Lian-Sheng Li

发表

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.

Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2007 .

Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.

C. Barbas, R. Lerner, F. Tanaka, 2004, Chemistry.

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation

C. Barbas, R. Lerner, C. Liu, 2007, Proceedings of the National Academy of Sciences.

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qiang Zhao, 2009, Bioorganic & medicinal chemistry letters.

Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.

C. Barbas, R. Lerner, Lian-Sheng Li, 2004, Journal of medicinal chemistry.

Asymmetric epoxidation of alkenes catalysed by chromium binaphthyl Schiff base complex supported on MCM-41

C. Che, Lian-Sheng Li, Jie‐Sheng Huang, 1999 .

Steroid-fullerene adducts from Diels-Alder reactions: characterization and the effect on the activity of Ca^2+-ATPase

Lian-Sheng Li, J. Yue, Yu-lin Wu, 2001 .

Preparation of integrin α(v)β(3)-targeting Ab 38C2 constructs

C. Barbas, R. Lerner, Lian-Sheng Li, 2007, Nature Protocols.

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.

P. A. Thompson, J. Khandurina, C. Kissinger, 2009, Bioorganic & medicinal chemistry letters.

Recent Progress in Syntheses of Higher 3-Deoxy-2-ulosonic Acids and Their Derivatives

Lian-Sheng Li, Yu-lin Wu, Yu‐lin Wu, 2003 .

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

Jingjing Zhao, Matthew A. Lardy, Frank Ruebsam, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 3-deoxy-2-ulosonic acid KDO and 4-epi-KDN, a highly efficient approach of 3-C homologation by propargylation and oxidation

Lian-Sheng Li, Yu-lin Wu, Yu‐lin Wu, 2002 .

Synthesis and structure of new types of organogermanium compounds containing α‐amino acid or α‐aminophosphonic acid moieties

Lian-Sheng Li, Zhongbiao Zhang, Ruyu Chen, 1999 .

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.

C. Kissinger, Qing Han, Michael Noble, 2008, Bioorganic & medicinal chemistry letters.

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Yuefen Zhou, S. Webber, D. Murphy, 2009, Bioorganic & medicinal chemistry letters.

Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2008 .

Asymmetric hetero-Diels–Alder reaction of 1-alkyl-3-silyloxy-1,3-dienes with ethyl glyoxylate catalyzed by a chiral (salen)cobalt(II) complex

Lian-Sheng Li, Yu-lin Wu, Yikang Wu, 1998 .

An efficient method for synthesis of α-keto acid esters from terminal alkynes

Lian-Sheng Li, Yu-lin Wu, Yu‐lin Wu, 2002 .

A bidirectional approach to the synthesis of a complete library of adjacent-bis-THF annonaceous acetogenins.

Lian-Sheng Li, Sunny Abraham, S. Sinha, 2005, The Journal of organic chemistry.

Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach.

Lian-Sheng Li, S. Sinha, 2009, Tetrahedron letters.

Stereoselective aldol-type cyclization reaction mediated by dibutylboron triflate/diisopropylethylamine.

Lian-Sheng Li, S. Sinha, Sanjib Das, 2004, Organic letters.

Efficient one-step aldol-type reaction of ketones with acetals and ketals mediated by dibutylboron triflate/diisopropylethyl amine.

Lian-Sheng Li, S. Sinha, Sanjib Das, 2004, Organic letters.

Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters

Yuefen Zhou, D. Murphy, Lian-Sheng Li, 2008 .

A new Schiff base fluorescent-colorimetric probe containing fluorene-naphthalene structure: Multifunction detection

Lian-Sheng Li, Z. Chang, Changyan Sun, 2019 .

Synthesis and evaluation of photolabile insulin prodrugs.

R. Lerner, J. Olefsky, Lian-Sheng Li, 2005, Bioorganic & medicinal chemistry letters.

Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.

R. Lerner, S. Dutta, Lian-Sheng Li, 2004, Proceedings of the National Academy of Sciences of the United States of America.

4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qing Han, 2008, Bioorganic & medicinal chemistry letters.

An Efficient Approach to the Synthesis of Ethyl Esters of 2,6-Anhydro-3-deoxy-D-gluco and D-allo-Heptanoates.

Lian-Sheng Li, Yikang Wu, Yu‐lin Wu, 2000 .

Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Yuefen Zhou, S. Webber, D. Murphy, 2007 .

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

C. Kissinger, Qiang Zhao, Yuefen Zhou, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.

Matthew A. Lardy, Yuefen Zhou, S. Webber, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.