV agents

T. Mansour, H. Jin, 1991 .

Divergent asymmetric syntheses of dioxolane nucleoside analogues

T. Mansour, M. Siddiqui, T. Breining, 1993 .

High-performance liquid chromatographic determination of the isomeric purity of a series of dioxolane nucleoside analogues

N. Nguyen-ba, T. Mansour, M. Siddiqui, 1993 .

Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro

T. Mansour, B. Korba, C. Evans, 1997 .

Structure-Activity Relationships Among a New Class of Antiviral Heterosubstituted 2′,3′-Dideoxynucleoside Analogues

M. Wainberg, H. Salomón, J. Gillard, 1995 .

ASYMMETRIC SYNTHESIS OF 2'-PHOSPHONOMETHYL(3',4'-DIHYDROXYBUTYL)CYTOSINE AND -GUANINE NUCLEOTIDES

T. Mansour, C. Evans, R. Hewgill, 1997 .

Synthesis of racemic 2-phosphonomethyl-1,3-dioxolane nucleoside analogues as potential antiviral agents

T. Mansour, C. Ashman, D. Dixit, 1995 .

Inhibitory activities of herpes simplex viruses type 1 and 2 and human cytomegalovirus by stereoisomers of 2′-deoxy-3′-oxa-5(E)-(2-bromovinyl)uridines and their 4′-thio analogues.

T. Mansour, Wei Wang, L. Yuen, 1994 .

Synthesis of optically active 2′,3′-dideoxy-3′-oxa-4′-thio-ribonucleoside analogues by transposition of a leaving group on chiral oxathiolanes via a reductive-oxidative process

T. Mansour, Wei Wang, H. Jin, 1994 .

Oxidative Degradation of L‐Ascorbic Acid Acetals to 2′,3′‐Dideoxy‐3′‐ oxaribofuranosides. Synthesis of Enantiomerically Pure 2′,3′‐Dideoxy‐3′ ‐oxacytidine Stereoisomers as Potential Antiviral Agents.

T. Mansour, B. Belleau, D. Dixit, 1993 .

Synthesis and anti HCMV activity of 3,4-disubstituted tetrahydrofuran derived nucleosides and nucleotides: A tethered series of PME derivatives

T. Mansour, Wei Wang, H. Jin, 1997 .

Synthesis of (.+-.)-1′-Azacarbocyclic Pyrimidine-2′,3′- dideoxynucleoside Analogues as Potential Anti-HIV Agents.

T. Mansour, H. Jin, 1992 .

Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues.

T. Mansour, M. Siddiqui, T. Breining, 1994 .

Heteroaryl ethers by oxidative palladium catalysis of pyridotriazol-1-yloxy pyrimidines with arylboronic acids.

T. Mansour, Zhao‐Kui Wan, S. Wacharasindhu, 2009, Organic letters.

1',2',6'-Thiadiazine 1',1'-Dioxide and Imidazo [4',5'-c][1',2',6']thiadiazine 2',2'-Dioxode 1,3-Oxathiolane Nucleoside Analogues: Synthesis and Anti-HIV-1 Activity

T. Mansour, N. Cammack, C. Ashman, 1995 .

Constrained analogues of 2'-nor cyclic nucleoside monophosphates

T. Mansour, J. Coates, D. J. Knight, 1997 .

Synthesis of 1‐(8‐phosphonomethoxy‐3,6‐dioxaoctyl)pyrimidines and purines, a novel series of acyclonucleotide analogues

T. Mansour, J. Coates, D. J. Knight, 1994 .

Discovery of Imidazo(1,2‐c)pyrimidin‐5(6H)‐one Heterosubstituted Nucleoside Analogues with Potent Activity Against Human Hepatitis B Virus in vitro.

T. Mansour, B. Korba, C. Evans, 1997 .

Structure-Activity Relationships Among a New Class of Antiviral Heterosubstituted 2′,3′-Dideoxynucleoside Analogues.

M. Wainberg, H. Salomón, J. Gillard, 2010 .

Inhibitory Activities of Herpes Simplex Viruses Type 1 and 2 and Human Cytomegalovirus by Stereoisomers of 2′-Deoxy-3′-oxa-5(E)-(2-bromovinyl) uridines and Their 4′-Thio Analogues.

T. Mansour, Wei Wang, L. Yuen, 1995 .

Asymmetric Synthesis of 2′‐Phosphonomethyl(3′,4′‐dihydroxybutyl) cytosine and ‐guanine Nucleotides.

T. Mansour, C. Evans, R. Hewgill, 1997 .

Synthesis of Optically Active 2′,3′-Dideoxy-3′-oxa-4′-thio- ribonucleoside Analogues by Transposition of a Leaving Group on Chiral Oxathiolanes via a Reductive-Oxidative Process.

T. Mansour, Wei Wang, H. Jin, 1994 .

Synthesis of Racemic 2‐Phosphonomethyl‐1,3‐dioxolane Nucleoside Analogues as Potential Antiviral Agents.

T. Mansour, C. Ashman, D. Dixit, 1995 .

Synthesis and anti HCMV Activity of 3,4‐Disubstituted Tetrahydrofuran Derived Nucleosides and Nucleotides: A Tethered Series of PME Derivatives.

T. Mansour, Wei Wang, H. Jin, 1998 .

Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

R. Abraham, J. Gibbons, L. Toral-Barza, 2010, Cancer research.

PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

L. Feldberg, R. Mallon, J. Lucas, 2010, Bioorganic & medicinal chemistry letters.

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.

R. Abraham, N. Brooijmans, L. Feldberg, 2010, Bioorganic & medicinal chemistry letters.

Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

Judy Lucas, Irwin Hollander, Robert Mallon, 2010, Journal of medicinal chemistry.

Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.

M. Follettie, N. Brooijmans, J. Lucas, 2010, Journal of medicinal chemistry.

2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer.

J. Lucas, T. Mansour, K. Arndt, 2009, Bioorganic & medicinal chemistry letters.

The Development of HKI‐272 and Related Compounds for the Treatment of Cancer

A. Wissner, T. Mansour, 2008, Archiv der Pharmazie.

Ortho lithiation of monosubstituted benzenes: a quantitative determination of pKa values in tetrahydrofuran

R. R. Fraser, T. Mansour, Monique Bresse, 1983 .

A novel anti-melanoma SRC-family kinase inhibitor

R. Halaban, M. Krauthammer, M. Sznol, 2019, Oncotarget.

Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate.

R. Bonomo, T. Mansour, J. Knox, 2003, Biochemistry.

Naphthyl Tetronic Acids as Multi‐Target Inhibitors of Bacterial Peptidoglycan Biosynthesis

C. Caufield, R. Chopra, K. Svenson, 2007, ChemMedChem.

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Shifeng Liu, R. Oballa, D. Sutherlin, 2016, ACS medicinal chemistry letters.

Synthesis of 3,3‐Dimethyl‐4‐chromanones: Improved Procedures Without Ring Opening

T. Mansour, A. Yamashita, Emily B. Norton, 2006 .

The Discovery of Pyrano[3,4‐b]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity

N. Kneteman, A. Howe, J. O'Connell, 2008, ChemMedChem.

Patent Update Anti-infectives: Emerging anti-HIV agents and targets

T. Mansour, 1996 .

Improved Procedures for Preparation of Racemic Capreomycidine

T. Mansour, A. Yamashita, Emily B. Norton, 2004 .

Improved Procedures for Preparation of Racemic Capreomycidine.

T. Mansour, A. Yamashita, Emily B. Norton, 2004 .

Mechanism of Inactivation of β-Lactamases by Novel 6-Methylidene Penems Elucidated Using Electrospray Ionization Mass Spectrometry

T. Mansour, M. Siegel, Xidong Feng, 2004 .

Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).

J. Bard, T. Mansour, E. Saiah, 2012, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179.

T. Mansour, S. Ayral-Kaloustian, L. McDonald, 2010, The Journal of organic chemistry.

Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors.

T. Mansour, V. Potluri, Pranab Maiti, 2019, Bioorganic & medicinal chemistry letters.

Regiointegrity of carbanions derived by selective metalations of dimethylpyridines and -quinolines

J. R. Mcclure, J. Garlich, T. Mansour, 1981 .

Emerging anti-HIV agents and targets

T. Mansour, 1996 .

Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.

J. McKew, T. Mansour, J. Xiang, 2008, Journal of medicinal chemistry.

Regio- and Stereoselective Ring Contraction of 1,2-Dithianes to 1,2-Dithiolanes

T. Mansour, S. Chowdhury, D. Bogucki, 2023, SSRN Electronic Journal.

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Rajiv Chopra, Atul Agarwal, Kevin Curran, 2007, Journal of medicinal chemistry.

beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.

J. McKew, T. Mansour, J. Xiang, 2007, Bioorganic & medicinal chemistry.

Structure‐Based Optimization of Protein Tyrosine Phosphatase‐1 B Inhibitors: Capturing Interactions with Arginine 24

Wei Li, A. Moretto, D. Joseph-McCarthy, 2008, ChemMedChem.

Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.

Wei Li, Xin Xu, Paul Morgan, 2009, Journal of medicinal chemistry.

Efficient resolution of oxidized cleland's reagent by C2-symmetric Boc-L-phenylalanyl esters

T. Mansour, Louise Bernier, C. Evans, 1997 .

3‐Dimethylamino‐1‐phenyl‐1‐propanone hydrochloride monohydrate

T. Mansour, E. Kaiser, E. O. Schlemper, 1982 .

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

R. Abraham, J. Gibbons, J. Lucas, 2009, Cancer Research.

The Development of HKI‐272 and Related Compounds for the Treatment of Cancer

A. Wissner, T. Mansour, 2008, Archiv der Pharmazie.

Potent dual EGFR/Her4 tyrosine kinase inhibitors containing novel (1,2-dithiolan-4-yl)acetamides.

T. Mansour, Vishnu Basetti, Rangarao Pallepati, 2020, Bioorganic & medicinal chemistry letters.

Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.

F. Moy, A. Gopalsamy, Kitae Lim, 2004, Journal of medicinal chemistry.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Journal of medicinal chemistry.

Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Journal of medicinal chemistry.

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.

R. Abraham, N. Brooijmans, R. Mallon, 2010, Bioorganic & medicinal chemistry letters.

In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.

T. Mansour, P. Bradford, S. Projan, 2004, Antimicrobial agents and chemotherapy.

N-Protected α-Aminomethyl Ketone Analogues of C-Terminal p-Nitrobenzyl-3-keto Esters of N-Protected Amino Acids.

T. Mansour, C. Evans, 1989 .

Dimethyl sulfoxide mediated elimination reactions in 3-aryl 2,3-dihalopropanoates: scope and mechanistic insights.

T. Mansour, K. Tabei, S. Wacharasindhu, 2007, The Journal of organic chemistry.