D. Murphy

发表

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.

Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2007 .

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qiang Zhao, 2009, Bioorganic & medicinal chemistry letters.

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

P. A. Thompson, C. Stumpf, Qing Han, 2018, Journal of medicinal chemistry.

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

A. Kuki, Michael D. Johnson, D. Murphy, 2002, Journal of medicinal chemistry.

Human glucagon receptor antagonists based on alkylidene hydrazides.

A. Kuki, D. Murphy, A. Polinsky, 2002, Bioorganic & medicinal chemistry letters.

Identification of alkylidene hydrazides as glucagon receptor antagonists.

A. Kuki, D. Murphy, A. Polinsky, 2001, Journal of medicinal chemistry.

Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2.

J. Brownell, D. Murphy, M. Jain, 1992, Journal of medicinal chemistry.

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.

P. A. Thompson, J. Khandurina, C. Kissinger, 2009, Bioorganic & medicinal chemistry letters.

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

Jingjing Zhao, Matthew A. Lardy, Frank Ruebsam, 2008, Bioorganic & medicinal chemistry letters.

Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides

Yuefen Zhou, D. Murphy, Zhongxiang Sun, 2004 .

Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.

Thomas Hermann, Sarah Fish, T. Hermann, 2007, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.

C. Kissinger, Qing Han, Michael Noble, 2008, Bioorganic & medicinal chemistry letters.

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Yuefen Zhou, S. Webber, D. Murphy, 2009, Bioorganic & medicinal chemistry letters.

Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2008 .

Novel Parallel Synthesis of N‐(4‐Oxo‐2‐Substituted‐4H‐quinazolin‐3‐yl)‐Substituted Sulfonamides.

Yuefen Zhou, D. Murphy, Zhongxiang Sun, 2005 .

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.

T. Hermann, Yuefen Zhou, S. Webber, 2008, Bioorganic & medicinal chemistry letters.

Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2008 .

Structure-Guided Discovery of Novel Aminoglycoside Mimetics as Antibacterial Translation Inhibitors

Thomas Hermann, Sarah Fish, T. Hermann, 2005, Antimicrobial Agents and Chemotherapy.

Efficient Large-Scale Synthesis of 2-Amino-5-methanesulfonylaminobenzenesulfonamide

D. Murphy, P. Dragovich, Chinh Tran, 2008 .

Efficient Large‐Scale Synthesis of 2‐Amino‐5‐methanesulfonylaminobenzenesulfonamide.

D. Murphy, P. Dragovich, Chinh Tran, 2008 .

Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Yuefen Zhou, S. Webber, D. Murphy, 2007 .

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.

Qiang Zhao, Helen McGuire, Alberto Gobbi, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

C. Kissinger, Qiang Zhao, Yuefen Zhou, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.

Matthew A. Lardy, Yuefen Zhou, S. Webber, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.

Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity.

D. Murphy, R. Lehr, C. Faltynek, 1995, Biochemistry.